Article
Clinical Neurology
Shadi Ziaie, Niloofar Namazi, Golnaz Afzal, Saghar Barati, Rezvaneh Mohebbi, Mahshad Mir, Hadi Esmaily, Gholamhossein Mehralian
Summary: The majority of multiple sclerosis patients use dietary supplements, but the number and duration of supplement use do not improve quality of life, and herbal supplements also fail to enhance quality of life.
Article
Pharmacology & Pharmacy
Chantal Cossette, Lisa A. Miller, Qiuji Ye, Shishir Chourey, Chintam Nagendra Reddy, Joshua Rokach, William S. Powell
Summary: The study found that the selective OXE receptor antagonist S-Y048 can inhibit allergen-induced pulmonary inflammation, reducing the numbers of eosinophils and neutrophils. This research provides evidence for the role of 5-oxo-ETE in the pathogenesis of diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Andrea Giordano, Silvia Testa, Marta Bassi, Sabina Cilia, Antonio Bertolotto, Maria Esmeralda Quartuccio, Erika Pietrolongo, Monica Falautano, Monica Grobberio, Claudia Niccolai, Beatrice Allegri, Rosa Gemma Viterbo, Paolo Confalonieri, Ambra Mara Giovannetti, Eleonora Cocco, Maria Grazia Grasso, Alessandra Lugaresi, Elisa Ferriani, Ugo Nocentini, Mauro Zaffaroni, Alysha De Livera, George Jelinek, Alessandra Solari, Rosalba Rosato
Summary: The study evaluated the performance of a bifactor model in explaining the structure of MSQOL-54, and found that the bifactor model outperformed other models in all statistics. All items, except for sexual function items, loaded satisfactorily onto the general HRQOL factor. The total score showed very satisfactory Omega coefficients, indicating that it can be used as an estimate of the general HRQOL latent score.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Health Care Sciences & Services
Andrea Giordano, Silvia Testa, Marta Bassi, Sabina Cilia, Antonio Bertolotto, Maria Esmeralda Quartuccio, Erika Pietrolongo, Monica Falautano, Monica Grobberio, Claudia Niccolai, Beatrice Allegri, Rosa Gemma Viterbo, Paolo Confalonieri, Ambra Mara Giovannetti, Eleonora Cocco, Maria Grazia Grasso, Alessandra Lugaresi, Elisa Ferriani, Ugo Nocentini, Mauro Zaffaroni, Alysha De Livera, George Jelinek, Alessandra Solari, Rosalba Rosato
Summary: This study evaluated the performance of MCAT on the MSQOL-54 and found that it had satisfactory performance in assessing the quality of life of patients with multiple sclerosis. Compared to the full-length MSQOL-54, the simulated MCAT required fewer items without losing precision for the general HRQOL factor.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Review
Nutrition & Dietetics
Jose Enrique de la Rubia Orti, Maria Cuerda-Ballester, Claudia Emmanuela Sanchis-Sanchis, Jose Maria Lajara Romance, Esther Navarro-Illana, Maria Pilar Garcia Pardo
Summary: This article discusses the impact of ketogenic diet (KD) on emotional symptoms in patients with multiple sclerosis (MS). The study found that KD can improve glutamate activity and reduce central inflammation by reducing obesity, improving insulin resistance, and dyslipidemia. This improvement may alleviate functional disability and emotional disorders such as anxiety and depression by reducing extrasynaptic glutamate activity.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Morteza Hassanzadeh, Seyed Mohsen Banitaba, Shadi Azizi
Summary: The present study aims to translate and validate a Persian version of MSQOL-29 (P-MSQOL-29). Results showed that P-MSQOL-29 is a valid and reliable questionnaire, and can be used for assessing quality of life in patients with multiple sclerosis.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Chemistry, Multidisciplinary
Yipeng Zhao, Jie Zhang, Xi Cheng, Wenping Huang, Shishi Shen, Shilin Wu, Yiying Huang, Guangjun Nie, Hai Wang, Wei Qiu
Summary: A nanoplatform is developed for delivering immunosuppressive drugs to lymph nodes, allowing for durable treatment of multiple sclerosis (MS). The nanoparticles, modified with human CD47 peptide and L-selectin targeting aptamer, efficiently deliver FTY720 to lymph nodes and delay disease progression in experimental autoimmune encephalomyelitis (EAE) mice. This targeted lymph nodes delivery strategy greatly improves therapeutic efficiency and may extend the treatment cycle of immunosuppressive drugs for durable MS treatment.
Review
Nutrition & Dietetics
Danila Di Majo, Francesco Cacciabaudo, Giulia Accardi, Giuditta Gambino, Giuseppe Giglia, Giuseppe Ferraro, Giuseppina Candore, Pierangelo Sardo
Summary: Ketogenic Diet is a dietary therapy often used in the treatment of inflammatory neurological disorders. This research focuses on investigating the cognitive impairments and neuroprotection in multiple sclerosis (MS) by analyzing the alteration of biomarkers. The proposed ketogenic diet combined with a modified Mediterranean diet could potentially improve neuroinflammation in MS.
Article
Biochemistry & Molecular Biology
Meijuan Bai, Yan Wang, Ruomei Han, Lijiao Xu, Meiqin Huang, Jingyu Zhao, Yijun Lin, Shuo Song, Yan Chen
Summary: Intermittent caloric restriction through a modified fasting-mimicking diet was effective in treating autoimmune encephalomyelitis (EAE) by reducing disease severity, immune cell infiltration, and demyelination, while promoting tissue recovery.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Review
Nutrition & Dietetics
Wei-Sheng Lin, Shan-Ju Lin, Pei-Yin Liao, Divya Suresh, Ting-Rong Hsu, Pei-Yu Wang
Summary: The ketogenic diet shows promise as a safe and potentially effective therapy for multiple sclerosis, but more research is needed to confirm its effects and mechanisms.
ADVANCES IN NUTRITION
(2022)
Article
Clinical Neurology
Unsong Oh, Emma Woolbright, Diana Lehner-Gulotta, Rachael Coleman, Mark Conaway, Myla D. Goldman, J. Nicholas Brenton
Summary: This study investigated the impact of ketogenic diets on the biomarker of neuroaxonal injury, neurofilament light chain (NfL), in patients with multiple sclerosis (MS). The results showed that ketogenic diets did not worsen the biomarkers of neurodegeneration in MS patients and NfL levels remained stable and low during the diet intervention. Furthermore, patients with higher levels of ketosis experienced a greater reduction in NfL levels during the ketogenic diet.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Review
Neurosciences
Malvina Hoxha, Erila Spahiu, Emanuela Prendi, Bruno Zappacosta
Summary: This systematic review examined the potential association between the arachidonic acid pathway and multiple sclerosis (MS) through in vivo animal studies and human clinical trials. The findings suggested that arachidonic acid mediators play significant roles in MS and modulate disease progression. Inhibitors of COX and LOX were found to have beneficial effects in treating MS, and hybrid compounds may offer an innovative approach for treatment.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Article
Neurosciences
L. Majernikova, A. Hudakova, A. Obrocnikova
Summary: The study aims to validate the linguistic and cultural adaptation of the Multiple Sclerosis Quality of Life Questionnaire - 54 (MSQOL-54). Using principal component analysis and confirmatory factor analysis, the study confirms the construct validity and reliability of the questionnaire. The results show significant correlations between the duration of multiple sclerosis and quality of life.
CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE
(2023)
Article
Medicine, Research & Experimental
Shan Jing, Wenfang Liu, Kexu Yang, Yang Lin, Xuekun Yao, Guilan Sun
Summary: The pharmacokinetics, safety, and tolerability of CSPCHA115 in Chinese healthy subjects were evaluated in single and multiple ascending dose studies. CSPCHA115 was rapidly absorbed with dose-proportional systemic exposure. The drug was well-tolerated with a low incidence of adverse events in healthy subjects.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Clinical Neurology
Giovanni Merlino, Riccardo Garbo, Simone Dal Bello, Ilaria Del Negro, Eleonora Lamon, Francesca Filippi, Andrea Bernardini, Simone Lorenzut, Laura Ceccarelli, Arianna Cella, Alessandro Mar, Yan Tereshko, Gian Luigi Gigli, Mariarosaria Valente
Summary: This study found that the ketogenic diet (KD) may improve sleep complaints in patients with multiple sclerosis (MS) and have a positive impact on their psychological status and quality of life (QoL) through improving sleep quality.
Article
Cell Biology
In Young Choi, Laura Piccio, Patra Childress, Bryan Bollman, Arko Ghosh, Sebastian Brandhorst, Jorge Suarez, Andreas Michalsen, Anne H. Cross, Todd E. Morgan, Min Wei, Friedemann Paul, Markus Bock, Valter D. Longo
Article
Microbiology
Alexander Swidsinski, Yvonne Doerffel, Vera Loening-Baucke, Christoph Gille, Oender Goektas, Anne Reisshauer, Juergen Neuhaus, Karsten-Henrich Weylandt, Alexander Guschin, Markus Bock
FRONTIERS IN MICROBIOLOGY
(2017)
Article
Ophthalmology
Markus Bock, Alexander U. Brandt, Joern Kuchenbecker, Jan Doerr, Caspar F. Pfueller, Nicholetta Weinges-Evers, Gunnar Gaede, Hanna Zimmermann, Judith Bellmann-Strobl, Stephanie Ohlraun, Frauke Zipp, Friedemann Paul
BRITISH JOURNAL OF OPHTHALMOLOGY
(2012)
Article
Clinical Neurology
Markus Bock, Alexander U. Brandt, Jan Doerr, Helga Kraft, Nicholetta Weinges-Evers, Gunnar Gaede, Caspar F. Pfueller, Katja Herges, Helena Radbruch, Stephanie Ohlraun, Judith Bellmann-Strobl, Joern Kuchenbecker, Frauke Zipp, Friedemann Paul
CLINICAL NEUROLOGY AND NEUROSURGERY
(2010)
Article
Clinical Neurology
Markus Bock, Alexander Ulrich Brandt, Jan Doerr, Caspar F. Pfueller, Stephanie Ohlraun, Frauke Zipp, Friedemann Paul
MULTIPLE SCLEROSIS JOURNAL
(2010)
Article
Clinical Neurology
Jan Doerr, Helena Radbruch, Markus Bock, Jens Wuerfel, Anne Brueggemann, Klaus P. Wandinger, Daniel Zeise, Caspar F. Pfueller, Frauke Zipp, Friedemann Paul
NATURE REVIEWS NEUROLOGY
(2009)
Article
Medicine, Research & Experimental
Markus Bock, Andreas Eisenschenk, Heiko Lorenzen, Martin Lautenbach