Review
Biochemistry & Molecular Biology
Abdallah S. Attia, Mohammad Hussein, Peter P. Issa, Ahmad Elnahla, Ashraf Farhoud, Brandon M. Magazine, Mohanad R. Youssef, Mohamed Aboueisha, Mohamed Shama, Eman Toraih, Emad Kandil
Summary: The BRAF(V600E) mutation is associated with the clinicopathological progression of PTMC, leading to more aggressive tumors and higher recurrence risk. Patients with BRAF(V600E) mutations may require earlier interventions, while those with wild-type BRAF(V600E) PTMC can be managed conservatively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yun-Suk Choi, Seong-Woon Choi, Jin-Wook Yi
Summary: This study identified TERT promoter mutations in PTC and found that they are associated with more aggressive behavior. Patients with TERT promoter mutations were older, had larger tumors, and exhibited other adverse clinical features, resulting in a poorer prognosis compared to those with wild-type TERT gene status.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yongyue Zhang, Fang Mei, Xiaoxi He, Jing Ma, Shumin Wang
Summary: This study aimed to investigate the relationship between sonographic features and histological manifestations in the tall-cell variant of papillary thyroid microcarcinoma (TCV-PTMC). The study proposed the concept of sonographic histology and examined its value in the clinical management of TCV-PTMC. The results showed that hypoechoic nodules with a localized central isoechoic lesion and hypoechoic halo around nodules were commonly observed in TCV-PTMC, correlating with specific histopathological features. TCV-PTMC also displayed more regular margins and less microcalcification compared to classical PTMC, leading to a potential underestimation of the risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Hee Young Na, Hyeong Won Yu, Woochul Kim, Jae Hoon Moon, Chang Ho Ahn, Sang Il Choi, Yeo Koon Kim, June Young Choi, So Yeon Park
Summary: This study reveals a relatively low frequency of TERT promoter mutations in Korean patients with PTC. Certain clinicopathological features including old age, tall cell variant, increased mitoses, tumour necrosis, and gross extrathyroidal extension were found to be indicative of TERT promoter mutations in PTCs.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Oncology
Min Jhi Kim, Jin Kyong Kim, Gi Jeong Kim, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Woong Youn Chung, Daham Kim, Kee-Hyun Nam
Summary: TERT promoter mutation, investigated for its clinical and prognostic significance in aggressive PTC, showed the lowest prevalence in Korea among a large cohort of PTC patients. The presence of TERT promoter mutations consistently correlated with aggressive PTCs, with a synergistic effect when coexisting with BRAF V600E mutation. Further prospective multicenter studies are needed to establish valuable oncologic outcomes.
Article
Endocrinology & Metabolism
Steven Craig, Cynthia Stretch, Farshad Farshidfar, Dropen Sheka, Nikolay Alabi, Ashar Siddiqui, Karen Kopciuk, Young Joo Park, Moosa Khalil, Faisal Khan, Adrian Harvey, Oliver F. Bathe
Summary: The clinical management of papillary thyroid cancer depends on accurate prognosis estimation. However, the standard prognostic methods based on clinicopathologic features have been found to be inaccurate. In this study, a machine learning algorithm was used to analyze 502 cases, leading to the identification of three distinct molecular subtypes with different biological features and implications for treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Athanasios Bikas, Kristine Wong, Theodora Pappa, Sara Ahmadi, Craig B. Wakefield, Ellen Marqusee, Pingping Xiang, Benjamin Altshuler, Jacob Haase, Justine A. Barletta, Inigo Landa, Erik K. Alexander
Summary: This study analyzed the clinicopathologic and genomic characteristics of tcPTC, PTCtcf, and classic PTC, and found that PTCtcf is an intermediate entity between tcPTC and classic PTC. tcPTC had higher advanced cancer stage, more macroscopic extrathyroidal extension, and worse negative composite outcome compared to PTCtcf. Additionally, tcPTC had a significantly higher incidence of hotspot TERT promoter mutations than PTCtcf.
Article
Oncology
Daniel W. Scholfield, Conall W. Fitzgerald, Bayan Alzumaili, Alana Eagan, Bin Xu, German Martinez, R. Michael Tuttle, Ashok R. Shaha, Jatin P. Shah, Richard J. Wong, Snehal G. Patel, Ronald A. Ghossein, Ian Ganly
Summary: This study compared the clinicopathological characteristics and oncological outcomes of diffuse sclerosing papillary thyroid carcinoma (DS-PTC) to classic PTC (cPTC) and tall cell PTC (TC-PTC). The results showed that DS-PTC patients were younger with more advanced disease and aggressive histopathological features. DS-PTC had lower 5-year recurrence-free survival but excellent disease-specific survival with successful salvage surgery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jun Park, Sungjoo Lee, Kyunga Kim, Hyunju Park, Chang-Seok Ki, Young Lyun Oh, Jung Hee Shin, Jee Soo Kim, Sun Wook Kim, Jae Hoon Chung, Tae Hyuk Kim
Summary: TERT promoter mutations were found to be an independent poor prognostic factor in patients with differentiated thyroid cancer, associated with older age, extrathyroidal invasion, distant metastasis, and advanced stage at diagnosis. These mutations were related to a lower 10-year survival rate and poor prognosis, regardless of histologic type or initial stage, potentially improving prognostic predictability for patients with differentiated thyroid carcinoma.
Review
Medicine, General & Internal
Eleni P. Kotanidou, Styliani Giza, Vasiliki Rengina Tsinopoulou, Kosmas Margaritis, Anastasia Papadopoulou, Eleni Sakellari, Savvas Kolanis, Eleni Litou, Anastasios Serbis, Assimina Galli-Tsinopoulou
Summary: Thyroid cancer is the most common endocrine cancer in children, with papillary thyroid cancer being the most frequent histological type. Mutated BRAF gene is significantly associated with distant metastasis among children/adolescents with PTC. However, mutated BRAF gene is not associated with tumor size, multifocality, vascular invasion, lymph node metastasis, extra-thyroid extension, or tumor recurrence in pediatric/adolescent PTC.
Review
Oncology
Salvatore Ulisse, Enke Baldini, Augusto Lauro, Daniele Pironi, Domenico Tripodi, Eleonora Lori, Iulia Catalina Ferent, Maria Ida Amabile, Antonio Catania, Filippo Maria Di Matteo, Flavio Forte, Alberto Santoro, Piergaspare Palumbo, Vito D'Andrea, Salvatore Sorrenti
Summary: This article discusses the revisions made to the prognostic stratification systems for differentiated thyroid cancer patients over the past few decades and potential future directions. It also summarizes the current staging systems, relevant clinicopathological parameters, and new molecular markers for thyroid cancer patients.
Article
Endocrinology & Metabolism
Tomoe Nakao, Michiko Matsuse, Vladimir Saenko, Tatiana Rogounovitch, Aya Tanaka, Keiji Suzuki, Miyoko Higuchi, Hisanori Sasai, Tsutomu Sano, Mitsuyoshi Hirokawa, Akira Miyauchi, Atsushi Kawakami, Norisato Mitsutake
Summary: The study found a high concordance rate of TERT-p mutations between preoperative fine-needle aspiration samples and postoperative formalin-fixed and paraffin-embedded specimens in papillary thyroid carcinomas (PTCs) aged 55 years or older. The TERT-p mutation was significantly associated with age, tumor size, extrathyroidal extension, and the Ki-67 labelling index in both FNA and FFPE samples, indicating potential clinical utility in predicting disease aggressiveness and guiding PTC management.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Qizhi Tang, Weiyu Pan, Liangyue Peng
Summary: This study assessed the association between Hashimoto thyroiditis (HT) and clinical outcomes of papillary thyroid carcinoma (PTC). The results showed that PTC patients with HT had lower risks of lymph node metastasis, distant metastasis, extrathyroidal extension, recurrence, vascular invasion, and a better 20-year survival rate, while had higher risks of multifocality, perineural infiltration, and bilaterality. This suggests that PTC patients with HT may have favorable clinicopathologic characteristics.
Article
Endocrinology & Metabolism
Weiman He, Yijia Sun, Jiawei Ge, Xuejie Wang, Bo Lin, Shuang Yu, Yanbing Li, Shubin Hong, Haipeng Xiao
Summary: In this study, STRA6 gene was found to be highly expressed in BRAF-mutant papillary thyroid carcinoma (PTC) and associated with poor prognosis. STRA6 may drive thyroid carcinogenesis through activation of the MAPK pathway and regulation of the tumor immunosuppressive microenvironment, making it a potential prognostic marker for BRAF-mutant PTC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Sabrina Daniela da Silva, Gregoire B. Morand, Luciana Diesel, Jefferson Muniz de Lima, Krikor Bijian, Senthilkumar Kailasam, Francois Lefebvre, Guillaume Bourque, Michael Hier, Moulay A. Alaoui-Jamali
Summary: In this study, a high-throughput RNA sequencing technology was used to investigate a group of papillary thyroid carcinomas (PTCs) with an unusually aggressive phenotype. It was found that metastatic PTCs with mutated BRAF (V600E) expressed an up-regulation of RSPO4 and genes involved in focal adhesion and cell-extracellular matrix signaling. Further validation confirmed the upregulation of these target genes in metastatic PTC cases. Preclinical studies supported the association between RSPO4 overexpression and BRAF V600E mutation, indicating the potential for co-targeting B-Raf, RSPO, and focal adhesion proteins as a pharmacological approach for aggressive BRAF V600E PTC.
Article
Plant Sciences
Jung Eun Min, Nguyen Phuoc Long, Ji Yeon Hong, Sun Jo Kim, Nguyen Hoang Anh, Daijie Wang, Xiao Wang, Jeong Hill Park, Sung Won Kwon, Seul Ji Lee
Summary: This study investigates the metabolic alterations during dehiscence in P. ginseng and suggests that morphological activities are the primary phenomena occurring during the dehiscence process, facilitating ginseng seed growth. These findings contribute to a better understanding of P. ginseng germination processes and promote further research on its germination and cultivation.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Infectious Diseases
Soedarsono Soedarsono, Rannissa Puspita Jayanti, Ni Made Mertaniasih, Tutik Kusmiati, Ariani Permatasari, Dwi Wahyu Indrawanto, Anita Nur Charisma, Rika Yuliwulandari, Nguyen Phuoc Long, Young-Kyung Choi, Pham Quang Hoa, Pham Vinh Hoa, Yong-Soon Cho, Jae-Gook Shin
Summary: In this study, a population pharmacokinetics model of isoniazid (INH) was developed for Indonesian patients with tuberculosis (TB), aiming to optimize pharmacotherapy through therapeutic drug monitoring (TDM). The study found that the NAT2 acetylator phenotype significantly affected the clearance of INH.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Oncology
Huy Gia Vuong, Tam N M Ngo, Hieu Trong Le, Ian F. Dunn
Summary: This study found that H3.3 mutation is associated with shorter survival in pediatric patients and longer survival in adult patients with DMGs. Patient age is a factor modulating the prognosis of H3.1 and H3.3 K27M mutations in DMG patients.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Clinical Neurology
Huy Gia Vuong, Ian F. Dunn
Summary: Chondrosarcomas and chordomas exhibit divergent clinical manifestations and prognoses depending on their anatomic location. Chondrosarcomas of the cranial base have better outcomes, while spinal chondrosarcomas and chordomas show opposite survival patterns.
WORLD NEUROSURGERY
(2022)
Review
Oncology
Huy Gia Vuong, Tam N. M. Ngo, Hieu Trong Le, Andrew Jea, Maya Hrachova, James Battiste, Rene McNall-Knapp, Ian F. Dunn
Summary: This study investigated the differences between pediatric and adult H3K27M-mutant midline gliomas by integrating data from published studies. The results showed that pediatric patients exhibited more aggressive features, such as higher rates of high-grade tumor pathology and shorter survival. Additionally, ACVR1 mutations were more common in the pediatric cohort, while MGMT methylation, FGFR1, and NF1 mutations were less prevalent in pediatric patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Huy Gia Vuong, Ian F. Dunn
Summary: This meta-analysis investigated the clinicopathological features, prognostic survivals, and molecular profiles of primary and secondary gliosarcomas. The results showed that these rare brain tumors have distinct clinicopathological profiles and prognoses but similar genetic profiles.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Tadao Nakazawa, Takuya Nagasaka, Keita Yoshida, Atsuko Hasegawa, Feng Guo, Di Wu, Kenzo Hiroshima, Ryohei Katoh
Summary: This study found that TIGIT expression is high in medullary thyroid carcinoma and high-grade thyroid carcinoma, and may have potential benefits in treatment.
BMC ENDOCRINE DISORDERS
(2022)
Article
Otorhinolaryngology
Minh-Khang Le, Toru Odate, Huy Gia Vuong, Kunio Mochizuki, Tetsuo Kondo
Summary: This study stratified the risk of distant metastasis in follicular thyroid carcinoma (FTC) patients using clinical parameters and developed a risk scoring table. It can efficiently separate patients into different risk groups and detect those with almost no risk of metastasis.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nguyen Ky Anh, Phamy My Tung, Min Jung Kim, Nguyen Phuoc Long, Yong-Soon Cho, Dong-Hyun Kim, Jae-Gook Shin
Summary: A method based on LC-MS/MS was developed to determine the concentration of isoniazid and its metabolites in human plasma, showing high sensitivity and stability. The method was successfully applied in TB patients and has broad applications in clinical research and treatment monitoring.
Article
Biochemistry & Molecular Biology
Nguyen Thi Hai Yen, Nguyen Ky Anh, Rannissa Puspita Jayanti, Nguyen Ky Phat, Dinh Hoa Vu, Jong-Lyul Ghim, Sangzin Ahn, Jae-Gook Shin, Jee Youn Oh, Nguyen Phuoc Long, Dong Hyun Kim
Summary: This study investigated the plasma metabolic profiles of tuberculosis (TB) patients and TB patients with type 2 diabetes mellitus (DM) using a multimodal metabolomics and lipidomics approach. Significant differences in biological processes and biomarkers were identified between TB and TB-DM, providing insights into the pathophysiology of TB-DM and potential improvements in TB treatment. The integration of multimodal metabolomics and lipidomics provides a comprehensive understanding of the metabolic changes associated with TB-DM, enhancing our knowledge of DM comorbidity in TB infection and contributing to the development of more effective treatment.
Review
Clinical Neurology
Huy Gia Vuong, Minh-Khang Le, Truong P. X. Nguyen, Kathryn Eschbacher
Summary: This integrated study aimed to investigate the similarities and differences in clinicopathological manifestations, prognoses, and molecular profiles of de novo versus secondary dedifferentiated chordoma (DC). The results showed that de novo and secondary DCs were statistically comparable in terms of patient demographics, clinical manifestations, and prognoses. Gross total excision and radiotherapy were optimal treatments associated with better outcomes of DC patients.
WORLD NEUROSURGERY
(2023)
Article
Multidisciplinary Sciences
Truong Thi My Nhung, Nguyen Phuoc Long, Tran Diem Nghi, Yeongjun Suh, Nguyen Hoang Anh, Cheol Woon Jung, Hong Minh Triet, Minkyo Jung, Youngsik Woo, Jinyeong Yoo, Sujin Noh, Soo Jeong Kim, Su Been Lee, Seongoh Park, Gary Thomas, Thomas Simmen, Jiyoung Mun, Hyun-Woo Rhee, Sung Won Kwon, Sang Ki Park
Summary: Mitochondria-associated ER membranes (MAMs), formed by the endoplasmic reticulum (ER) and mitochondria, play an important role in maintaining calcium homeostasis and neurotransmitter release in the neuronal system. The kinase CK2A1 and its interaction with PACS2 regulate the composition and calcium transport of MAMs. Mutations in PACS2 associated with developmental and epileptic encephalopathy disrupt MAM integrity, leading to impaired mitochondrial calcium uptake and increased cytosolic calcium levels, ultimately causing abnormal neurotransmitter release.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Nguyen Ky Phat, Nguyen Tran Nam Tien, Nguyen Ky Anh, Nguyen Thi Hai Yen, Yoon Ah Lee, Hoang Kim Tu Trinh, Kieu-Minh Le, Sangzin Ahn, Yong-Soon Cho, Seongoh Park, Dong Hyun Kim, Nguyen Phuoc Long, Jae-Gook Shin
Summary: This study investigated the expression of lipid-related genes during anti-TB treatment and their potential use as biomarkers of treatment response. The expression levels of 10 genes were altered during standard anti-TB treatment. The 10-lipid-gene signature could distinguish patients with TB from those with latent tuberculosis infection and non-TB controls, and it could also be useful for monitoring response to anti-TB treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Huy Gia Vuong, Ian F. Dunn
Summary: This study compared silent corticotroph tumors (SCT) with other non-functioning pituitary neuroendocrine tumors (NFT) and functioning corticotroph tumors (FCT) and found that SCTs have demographic, clinicopathological and prognostic differences. These differences indicate that SCTs are high-risk tumors, and appropriate treatment decisions and stricter follow-up plans should be tailored to improve patient outcomes.
Article
Medical Informatics
Van Lam Nguyen, Sangjin Ahn, Pham Quang Hoa, Nguyen Phuoc Long, Sangzin Ahn, Yong-Soon Cho, Jae-Gook Shin
Summary: Tuberculosis is a significant global public health issue and is considered a leading cause of death worldwide. Despite a decline in mortality and incidence rates in Korea, tuberculosis management still poses challenges and requires more effective efforts.
HEALTHCARE INFORMATICS RESEARCH
(2022)