Article
Clinical Neurology
Charles C. Edwards III, Charles C. Edwards II, Scott Heinlein, Peter C. Rowe
Summary: This study reviewed the outcomes of surgical management of cervical stenosis, providing further evidence that cervical stenosis can exacerbate or cause orthostatic intolerance and ME/CFS. Surgical interventions may offer relief for selected patients with refractory symptoms and neurological signs in this complex condition.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
C. (Linda) M. C. van Campen, Peter C. Rowe, Freek W. A. Verheugt, Frans C. Visser
Summary: Muscle pain, fatigue, and concentration problems are common symptoms among individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study found that orthostatic stress is an important determinant of postexertional malaise (PEM) in ME/CFS patients, as indicated by significantly increased numeric rating scales (NRS) for pain, fatigue, and concentration even at 7 days post head-up tilt testing (HUT).
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser
Summary: The study found that orthostatic intolerance in ME/CFS patients is not caused by deconditioning as defined in cardiopulmonary exercise testing. An abnormally high decline in cerebral blood flow during orthostatic stress was present in all ME/CFS patients regardless of their %peak VO2 results on cardiopulmonary exercise testing.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Kunihisa Miwa
Summary: Oral minocycline therapy may be an effective treatment option for patients with ME, especially in the initial stage of the disease. Favorable effects were observed after treatment, but a considerable number of patients discontinued treatment due to acute adverse effects.
Review
Pharmacology & Pharmacy
Peter L. Toogood, Daniel J. Clauw, Sameer Phadke, David Hoffman
Summary: ME/CFS is a chronic debilitating disease characterized by severe fatigue, pain, sleep disruption, and cognitive dysfunction. Current treatments focus on symptom management and addressing psychological sequelae, with ongoing efforts towards identifying effective therapies and understanding the mechanistic basis of the disease.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Ryuhei Jinushi, Sakue Masuda, Yuki Tanisaka, Sho Nishiguchi, Kento Shionoya, Ryo Sato, Kei Sugimoto, Takahiro Shin, Rie Shiomi, Akashi Fujita, Masafumi Mizuide, Shomei Ryozawa
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome/systemic exertion intolerance disease (ME/CFS/SEID) is diagnosed based on clinical symptoms, but there is no specific test for it. Previous studies have found that patients with ME/CFS/SEID have low serum acylcarnitine levels. This systematic review and meta-analysis confirmed the significant difference in serum acylcarnitine levels between patients with ME/CFS/SEID and healthy controls.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Suzanne D. Vernon, Sherlyn Funk, Lucinda Bateman, Gregory J. Stoddard, Sarah Hammer, Karen Sullivan, Jennifer Bell, Saeed Abbaszadeh, W. Ian Lipkin, Anthony L. Komaroff
Summary: This study found that an orthostatic stress test performed in an office setting can reveal different symptomatic, hemodynamic, and cognitive abnormalities in individuals with Long COVID and ME/CFS compared to healthy control subjects.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
C. (Linda) M. C. van Campen, Frans C. Visser
Summary: The symptoms and disease characteristics of long-haul COVID patients are similar to those of ME/CFS patients, and orthostatic intolerance plays an important role in COVID infection symptoms. Long-haul COVID is essentially the same disease as ME/CFS.
Article
Pediatrics
C. (Linda) M. C. van Campen, Peter C. Rowe, Frans C. Visser
Summary: This study investigated the effects of a 20-degree and a 70-degree head-up tilt test on cerebral blood flow in young ME/CFS patients. The results showed that the reduction in cerebral blood flow at 20 degrees was slightly less than at 70 degrees, and there was no postural orthostatic tachycardia at 20 degrees. These findings highlight the importance of using the 70-degree angle for diagnosis.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Bindu D. Paul, Marian D. Lemle, Anthony L. Komaroff, Solomon H. Snyder
Summary: The review summarizes evidence of biological abnormalities in patients with acute COVID-19 and ME/CFS, including redox imbalance, systemic inflammation, neuroinflammation, impaired ATP generation, and general hypometabolism. Although these phenomena have not been extensively studied in individuals with long COVID-19, understanding these abnormalities may lead to the development of novel therapeutics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Kiran Thapaliya, Sonya Marshall-Gradisnik, Markus Barth, Natalie Eaton-Fitch, Leighton Barnden
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID patients share similar neurological, autonomic, pain, and post-exertional symptoms. Comparing brainstem volumes in ME/CFS, long COVID, and healthy control subjects, the study found enlarged volumes in pons and whole brainstem for both ME/CFS and long COVID patients. Positive correlations were found between pons and whole brainstem volumes with pain in ME/CFS, while a strong negative relationship was detected between midbrain volume and breathing difficulty in long COVID patients. The study demonstrated abnormal brainstem volumes consistent with overlapping symptoms in both ME/CFS and long COVID.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Rebekah Maksoud, Chandi Magawa, Natalie Eaton-Fitch, Kiran Thapaliya, Sonya Marshall-Gradisnik
Summary: This systematic review aimed to evaluate potential biomarkers that could effectively differentiate ME/CFS patients from healthy controls. A total of 101 studies were included, and potential biomarkers ranged from genetic/epigenetic, immunological, metabolomics/mitochondrial/microbiome, endovascular/circulatory, neurological, ion channel, to physical dysfunction biomarkers. The findings indicated evidence of immune dysfunction in ME/CFS and the use of lymphocytes as a model to investigate the pathomechanism of the illness.
Article
Neurosciences
Kiran Thapaliya, Sonya Marshall-Gradisnik, Donald Staines, Jiasheng Su, Leighton Barnden
Summary: This study investigates cortical volumetric and thickness changes in Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) patients and healthy controls, revealing differences and abnormal correlations with key symptoms in ME/CFS patients.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Rheumatology
C. (L) M. C. van Campen, P. C. Rowe, F. W. A. Verheugt, F. C. Visser
Summary: The study demonstrated that the pressure pain threshold decreased in ME/CFS patients after head-up tilt test, while healthy controls did not show significant changes; The temporal summation in ME/CFS patients compared to healthy controls was higher both pre- and post-HUT, but did not change post-HUT.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Irene Soffritti, Sabine Gravelsina, Maria D'Accolti, Francesca Bini, Eleonora Mazziga, Anda Vilmane, Santa Rasa-Dzelzkaleja, Zaiga Nora-Krukle, Angelika Krumina, Modra Murovska, Elisabetta Caselli
Summary: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease without diagnostic biomarkers, but there is evidence supporting a role of herpesviruses and microRNAs in its development. This study found that six out of eight selected microRNAs were differently expressed in ME/CFS patients compared to healthy controls. The levels of these microRNAs correlated with disease severity but not with pro-inflammatory cytokines or HHV-6A/6B genome levels. These results suggest that microRNAs could serve as potential biomarkers and provide insights into ME/CFS pathogenic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)