Review
Cell & Tissue Engineering
Yufeng Xi, Guang Yue, Shuqiang Gao, Rong Ju, Yujia Wang
Summary: Perinatal brain injury is a major cause of death and disability in children. Transplantation of human umbilical cord blood mononuclear cells has shown significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biology
Seeta Devi, Anupkumar M. Bongale, Minyechil Alehegn Tefera, Prashant Dixit, Prasad Bhanap
Summary: Umbilical cord blood is being increasingly used as a source of hematopoietic cells for regenerative medicine, particularly in Asian countries. This article reviews the collection, banking, and cryopreservation methods for umbilical cord blood, and also discusses the use of mesenchymal stem cells in transplantation medicine. Understanding the protocols for collecting, transporting, and storing umbilical cord blood is essential for healthcare professionals, especially those working in maternity wards.
Article
Obstetrics & Gynecology
Patricia Farina-Eckhardt, Cristina Granado, Doris Mueller-Borer, Andreas Schotzau, Dimitrios A. Tsakiris, Irene Hosli, Gwendolin Manegold-Brauer
Summary: The study found that factors associated with higher TNC counts in umbilical cord blood donations may include maternal age, BMI, parity, gestational diabetes, gestational week, birth weight, and mode of delivery.
ZEITSCHRIFT FUR GEBURTSHILFE UND NEONATOLOGIE
(2022)
Review
Obstetrics & Gynecology
Jessica Laue, Johanna Ambuhl, Daniel Surbek
Summary: Hybrid banking is a combination of public and private cord blood banks, aiming to find an optimized solution. However, there is a lack of literature about this novel model of cord blood banking. This literature review assesses different options of umbilical cord blood banking and whether hybrid banking could be a valuable alternative to the existing models.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Multidisciplinary Sciences
Dhanny Primantara Johari Santoso, Annisa Dewi Nugrahani, Amillia Siddiq, Akhmad Yogi Pramatirta, Muhammad Alamsyah Aziz, Setyorini Irianti, Adhi Pribadi, Anita Deborah Anwar, Jusuf Sulaeman Effendi
Summary: The use of magnesium sulfate treatment in preterm delivery can decrease umbilical cord GFAP levels, but there is no correlation between magnesium and calcium levels and GFAP levels.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ximena Bonilla, Ana Milena Lara, Manuela Llano-Leon, David A. Lopez-Gonzalez, David G. Hernandez-Mejia, Rosa Helena Bustos, Bernardo Camacho-Rodriguez, Ana-Maria Perdomo-Arciniegas
Summary: Umbilical cord blood is an important source of hematopoietic stem and progenitor cells, and recent research has focused on developing ex vivo expansion strategies for these cells. Co-culturing the cells with specific mesenchymal stromal cells has been found to significantly increase their cellular dose and regulate their proliferation capacity. Additionally, the secretory profile of umbilical cord blood-derived cells closely resembles that of bone marrow-derived cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Elisha Purcell, Timothy Nguyen, Madeleine Smith, Tayla Penny, Madison C. B. Paton, Lindsay Zhou, Graham Jenkin, Suzanne L. Miller, Courtney A. McDonald, Atul Malhotra
Summary: This study systematically reviewed the effects of UCBCs on brain outcomes in animal models of perinatal brain injury. It found differential benefits of UCBCs across different subgroups, such as greater efficacy in IVH model compared to HI model, UCB-MSCs compared to UCB-MNCs, and local administrative routes compared to systemic routes. However, the study identified a serious risk of bias and overall low certainty of evidence.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Joanie Hare, Paulina Garcia DeLeon, Krystle Pool, Donna Reioux, Milford Fontenot, Richard E. Champlin, Erin N. Eaton, David Marin, Katayoun Rezvani, Elizabeth J. Shpall, Jeffrey M. Wilson, Chitra Hosing
Summary: The success of umbilical cord blood transplant depends on the dose of total nucleated and CD34+ cells infused, highlighting the importance of collecting high-quality cord blood units with high cell doses. Maternal gestational age and race, and neonatal weight and sex were found to correlate with the total nucleated cell dose, emphasizing the impact of these factors on cell dose. Optimized collection of umbilical cord blood is crucial for its use as a source of stem cells for transplantation.
Review
Genetics & Heredity
Paz de la Torre, Ana I. Flores
Summary: The placenta, a temporary organ discarded after birth, is a promising source of cells and tissues for regenerative medicine and tissue engineering. Different perinatal tissues contain various stem cells that can be used for cell therapy and regenerative medicine, with cord blood being the primary source. These perinatal stem cells have been used in clinical trials for over 30 years to treat various disorders, with a special focus on mesenchymal stromal cells. Research on the clinical applications and potential of perinatal derived cells is ongoing, particularly in the context of treating COVID19 pneumonia. Technologies in the field of perinatal stem cells are advancing rapidly, offering new opportunities and facing challenges.
Review
Cell Biology
Huagui Huang, Xin Liu, Jinzuo Wang, Moran Suo, Jing Zhang, Tianze Sun, Wentao Zhang, Zhonghai Li
Summary: Intervertebral disc degeneration is a complex and not yet fully understood cause of low back pain. In recent years, mesenchymal stem cells derived from the fetal umbilical cord have shown promising results in regenerating intervertebral discs. These cells have excellent characteristics and can potentially replace the commonly used sources of mesenchymal stem cells. However, the survival of umbilical cord mesenchymal stem cells within the disc is crucial for their regenerative capacity, and biomaterial scaffolds have shown potential in aiding their survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell & Tissue Engineering
Gabriela Sanchez-Petitto, Katayoun Rezvani, May Daher, Hind Rafei, Partow Kebriaei, Elizabeth J. Shpall, Amanda Olson
Summary: Umbilical cord blood transplantation is an attractive alternative source of hematopoietic stem cells, with unique immune tolerance and engraftment kinetics. It has a lower risk of GvHD and comparable clinical outcomes to bone marrow transplantation. However, limitations in cell numbers and delayed engraftment pose challenges for its wider application. Research is being conducted to address these limitations and explore the potential of cord blood in treating various disorders.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Serena Barachini, Marina Montali, Francesca M. Panvini, Vittoria Carnicelli, Gian Luca Gatti, Nicola Piolanti, Enrico Bonicoli, Michelangelo Scaglione, Gabriele Buda, Paolo D. Parchi
Summary: Mesangiogenic progenitor cells (MPCs) isolated from human bone marrow mononuclear cells have the ability to differentiate into mesenchymal stromal cells while retaining endothelial differentiative potential. Their power to couple mesengenesis and angiogenesis highlights their tissue regenerative potential, particularly in musculoskeletal tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Lindsay Zhou, Courtney McDonald, Tamara Yawno, Graham Jenkin, Suzanne Miller, Atul Malhotra
Summary: Cell therapies using umbilical cord blood and cord tissue have emerged as a promising approach for preventing and treating neonatal morbidities. Published clinical studies mainly focus on safety and feasibility, with limited assessment of efficacy. There are ongoing trials investigating the potential of these therapies in neonates.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Cell Biology
Yufeng Shang, Haotong Guan, Fuling Zhou
Summary: Umbilical cord mesenchymal stem cells (UC-MSCs) have the characteristics of inhibiting tumor cell proliferation and migration, supporting hematopoietic microenvironment, and suppressing the immune system, showing great potential in the treatment of hematologic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pediatrics
Wai Kit Chia, Fook Choe Cheah, Nor Haslinda Abdul Aziz, Nirmala Chandralega Kampan, Salwati Shuib, Teck Yee Khong, Geok Chin Tan, Yin Ping Wong
Summary: Bronchopulmonary dysplasia (BPD) is a devastating lung disorder in preterm infants caused by abnormal reparative response, and current treatment strategies have limited success. Stem cell therapy, particularly using placenta-derived and umbilical cord-derived stem cells, shows potential in mitigating BPD, but further research and clinical trials are needed to confirm its effectiveness.
FRONTIERS IN PEDIATRICS
(2021)
