Fluorine-19 MRI for detection and quantification of immune cell therapy for cancer

19F-perfluorocarbon-labeled human peripheral blood mononuclear cells can be detected in vivo using clinical MRI parameters in a therapeutic cell setting

(2018) Corby Fink et al.   Scientific Reports

Rapid quantification of inflammation in tissue samples using perfluorocarbon emulsion and fluorine-19 nuclear magnetic resonance

(2018) Eric T. Ahrens et al.   BIOTECHNIQUES

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

(2017) Donald M. O’Rourke et al.   Science Translational Medicine

Labeling of cell therapies: How can we get it right?

(2017) Sonia Waiczies et al.   OncoImmunology

Quantifying tumor associated macrophages in breast cancer: a comparison of iron and fluorine-based MRI cell tracking

(2017) Ashley V. Makela et al.   Scientific Reports

Fluorine-19 nuclear magnetic resonance of chimeric antigen receptor T cell biodistribution in murine cancer model

(2017) Fanny Chapelin et al.   Scientific Reports

ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas

(2016) M.-C. Ku et al.   MOLECULAR CANCER THERAPEUTICS

Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging

(2016) Alexander A. Kislukhin et al.   NATURE MATERIALS

19F-MRI for monitoring human NK cellsin vivo

(2016) Myriam N. Bouchlaka et al.   OncoImmunology

In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI

(2016) Christine Gonzales et al.   PLoS One

Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain

(2015) Se Jeong Lee et al.   BMC CANCER

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy

(2015) R. Tavare et al.   CANCER RESEARCH

Immuno-PET of Murine T Cell Reconstitution Postadoptive Stem Cell Transplantation Using Anti-CD4 and Anti-CD8 Cys-Diabodies

(2015) R. Tavare et al.   JOURNAL OF NUCLEAR MEDICINE

Utilizing Chimeric Antigen Receptors to Direct Natural Killer Cell Activity

(2015) David L. Hermanson et al.   Frontiers in Immunology

Natural Killer Cell-Based Therapies Targeting Cancer: Possible Strategies to Gain and Sustain Anti-Tumor Activity

(2015) Carin I. M. Dahlberg et al.   Frontiers in Immunology

CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study

(2015) Benedikt Fritzsching et al.   OncoImmunology

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival

(2015) Aurelie Poli et al.   Oncotarget

Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer

(2014) M.-G. Anitei et al.   CLINICAL CANCER RESEARCH

Ultrasound elastography and contrast-enhanced ultrasound in infants, children and adolescents

(2014) Martin Stenzel et al.   EUROPEAN JOURNAL OF RADIOLOGY

In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence

(2014) Emeline Ribot et al.   International Journal of Nanomedicine

Combining perfluorocarbon and superparamagnetic iron-oxide cell labeling for improved and expanded applications of cellular MRI

(2014) T. Kevin Hitchens et al.   MAGNETIC RESONANCE IN MEDICINE

Clinical cell therapy imaging using a perfluorocarbon tracer and fluorine-19 MRI

(2014) Eric T. Ahrens et al.   MAGNETIC RESONANCE IN MEDICINE

Engineered antibody fragments for immuno-PET imaging of endogenous CD8+ T cells in vivo

(2014) R. Tavare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology

(2013) Michael Kalos et al.   IMMUNITY

Design and evaluation of theranostic perfluorocarbon particles for simultaneous antigen-loading and 19F-MRI tracking of dendritic cells

(2013) Heleen Dewitte et al.   JOURNAL OF CONTROLLED RELEASE

Intracellular pH Measurements Using Perfluorocarbon Nanoemulsions

(2013) Michael J. Patrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vivo Intracellular Oxygen Dynamics in Murine Brain Glioma and Immunotherapeutic Response of Cytotoxic T Cells Observed by Fluorine-19 Magnetic Resonance Imaging

(2013) Jia Zhong et al.   PLoS One

Iron Administration before Stem Cell Harvest Enables MR Imaging Tracking after Transplantation

(2013) Aman Khurana et al.   RADIOLOGY

A novel probe for the non-invasive detection of tumor-associated inflammation

(2013) Anthony Balducci et al.   OncoImmunology

Non-invasive imaging of transplanted human neural stem cells and ECM scaffold remodeling in the stroke-damaged rat brain by 19F- and diffusion-MRI

(2012) Ellen Bible et al.   BIOMATERIALS

Labeling cells for in vivo tracking using 19F MRI

(2012) Mangala Srinivas et al.   BIOMATERIALS

Cancer and Innate Immune System Interactions

(2012) Yanan Liu et al.   JOURNAL OF IMMUNOTHERAPY

Accelerated fluorine-19 MRI cell tracking using compressed sensing

(2012) Jia Zhong et al.   MAGNETIC RESONANCE IN MEDICINE

Noninvasive cell-tracking methods

(2011) Moritz F. Kircher et al.   Nature Reviews Clinical Oncology

Perfluorocarbon Particle Size Influences Magnetic Resonance Signal and Immunological Properties of Dendritic Cells

(2011) Helmar Waiczies et al.   PLoS One

Functional assessment of human dendritic cells labeled for in vivo 19F magnetic resonance imaging cell tracking

(2010) Brooke M. Helfer et al.   CYTOTHERAPY

In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI

(2010) Deepak K. K. Kadayakkara et al.   MAGNETIC RESONANCE IN MEDICINE

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fluorine (19F) MRS and MRI in biomedicine

(2010) Jesús Ruiz-Cabello et al.   NMR IN BIOMEDICINE

Immunotherapy of cancer

(2009) Hossein Borghaei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

(2009) Gianpietro Dotti et al.   HUMAN GENE THERAPY

In vivo cytometry of antigen-specific t cells using19F MRI

(2009) Mangala Srinivas et al.   MAGNETIC RESONANCE IN MEDICINE

Fluorine-containing nanoemulsions for MRI cell tracking

(2009) Jelena M. Janjic et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Molecular-Genetic Imaging Based on Reporter Gene Expression

(2008) J. H. Kang et al.   JOURNAL OF NUCLEAR MEDICINE

Self-delivering Nanoemulsions for Dual Fluorine-19 MRI and Fluorescence Detection

(2008) Jelena M. Janjic et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In vivo “hot spot” MR imaging of neural stem cells using fluorinated nanoparticles

(2008) Jesús Ruiz-Cabello et al.   MAGNETIC RESONANCE IN MEDICINE

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE