Strong C(sp3)-H Arylation by Synergistic Decatungstate Photo-HAT and Nickel Catalysis

Direct and selective functionalization of sp(3) C-H bonds, which are ubiquitous in organic compounds, remains a long-standing challenging reaction. In a recent paper in Nature, MacMillan and colleagues disclosed that the merger of decatungstate photo-HAT and nickel catalysis provided a mild, generally applicable platform for direct and selective arylation of strong C(sp(3))-H bonds.