Review
Biochemistry & Molecular Biology
Charlotte Hinault, Philippe Caroli-Bosc, Frederic Bost, Nicolas Chevalier
Summary: Diabetes mellitus is a significant global health problem, impacting individuals and economies. The chronic hyperglycemia associated with diabetes leads to severe complications, including retinopathy, kidney failure, and cardiovascular diseases. While genetic factors and environmental factors like sedentary lifestyles, overweight, and obesity contribute to the development of diabetes, there is growing evidence suggesting the role of endocrine-disrupting chemicals (EDCs) in the pathophysiology of diabetes and metabolic disorders. This narrative review critically examines the impact of EDCs on our endocrine system and their link to diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Mafalda Presunto, Melissa Mariana, Margarida Lorigo, Elisa Cairrao
Summary: Endocrine disruptor chemicals (EDCs) can harm the endocrine system and negatively impact development, reproduction, neurological functions, cardiovascular health, immune system, and metabolism in both humans and wildlife. Bisphenol A (BPA), a proven EDC, can mimic or block receptors and alter hormone levels and metabolism, even at low doses. Exposure to BPA in humans has been linked to the development of various diseases. This literature review highlights the harmful effects of BPA on human male fertility, including hormonal and semen changes, but more extensive and reproducible scientific studies are needed to strengthen these conclusions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Hala F. S. Abulehia, Noor Shafina Mohd Nor, Siti Hamimah Sheikh Abdul Kadir
Summary: Prenatal exposure to low doses of bisphenol A (BPA) may increase the risk of obesity and type 2 diabetes mellitus (T2DM).
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Article
Biochemistry & Molecular Biology
Selvaraj Jayaraman, Kalaiselvi Krishnamoorthy, Monisha Prasad, Vishnu Priya Veeraraghavan, Rajapandiyan Krishnamoorthy, Mohammad A. Alshuniaber, Mansour K. Gatasheh, Mohamed Elrobh, Gunassekaran
Summary: Herbicides, particularly glyphosate, have been found to increase the risk of developing diabetes by negatively affecting insulin signaling pathways in skeletal muscle. Glyphosate exposure leads to hyperglycemia, dyslipidemia, and oxidative stress, while reducing antioxidant enzymes. It alters the expression of key molecules involved in insulin metabolism and shows a high binding affinity with them. These findings provide experimental evidence linking glyphosate exposure to insulin resistance and the development of type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Laura Maria Daian, Gabriela Tanko, Andrei Mircea Vacaru, Luiza Ghila, Simona Chera, Ana-Maria Vacaru
Summary: Diabetes, affecting nearly half a billion people worldwide, is linked to dysfunction of beta-cells. Exposure to endocrine-disrupting chemicals, such as bisphenol A (BPA), has been correlated with increased diabetes incidence. This study explores the activation of unfolded protein response (UPR) pathways in beta-cells under BPA treatment and the potential recovery of endoplasmic reticulum (ER) homeostasis. The findings suggest that modulators of UPR, like the chemical chaperone TUDCA, could be used as therapeutic interventions to restore beta-cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Mengjiao Wang, Min Chen, Rui Guo, Yangyang Ding, Haihui Zhang, Yuanqing He
Summary: This review summarizes the role of sulforaphane in improving T2DM and its potential mechanisms, especially in insulin resistance, glucose metabolism, lipid metabolism, oxidative stress, and inflammatory factors. It also emphasizes the effects of sulforaphane on T2DM complications and provides evidence for further research and development as a hypoglycemic drug.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Neurosciences
S. Sri Sabari, Kiruthika Balasubramani, Mahalaxmi Iyer, Harysh Winster Sureshbabu, Dhivya Venkatesan, Abilash Valsala Gopalakrishnan, Arul Narayanaswamy, Nachimuthu Senthil Kumar, Balachandar Vellingiri
Summary: Growing evidence suggests a connection between insulin dysregulation in the brain and Parkinson's disease (PD), although the link between PD and type 2 diabetes mellitus (T2DM) is still debated. Insulin plays a crucial role in brain function, and changes in insulin metabolism and signaling can lead to various brain disorders. T2DM is linked to PD and other neurodegenerative diseases, sharing pathophysiological factors such as insulin dysregulation, oxidative stress, microglial activation, and inflammation. Further research should focus on understanding the role of insulin in order to develop effective therapies for T2DM-associated PD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kangkang Huang, Yunlai Liang, Kun Wang, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study evaluated the correlation between nesfatin-1, GSH, and SOD levels with beta-cell insulin secretion and found that these biomarkers were significantly decreased in patients with type 2 diabetes mellitus (T2DM) compared to prediabetes and healthy participants. Furthermore, the study showed that circulating levels of nesfatin-1, GSH, and SOD were strongly correlated with beta-cell insulin secretion and significantly influenced the secretion.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Marwa Matboli, Marwa Mostafa Kamel, Nada Essawy, Meram Mohamed Bekhit, Basant Abdulrahman, Ghada F. Mohamed, Sanaa Eissa
Summary: The study constructed a ceRNA network associated with insulin resistance, validated its expression in clinical samples and cell lines, and successfully knocked out a specific lncRNA using CRISPR/Cas9. The findings highlight the significance of this network as a therapeutic target for gene editing in T2DM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Huimin Wang, Xuepei Lei, Zhuo Zhang, Mohammad Mehdi Ommati, Zhongwei Tang, Jianqin Yuan
Summary: The study indicates that BPA exposure has detrimental effects on cognitive function and insulin signaling pathway in male offspring mice, potentially posing a risk for long-term neurodegeneration.
Article
Biotechnology & Applied Microbiology
Jiangshan You, Mengyao Zhao, Shumin Chen, Lihua Jiang, Shuhong Gao, Hao Yin, Liming Zhao
Summary: Chitooligosaccharides (COS), naturally present in the ocean, have a variety of physiological activities. This study found that COS has therapeutic effects on mice with type 2 diabetes, as it effectively reduces blood glucose and blood lipid levels, improves glucose tolerance, and inhibits alpha-glucosidase. Additionally, COS enhances insulin signal transduction, glycogen synthesis, and protects and restores islet cell function.
BIORESOURCES AND BIOPROCESSING
(2022)
Article
Endocrinology & Metabolism
Xu Wu, Yashan Li, Baohua Man, Dexuan Li
Summary: The study found significant differences in OGTT, C-peptide, and insulin tests between T2DM/FD-T2DM and NGT/FD-NGT groups, as well as significantly higher expression of miR-375 in T2DM and FD-T2DM groups compared to NGT and FD-NGT groups. MiR-375 may serve as a stable biomarker for the early prediction of T2DM among high-risk individuals.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Environmental Sciences
Xiaodie Yao, Shijie Geng, Lijun Zhu, Hua Jiang, Juan Wen
Summary: In addition to known sociodemographic factors, long-term exposure to environmental pollutants has been found to contribute to the development of gestational diabetes mellitus (GDM), although there is controversy surrounding the conclusions. A systematic review and meta-analysis were conducted to comprehensively examine the association between environmental pollutants and GDM. The analysis of epidemiological studies revealed associations between GDM and exposure to certain pollutants, such as phthalates, per-and poly-fluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). Experimental studies suggested potential biological mechanisms linking pollution exposure and GDM, including insulin resistance, beta-cell dysfunction, inflammation, and alterations in gut microbiome.
Article
Biochemistry & Molecular Biology
Jyotirmoy Rakshit, Ayushi Priyam, Karthik Kumar Gowrishetty, Sudhanshu Mishra, Jaya Bandyopadhyay
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Ayushi Priyam, Ratul Kumar Das, Aaron Schultz, Pushplata Prasad Singh
SCIENTIFIC REPORTS
(2019)
Article
Materials Science, Biomaterials
Indu Singh, Ayushi Priyam, Diksha Jha, Gagan Dhawan, Hemant K. Gautam, P. Kumar
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Chemistry, Medicinal
Charu Garg, Ayushi Priyam, Pradeep Kumar, Ashwani Kumar Sharma, Alka Gupta
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Biotechnology & Applied Microbiology
Vatsala Koul, Divya Srivastava, Pushplata Prasad Singh, Mandira Kochar
Article
Environmental Sciences
Ayushi Priyam, Luis O. B. Afonso, Aaron G. Schultz, Pushplata Prasad Singh
Summary: This study examined the acute toxic effects and trophic transfer of different types of P-based nanomaterials on Caenorhabditis elegans. The results showed minimal impact on the nematodes and no additional toxicity was observed at environmentally relevant concentrations. Confocal microscopy confirmed the interaction and internalization of the nanomaterials, providing key information on the environmental safety of agriculturally relevant nanomaterials on non-target species.
Article
Microbiology
Pushplata Prasad Singh, Divya Srivastava, Sadhana Shukla, Varsha
Summary: Arbuscular mycorrhizal (AM) fungi are endosymbionts of terrestrial plants, enhancing plant nutrient extraction and stress tolerance. This study presents the first draft of the genome sequence of Rhizophagus proliferus, an important AM species in biofertilizer consortia. Genome analysis revealed a high number of carbohydrate esterases (CE) in R. proliferus, suggesting potential saprotrophic activity and a role in linking plants to soil mineral nutrients. This genome sequence serves as an important reference for future functional genomics studies in developing biofertilizer formulations and understanding host-specific interactions and agricultural benefits in AM fungi.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ayushi Priyam, Pushplata Prasad Singh, Luis O. B. Afonso, Aaron G. Schultz
Summary: The study found that biogenic nHAPs did not cause acute or sublethal toxic effects in zebrafish embryos, while nP caused sublethal toxicity at higher doses, resulting in spinal curvature, yolk sac edema, and pericardial edema.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Environmental Sciences
Ayushi Priyam, Pushplata Prasad Singh, Luis O. B. Afonso, Aaron G. Schultz
Summary: Nanoscale phosphorus-based formulations in agriculture have the potential to be new fertilizers, addressing the challenges of conventional bulk P fertilizers. These formulations show no acute toxicity and minimal sublethal toxicity to aquatic organisms under environmentally realistic conditions. The properties of the nanomaterials change over time and in the presence of certain factors.
Article
Multidisciplinary Sciences
Ayushi Priyam, Natasha Yadav, Pallavolu M. Reddy, Luis O. B. Afonso, Aaron G. Schultz, Pushplata Prasad Singh
Summary: This study investigates the fertilizing efficacy of phosphorous-based nanomaterials on tomato plants. The results show that these nanomaterials enhance germination and plant growth, increase phosphorous levels in plants, and do not cause stress to the plants.
Article
Horticulture
Pushplata Prasad Singh, Ayushi Priyam, Jagdeep Singh, Naveen Gupta
Summary: The use of nanoparticles as plant nutrient supplementing source is an advanced and sustainable solution to reduce conventional fertilizer dosages and enhance crop health and yield, leading to the minimization of carbon footprint in agriculture.
SCIENTIA HORTICULTURAE
(2023)
Review
Chemistry, Analytical
Sadhana Shukla, Pushplata Singh, Shruti Shukla, Sajad Ali, Nidhi Didwania
Summary: Medicinal plants are vulnerable to various biotic inconveniences, such as Alternaria pathogens, which cause economic losses and impact product quality. Traditional detection methods are time-consuming and expensive. Nanotechnology offers a promising solution with the development of portable biosensors for early and accurate detection of plant pathogens. This review summarizes traditional and advanced sensing technologies and proposes the use of electrochemical and/or colorimetric properties-based nano-biosensors for detecting Alternaria and other plant pathogens in medicinal plants.
Article
Agriculture, Multidisciplinary
Ayushi Priyam, Natasha Yadav, Pallavolu M. Reddy, Luis O. B. Afonso, Aaron G. Schultz, Pushplata Prasad Singh
Summary: This study provides the first evidence of the uptake and localization of biogenic P-based nanomaterials in rice plants, demonstrating their benefits for plant growth in various soil types.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)