Article
Rheumatology
Michelle Barraclough, Shane McKie, Ben Parker, Rebecca Elliott, Ian N. Bruce
Summary: This study found altered functional connectivity within the default mode network in SLE patients regardless of disease activity, with depression accounting for some of the effect but SLE itself accounting for more. Further research is needed to assess if these changes may be a precursor to cognitive dysfunction in SLE. If so, rs-fMRI could be an early marker for cognitive dysfunction in SLE and assist in future treatment trials.
Article
Multidisciplinary Sciences
Morten L. Kringelbach, Yonatan Sanz Perl, Enzo Tagliazucchi, Gustavo Deco
Summary: Using a large-scale neuroimaging dataset, this study investigates the hierarchical reorganization of the brain's functional activity during naturalistic movie-watching compared to cognitive tasks and resting. The findings show that the hierarchy is flatter and the non-reversibility is smaller during movie-watching. The underlying mechanisms are revealed by a model-based generative effective connectivity (GEC). Overall, this study demonstrates the benefits of using naturalistic neuroscience in understanding brain function.
Article
Geriatrics & Gerontology
Meiqi Yan, Jindong Chen, Feng Liu, Huabing Li, Jingping Zhao, Wenbin Guo
Summary: This study found that patients with major depressive disorder (MDD) who have gastrointestinal (GI) symptoms experience more severe depressive symptoms compared to those without GI symptoms. Distinct patterns in the default mode network (DMN) were also observed in MDD patients with GI symptoms, which can potentially serve as a brain imaging marker for differentiating patients with GI symptoms from those without GI symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuping Cao, Huan Yang, Zhenhe Zhou, Zaohuo Cheng, Xingfu Zhao
Summary: The study demonstrates abnormal DMN network homogeneity in MCI patients, with significant differences in specific brain regions. These results emphasize the importance of the DMN in the pathophysiology of cognitive problems in MCI.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Richard E. Daws, Christopher Timmermann, Bruna Giribaldi, James D. Sexton, Matthew B. Wall, David Erritzoe, Leor Roseman, David Nutt, Robin Carhart-Harris
Summary: Psilocybin therapy has the potential to treat depression by increasing brain network integration, according to two clinical trials. The antidepressant response to psilocybin was rapid and sustained, while escitalopram had milder effects on brain network organization.
Article
Neurosciences
Obada Al Zoubi, Masaya Misaki, Jerzy Bodurka, Rayus Kuplicki, Colleen Wohlrab, William A. Schoenhals, Hazem H. Refai, Sahib S. Khalsa, Murray B. Stein, Martin P. Paulus, Justin S. Feinstein
Summary: Floatation-Reduced Environmental Stimulation Therapy (REST) reduces sensory stimulation by minimizing various sensory signals, leading to short-term reductions in anxiety, depression, and pain. The functional neuroimaging investigation revealed altered patterns of resting-state functional connectivity in the brain networks responsible for creating and mapping our sense of self, with significant decreases within and between posterior hubs of the default-mode network and somatomotor cortices.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Lei Li, Xinyue Huang, Jinming Xiao, Qingyu Zheng, Xiaolong Shan, Changchun He, Wei Liao, Huafu Chen, Vinod Menon, Xujun Duan
Summary: Marital attachment is crucial for maintaining intimate relationships and psychological well-being. Research suggests that shared neural responses during marital communication are strong predictors of marital satisfaction, reflecting shared values and beliefs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Chuanjun Tong, Cirong Liu, Kaiwei Zhang, Binshi Bo, Ying Xia, Hao Yang, Yanqiu Feng, Zhifeng Liang
Summary: This study explores the biological basis of functional connectivity gradients by investigating their relationship with structural wiring and arousal levels in awake marmosets. The results reveal that while the functional gradients are determined by structural connectivity, they can be modulated by arousal levels. The study provides insights into the interaction between structural connectivity and neuromodulation in shaping the dynamics of functional gradients.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Liqiong Luo, Xijun Lei, Canmin Zhu, Jun Wu, Hongwei Ren, Jing Zhan, Yongzhang Qin
Summary: This study aimed to compare the network homogeneity (NH) values in the ventral attentional network (VAN) between patients with major depressive disorder (MDD) and normal controls (NCs). The results showed that treatment-naive MDD patients had decreased NH in the right precuneus (PCu) and abnormal executive control reaction time (ECRT). However, no significant correlation was found between the NH values and clinical variables.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Andrea Wiglesworth, Conner A. Falke, Mark Fiecas, Monica Luciana, Kathryn R. Cullen, Bonnie Klimes-Dougan
Summary: This study explores the neural correlates of suicide ideation in children and identifies aberrant functioning in the default mode network (DMN) as a potential mechanism. These findings have important implications for suicide prevention efforts.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Shubao Wei, Chunhui Lu, Xiuqiong Chen, Lu Yang, Jing Wei, Wenyan Jiang, Yang Liu, Hui Hui Li, Yuhong Qin, Yiwu Lei, Chao Qin, Caiyou Hu, Shuguang Luo
Summary: The study revealed altered regional homogeneity (ReHo) in cervical dystonia patients, particularly in regions related to the pain matrix, salience network, motor network, and cerebellum. There was a significant positive correlation between symptom severity and ReHo value in the right cerebellum crus I in patients with cervical dystonia.
Article
Psychology, Clinical
Marta Martin-Subero, Paola Fuentes-Claramonte, Pilar Salgado-Pineda, Josep Salavert, Antoni Arevalo, Clara Bosque, Carmen Sarri, Amalia Guerrero-Pedraza, Aniol Santo-Angles, Antoni Capdevila, Salvador Sarro, Raymond Salvador, Peter J. McKenna, Edith Pomarol-Clotet
Summary: This study found that patients with schizophrenia show intact activation of the default mode network and other regions associated with recall of autobiographical memories. The failure of de-activation outside the network suggests that schizophrenia may be associated with a general difficulty in de-activation rather than dysfunction of the default mode network per se.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Pauline Jahn, Bettina Deak, Astrid Mayr, Anne Stankewitz, Daniel Keeser, Ludovica Griffanti, Viktor Witkovsky, Stephanie Irving, Enrico Schulz
Summary: This study revealed changes in intrinsic functional network activity in chronic pain patients as the intensity of pain fluctuates, demonstrating the complexity of chronic pain experiences in individuals.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Lars Jonasson Stiernman, Filip Grill, Andreas Hahn, Lucas Rischka, Rupert Lanzenberger, Vania Panes Lundmark, Katrine Riklund, Jan Axelsson, Anna Rieckmann
Summary: The study indicates that during cognitive control, the DMN shows negative BOLD responses without corresponding relative increases in metabolic activity, suggesting functional heterogeneity within this network. The neurovascular coupling underlying BOLD response patterns in the DMN during rest and task appears fundamentally different from BOLD responses in other association networks during cognitive control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychiatry
Sujuan Li, Ziwei Teng, Yan Qiu, Pan Pan, Chujun Wu, Kun Jin, Lu Wang, Jindong Chen, Hui Tang, Hui Xiang, Sara Arenas De Leon, Jing Huang, Wenbin Guo, Bolun Wang, Haishan Wu
Summary: This study found that patients with BD exhibited increased NH in the left superior medial prefrontal cortex and decreased NH in the right posterior cingulate cortex and bilateral precuneus compared to healthy controls. NH in the right PCC was positively correlated with the verbal fluency test and verbal function total scores. NH in the left superior MPFC was negatively correlated with triglyceride (TG) levels, while NH in the right PCC was positively correlated with TG but negatively correlated with high-density lipoprotein cholesterol (HDL-C). NH in the bilateral precuneus was positively correlated with cholesterol and low-density lipoprotein cholesterol (LDL-C). Additionally, NH in the left superior MPFC showed high sensitivity (80.00%), specificity (71.43%), and accuracy (75.61%) in the SVM results.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Yujun Gao, Zhenying Xiong, Xi Wang, Hongwei Ren, Ruoshi Liu, Bing Bai, Liming Zhang, Dongbin Li
Summary: This study found abnormal functional connectivity in patients with right temporal lobe epilepsy (rTLE), and the analysis of these abnormalities can be used for the diagnosis of the disease.
Article
Psychiatry
Dongbin Li, Ruoshi Liu, Lili Meng, Pingan Xiong, Hongwei Ren, Liming Zhang, Yujun Gao
Summary: This study found altered network homogeneity in the ventral somatomotor network in patients with temporal lobe epilepsy, which may be associated with the pathophysiology of the condition.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Yujun Gao, Xinfu Zhao, JiChao Huang, Sanwang Wang, Xuan Chen, Mingzhe Li, Fengjiao Sun, Gaohua Wang, Yi Zhong
Summary: The aim of this study was to explore neuroimaging biomarkers for predicting mild cognitive impairment (MCI) using support vector machine (SVM) classification. Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 53 MCI patients and 68 healthy controls. The results showed decreased regional homogeneity (ReHo) in the right caudate of MCI patients compared to healthy controls. SVM classification achieved an overall accuracy of 68.6%, sensitivity of 62.26%, and specificity of 58.82%.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Yujun Gao, Xin Tong, Jianxiu Hu, Hanjun Huang, Tian Guo, Gang Wang, Yi Li, Gaohua Wang
Summary: This study found that patients with schizophrenia show reduced ALFF values in specific brain regions compared to healthy controls. The support vector machine (SVM) analysis identified that reductions in ALFF values in the bilateral precuneus (PCu) can effectively differentiate between schizophrenia patients and healthy controls.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Hang Lin, Xi Xiang, Junli Huang, Shihong Xiong, Hongwei Ren, Yujun Gao
Summary: This study revealed abnormal degree centrality (DC) in patients with major depressive disorder (MDD) using resting-state functional magnetic resonance imaging (rs-fMRI). The researchers identified the left anterior cerebellar lobe and right caudate as potential imaging biomarkers for the diagnosis of MDD.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Xin Guo, Wei Wang, Lijun Kang, Chang Shu, Hanpin Bai, Ning Tu, Lihong Bu, Yujun Gao, Gaohua Wang, Zhongchun Liu
Summary: This study investigates the relationship between adolescent depression and whole-brain network centrality abnormalities, and finds that changes in brain voxel-level functional connectivity may be a potential biomarker for adolescent depression.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Qian Wang, Yujun Gao, Yuandong Zhang, Xi Wang, Xuying Li, Hang Lin, Ling Xiong, Chunyan Huang
Summary: This study used functional magnetic resonance imaging (fMRI) technology combined with a support vector machine (SVM) to study the imaging pathological mechanism of migraines, aiming to improve the diagnostic accuracy. The findings showed that the DC values of bilateral inferior temporal gyrus (ITG) were significantly lower in migraine patients compared to healthy controls, and the DC value of the left ITG had the highest diagnostic accuracy, sensitivity, and specificity for migraine patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Psychiatry
Xuebing Liu, Xianzhi Sun, Lu Li, Kuan Zeng, Yi Li, Yujun Gao, Jun Ma
Summary: This study found that compared with the group without co-prescribed aripiprazole, the group with co-prescribed aripiprazole had significantly higher levels of fasting blood glucose, blood uric acid, total cholesterol, triglyceride, and low-density lipoprotein cholesterol in long-term hospitalized chronic schizophrenia patients with co-morbid type 2 diabetes. However, there was no difference in prolactin levels. Co-prescribing aripiprazole had no impact on prolactin levels in patients with co-morbid type 2 diabetes.
FRONTIERS IN PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Yujun Gao, Qinji Su, Liang Liang, Haohao Yan, Fengyu Zhang
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Ze Yuan, Xiao Lin, Peng Li, Yu-Jun Gao, Kai Yuan, Wei Yan, Yu-Xin Zhang, Lin Liu, Xi-Mei Zhu, Yi-Jing Zhang, Yan-Ping Bao, Su-Hua Chang, Lin Lu, Le Shi
Summary: This study examines the neural association between depressive symptoms and negative emotional bias. A negative correlation between depressive symptoms and emotional recognition was found. The structure and function of the inferior and lateral orbitofrontal gyrus were found to be related to depressive symptoms and emotional recognition. The core brain regions centered on the inferior orbitofrontal cortex are potential neuroimaging basis for the interaction between depressive symptoms and emotional recognition.
FRONTIERS IN PSYCHIATRY
(2023)
Letter
Psychiatry
Yi Zhong, Yu-jun Chen, Yang Zhou, Yan-Ao-Hai Lyu, Jia-Jun Yin, Yu-jun Gao
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Yi Zhong, Jichao Huang, Wen Zhang, Shuiqing Li, Yujun Gao
Summary: As of 11 Jan 2023, the Coronavirus has infected up to 900 million people in China Mainland, which is more than 60% of the population. The pandemic's sudden and unprecedented nature has led to various psycho-somatic issues among the population. Addressing these issues is crucial as they can have severe consequences for individuals' mental and physical health. The lifting of lockdown measures in China creates an opportunity to provide support and assistance to those who have been affected.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Yujun Gao, Xin Guo, Yi Zhong, Xiaoxin Liu, Shanshan Tian, Jiahui Deng, Xiao Lin, Yanpin Bao, Lin Lu, Gaohua Wang
Summary: This study aimed to explore the changes in brain network homogeneity (NH) in patients with major depressive disorder (MDD) and determine the role of this parameter in differentiating between MDD patients and healthy controls. The results showed reduced NH in the left supramarginal gyrus (SMG) in MDD patients compared to healthy controls. Support vector machine analysis revealed that the NH of the left SMG could effectively differentiate between MDD patients and healthy controls with high accuracy, specificity, and sensitivity. These findings suggest that NH changes in the dorsal attention network may serve as a neuroimaging biomarker for distinguishing MDD patients from healthy individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Y. J. Gao, X. Wang, P-G Xiong, H-W Ren, S-Y Zhou, Y-G Yan, Z-B Zhou, W. Tan, J. Wu
Summary: The study found abnormal network homogeneity in the DMN of patients with initial untreated ITLE, including decreased NH in the right ITG and left MTG, and increased NH in the bilateral PCu and right IPL. Patients with ITLE also exhibited longer executive control reaction times.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
D-B Li, R-S Liu, X. Wang, P-A Xiong, H-W Ren, Y-F Wei, L-M Zhang, Y-J Gao
Summary: In this study, it was found that patients with right temporal lobe epilepsy have lower network homogeneity in the VAN and longer executive control reaction time compared to healthy controls. However, abnormal NH values were not significantly associated with clinical measurements.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
