Article
Biochemistry & Molecular Biology
Elizabeth Bester, Anel Petzer, Jacobus P. Petzer
Summary: Inhibition of DAAO represents a potential treatment for schizophrenia by increasing NMDA receptor function. The compounds studied in this research not only showed inhibition of DAAO, but also demonstrated potential as MAO inhibitors for the treatment of depression and Parkinson's disease.
BIOORGANIC CHEMISTRY
(2022)
Article
Cell Biology
Ning- Yang, Chi-Hsiao Yeh, Tsung-Hsien Tsai, Yi-Ju Chou, Paul Wei-Che Hsu, Chun-Hsien Li, Yun-Hsuan Chan, Li-Tang Kuo, Chun-Tai Mao, Yu-Chiau Shyu, Ming-Jui Hung, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Summary: The study demonstrates that an AI-assisted identification of SNP signatures combined with clinical parameters is effective in identifying asymptomatic high-risk individuals predisposed to HF and predicting HF progression.
Article
Biochemistry & Molecular Biology
Chi-Hsiao Yeh, Yi-Ju Chou, Tsung-Hsien Tsai, Paul Wei-Che Hsu, Chun-Hsien Li, Yun-Hsuan Chan, Shih-Feng Tsai, Soh-Ching Ng, Kuei-Mei Chou, Yu-Ching Lin, Yu-Hsiang Juan, Tieh-Cheng Fu, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Summary: A study in Taiwan found a high proportion of clopidogrel resistance among diabetic PAD patients, suggesting that platelet function test-guided therapy could reduce adverse events. AI-assisted genome-wide association study identified a SNP signature composed of 20 SNPs in 9 protein-coding genes, revealing a protein interaction network related to the endocytosis and recycling of the drug target of clopidogrel. The findings suggest potential for developing precision medicine for antiplatelet therapy in diabetic PAD patients.
Article
Neuroimaging
Wenjun Su, Tianyuan Zhu, Lihua Xu, Yanyan Wei, Botao Zeng, Tianhong Zhang, Huiru Cui, Junjie Wang, Yuping Jia, Jinhong Wang, Donald C. Goff, Yingying Tang, Jijun Wang
Summary: In this study, we found that patients with FES exhibited abnormal white matter integrity, which was associated with the genetic variation of DAOA rs2391191. AA homozygotes showed lower integrity. This finding may offer additional support to the role of DAOA in regulating glutamatergic neurotransmission and mitochondrial function in the pathophysiology of schizophrenia.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Automation & Control Systems
Wenbo Zheng, Lan Yan, Wenwen Zhang, Liwei Ouyang, Ding Wen
Summary: Metaverse is the fusion of cyber-physical-social intelligence, and it becomes the core property of the metaverse. The education domain leads to the birth of the education metaverse, and this article explores smart services in this domain by addressing learning scene, technical framework, and initial expansion. The learning scene in the education metaverse consists of the learner, time, space, and learning events, and a data-knowledge-driven group intelligence framework is proposed to transform data into knowledge and integrate intelligence with knowledge. The application of this framework includes transaction and management services, and it promotes future research in this field.
IEEE TRANSACTIONS ON SYSTEMS MAN CYBERNETICS-SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Arfat Ahmad Khan, Rakesh Kumar Madendran, Usharani Thirunavukkarasu, Muhammad Faheem
Summary: Epilepsy is a serious brain disorder characterized by frequent seizures caused by unexpected electrical changes in brain neural activity. Existing research on predicting epileptic seizures has faced challenges in obtaining patients' characteristics, affecting the reliability of the models. To address these issues, a deep learning approach called D(2)PAM is proposed for classifying pre-ictal signals of epilepsy patients based on brain signals. Integrating deep neural networks with D(2)PAM reduces the impact of patient differences and improves the generalizability and stability of the trained model. The proposed model transforms brain signals into data blocks suitable for pre-ictal classification, providing early warning and auxiliary diagnosis.
CAAI TRANSACTIONS ON INTELLIGENCE TECHNOLOGY
(2023)
Review
Food Science & Technology
Chao Lu, Weihua Zhou, Xinjue He, Xinxin Zhou, Chaohui Yu
Summary: The study found that patients with celiac disease have lower Vitamin D levels compared to controls, which improve after treatment, but there is no difference in Vitamin D Receptor genotypes between the two groups.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Yu-Jung Cheng, Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: Recent studies have shown the association of d-amino acids, especially d-serine, with brain and neurological disorders, affecting neurotransmission and learning and memory functions through NMDARs modulation. Aberrant levels of d-amino acids and gene polymorphisms related to d-amino acid metabolism are linked to neurodegenerative brain conditions. The roles of d-amino acids and pLG72 in schizophrenia and Alzheimer's disease, as well as their diagnostic and therapeutic value, are reviewed in this study.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Masanobu Yoshikawa, Takugi Kan, Kosuke Shirose, Mariko Watanabe, Mitsumasa Matsuda, Kenji Ito, Mitsuru Kawaguchi
Summary: High concentrations of d-aspartic acid and low concentrations of d-serine and d-alanine were found in the parotid, submandibular, and sublingual glands in rats. Enzymes including d-amino acid oxidase, d-aspartate oxidase, and serine racemase were detected in these major salivary glands. The N-methyl-d-aspartic acid receptor subunits NR1 and NR2D were also present. These findings suggest that d-amino acids play a physiological role in the endocrine and exocrine functions of salivary glands.
Letter
Biochemistry & Molecular Biology
Yusuke Gonda, Chiharu Ishii, Masashi Mita, Naoto Nishizaki, Yoshiyuki Ohtomo, Kenji Hamase, Toshiaki Shimizu, Jumpei Sasabe
Summary: Astrocytic DAO specifically regulates D-serine in the hindbrain, without affecting D-amino acid levels in the forebrain or periphery.
Article
Medicine, General & Internal
Suchitra Kumari, A. Raj Kumar Patro, Baijayantimala Mishra, Saubhagya Kumar Jena, Sweta Singh
Summary: This study found that the A allele of rs1800449 polymorphism of the LOX gene is associated with an increased risk of ovarian cancer in East Indian population. Serum LOX levels could be a potential biomarker for the diagnosis and prognosis of ovarian cancer.
Article
Psychiatry
Raymond Salvador, Maria Angeles Garcia-Leon, Isabel Feria-Raposo, Carlota Botillo-Martin, Carlos Martin-Lorenzo, Carmen Corte-Souto, Tania Aguilar-Valero, David Gil-Sanz, David Porta-Pelayo, Manuel Martin-Carrasco, Francisco del Olmo-Romero, Jose Maria Santiago-Bautista, Pilar Herrero-Munecas, Eglee Castillo-Oramas, Jesus Larrubia-Romero, Zoila Rios-Alvarado, Jose Antonio Larraz-Romeo, Maria Guardiola-Ripoll, Carmen Almodovar-Paya, Mar Fatjo-Vilas Mestre, Salvador Sarro, Peter J. McKenna, Edith Pomarol-Clotet
Summary: In this study, a deep learning classification algorithm based on convolutional neural networks was developed to identify the risk of schizophrenia using fingerprints. The results suggest that fingerprints can be used as early predictors of psychosis.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Medicine, General & Internal
Shaowei Jiang, Yang Wang, Liang Chen, Honghua Mu, Connor Meaney, Yiwen Fan, Janesh Pillay, Hairong Wang, Jincheng Zhang, Shuming Pan, Chengjin Gao
Summary: This study investigates the associations among serum levels of PAI-1, PAI-1 gene polymorphisms, immunological indicators, and clinical outcomes in septic patients. The results suggest that genetic polymorphisms of PAI-1 can affect serum levels of PAI-1, which in turn may influence mortality by affecting neutrophil activity.
CHINESE MEDICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kai Yang, Bin Huang, Charles Amanze, Zhen Yan, Guanzhou Qiu, Xueduan Liu, Hongbo Zhou, Weimin Zeng
Summary: In this study, the catalytic activity of DAAO towards D-glufosinate (D-PPT) was significantly increased through mutagenesis, leading to the establishment of an efficient enzymatic route for synthesizing L-PPT. This research also proposes a new perspective on enzyme engineering for the biosynthesis of unnatural amino acids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Yen-Shan Lin, Wei-Chung Mao, Nai-Tzu Yao, Guochuan Emil Tsai
Summary: This study evaluated the safety and pharmacokinetic profile of sodium benzoate after single-dose oral administration in healthy volunteers. The results showed a nonlinear increase in C-max and AUC of sodium benzoate within the dose range. Sodium benzoate was rapidly absorbed and converted to benzoic acid, and no adverse events related to sodium benzoate were reported during the treatment.
CLINICAL THERAPEUTICS
(2022)