Metformin Promotes Osteogenic Differentiation of Adipose-Derived Stromal Cells and Exerts Pro-Osteogenic Effect Stimulating Bone Regeneration

Revisiting the Advances in Isolation, Characterization and Secretome of Adipose-Derived Stromal/Stem Cells

(2018) Navneet Dubey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant and Anti-Senescence Effect of Metformin on Mouse Olfactory Ensheathing Cells (mOECs) May Be Associated with Increased Brain-Derived Neurotrophic Factor Levels—An Ex Vivo Study

(2017) Agnieszka Śmieszek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced cytocompatibility and osteoinductive properties of sol–gel-derived silica/zirconium dioxide coatings by metformin functionalization

(2017) Agnieszka Śmieszek et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells

(2017) Ping Wang et al.   Journal of Tissue Engineering and Regenerative Medicine

Ultrastructural changes during osteogenic differentiation in mesenchymal stromal cells cultured in alginate hydrogel

(2017) Jakub Grzesiak et al.   Cell and Bioscience

AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity

(2016) Ting Luo et al.   DIABETES

Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose-Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone Density In Vivo

(2016) Krzysztof Marycz et al.   Oxidative Medicine and Cellular Longevity

Potential Biomedical Application of Enzymatically Treated Alginate/Chitosan Hydrosols in Sponges—Biocompatible Scaffolds Inducing Chondrogenic Differentiation of Human Adipose Derived Multipotent Stromal Cells

(2016) Anna Zimoch-Korzycka et al.   Polymers

The pleiotropic effects of metformin: time for prospective studies

(2015) Daniel I Bromage et al.   Cardiovascular Diabetology

Increased osteogenesis in osteoporotic bone marrow stromal cells by overexpression of leptin

(2015) Baoyu Zheng et al.   CELL AND TISSUE RESEARCH

The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells – new opportunities in regenerative medicine

(2015) Krzysztof Marycz et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms

(2015) Vincenza Cifarelli et al.   DIABETES

Pleiotropic Benefits of Metformin: Macrophage Targeting Its Anti-inflammatory Mechanisms: Figure 1

(2015) Yuichi Hattori et al.   DIABETES

Metformin and other antidiabetic agents in renal failure patients

(2015) Jean-Daniel Lalau et al.   KIDNEY INTERNATIONAL

Burden of high fracture probability worldwide: secular increases 2010–2040

(2015) A. Odén et al.   OSTEOPOROSIS INTERNATIONAL

Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy

(2015) Chun-yu Li et al.   Stem Cell Research & Therapy

In VitroandIn VivoEffects of Metformin on Osteopontin Expression in Mice Adipose-Derived Multipotent Stromal Cells and Adipose Tissue

(2015) Agnieszka Śmieszek et al.   Journal of Diabetes Research

Evaluation of the anti-osteoporotic effects of metformin and sitagliptin in postmenopausal diabetic women

(2014) Sahar Kamal Hegazy   JOURNAL OF BONE AND MINERAL METABOLISM

Metformin Attenuates Experimental Autoimmune Arthritis through Reciprocal Regulation of Th17/Treg Balance and Osteoclastogenesis

(2014) Hye-Jin Son et al.   MEDIATORS OF INFLAMMATION

The anti-diabetic drug metformin does not affect bone mass in vivo or fracture healing

(2013) J. Jeyabalan et al.   OSTEOPOROSIS INTERNATIONAL

The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)—quality of life during the first 4 months after fracture

(2013) F. Borgström et al.   OSTEOPOROSIS INTERNATIONAL

Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells

(2012) Aleksandar Pantovic et al.   BONE

A randomized, parallel group, double-blind, multicentre study comparing the efficacy and safety of Avandamet (rosiglitazone/metformin) and metformin on long-term glycaemic control and bone mineral density after 80 weeks of treatment in drug-naïve type 2 d

(2011) J. L. C. Borges et al.   DIABETES OBESITY & METABOLISM

Metformin prevents anti-osteogenic in vivo and ex vivo effects of rosiglitazone in rats

(2011) Claudia Sedlinsky et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adipose-derived stromal cells: Their identity and uses in clinical trials, an update

(2011) Louis Casteilla   World Journal of Stem Cells

Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma

(2010) Philipp Niemeyer et al.   BIOMATERIALS

BoneJ: Free and extensible bone image analysis in ImageJ

(2010) Michael Doube et al.   BONE

Effect of the anti-diabetic drug metformin on bone mass in ovariectomized rats

(2010) Ying Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells

(2010) Ying Gao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effect of metformin on bone marrow progenitor cell differentiation: In vivo and in vitro studies

(2009) M Silvina Molinuevo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes

(2008) Yanfang Guo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression

(2008) Ippei Kanazawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS