Article
Thermodynamics
Yi Li, Hao Yu, Yi Li, Xian Luo, Yinjiang Liu, Guijin Zhang, Dong Tang, Yaning Liu
Summary: A 3D model of the wellbore-reservoir system is developed to investigate the operational characteristics of inter-seasonal compressed air storage in aquifers. The hydrodynamic and thermodynamic properties during different operational periods are analysed, and the effects of well spacing and air injection temperature on the storage process are investigated. The results demonstrate the feasibility of IS-CAESA, with acceptable wellbore-aquifer pressure and temperature variation, high energy storage efficiency, and optimal performance at a well spacing of 150 m and an air injection temperature of 20 degrees C.
Article
Energy & Fuels
Jeffrey A. Bennett, Jeffrey P. Fitts, Andres F. Clarens
Summary: The growth of intermittent offshore wind energy installations has created a need for energy storage technologies, and offshore compressed air energy storage (OCAES) is one proposed option. This study presents a method for assessing the round-trip efficiency of OCAES, demonstrating its usefulness in the Baltimore Canyon Trough. Results show that OCAES round-trip efficiencies of 60-62% could provide 8.1 TWh of storage.
Article
Energy & Fuels
Jeffrey A. Bennett, Juliet G. Simpson, Chao Qin, Roger Fittro, Gary M. Koenig, Andres F. Clarens, Eric Loth
Summary: Offshore wind power projects are becoming increasingly attractive, with Offshore Compressed Air Energy Storage (OCAES) systems providing a solution to intermittency issues. This system offers improved efficiency and value, with the ability to stabilize power output from wind farms.
Article
Green & Sustainable Science & Technology
Yi Li, Hao Yu, Dong Tang, Yi Li, Guijin Zhang, Yaning Liu
Summary: This study compares compressed carbon dioxide energy storage (CCESA) and compressed air energy storage (CAESA) using numerical methods. The results show that CCESA has advantages in terms of pressure, transportation distance, floor space utilization, and energy efficiency, making it a better choice when there is sufficient nearby carbon dioxide source.
Article
Green & Sustainable Science & Technology
Seyed Mostafa Jafari Raad, Yuri Leonenko, Hassan Hassanzadeh
Summary: Hydrogen is an essential part of future decarbonized and sustainable energy systems, playing a significant role in energy security, affordability, and decarbonization. Aquifers are economically attractive and environmentally friendly options for geological hydrogen storage. It is crucial to select suitable storage sites and understand the mechanisms controlling subsurface hydrogen transport properties. Additionally, a dynamic regulatory framework and participation strategy are needed for large-scale aquifer storage, ensuring safety and efficiency.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Energy & Fuels
Chaobin Guo, Cai Li, Keni Zhang, Zuansi Cai, Tianran Ma, Federico Maggi, Yixiang Gan, Abbas El-Zein, Zhejun Pan, Luming Shen
Summary: Compressed air energy storage in aquifers (CAESA) is gaining attention as a potential method to address the intermittency of solar or wind energy sources. While some field tests show the possibility of creating a large bubble in aquifers to sustain working cycles, challenges still exist before wide deployment can be recommended. Methods to improve CAESA efficiency, such as combining with thermal storage, using CO2 as cushion gas, horizontal wells or hydraulic fracturing, and man-made boundaries, need further study for future applications.
Article
Engineering, Multidisciplinary
Yan Shi, Yadong Lu, Yushi Rong, Ze Bai, Hao Bai, Mingqi Li, Qingchen Zhang
Summary: This paper numerically studied the geochemical reaction mechanism of CO2 storage in saline aquifers and its effects on the reservoir rocks and CO2 consumption. The results showed that the long-term geochemical reactions did not affect the porosity and permeability of the rocks and had no adverse consequences for extraction. The captured CO2 was distributed in gas, aqueous phase, and minerals, accounting for 27%, 65%, and 8% respectively. The study provides a theoretical reference for underground energy storage projects involving fluid-rock interactions.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Green & Sustainable Science & Technology
Yi Li, Yaning Liu, Yi Li, Bin Hu, Peng Gai
Summary: In this study, a coupled wellbore-reservoir underground anticline model was simulated to investigate the potential leakage influences of compressed air energy storage in aquifers. The results showed that the leakage rate in an anticline would decline and reach a relatively steady state as the cycles continue, with hysteresis effect observed in the leakage rate. This research deepens the understanding of the leakage process and aids in the evaluation and prevention of environmental contamination incidents in gas storage in aquifers.
Article
Energy & Fuels
Yi Li, Ruikang Sun, Yi Li, Bin Hu, Jiawei Dong
Summary: Compressed air energy storage in aquifers (CAESA) is a cost-effective application for large-scale energy storage, balancing power systems generated by wind and solar energy. Geothermal energy plays a significant role in CAESA, affecting pressure and air distribution in underground processes.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Energy & Fuels
Chao (Chris) Qin, Eric Loth
Summary: The study proposes a concept that leverages underground reservoirs of abandoned oil or gas wells to enhance the dispatchability of wind farms and reduce overall costs. This approach can not only lower the cost of generator sizing, but also increase energy production and decrease storage system costs, while attracting more infrastructure investments.
Article
Energy & Fuels
Yi Li, Yi Li, Yaning Liu
Summary: Compressed air energy storage in aquifers is a potential solution to overcome the limitation of air storage space in CAES technology and efficiently utilize intermittent renewable energy. This study focuses on the layered heterogeneity in deep aquifers and its influence on air-water-heat flow during the injection-production cyclic operation. Results show that heterogeneity distribution strongly affects air flow, leading to multi-fingering in the aquifer. Simulation results also demonstrate the advantages of heterogeneous aquifers in terms of smaller pressure fluctuation and higher energy efficiency compared to homogeneous models. A two-layer heterogeneous sequence model is discussed to facilitate site evaluation, showing that a layer with high porosity and permeability on top is more advantageous. This research deepens understanding of the role of target aquifers and helps evaluate candidate sites for compressed air energy storage.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Energy & Fuels
Dongmei Sun, Zhubin Chu, Wenyuan Chen, Ping Feng, Jiaxin Zhang
Summary: Most studies suggest that aquifers with anticlinal structures are the most suitable for compressed air energy storage (CAES) due to their trapping ability. However, this limits the potential locations for CAES plants, as horizontal aquifers are only common in offshore areas with abundant wind power. This study compared the characteristics of CAES in dome-shaped and horizontal aquifers using numerical simulation based on the Pittsfield aquifer field test. The results showed that the energy recovery efficiency of the horizontal aquifer can reach approximately 80% of that in the dome-shaped aquifer, indicating that horizontal aquifers may be a potential choice for CAES storage in offshore areas without suitable aquifers with anticlinal structures.
Review
Engineering, Chemical
Yi Li, Yi Li, Yaning Liu, Xiaoyuan Cao
Summary: CAESA is a potential large-scale energy storage technology, yet currently lacks in-depth research and actual engineering practices due to a lack of theoretical and technical support. This article provides a summary and analysis of key issues in CAESA, addressing theoretical foundations, aquifer selection criteria, optimal design, operational parameters, and possible enhancements for expanding its application. The conclusions drawn and application outlook presented aim to further the development of CAESA technology.
REVIEWS IN CHEMICAL ENGINEERING
(2021)
Article
Energy & Fuels
Julian David Hunt, Behnam Zakeri, Andreas Nascimento, Diego Augusto de Jesus Pacheco, Epari Ritesh Patro, Bojan Durin, Marcio Giannini Pereira, Walter Leal Filho, Yoshihide Wada
Summary: There is a global energy transition driven by wind and solar power, necessitating the use of energy storage technologies to integrate intermittent sources. Isothermal deep ocean compressed air energy storage (IDO-CAES) is proposed as an innovative solution to provide weekly, monthly, and seasonal energy storage cycles. With estimated costs of $1500-3000 USD/kW for installed capacity and $1-10 USD/kWh for energy storage, IDO-CAES should complement batteries in future sustainable energy grids.
Article
Energy & Fuels
Stanislaw Salyga, Lukasz Szablowski, Krzysztof Badyda
Summary: The article introduces three constant volume CAES systems and builds dynamic mathematical models using Aspen HYSYS software. Among them, the adiabatic compressed air energy storage system with liquid thermal energy storage achieved a round trip efficiency of 64.8%.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Clinical Neurology
Mary R. O'Brien, Christopher McDermott, Samar Aoun, David Oliver, Jennifer A. Kirton
Summary: This study explores the perspectives of individuals diagnosed with MND and their family caregivers on the consultation process, diagnosis delivery, and adherence to the UK NICE MND guideline. A survey was conducted in 2018-19, with 69 MND patients and 39 caregivers participating. The results show that MND patients have higher satisfaction with their neurologist's skills and ability, but many of the guideline recommendations were not met. There is a need for greater awareness of the needs of MND patients and caregivers, as well as better promotion and resources for the NICE MND guideline.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Jill Ann Goslinga, Mark Terrelonge, Richard Bedlack, Paul Barkhaus, Benjamin Barnes, Tulio Bertorini, Mark Bromberg, Gregory Carter, Amy Chen, Jesse Crayle, Mazen Dimachkie, Leanne Jiang, Gleb Levitsky, Isaac Lund, Sarah Martin, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Lenka Slachtova, Yuyao Sun, Paul Wicks
Summary: This article reviews the evidence of glucocorticoids in ALS treatment and concludes that they do not provide clinical benefits and have serious risks.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
C. A. Young, J. Ealing, C. J. McDermott, T. L. Williams, A. Al-Chalabi, T. Majeed, K. Talbot, T. Harrower, C. Faull, A. Malaspina, J. Annadale, R. J. Mills, A. Tennant
Summary: This study reveals that the prevalence of depression in ALS patients is close to a quarter, with most patients belonging to a single trajectory group. Estimates based on screening for current depressive symptoms underestimate the actual prevalence of depression.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Review
Clinical Neurology
Xiaoyan Li, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. Feldman, Jonathan Glass, Jill Goslinga, Terry Heiman-Patterson, Sartaj Jhooty, Rachel Lichtenstein, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Kristiana Salmon, Paul Wicks, Richard Bedlack
Summary: ALSUntangled reviews alternative and off-label treatments for ALS and finds that rituximab, a drug depleting B lymphocytes, lacks evidence of efficacy in ALS. One patient's experience with rituximab showed no benefit. Due to the known risks, we advise against using rituximab as an ALS treatment.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Timothy Fullam, Carmel Armon, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Robert Bowser, Mark Bromberg, Javier Mascias Cadavid, Gregory T. Carter, Mazen Dimachkie, Dave Ennist, Eva L. Feldman, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Dylan Ratner, Paul Wicks, Richard Bedlack
Summary: ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review astaxanthin which has plausible mechanisms for slowing ALS progression including antioxidant, anti-inflammatory, and anti-apoptotic effects. While there are no ALS-specific pre-clinical studies, one verified ALS reversal occurred in a person using a combination of alternative therapies which included astaxanthin. There have been no trials of astaxanthin in people living with ALS. Natural astaxanthin appears to be safe and inexpensive. Based on the above information, we support further pre-clinical and/or clinical trials of astaxanthin in disease models and PALS, respectively, to further elucidate efficacy.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Yuyao Sun, Paul Barkhaus, Benjamin Barnes, Morgan Beauchamp, Michael Benatar, Tulio Bertorini, Mark Bromberg, Gregory T. T. Carter, Jesse Crayle, Merit Cudkowicz, Mazen Dimachkie, Eva L. L. Feldman, Timothy Fullam, Terry Heiman-Patterson, Sartaj Jhooty, Isaac Lund, Christopher Mcdermott, Gary Pattee, Kaitlyn Pierce, Dylan Ratner, Paul Wicks, Richard Bedlack
Summary: ALSUntangled reviews the use of ozone therapy in ALS patients, as it has potential mechanisms to slow down ALS progression. Although a non-peer-reviewed report suggests that ozone treatment may slow down ALS progression in a mouse model, there are no clinical trials using ozone in PALS. One verified case of ALS reversal was observed with a combination of alternative treatments including ozone. However, potential serious side effects associated with ozone therapy need to be further investigated before recommending it as a treatment for PALS.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Danielle Boyce, Michael Robinson, Jesse M. Cedarbaum, Lisa M. Shank, Christopher J. McDermott, Ruben P. A. van Eijk
Summary: This study aims to identify potential limitations of the ALSFRS-R from the perspective of people living with ALS and their caregivers. The results show that many participants expressed concerns about certain items, believing that they do not accurately reflect their abilities. Therefore, it is recommended to revise the ALSFRS-R based on co-development with patients and caregivers, or consider using alternative assessment methods.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Kelly G. Gwathmey, Philippe Corcia, Chris J. McDermott, Angela Genge, Stefan Sennfalt, Mamede de Carvalho, Caroline Ingre
Summary: ALS is a fatal neurodegenerative disease with a long delay in diagnosis. This delay is influenced by lack of recognition and misdiagnosis by general practitioners, as well as patient factors such as illness behavior and site of symptom onset.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Health Care Sciences & Services
Sean White, Alicia O'Cathain, Vanessa Halliday, Liz Croot, Christopher. J. J. McDermott
Summary: This study aims to understand how individual, clinical team, and organizational factors influence motor neuron disease patients' decisions about gastrostomy and ventilation interventions. The findings show that these decisions are emotionally driven and involve interactions with healthcare professionals and caregivers. The attitudes of healthcare professionals can affect patients' perceived agency over decisions. Patients who agree to interventions reach a tipping point where they accept the need for change.
HEALTH EXPECTATIONS
(2023)
Article
Clinical Neurology
Jordi W. J. van Unnik, Stavros Nikolakopoulos, Marinus J. C. Eijkemans, Jesus Gonzalez-Bermejo, Gaelle Bruneteau, Capucine H. Morelot-Panzini, Leonard E. van den Berg, Merit J. Cudkowicz, Christopher McDermott, Thomas Similowski, Ruben P. A. van Eijk, DiPALS, RespiStimALS, Ceftriaxone Study Grp
Summary: In this study, an algorithm was developed to optimize interim analysis plans for ALS clinical trials, using prior knowledge and drug-specific information to improve efficiency and minimize risks to patients.
Article
Medicine, Research & Experimental
Louise Rose, Thilipan Thaventhiran, Esther Hobson, Rebecca Rogers, Kirsty James, Petrina Chu, Ben Carter, Christina Faull, Sian Saha, Jeong Su Lee, Georgios Kaltsakas, Christopher McDermott, Michelle Ramsay
Summary: This study aims to evaluate the efficacy of a virtual peer support programme in improving the psychological well-being and caregiving outcomes of family caregivers of individuals with motor neurone disease. Informal caregivers will be randomly assigned to either a 12-week virtual peer support programme or usual care. The primary outcome measure is the Hospital Anxiety and Depression Scale assessed at 12 weeks.
Review
Clinical Neurology
Albert Ludolph, Luc Dupuis, Edward Kasarskis, Frederik Steyn, Shyuan Ngo, Christopher McDermott
Summary: Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease with non-motor symptoms. Nutritional status and metabolic balance have been found to contribute to faster disease progression and earlier death. Cellular changes, including mitochondrial dysfunction, are also shown to contribute to bioenergetic failure in ALS. Modifying energy balance in ALS shows potential as a treatment option and multiple clinical trials are underway.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Sarah Roscoe, Ellie Skinner, Elaine Kabucho Kibirige, Charmaine Childs, C. Elizabeth Weekes, Stephen Wootton, Scott Allen, Christopher McDermott, Theocharis Stavroulakis
Summary: People with motor neuron disease often struggle to consume enough calories, leading to malnutrition and weight loss. Energy prediction equations are not accurate in estimating resting energy expenditure and metabolic index at an individual level.
CLINICAL NUTRITION ESPEN
(2023)
Article
Medicine, Research & Experimental
Rebecca Gould, Charlotte K. Rawlinson, Ben Thompson, Kirsty Weeks, Rebecca Gossage-Worrall, Hannah A. Cantrill, Marc Serfaty, Christopher Graham, Lance H. McCracken, David White, Robert Howard, Matt Bursnall, Mike Bradburn, Ammar Al-Chalabi, Richard Orrell, Suresh Chhetri, Rupert Noad, Aleksandar Radunovic, Tim J. Williams, Carolyn J. Young, David Dick, Vanessa Lawrence, Laura Goldstein, Tracey Young, John Ealing, Hamish McLeod, Nicola Williams, Helen Weatherly, Richard Cave, Theresa Chiwera, Francesco Pagnini, Cindy Cooper, Pamela Shaw, Christopher McDermott, COMMEND Collaboration Group
Summary: This study examined the feasibility and acceptability of Acceptance and Commitment Therapy (ACT) for improving the psychological health of people living with Motor Neuron Disease (MND). The results showed that ACT may have some positive effects on the psychological health of the participants, but further research with a larger sample size is needed for confirmation.
PILOT AND FEASIBILITY STUDIES
(2023)
Review
Clinical Neurology
Andrew Brown, Carmel Armon, Paul Barkhaus, Morgan Beauchamp, Tulio Bertorini, Mark Bromberg, Javier Mascias Cadavid, Gregory T. Carter, Jesse Crayle, Eva L. Feldman, Terry Heiman-Patterson, Sartaj Jhooty, Alexandra Linares, Xiaoyan Li, Elise Mallon, Christopher Mcdermott, Tasnim Mushannen, George Nathaniel, Gary Pattee, Kaitlyn Pierce, Ari Rappoport, Dylan Ratner, Lenka Slactova, Paul Wicks, Richard Bedlack
Summary: ALSUntangled evaluates alternative and off-label treatments for amyotrophic lateral sclerosis (ALS), including insulin. While insulin has a plausible mechanism for slowing ALS progression, limited pre-clinical studies and no trials in patients have been conducted. Moreover, insulin use in patients without metabolic needs may result in serious and potentially lethal side effects. Therefore, insulin treatment to slow ALS progression cannot be endorsed at this time.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
