Article
Biochemistry & Molecular Biology
Maravillas Sanchez Macarro, Vicente Avila-Gandia, Silvia Perez-Pinero, Fernando Canovas, Ana Maria Garcia-Munoz, Maria Salud Abellan-Ruiz, Desiree Victoria-Montesinos, Antonio J. Luque-Rubia, Eric Climent, Salvador Genoves, Daniel Ramon, Empar Chenoll, Francisco Javier Lopez-Roman
Summary: This study aimed to assess the impact of a 6-week intake of a probiotic product on an oxidative stress model of physical exercise in male cyclists. Results showed significant reductions in urinary 8-OHdG, serum MDA, and Ox-LDL in the probiotic group compared to placebo, suggesting an antioxidant effect on oxidative stress mechanisms in healthy subjects. Serum GPx did not increase in the probiotic group, while it significantly increased in the placebo group.
Article
Medicine, Research & Experimental
Hossein Amiri, Fatemeh Shabkhiz, Parisa Pournemati, Amir Hossein Saffar Kohneh Quchan, Reza Zeighami Fard
Summary: This study investigated the effects of swimming exercise on oxidative stress and liver cell damage caused by electromagnetic radiation in rats. The results showed that swimming exercise attenuated the liver damage caused by electromagnetic radiation. In the electromagnetic radiation group, the activity of superoxide dismutase and catalase decreased significantly, and the concentration of malondialdehyde and liver enzymes increased significantly; while in the swimming exercise and electromagnetic radiation + swimming exercise groups, the activity of superoxide dismutase and catalase increased significantly, and the concentration of malondialdehyde and liver enzymes decreased significantly.
Article
Multidisciplinary Sciences
Joyita Bhadra, Nakul Sridhar, Apresio Kefin Fajrial, Nia Hammond, Ding Xue, Xiaoyun Ding
Summary: An Acoustic Gym on a chip was created using surface acoustic wave microfluidic technology to precisely control swimming exercise intensity and duration. It was found that accurately dosed swimming exercise enabled by acoustic streaming can reduce neuronal loss in two neurodegenerative disease models. These findings highlight the importance of optimal exercise conditions for effective neuronal protection and provide avenues for drug target identification.
Article
Obstetrics & Gynecology
Nathalia C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Debora C. Damasceno
Summary: The study aims to confirm the effects of moderate-intensity swimming on glycemic control and oxidative stress levels in diabetic rats, as well as its influence on pancreatic adaptations, embryo implantation, and placental efficiency. The results show that moderate exercise can improve glucose metabolism and reduce post-implantation loss in diabetic rats, but may cause muscle and lipid membrane damages that need to be addressed with adjusted exercise intensity.
REPRODUCTIVE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Jun Liu, Yixin Wang, William John Heelan, Yu Chen, Zhaoting Li, Quanyin Hu
Summary: Inflammatory bowel diseases (IBDs) are associated with elevated levels of reactive oxygen species (ROS) and dysregulated gut microbiota. In this study, researchers developed ROS-scavenging nanoparticles (HPN) to effectively scavenge ROS. They targeted the colon tissue by conjugating HPN to modified probiotic Escherichia coli Nissle 1917 (EcN). To enhance the efficacy of bacteriotherapy, the EcN cells were encapsulated with a poly-norepinephrine (NE) layer for protection against environmental assaults and prolonged retention in the intestine. The HPN-NE-EcN treatment showed enhanced efficacy in colitis models and increased abundance and diversity of gut microbiota.
Editorial Material
Hematology
Laurent A. Messonnier
Summary: Although sickle cell disease (SCD) is related to a single point mutation, there is extreme variability in the clinical presentation among patients. Genetic variants may contribute to this variability. In this study, Dosunmu-Ogunbi et al. highlighted the importance of a genetic variant affecting mitochondrial function in the cardiovascular pathophysiology of SCD. Their findings provide important insights and perspectives for patient management.
Article
Biochemistry & Molecular Biology
Carlos Espirito-Santo, Carmen Alburquerque, Francisco A. Guardiola, Rodrigo O. A. Ozorio, Leonardo J. Magnoni
Summary: Swimming has physiological effects on farmed fish, but the potential link between swimming and oxidative stress is still poorly understood. This study investigated the impact of different moderate swimming conditions on the antioxidant status of gilthead seabream, revealing that swimming modulated the activity of antioxidant enzymes in the liver and skeletal muscle. Adequate swimming conditions were found to minimize oxidative stress in gilthead seabream.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2024)
Article
Medicine, Research & Experimental
Cindy Medici Toscano, Filipe Martinuzo Filetti, Camila Cruz Pereira Almenara, Mirian Fioresi, Dalton Valentim Vassallo
Summary: Excessive copper exposure increases blood pressure and cardiac force, enhances Ca2+ inflow, reduces Ca2+ reuptake by the sarcoplasmic reticulum, and increases the production of hydroxyl radicals locally.
Review
Biochemistry & Molecular Biology
Maria Cecilia Teles, Alexandre Martins Oliveira Portes, Bianca Iara Campos Coelho, Leticia Teresinha Resende, Mauro Cesar Isoldi
Summary: Systemic arterial hypertension is a clinical condition characterized by high and sustained levels of blood pressure. Research on spontaneously hypertensive animals has provided insights into the physiological changes that affect the heart in hypertension. Aerobic exercise has shown to improve cardiac function and reduce inflammation and oxidative stress in the heart, although the precise mechanisms are not fully understood. This review provides an overview of the pathological changes in the heart of spontaneously hypertensive animals and the modulatory effects of aerobic exercise.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shishir Upadhyay, Kunj Bihari Gupta, Anil Kumar Mantha, Monisha Dhiman
Summary: Doxorubicin (DOX) is beneficial for cancer patients, but its toxic effects on the heart can lead to cardiac dysfunction. Oxidative stress induced by DOX disrupts cardiac contractile muscle proteins, affecting the heart's rhythmic mechanism and oxygen consumption rate. This damage to contractile components and associated factors ultimately results in left ventricular ejection and dilation, highlighting the need for clinical markers and medications to address DOX-induced cardiotoxicity.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Yimin He, Weichuan Lin, Ce Shi, Ronghua Li, Changkao Mu, Chunlin Wang, Yangfang Ye
Summary: The study found that DBP accumulates in swimming crabs in a concentration-dependent manner and is metabolized to monobutyl phthalate (MBP) and phthalic acid (PA) through de-esterification. Exposure to DBP induced different responses in cytochrome P450 members, antioxidant enzyme genes, and heat stress proteins, leading to malondialdehyde accumulation, decreased glutathione levels, and inhibited antioxidant enzyme activities. Survival, size, and weight of crabs were not significantly affected by DBP, but molting was delayed. Despite this, the study suggests that DBP triggers strong detoxification and antioxidative defense mechanisms in swimming crab juveniles.
Article
Biology
G. Godoy, P. B. Travassos, M. M. Antunes, C. C. Iwanaga, A. B. Sa-Nakanishi, R. Curi, J. F. Comar, R. B. Bazotte
Summary: This study measured the non-enzymatic antioxidant capacity in rat plasma after acute strenuous swimming exercise and exercise until exhaustion. The results showed significant increases in plasma lactate concentrations and non-enzymatic antioxidant parameters after the exercise. Plasma lactate may contribute to plasma antioxidant defenses, and the TRAP assay is the most sensitive method for assessing plasma non-enzymatic antioxidant capacity after strenuous exercise.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sneha Damal Villivalam, Scott M. Ebert, Hee Woong Lim, Jinse Kim, Dongjoo You, Byung Chul Jung, Hector H. Palacios, Tabitha Tcheau, Christopher M. Adams, Sona Kang
Summary: Exercise can significantly increase the expression of DNMT3A in oxidative red muscle, playing a pivotal role in endurance exercise by controlling intracellular oxidative stress. Deficiency of DNMT3A leads to reduced tolerance to endurance exercise, which can be rescued by inhibiting the ALDH1L1 pathway.
Article
Peripheral Vascular Disease
Ariana A. Silva, Mauro S. Perilhao, Leslie Andrews Portes, Andrey J. Serra, Paulo Jose Ferreira Tucci, Andre Soares Leopoldo, Leonardo Dos Santos, Danilo S. Bocalini
Summary: This study evaluated the effect of exercise on cardiac remodelling in chronically stressed rats. The results showed that while exercise reduced blood pressure and prevented an increase in corticosterone levels, it was unable to impede the myocardial damages caused by chronic stress.
JOURNAL OF HYPERTENSION
(2022)
Article
Biochemistry & Molecular Biology
Andreea Ioana Inceu, Maria Adriana Neag, Adrian Catinean, Corina Ioana Bocsan, Cristian Ioan Craciun, Carmen Stanca Melincovici, Dana Maria Muntean, Madalin Mihai Onofrei, Raluca Maria Pop, Anca Dana Buzoianu
Summary: Spore-forming probiotic bacteria may have a beneficial effect on dexamethasone-induced metabolic disturbances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Ece Koc Yildirim, Muharrem Balkaya
Summary: Research showed that a 50% calorie restriction after breast cancer development can effectively reduce tumor volume, with all tumors being benign in the CR-50% group. Serum adiponectin concentrations were higher in the calorie restriction group and alternate day feeding group compared to the cancer control group. The highest incidence of malignant and invasive tumors occurred in the cancer control group.
BIOTECHNIC & HISTOCHEMISTRY
(2021)
Article
Anatomy & Morphology
Ulker Eren, Sadiye Kum, Ahmet Nazligul, Ozay Gules, Ebru Aka, Mustafa Yildiz, Secil Zorlu
Summary: This study demonstrates the innate immunity and antigen presentation capacity of cecal tonsils in chicks, showing that regardless of antigenic stimulation, TLR2, TLR4, CD83, and MHC class II molecules are present in proximal cecal tissue. The development of cecal tonsil was completed histologically by day 10, with CD83-positive dendritic cells first distinguished on day 7. The results suggest that both innate and adaptive cecal defense mechanisms are in the learning period during the first 2 weeks, with potential implications for vaccination programs in chicks.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2022)
Article
Chemistry, Multidisciplinary
Huseyin Gungor, Mehmet Ekici, Mehmet Burak Ates
Summary: The study demonstrates that isorhamnetin has a significant protective effect against acetaminophen-induced hepatotoxicity in mice through its lipid-lowering, antioxidant, and anti-inflammatory effects.
DRUG AND CHEMICAL TOXICOLOGY
(2023)
Article
Biology
Mehmet Ekici, Huseyin Gungor, Mehmet Onder Karayigit, Nergiz Hacer Turgut, Mustafa Kockaya, Ozhan Karatas, Aykut Gokturk Uner
Summary: The study shows that empagliflozin has cardioprotective effects in experimental myocardial infarction by improving oxidative stress, apoptosis, lipid profile, and oxidative DNA damage.
Article
Veterinary Sciences
Mehmet Ekici, Mustafa Kockaya, Hacer Bas-Ekici
Summary: The objective of this study was to investigate bone metabolism in aging Kangal shepherd dogs and evaluate the use of biochemical bone indicators in veterinary practice. The results showed that age had an effect on the concentrations of bone alkaline phosphatase, osteocalcin, C-terminal telopeptide of type I collagen, and cross-linked C-telopeptide of type I collagen. Sex and age-sex interactions did not have significant effects, except for serum AST activities which decreased with age in females. Serum Ca concentrations were significantly affected by age and age-sex interactions, but not by sex.
VETERINARY CLINICAL PATHOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
T. Akkus, M. Ekici
Summary: This study compared the changes in oxidative stress levels and some trace elements in the blood serum of healthy bitches and bitches with transmissible venereal tumor (TVT). The results showed that bitches with TVT had higher levels of oxidative stress and changes in certain trace elements associated with oxidative stress.
INDIAN JOURNAL OF ANIMAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Huseyin Gungor, Mehmet Ekici, Ozhan Karatas, Burak Dik
Summary: This study investigated the protective effect of ethanolic extract of Allium scorodoprasum (ASE) on cyclophosphamide-induced liver injury. The results showed that ASE can alleviate liver damage caused by cyclophosphamide and has potential antioxidant and anti-inflammatory ingredients.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Veterinary Sciences
Tugra Akkus, Mehmet Ekici
Summary: The aim of this study was to investigate the changes in complete blood indices and thiols in cats undergoing ovariohysterectomy (OHE). The results showed that neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) increased significantly after OHE, while lymphocyte count and thiols decreased. The findings suggest that these indices and thiols may play an important role in assessing inflammation and stress responses after OHE in cats.
REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS
(2023)
Article
Veterinary Sciences
M. Ekici, H. Gungor, D. G. Mert
Summary: This study aimed to investigate the effect of Kaempferol and Isorhamnetin in a Lipopolysaccharide (LPS)-induced anxiety and depression model in mice. The results showed that these substances could alleviate LPS-induced anxiety and depression, as well as reduce oxidative stress and inflammation levels. The study highlights the potential therapeutic role of Kaempferol and Isorhamnetin in anxiety and depression, along with the importance of oxidative stress, inflammation, and BDNF in their etiopathogenesis.
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
(2023)
Article
Agriculture, Dairy & Animal Science
T. Akkus, P. F. Polat Dincer, M. Ekici, Z. Yerlikaya
Summary: This study evaluated the relationship between oxidative stress and blood parameters in cows with and without sub-clinical mastitis. The results showed that oxidative stress and blood-biochemistry values were significantly affected in cows with sub-clinical mastitis.
INDIAN JOURNAL OF ANIMAL RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
M. Ekici, H. Gungor, T. Demir, M. B. Ates, A. S. Kumru
Summary: The study investigated the antioxidant and anti-inflammatory effects of Allium scorodoprasum L. ethanolic extract (ASE) in a mouse paw edema model induced by carrageenan. Results showed that ASE significantly reduced paw swelling and inflammatory markers, while also improving antioxidant status.
JOURNAL OF ANIMAL AND PLANT SCIENCES-JAPS
(2022)
Article
Biology
N. E. R. G. I. Z. H. A. C. E. R. TURGUT, H. U. S. E. Y. I. N. GUNGOR, M. E. H. M. E. T. EKICI, M. U. M. I. N. A. L. P. E. R. ERDOGAN, M. E. H. M. E. T. O. N. D. E. R. KARAYIGIT, H. A. K. KARA
Summary: The study found that Shouraashtri has a protective effect against cisplatin-induced renal injury by improving oxidative stress, inflammation, and histopathological changes.
Letter
Cardiac & Cardiovascular Systems
Ferhat Dindas, Huseyin Gungor, Mehmet Ekici, Pinar Akokay, Fusun Erhan, Mustafa Dogdus, Mehmet Birhan Yilmaz
ANATOLIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Neurosciences
Mehmet Ekici, Muharrem Balkaya
Summary: The study showed that Pg has a protective effect and can alleviate peripheral neuropathy induced by Ptx in rats. There were improvements in body weight loss and motor nerve conduction velocity in the Pg-administered group.
NEUROLOGICAL SCIENCES AND NEUROPHYSIOLOGY
(2021)