Article
Biotechnology & Applied Microbiology
Wei Zhao, Jingwen Liu, Jie Wu, Xiaozhou Ma, Xi Wang, Leyu Zhang, Zhe Han, Jianming Yang, Yameng Cui, Xin Hu, Jiayin Deng
Summary: This study preliminarily demonstrates the characteristics of m(6)A-circRNAs in oral squamous cell carcinoma, providing insights into the roles of m(6)A-circRNAs in this cancer.
Article
Dentistry, Oral Surgery & Medicine
Zhihong Xu, Xiaodong Li, Lanlan Pan, Ruolan Tan, Ping Ji, Han Tang
Summary: A signature based on lncRNAs was established to accurately predict the prognosis of oral squamous cell carcinoma (OSCC) patients. The signature consisting of 14 potential lncRNAs divided patients into low- and high-risk subgroups with different survival times, while also showing significant immune cell infiltration in the low-risk group. Furthermore, a regulatory network involving lncRNAs and protein-coding genes related to immune processes was constructed, providing new insights for clinical management and potential immunotherapy in OSCC patients.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Review
Medicine, General & Internal
Qingjie Lin, Yong Zhang, Yanguo Liu, Xin Xu
Summary: This study provides a comprehensive review of the impact of lncRNA on the prognosis and clinicopathological features of oral squamous cell carcinoma.
The results of this study could serve as important references for the treatment and clinical management of patients with oral squamous cell carcinoma.
Article
Immunology
Chen Zou, Siyuan Wu, Haigang Wei, Hailing Luo, Zhe Tang, Xia Li, Xiaozhi Lv, Yilong Ai
Summary: The study found that overexpression of LINC01355 in oral squamous cell carcinoma (OSCC) cells, and its impact on the antitumor activity of CD8+ T cells. Silencing LINC01355 could inhibit OSCC tumor growth by enhancing the immune response of CD8+ T cells.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Alina Isakova, Norma Neff, Stephen R. Quake
Summary: Smart-seq-total is a method capable of assaying a broad spectrum of coding and noncoding RNA from a single cell, outperforming current RNA-seq protocols by capturing a wide range of transcripts. By analyzing the total RNAome of single cells, it can reveal new roles of noncoding RNA in essential processes such as cell cycle and embryonic development, as well as determine cell-type identity using different classes of short-noncoding RNA.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Min Su, Jinming Tang, Baihua Zhang, Desong Yang, Zhining Wu, Jie Wu, Yong Zhou, Qianjin Liao, Hui Wang, Wenxiang Wang, Yuhang Xiao
Summary: This study demonstrates that GACAT3 acts as an oncogene in ESCC by interacting with miR-149 to promote tumor progression, and also functions as a ceRNA to modulate FOXM1 expression. These findings suggest that GACAT3 may serve as a potential therapeutic target in ESCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Sebastian Blatt, Maximilian Krueger, Kawe Sagheb, Marie Barth, Peer W. Kaemmerer, Bilal Al-Nawas, Keyvan Sagheb
Summary: Tumor recurrence is common in oral squamous cell carcinoma (OSCC), with clinical examination being the primary detection method. 24% of recurrences were detected within the first 12 months. Lymph node metastasis and histopathological grading are significantly correlated with tumor recurrence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Yue Li, Boyu Chen, Xingyu Jiang, Yudong Li, Xin Wang, Shumei Huang, Xuxia Wu, Yunyun Xiao, Dongni Shi, Xinjian Huang, Lixin He, Xiangfu Chen, Ying Ouyang, Jun Li, Libing Song, Chuyong Lin
Summary: Wnt signaling induces a splicing switch of lncRNA-DGCR5, leading to the generation of a short variant (DGCR5-S) that is associated with poor prognosis in esophageal squamous cell carcinoma (ESCC). DGCR5-S inhibits TTP's anti-inflammatory activity by protecting it from PP2A-mediated dephosphorylation, thereby promoting tumor-promoting inflammation. Synthetic splice-switching oligonucleotides (SSOs) disrupt the splicing switch of DGCR5 and effectively suppress ESCC tumor growth.
Article
Biochemistry & Molecular Biology
Jinfeng Zhang, Xiaodong Ling, Chengyuan Fang, Jianqun Ma
Summary: This study identified an eight-lncRNA signature that can be used for the diagnosis and treatment of esophageal squamous cell carcinoma. Further functional experiments revealed that one of the lncRNAs (LINC00470) plays a crucial role in cell proliferation and migration.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jie Deng, Yiqun Wang, Sheng Zhang, Lin Chen
Summary: This study investigates the role of lncRNA-AC103563.8 in promoting oral squamous cell carcinoma (OSCC) development and explores its mechanism. The upregulation of lncRNA-AC103563.8 in OSCC tissue is observed, and it is found to promote cell invasion and metastasis. The study also identifies proteins that directly bind to lncRNA-AC103563.8 and explores their involvement in various biological processes.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Oncology
Yunfeng Niu, Gaoyan Wang, Yan Li, Wei Guo, Yanli Guo, Zhiming Dong
Summary: FOXP4-AS1 is significantly increased in ESCC tissues and cell lines, promoting proliferation, invasion, and migration of ESCC cells. It upregulates FOXP4 expression by enriching MLL2 and H3K4me3 in the FOXP4 promoter through a molecular scaffold, ultimately leading to malignant progression of ESCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zehang Zhuang, Jing Huang, Weiwang Wang, Cheng Wang, Pei Yu, Jing Hu, Haichao Liu, Hanqi Yin, Jinsong Hou, Xiqiang Liu
Summary: This study identified a differentiation-related lncRNA, TINCR, in oral squamous cell carcinoma (OSCC). TINCR was found to be downregulated in tumor tissues and correlated with pathological differentiation and lymph node metastasis. Function experiments showed that TINCR played a crucial role in cell differentiation and suppressed cell migration and invasion in OSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chandra Sekhar Bhol, Soumya Ranjan Mishra, Shankargouda Patil, Sunil Kumar Sahu, R. Kirtana, Soumen Manna, Muthu Kumaraswamy Shanmugam, Gautam Sethi, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: Procaine inhibits DNA methylation by suppressing DNMT activity and increases the expression of PAX9 in oral squamous cell carcinoma cells, triggering an anticancer mechanism and potentially offering a new therapeutic strategy for OSCC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xiao-Feng Cui, Si-Lin Zhang, Wei-Ping Wang, Xiao-Wu Huang, Xiang-Jun Chen
Summary: In this study, key long noncoding RNAs (lncRNAs) involved in the competitive endogenous RNA (ceRNA) network associated with laryngeal squamous cell carcinoma (LSCC) were investigated. Through functional enrichment analysis and construction of the ceRNA regulatory network, the functions of these lncRNAs and their importance in LSCC were determined. The results were further validated by quantitative real-time polymerase chain reaction (qRT-PCR) analysis.
Article
Genetics & Heredity
Xu Zhao, Yulun Wang, Fanbiao Meng, Zhuang Liu, Bo Xu
Summary: A risk model composed of autophagy-related lncRNAs is established as a potential biomarker for esophageal squamous cell carcinoma (ESCC) risk stratification. The risk model provides a useful tool for predicting prognosis and may provide novel targets for ESCC treatment.
FRONTIERS IN GENETICS
(2022)
Article
Biotechnology & Applied Microbiology
Shuai Sun, Bowen Li, Yufan Wang, Xiang Li, Panpan Wang, Feng Wang, Wei Zhang, Hongyu Yang
Article
Biotechnology & Applied Microbiology
Bowen Li, Feng Wang, Xiang Li, Shuai Sun, Yuehong Shen, Hongyu Yang
Article
Immunology
Zhanpeng Ou, Ling Qiu, Haixu Rong, Bowen Li, Siqi Ren, Shijia Kuang, Tianjun Lan, Hsinyu Lin, Qunxing Li, Fan Wu, Tingting Cai, Lingjian Yan, Yushan Ye, Song Fan, Jinsong Li
Summary: CAR-based immunotherapy is a promising treatment for cancer patients, and there is an emerging movement toward using advanced gene modification technologies to overcome therapeutic challenges, especially in solid tumors, and to generate safer and more effective universal CAR-engineered cell products.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Lizao Zhang, Bowen Li, Yu Peng, Fan Wu, Qunxing Li, Zhaoyu Lin, Shule Xie, Liping Xiao, Xinyu Lin, Zhanpeng Ou, Tingting Cai, Haixu Rong, Song Fan, Jinsong Li
