Article
Biochemistry & Molecular Biology
Gaio Paradossi, Rachel Grossman, Francesco Riccitelli, Federica Todaro, Zvi Ram, Sara Schioppa, Fabio Domenici
Summary: Researchers have developed injectable poly(vinyl alcohol) echogenic microbubbles (MBs) that can actively target tumor tissues by attaching a ligand with the tripeptide sequence RGD on their surface. The findings demonstrate that RGD-MBs have high adhesion to HUVEC cells and successfully bind to the drug TMZ. These improved PVA-MBs possess adhesion ability, cytotoxicity on glioblastoma cells, and support imaging.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Hao Cai, Yufan Xiang, Yujun Zeng, Zhiqian Li, Xiuli Zheng, Qiang Luo, Hongyan Zhu, Qiyong Gong, Zhongwei Gu, Yanhui Liu, Hu Zhang, Kui Luo
Summary: Multi-modal therapeutics using polymeric carriers for simultaneous diagnosis and treatment of cancer have been developed. A theranostic nanomedicine, branched glycopolymer-PTX-DOTA-Gd, showed extended circulation time, enhanced tumor accumulation, and excellent biocompatibility with reduced gadolinium ion retention. This branched polymeric prodrug-based nanomedicine has great potential for safe and effective cancer diagnosis and treatment, achieving enhanced imaging contrast and high antitumor efficacy.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Polina G. Rudakovskaya, Roman A. Barmin, Pavel S. Kuzmin, Elena P. Fedotkina, Alexander N. Sencha, Dmitry A. Gorin
Summary: This review provides a comprehensive summary and critical evaluation of known protein microbubbles over decades, aiming to optimize their safety and imaging efficiency, as well as exploring biomedical applications beyond ultrasound imaging.
Article
Chemistry, Multidisciplinary
Jannik Paulus, Beate Nachtigall, Peter Meyer, Norbert Sewald
Summary: A library of sulfonamide-modified RGD mimetics with high affinity for integrin alpha(V)beta(3) was synthesized. The best structure was selected and conjugated with a cleavable linker and the drug MMAE to form a SMDC. The resulting SMDC showed high affinity and selectivity for alpha(V)beta(3).
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Biomedical
Xue Zhou, Ning Yan, Erik J. Cornel, Haidong Cai, Shaobo Xue, Hao Xi, Zhen Fan, Shisheng He, Jianzhong Du
Summary: This bone-targeting polymer vesicle offers a new platform for the real-time diagnosis and therapy of malignant bone tumors, showing excellent imaging capability and high drug delivery efficiency. The vesicle can be self-assembled in water without the need for a cosolvent, and effectively reduces tumor size while inducing tumor cell necrosis and apoptosis.
Review
Chemistry, Inorganic & Nuclear
Hardev Singh, Divya Sareen, Jiya Mary George, Vineet Bhardwaj, Saehee Rha, Suk Joong Lee, Sheetal Sharma, Amit Sharma, Jong Seung Kim
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Hendrik Schneider, Simon Englert, Arturo Macarron Palacios, Jorge Alberto Lerma Romero, Ataurehman Ali, Olga Avrutina, Harald Kolmar
Summary: The study showcases the design, synthesis, and biological evaluation of integrin-targeting molecular hybrids combining RGD peptides and a potent cytotoxin on dextran polysaccharides. The constructs demonstrated good binding properties to integrin-overexpressing tumor cells and remarkable antiproliferative activity, suggesting a promising approach for developing tailor-made multimeric molecular hybrids with potential antitumor effects.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Elahe Memari, Fiona Hui, Hossein Yusefi, Brandon Helfield
Summary: This study aimed to investigate the effect of fluid flow rate and repeated short-pulse ultrasound on microbubble-mediated endothelial cell permeability. The results demonstrate that fast-flowing microbubbles significantly increased cell membrane permeability, and multiple short pulses of ultrasound also elevated endothelial cell permeability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Medicinal
Truc Thao Huynh, Sreeja Sreekumar, Cedric Mpoy, Buck Edward Rogers
Summary: This study investigates the feasibility of targeting Integrin alpha(nu)beta(6) with radiolabeled peptides. By using albumin binders, tumor uptake was increased for therapeutic applications, while a non-albumin peptide was evaluated as a potential PET imaging agent. The results showed good specific tumor uptake and therapeutic efficacy for these peptides targeting alpha(nu)beta(6)-positive tumors.
Article
Chemistry, Analytical
Kai Jiang, Zhifeng Guan, Yifan Wang, Jiamin Sun, Weiwei Xiong, Fenfen Zheng, Yemei Wang, Jun-Jie Zhu
Summary: In this study, a new nanoplatform with targeting ability, imaging function, and photothermal/photodynamic therapy was developed. This nanoplatform, composed of cancer cell-derived carbon nanodots, exhibited wide light absorption and emission characteristics, as well as excellent biocompatibility and targeted ability. Under laser irradiation, the nanoplatform also demonstrated significant photothermal and photodynamic effects, showing great potential for cancer treatment.
ANALYTICAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Arvin Honari, Shashank R. Sirsi
Summary: Despite recent advancements in ultrasound-mediated drug delivery, no platform utilizing ultrasound contrast agents has received FDA approval. The sonoporation effect has promising applications in clinical settings, but there are safety concerns. Clinical trials are being conducted to evaluate sonoporation's efficacy in treating tumors.
Article
Chemistry, Multidisciplinary
Shan He, Wei Pang, Xiaoyu Wu, Yang Yang, Wenjun Li, Hang Qi, Chongling Sun, Xuexin Duan, Yanyan Wang
Summary: This study proposes a hydrodynamic intracellular delivery system based on the gigahertz acoustic streaming effect, which allows for tunable delivery range by adjusting the acoustic streaming radius. With the assistance of acoustic streaming, AuNRs with different modifications can be targetedly delivered to specific organelles. Additionally, the large quantities of AuNRs introduced via acoustic streaming demonstrate a photothermal effect, which has the potential to shorten the treatment cycle of photothermal therapy. This efficient hydrodynamic technology provides a new idea for precise medical treatment.
Review
Chemistry, Multidisciplinary
Yang Qin, Xiaorui Geng, Yue Sun, Yitong Zhao, Wenyu Chai, Xiaobing Wang, Pan Wang
Summary: Ultrasound (US) is a mechanical wave that can penetrate biological tissues and has diverse applications in diagnosis and treatment. With the advancements in nanotechnology, US has found wider applications in precision medicine, particularly in tumor theranostics. This review focuses on the combination of US with micro and nanoparticles for tumor theranostics, discussing topics such as US-assisted drug delivery and sonodynamic antitumor strategy. The collaborative efficiency and physicochemical processes of US and nano-sensitizers are also analyzed. Furthermore, the review highlights the new applications of US and diagnostic nanoparticles in tumor monitoring and image-guided combined therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biology
Bing Jiang, Xiaohua Jia, Tianjiao Ji, Meng Zhou, Jiuyang He, Kun Wang, Jie Tian, Xiyun Yan, Kelong Fan
Summary: The use of HFn nanoparticles and HFn-Dox drug delivery system enables early diagnosis and treatment of tumors, providing promising strategies for tumor therapy.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Cell Biology
Tsai-Mu Cheng, Wong-Jin Chang, Hsiu-Yi Chu, Roberto De Luca, Jens Z. Pedersen, Sandra Incerpi, Zi-Lin Li, Ya-Jung Shih, Hung-Yun Lin, Kuan Wang, Jacqueline Whang-Peng
Summary: Integrin alpha v beta 3 plays a crucial role in cancer cell proliferation and metastasis, with its ligands and crosstalk with other signaling pathways regulating cancer growth. Inhibition of signals related to integrin alpha v beta 3 has shown promise as a target for cancer therapies. Nanotechnologies, such as the use of nanomaterial carriers, are being increasingly explored for their potential potentiation in cancer treatments targeting integrin alpha v beta 3.