Article
Endocrinology & Metabolism
Elisa M. Ledet, Earle F. Burgess, Alexandra O. Sokolova, Ellen B. Jaeger, Whitley Hatton, Marcus Moses, Patrick Miller, Patrick Cotogno, Jodi Layton, Pedro Barata, Brian E. Lewis, Mari Nakazawa, Jason Zhu, Beth Dellinger, Sara Elrefai, Nellie N. Nafissi, Jan B. Egan, Neal Shore, Rana R. McKay, Alan H. Bryce, Heather H. Cheng, Emmanuel S. Antonarakis, Oliver Sartor
Summary: In metastatic prostate cancer patients, genetic variants did not significantly differ between different races, but BRCA1 variants were more common in African American patients, while variants in non-BRCA DNA repair genes were less likely to be found in African Americans. Family history was associated with genetic testing results in Caucasians only.
Article
Biochemistry & Molecular Biology
Anindita Ravindran, Danthasinghe Waduge Badrajee Piyarathna, Jie Gohlke, Vasanta Putluri, Tanu Soni, Stacy Lloyd, Patricia Castro, Subramaniam Pennathur, Jeffrey A. Jones, Michael Ittmann, Nagireddy Putluri, George Michailidis, Thekkelnaycke M. Rajendiran, Arun Sreekumar
Summary: African-American men are more likely to die of prostate cancer than European American men. This study reveals the association between lipid metabolic pathway alterations and prostate cancer disparities, as well as specific lipid changes associated with early biochemical recurrence.
Article
Oncology
Fei Ye, Xiaoxia Han, Yonzhao Shao, Jingzhi Lo, Fengxia Zhang, Jinhua Wang, Jonathan Melamed, Fang-Ming Deng, Karen S. Sfanos, Angelo De Marzo, Guoping Ren, Dongwen Wang, David Zhang, Peng Lee
Summary: This study identifies differential expression of Aurora, Cyclin D1, and HNF-3a proteins between African American and Caucasian prostate cancer tissue. These proteins may be involved in different pathways leading to aggressive prostate cancer behavior in African American patients and could potentially serve as biomarkers for prostate cancer racial disparity.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Colleen M. McBride, Sarita Pathak, Courtney E. Johnson, Anthony J. Alberg, Elisa V. Bandera, Jill S. Barnholtz-Sloan, Melissa L. Bondy, Michele L. Cote, Patricia G. Moorman, Lauren C. Peres, Edward S. Peters, Ann G. Schwartz, Paul D. Terry, Joellen M. Schildkraut
Summary: The study found that only a minority of African American women participants underwent genetic testing, with lower income and experiencing job discrimination decreasing the likelihood of testing. The results support the need for interventions to improve the uptake of genetic testing among African American women by reducing cost barriers and providing assurances that genetic results will be kept private.
Article
Multidisciplinary Sciences
Donghai Wang, Raag Agrawal, Shuli Zou, M. A. Haseeb, Raavi Gupta
Summary: Among all racial groups in the U.S., African Americans have the highest incidence and mortality from colorectal cancer. Socioeconomic factors are major contributors to racial disparities in CRC, but biological differences are also significant. African American patients with CRC have distinct clinicopathologic features, including a higher frequency of KRAS mutation, which may contribute to their poorer outcomes compared to white patients.
Review
Oncology
Claire Stevens, Alexandria Hightower, Sarah G. Buxbaum, Sara M. Falzarano, Suhn K. Rhie
Summary: Prostate cancer is the second most common cancer in men in the United States, and racial disparities are greatly observed in the disease. In order to narrow the gap between clinical outcomes for African American and European American prostate cancer patients, genetic and molecular signatures contributing to this disparity have been characterized.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Maeve Kiely, Stefan Ambs
Summary: Men of African descent have a higher mortality rate from prostate cancer, which may be related to differences in disease biology and risk factor exposure. Inflammation and immune response are suggested to play a role in prostate cancer disparities, with potential for new intervention strategies. Targeting these immunogenic and inflammatory vulnerabilities could improve survival outcomes for African American men with prostate cancer.
Article
Medicine, General & Internal
Margaret S. Pichardo, Tsion Zewdu Minas, Catherine M. Pichardo, Maeve Bailey-Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Brid M. Ryan, Christopher A. Loffredo, Stefan Ambs
Summary: This study found that African American men living in deprived neighborhoods have a higher risk of prostate cancer and related mortality, potentially due to their systemic immune function and inflammation levels.
Article
Oncology
Michal Marczyk, Tao Qing, Tess O'Meara, Vesal Yagahoobi, Vasiliki Pelekanou, Yalai Bai, Emily Reisenbichler, Kimberly S. Cole, Xiaotong Li, Vignesh Gunasekharan, Eiman Ibrahim, Kristina Fanucci, Wei Wei, David L. Rimm, Lajos Pusztai, Kim R. M. Blenman
Summary: Differences in the tumor immune microenvironment may exist between African American and NonAA breast cancer patients, which may impact treatment response and prognosis.
Article
Multidisciplinary Sciences
Amr Elkholy, Nagavardhini Avuthu, Mohammed Abdalla, Michael Behring, Prachi Bajpai, Hyung-Gyoon Kim, Doaa Header, Reham AH. Abo Elwafa, Hesham Saed, Amira Embaby, Nefertiti El-Nikhely, Sarah Obuya, Mostafa Mohamed, Ahmed Ashour Badawy, Ahmed Nawar, Farrukh Afaq, Laura Q. Rogers, Sejong Bae, James M. Shikany, Lori Brand Bateman, Mona Fouad, Mansoor Saleh, Temesgen Samuel, Sooryanarayana Varambally, Chittibabu Guda, Waleed Arafat, Upender Manne
Summary: Microbiome dysbiosis in colorectal cancer (CRC) patients varies among Egyptian, African American (AA), and European American (EA) populations. Analysis of samples from these populations revealed differences in microbiome composition and metabolic pathways. These findings provide a basis for future studies linking racial/ethnic microbiome differences with distinct clinical behaviors in CRC.
Article
Oncology
Xue Qin Yu, David Goldsbury, Eleonora Feletto, Cherry E. Koh, Karen Canfell, Dianne L. O'Connell
Summary: The study quantified the contributions of prognostic factors to socioeconomic disparities in colorectal cancer survival, with disease-related factors explaining a large proportion of survival differences for both colon and rectal cancers. Neighbourhood socioeconomic measures played a significant role in colon cancer survival differences, while patient- and disease-related factors were main drivers for rectal cancer. Improving access to optimal care may help reduce these survival disparities.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Oncology
Pranabananda Dutta, Man Y. Keung, Yanyuan Wu, Jaydutt V. Vadgama
Summary: This study examined the genetic makeup of breast cancers in African-American and Hispanic/Latinx patients, and identified specific genetic mutations associated with breast cancer in these minority populations. The results showed common mutations across both ethnicities, but there were also differences in specific genetic variants.
Article
Oncology
Gaurav Kumar, Jungyoon Kim, Paraskevi A. Farazi, Hongmei Wang, Dejun Su
Summary: This study found that compared to White cancer survivors, African American cancer survivors had lower awareness of and willingness to participate in CCTs. These differences may be related to the differential perception of CCTs, psychosocial factors, and trust in physicians between the two groups.
Article
Oncology
Shivanshu Awasthi, Anders Berglund, Julieta Abraham-Miranda, Robert J. Rounbehler, Kevin Kensler, Amparo Serna, Adriana Vidal, Sungyong You, Michael R. Freeman, Elai Davicioni, Yang Liu, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Bruce J. Trock, Joshua D. Campbell, David J. Einstein, Raavi Gupta, Steven Balk, Priti Lal, Jong Y. Park, John L. Cleveland, Timothy R. Rebbeck, Stephen J. Freedland, Kosj Yamoah
Summary: Prostate tumors in African American men exhibit a unique immune profile with significant enrichment in proinflammatory immune pathways. The tumor microenvironment of African American men shows higher immune content compared to European American men, as well as lower DNA damage repair and increased genomic radiosensitivity. Overexpression of proinflammatory genes in African American men, such as IFITM3, is associated with higher risk of biochemical recurrence and poorer outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kazim Husain, Domenico Coppola, Chung S. Yang, Mokenge P. Malafa
Summary: FDMC inhibits the growth and metastasis of colon cancer stem cells, reducing key processes of tumor growth and metastasis, and exhibiting anti-tumor effects in in vivo models.
SCIENTIFIC REPORTS
(2021)