Article
Chemistry, Physical
Lijun Lu, Feiyu Qiu, Hesham Alhumade, Heng Zhang, Aiwen Lei
Summary: This work demonstrated metal-controlled mono-and double-carbonylation reactions of alkanes with amines, resulting in the preparation of alkyl amides and alkyl alpha-ketoamides, with Co and Cu catalysis systems affording different selectivities.
Article
Chemistry, Physical
Yichang Liu, Yi-Hung Chen, Hong Yi, Aiwen Lei
Summary: Carbonyl derivatives are widely present in pharmaceuticals, agricultural chemicals, materials, and natural products. Developing novel, efficient, and green carbonylation methods is one of the hottest research topics in organic synthesis. C-H functionalization/carbonylation is among the most atom- and step-economical methods.
Article
Engineering, Chemical
Hanyu Xiao, Jiangbei Dai, Jie Kuang, Jieping Fan, Jun Du, Hailong Peng
Summary: In this study, nanofibrous and porous carbon microspheres were successfully prepared and loaded with deep eutectic solvents (DESs) to form a novel adsorbent with a three-dimensional porous structure. The adsorbent exhibited high adsorption capacity for SO2, even at low concentrations in mixed gas. The excellent adsorption capability was attributed to the porous structure of the adsorbent and the multiple interactions between DESs and SO2. Additionally, the adsorbent showed good reversibility and selectivity for SO2 adsorption.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Organic
Chenhao Lou, Xin Wang, Leiyang Lv, Zhiping Li
Summary: The iron-catalyzed three-component reaction of cyclopropanols with alkenes and tert-butyl hydroperoxide enables the efficient synthesis of 5-oxo peroxides, allowing for the modification of biologically active molecules and various downstream derivatizations.
Article
Chemistry, Physical
Yukiko Hosono, Hikaru Saito, Takuma Higo, Kosuke Watanabe, Kazuharu Ito, Hideaki Tsuneki, Shun Maeda, Kunihide Hashimoto, Yasushi Sekine
Summary: The study demonstrates that Ce0.8Co0.2O2 catalyst doped with transition metal shows high activity and selectivity for ethylene production in the presence of steam, operating through the Mars-van Krevelen mechanism. The Co-CeO2 interactions play a crucial role in controlling the characteristics of the reactive lattice oxygen suitable for EDH.
JOURNAL OF PHYSICAL CHEMISTRY C
(2021)
Review
Chemistry, Multidisciplinary
Douglas W. W. Stephan
Summary: Transition metal species readily capture and react with CO, while main group CO adducts and their subsequent reactivity have been less studied. This review focuses on the application of Frustrated Lewis Pairs (FLPs) to develop main group chemistry of CO, illustrating the ability to capture CO and subsequent reduction reactions. These developments suggest that FLPs provide an alternative strategy to enhance the reactivity of CO, promising future advances in homogeneous CO chemistry.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Organic
Riccardo Giovanelli, Lorenzo Lombardi, Riccardo Pedrazzani, Magda Monari, Marta Castineira Reis, Carlos Silva Lopez, Giulio Bertuzzi, Marco Bandini
Summary: This study presents a carbonylation-carboxylation synthetic sequence through double CO2 fixation. By utilizing AlCl3, a Ni-catalyzed cross-electrophile coupling reaction triggered a cascade reaction, resulting in the formation of three consecutive C-C bonds in a single operation. This strategy offers a novel synthetic route to ketones through Lewis acid assisted carbon dioxide valorization. Computational insights revealed the unique dual function of AlCl3, and labeling experiments with (CO2)-C-13 confirmed the genuine incorporation of CO2 in both functional groups.
Article
Chemistry, Organic
Riccardo Giovanelli, Lorenzo Lombardi, Riccardo Pedrazzani, Magda Monari, Marta Castineira Reis, Carlos Silva Lopez, Giulio Bertuzzi, Marco Bandini
Summary: A carbonylation-carboxylation synthetic sequence is achieved via double CO2 fixation. The combination of Ni-catalyzed cross-electrophile coupling and AlCl3 triggers a cascade reaction resulting in the formation of three consecutive C-C bonds in a single operation. This strategy provides a novel synthesis route for ketones through Lewis acid-assisted carbon dioxide valorization, demonstrated by computational insights and labeling experiments.
Article
Chemistry, Physical
Jiajun Wang, Tingjun Fu, Fanhui Meng, Dan Zhao, Steven S. . C. Chuang, Zhong Li
Summary: A micropore-rich mesoporous carbon (MMC) derived from ordered mesoporous carbon (OMC) is used as a support to prepare a highly active nano Cu2O catalyst for methanol oxidation carbonylation. The well-dispersed Cu nanoparticles with high purity of Cu2O are obtained, leading to significantly enhanced performance in terms of space-time yield and turnover frequency of DMC. The introduction of plentiful under-coordinated carbon atoms in the micropores plays a key role in immobilizing Cu precursors and accelerating the auto-reduction of CuO to form high-purity Cu2O, thereby enhancing the intrinsic activity of the catalyst.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Engineering, Biomedical
Feng Han, Qifan Yu, Genglei Chu, Jiaying Li, Zhuang Zhu, Zhengdong Tu, Changjiang Liu, Weidong Zhang, Runze Zhao, Haijiao Mao, Fengxuan Han, Bin Li
Summary: This study explores the use of electrospinning technology to create nanofibrous scaffolds loaded with transforming growth factor-beta 3 (TGF beta 3) and ibuprofen (IBU) for the treatment of annulus fibrosus (AF) impairment caused by intervertebral disc (IVD) degeneration or surgical injury. The findings demonstrate that the multifunctional scaffolds with good anti-inflammatory ability enhance extracellular matrix formation and maintain the mechanical properties of the IVD.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xueling Liu, Tongshun An, Zhiping Yin, Wenzhou Zhang
Summary: A new palladium-catalyzed reductive double carbonylation of nitroarenes with aryl halides has been developed for the synthesis of benzoxazin-4-ones. This method utilizes Mo(CO)(6) as a reductant and solid carbonyl sources, and can produce benzoxazin-4-one derivatives in moderate to good yields. Importantly, it avoids the use of toxic CO gas and is applicable for late-stage modification of estrone.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Ning Liu, Xianqing Wu, Chenglong Wang, Jingping Qu, Yifeng Chen
Summary: A nickel-catalyzed alkoxycarbonylation reaction of aromatic iodides with alcohols under atmospheric pressure of carbon monoxide is demonstrated. This operationally simple protocol enables the facile synthesis of (hetero)aromatic esters, showing broad substrate scope and excellent functional group tolerance. Various primary and secondary aliphatic alcohols as well as phenols are suitable for this transformation.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Mineyoshi Hiyoshi, Harumi Osago, Mikiko Kobayashi-Miura, Nobumasa Hara
Summary: Liver damage was induced in animal experiments using carbon tetrachloride (CCl4). CCl4 is activated by cytochrome P450 2E1, resulting in the formation of various metabolites including phosgene. D-dopachrome tautomerase (DDT) was found to have a glutathionyl carbonylated group at its N-terminal proline in rat livers damaged by CCl4. Major targets for glutathionyl carbonylation were identified as macrophage migration inhibitory factor (MIF) and other MIF family proteins.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Engineering, Chemical
Wenting Zhu, Wenting Li, Zhongtian Li, Yanhui Lu, Jieping Fan, Hua Xiong, Hailong Peng
Summary: Magnetic porous carbon microsphere composed of molecularly imprinted nanofibers (MPCM@MINs) were constructed and used as an efficient adsorbent for the extraction of Brilliant Blue (BB) in food samples. The adsorbent showed high surface area, good selectivity, and fast separation ability, enabling easy and rapid detection of BB in food samples.
SEPARATION AND PURIFICATION TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ye Liu, Shi-Huan Li, Shi-Yu Chen, Xiao-Bing Lu
Summary: In this study, propylene was successfully incorporated into an ethylene/CO copolymer chain using a cost-effective nickel catalyst. The electronic and steric effect of different moieties in the catalyst was systematically investigated for terpolymerization. It was observed that the melting temperature (Tm) of the resulting polyketones was proportional to the amount of propylene incorporated into the polymer chain, without significant impact on the degradation temperature. The PNPO catalysts showed higher preference for propylene consumption compared to dppp-type catalysts, which is important for efficient utilization of alpha-olefin resources.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhipeng Guan, Shuxiang Zhu, Yayu Ye, Xiangwei Li, Yanlong Liu, Pengjie Wang, Heng Zhang, Zhiliang Huang, Aiwen Lei
Summary: In this study, an electrochemical mediator-induced intermolecular selective (3+2) annulation was developed for the synthesis of a library of decorated cyclopentenes and cyclopentanes. This method offers high efficiency, mild reaction conditions, broad substrate scope, good functional group tolerance, and high regioselectivity.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Zhaoliang Yang, Dali Yang, Jianye Zhang, Chenyu Tan, Jiajun Li, Shengchun Wang, Heng Zhang, Zhiliang Huang, Aiwen Lei
Summary: This study reports a method for the ring-opening functionalization of cycloalkanols using electrophotochemical catalysis. The method allows for selective cleavage of cycloalkanols with different ring sizes while tolerating various functional groups. The presence of chloride enables the selective formation of different types of bonds without the use of external oxidants.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Multidisciplinary Sciences
Shengzhang Liu, Shengchun Wang, Pengjie Wang, Zhiliang Huang, Tao Wang, Aiwen Lei
Summary: This article reports an electro-oxidative method for the 1,2-amino oxygenation of alkenes without the need for additional oxidants. This method offers a cheap, scalable, and efficient route for the synthesis of valuable beta-amino alcohol derivatives. The method also shows broad substrate scope and potential for application in continuous-flow reactors, as well as the possibility for further amino-functionalization reactions of alkenes.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Lijun Lu, Feiyu Qiu, Hesham Alhumade, Heng Zhang, Aiwen Lei
Summary: This work demonstrated metal-controlled mono-and double-carbonylation reactions of alkanes with amines, resulting in the preparation of alkyl amides and alkyl alpha-ketoamides, with Co and Cu catalysis systems affording different selectivities.
Article
Engineering, Environmental
Jie Zou, Shufen Li, Zhanhong Yuan, Xianglin Pei, Hui Yu, Pan Chen, Dongdong Ye
Summary: This study presents a temperature-mediated approach to construct a biodegradable thick-walled cellulose sponge insole from cotton linters, which effectively reduces plantar pressure, provides thermal insulation, and shows improved mechanical strength and structural stability. The results demonstrate that it can effectively decompress, disperse external stresses, prevent heat loss, and completely degrade within 50 days, making it a potential replacement for traditional petroleum-based sponge insoles.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yongli Li, Huamin Wang, Zhuning Wang, Hesham Alhumade, Zhiliang Huang, Aiwen Lei
Summary: This article describes a method for selectively activating C(sp(3))-S bonds, which is achieved through a radical-mediated electrochemical strategy for the synthesis of valuable disulfides from thioethers. The method features mild reaction conditions and excellent chemoselectivity.
Article
Chemistry, Organic
Jianguo Hu, Shengchun Wang, Bin Li, Aiwen Lei
Summary: We report a protocol for constructing tetrahydroquinolines from bulk chemicals (alkenes and anilines) induced by K2S2O8. The method exhibits operational simplicity, wide scope, mild conditions, and a transition-metal-free system.
Article
Chemistry, Organic
Chang-Ming You, Cheng Huang, Sheng Tang, Peng Xiao, Shengchun Wang, Zhenhong Wei, Aiwen Lei, Hu Cai
Summary: Direct N-allylation of azoles with hydrogen evolution has been achieved by the synergistic combination of organic photocatalysis and cobalt catalysis. This protocol eliminates the need for stoichiometric oxidants and prefunctionalization of alkenes, and produces hydrogen (H2) as a byproduct. The transformation highlights high step and atom economy, high efficiency, and broad functional group tolerance, opening up a pathway for valuable C-N bond formation in heterocyclic chemistry.
Article
Multidisciplinary Sciences
Dongfeng Yang, Zhipeng Guan, Yanan Peng, Shuxiang Zhu, Pengjie Wang, Zhiliang Huang, Hesham Alhumade, Dong Gu, Hong Yi, Aiwen Lei
Summary: By electrochemical oxidative difunctionalization, the authors achieved functionalization of diazo compounds with two different nucleophiles. This method allows the synthesis of structurally diverse heteroatom-containing compounds, which are difficult to access by traditional methods, and display important synthetic applications. The reaction conditions are mild, exhibiting excellent functional group tolerance and efficiency for large-scale synthesis.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Chemistry, Physical
Shengchun Wang, Aiwen Lei
Summary: A detailed mechanistic picture of electron transfer in polypyridine nickel systems has been reported, providing an answer to the challenging puzzle of electron transfer in these complexes.
Review
Chemistry, Multidisciplinary
Wuyin Wang, Wentao Mo, Zishan Hang, Yueying Huang, Hong Yi, Zhijun Sun, Aiwen Lei
Summary: Transition metal element, copper, plays diverse and pivotal roles in oncology. It acts as constituents of metalloenzymes involved in cellular metabolism, function as signaling molecules to regulate the proliferation and metastasis of tumors, and are integral components of metal-based anticancer drugs. Notably, recent research reveals that excessive copper can also modulate the occurrence of programmed cell death (PCD), known as cuprotosis, in cancer cells.
Review
Chemistry, Multidisciplinary
Li Zeng, Jianxing Wang, Daoxin Wang, Hong Yi, Aiwen Lei
Summary: Organic electrosynthesis using alternating current (AC) is still in its early stages due to the lack of a comprehensive theoretical framework. This article provides an overview of recent advancements in AC-driven organic transformations and explores the differences between DC and AC electrolytic methodologies based on their physical principles. These differences include the prevention of metal catalyst deposition, precise modulation of oxidation and reduction intensities, and mitigation of mass transfer processes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Xingchen Liu, Haohua Chen, Dali Yang, Binjing Hu, Ying Hu, Shengchun Wang, Yu Lan, Aiwen Lei, Jie Li
Summary: A multicomponent sulfonylation reaction using sulfonyl chlorides and OPiv-supported organozinc reagents was achieved via cobalt-catalyzed alkene difunctionalizations. Anion-coordination played a critical role in modifying the reactivity and chemical properties of organozinc reagents. The OPiv-coordination resulted in the lower reducibility of arylzinc pivalates, allowing for the in situ formation of catalytically relevant Co(I) species as the active catalyst in carbosulfonylation reactions.
Article
Chemistry, Multidisciplinary
Jinming Wang, Yichang Liu, Xupeng Zong, Aiwen Lei, Zaicheng Sun
Summary: Photochemistry has become increasingly important in organic synthesis and heterogeneous photocatalysts have advantages over traditional homogeneous photocatalysts in terms of production, separation, catalyst recycling, and stability. In this review, the development and advantages of a heterogeneous catalytic system for C-N bond formation as a typical coupling reaction are summarized. Important heterogeneous photocatalysts such as titanium dioxide, semiconductor quantum dots, covalent organic frameworks, and carbon nitrides are discussed in detail. The combination and electron transfer pathway between heterogeneous catalysts and transition-metal catalysts are the focus of this review. These advances not only apply to C-N coupling, but also extend to other coupling reactions.
Article
Chemistry, Multidisciplinary
Yiran Xu, Shengchun Wang, Zhao Liu, Mian Guo, Aiwen Lei
Summary: A photo/nickel dual-catalyzed defluorinative sulfonylation method has been developed to synthesize gem-difluoro allylsulfones rapidly and reliably. This protocol demonstrates mild conditions and a wide scope, providing a novel strategy for the sulfonyl radical participating in radical defluorinative coupling.
CHEMICAL COMMUNICATIONS
(2023)
