Article
Immunology
Michael W. Dunne, Steven Aronin, Anita F. Das, Karthik Akinapelli, Jeanne Breen, Michael T. Zelasky, Sailaja Puttagunta
Summary: This study compared the clinical and microbiological responses of different treatment regimens in patients with complicated urinary tract infections, and the results showed that sulopenem was not superior to the comparator regimen.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Ying Li, Yousheng Yin, Xiaomei Peng, Hongguang Zheng, Fajun Fu, Zhenxiang Liu, Xiongfei Wu, Xiaoyan Wu, Song Zheng, Nan Chen, Leye He, Laicheng Ren, Zhaohui Ni, Detian Li, Peiyu Liang, Xiaoju Lv, Yingyuan Zhang
Summary: In this randomized, active-controlled clinical trial, oral sitafloxacin and levofloxacin showed similar clinical cure rate and bacterial eradication rate in treating acute uncomplicated and complicated UTIs. The incidence of drug-related adverse events was also comparable between the two drugs.
ANNALS OF MEDICINE
(2021)
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Infectious Diseases
Candida Diaz-Brochero, Martha Carolina Valderrama-Rios, Laura Cristina Nocua-Baez, Jorge Alberto Cortes
Summary: First-generation cephalosporins could be a potential therapy for community-acquired complicated upper UTI in adults requiring hospital care, although further comparative studies are needed to evaluate their benefits and harms due to limitations in the existing evidence.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Lalitha Maniam, Kumutha Malar Vellasamy, Teng Aik Ong, Cindy Shuan Ju Teh, Kartini Abdul Jabar, Vanitha Mariappan, Vallikkannu Narayanan, Jamuna Vadivelu, Vinod Pallath
Summary: This study aimed to investigate the distribution of virulence determinants and antimicrobial resistance among different phylogroups of UPEC isolated from various clinical categories of cUTI and ASB E. coli isolates. The findings showed that the virulence factors and antibiotic resistance of UPEC isolates varied in different cUTI categories, and specific genotypic characteristics of UPEC were associated with severe UTI.
Article
Medicine, General & Internal
Masayuki Maeda, Takeshi Hasegawa, Hisashi Noma, Erika Ota
Summary: This systematic review and meta-analysis aims to explore and compare the clinical outcomes of complicated urinary tract infections caused by antimicrobial-resistant uropathogens treated with carbapenem and non-carbapenem antibiotics. The study will search and assess relevant articles published until December 2022, and estimate the treatment effects using the random-effects model.
Article
Veterinary Sciences
Silvia Pavone, Roberto Rinoldo, Elisa Albini, Alessandro Fiorucci, Biagio Caponi, Anna Fratto, Elisabetta Manuali, Paola Papa, Chiara Francesca Magistrali
Summary: This is the first report of C. kerstersii infection in animals (goat), showing severe pyelonephritis and multi-organ vasculitis. The findings suggest C. kerstersii as a possible cause of urinary tract infection from extraintestinal sites.
BMC VETERINARY RESEARCH
(2021)
Review
Immunology
Manu P. Bilsen, Rosa M. H. Jongeneel, Caroline Schneeberger, Tamara N. Platteel, Cees van Nieuwkoop, Lona Mody, Jeffrey M. Caterino, Suzanne E. Geerlings, Bela Koves, Florian Wagenlehner, Simon P. Conroy, Leo G. Visser, Merel M. C. Lambregts
Summary: Urinary tract infection (UTI) definitions in current research studies are highly varied in terms of clinical signs and diagnostic tests. Most studies do not meet the criteria outlined in existing research guidelines. This systematic review highlights the need for a consensus-based, research reference standard for defining UTI.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Hanna P. Wallin, Mika Gissler, Paivi E. Korhonen, Mikael O. Ekblad
Summary: This study found a correlation between maternal smoking and an increased prevalence of UTIs during pregnancy. However, this association was attenuated in the pregnancy-pair analysis. This suggests that the association between maternal smoking during pregnancy and adverse maternal health effects might be more complex than previously thought.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Biotechnology & Applied Microbiology
Grazyna Krzemie, Malgorzata Panczyk-Tomaszewska, Elzbieta Gorska, Agnieszka Szmigielska
Summary: The study found that Vanin-1 is not a reliable predictor of acute pyelonephritis, as its diagnostic value is inferior to other conventional serum inflammatory markers.
Article
Pediatrics
Dimitri Rast, Katrina Suzanne Evers, Adrian Egli, Christoph Rudin, Alexandra Goischke, Nicole Ritz
Summary: Beyond malodorous urine, A. urinae detection is associated with more severe presentations including UTI in the pediatric population. A. urinae was mainly detected in boys with pre-existing urogenital disorders; therefore, a nephro-urological investigation should be considered in cases of A. urinae detection in the pediatric population.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Microbiology
David Melnick, Angela K. Talley, Vipul K. Gupta, Ian A. Critchley, Paul B. Eckburg, Kamal A. Hamed, Nivedita Bhatt, Gary Moore, Daren Austin, Christopher M. Rubino, Sujata M. Bhavnani, Paul G. Ambrose
Summary: The clinical relevance of bacteriuria after antibiotic treatment of complicated urinary tract infections is controversial. This study evaluated the impact of urine pharmacokinetics on the timing of recurrent bacteriuria in a clinical trial comparing oral tebipenem pivoxil hydrobromide and intravenous ertapenem. The prolonged urinary clearance and dwell time of ertapenem were associated with a temporal difference in the repopulation of bladder urine with bacteria following treatment, potentially confounding efficacy assessment.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Jian Liu, Ying Jiang, Zhe Liu, Qun Song, Zhuo Li
Summary: Upper urinary tract obstruction caused by fungal balls is a rare disease. This article reports a case of an elderly man who was initially misdiagnosed with emphysematous pyelonephritis with Aerogenes infection. The patient eventually underwent surgery and antifungal therapy.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Akahito Sako, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Hidekatsu Yanai, Yoshiaki Gu, Norio Ohmagari
Summary: This study used a nationwide Japanese database to investigate the incidence of hospitalization due to urinary tract infections, revealing that UTI poses a significant clinical and economic burden in Japan.
BMC INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Mariela Corrales, Elizabeth Corrales-Acosta, Juan Guillermo Corrales-Riveros
Summary: Urinary tract infection (UTI) is a common issue in pregnant women, and proper antibiotic selection is crucial for the safety of both mother and fetus. Multiple international guidelines provide recommendations for UTI treatment during pregnancy, with some variations but overall consensus on key points regarding antibiotic use.
JOURNAL OF CLINICAL MEDICINE
(2022)