Article
Engineering, Biomedical
Vignesh K. Manivasagam, Gopinath Perumal, Harpreet Singh Arora, Ketul C. Popat
Summary: Micro/nano scale surface modifications of titanium based orthopedic and cardiovascular implants have been shown to improve biocompatibility. However, bacterial infection remains a major concern for implant failure. Recent studies have found that superhydrophobic surfaces can prevent protein and bacterial cell adhesion. This study used a thermochemical treatment to modify the properties of the titanium surface and achieved superhydrophilic and superhydrophobic surfaces by modifying with polyethylene glycol and silane, respectively. The modified surfaces significantly reduced bacterial cell adhesion and prevented biofilm formation.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Biotechnology & Applied Microbiology
Vignesh K. Manivasagam, Ketul C. Popat
Summary: The aim is to develop a superhydrophobic implant surface with a novel micro-nano topography using a facile thermochemical process. The blood compatibility on different surfaces is assessed by evaluating hemolysis, fibrinogen adsorption, cell adhesion and identification, thrombin generation, complement activation, and whole blood clotting kinetics. The results indicate that the super-hemo/hydrophobic micro-nano titanium surface improves hemocompatibility, making it highly potential as an implant.
BIOENGINEERING-BASEL
(2023)
Article
Chemistry, Physical
Serena De Santis, Edoardo Rossi, Marco Sebastiani, Simona Sennato, Edoardo Bemporad, Monica Orsini
Summary: Surface free energy (SFE) of titanium surfaces plays a significant role in tissue engineering, affecting the effectiveness and long-term stability of active coatings and functionalization as well as the establishment of strong bonds to newly growing bone. This study used a high-resolution non-destructive elastic contacting nanoindentation method to investigate the SFE of micro- and nano-structured titanium surfaces, both immediately after preparation and after exposure to air. The effectiveness of different surface treatments in enhancing SFE was evaluated. The study observed a time-dependent decay of SFE within a few hours, with kinetics related to sample preparation. The fast, non-destructive method allowed for accurate measurement of SFE in very hydrophilic conditions, allowing for reliable comparison between surfaces with different properties.
Article
Nanoscience & Nanotechnology
Navid Saneie, Varun Kulkarni, Kamel Fezzaa, Neelesh A. Patankar, Sushant Anand
Summary: Manipulating surface topography is a promising strategy for increasing droplet contact efficiency with superheated surfaces. A study found that the Leidenfrost temperature paradoxically increases as the texture spacing is reduced below a critical value. Despite appearing to boil upon contact, the behavior of droplets on such surfaces is dominated by hydrodynamic instabilities. The comprehensive map of boiling behavior of droplets on textured surfaces has significant implications for applications such as electronics cooling, spray cooling, nuclear reactor safety, and containment of fire calamities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Xiang Zhang, Azhen Du, Yongsheng Luo, Cunjing Lv, Yu Shrike Zhang, Shujie Yan, Yuanda Wu, Jingjiang Qiu, Yong He, Lixia Wang, Qian Li
Summary: Controlling the morphology and spreading behavior of liquids on solid surfaces can be achieved by designing hydrophilic micropillar arrays. The arrangement and shape of the micropillars play a crucial role in determining the shape of the liquid droplet and the spreading pattern. Surface energy barriers caused by micropillar edges were found to be key factors influencing the anisotropic spreading of the liquid.
SURFACES AND INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Wenyue Yang, Xiao Liu, Yingjing Fang, Shokouh Attarilar, Chenyuan Zhu, Liqiang Wang, Qing Luo, Yuanfei Fu
Summary: The incorporation of TiO2 nanoparticles into the TNTZ matrix using friction stir processing (FSP) improved the osteogenic capacity of rat bone marrow stromal stem cells (BMSCs). The TiO2/TNTZ composite showed a refined grain structure and enhanced surface characteristics, promoting BMSCs adhesion, proliferation, and spreading, and upregulating osteogenic gene expression. This novel micro-nano composite has great potential for future clinical applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Review
Chemistry, Multidisciplinary
Wei Wang, Ping-Fan Li, Rui Xie, Xiao-Jie Ju, Zhuang Liu, Liang-Yin Chu
Summary: Smart polymeric materials that can respond to environmental stimuli and dynamically adjust their physico-chemical characteristics have gained significant attention in various fields. The combination of micro-/nano-structures and molecular design offers promising opportunities for the development of advanced smart polymeric materials. This review highlights recent progress in the design and fabrication of smart polymeric materials that incorporate micro-/nano-structures and molecular design to achieve desired functions. Various examples, including smart hydrogels, gating membranes, gratings, milli-particles, micro-particles, and microvalves, are discussed, emphasizing the interplay between their micro-/nano-structures and responsive properties for practical applications. The review concludes with perspectives on the current challenges and future opportunities in the development of micro-/nano-structured smart polymeric materials.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoran Yu, Ruogu Xu, Zhengchuan Zhang, Qiming Jiang, Yun Liu, Xiaolin Yu, Feilong Deng
Summary: The study shows that TNTs and TNNs have dual advantages in promoting osteogenesis and inhibiting osteoclastogenesis. TNTs are stronger in promoting osteogenesis, while TNNs perform better in inhibiting osteoclast activity.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biophysics
Wentao Liu, Luxin Liang, Bo Liu, Dapeng Zhao, Yingtao Tian, Qianli Huang, Hong Wu
Summary: This study demonstrated the significant impact of micro/nano-structured Ti surfaces on the morphology and function of macrophages, as well as their ability to polarize macrophages towards the M2 phenotype, promote osteoblast maturation, and exhibit strong anti-inflammatory and osteo-immunomodulatory effects. Introducing micro/nano-topographies onto Ti-based implant surfaces has promising potential to regulate inflammatory responses and mediate osteogenesis.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Morena Petrini, Tania Vanessa Pierfelice, Emira D'Amico, Natalia Di Pietro, Assunta Pandolfi, Camillo D'Arcangelo, Francesco De Angelis, Domitilla Mandatori, Valeria Schiavone, Adriano Piattelli, Giovanna Iezzi
Summary: Current research on dental implants has focused on the influence of surface roughness on osseointegration rate, while studies on developing surfaces to improve interaction with peri-implant soft tissues are lacking. This study showed that implant discs with Ti-S surfaces promoted adhesion and proliferation of gingival fibroblasts in vitro, suggesting their potential for in vivo applications. Further research is needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Esfandyar Askari, Mahdieh Shokrollahi Barough, Mehdi Rahmanian, Nazanin Mojtabavi, Ramin Sarrami Forooshani, Amir Seyfoori, Mohsen Akbari
Summary: This article summarizes the applications of micro/nanostructured hydrogels in cancer immunotherapy, focusing on their local and systemic effects and potential clinical translation. Hydrogels as carriers can stimulate immune cells by releasing tumor lysate, drugs, or nanovaccines, activating systemic antitumor immune responses and inhibiting tumor metastasis and recurrence.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biophysics
Priya Mandal, Jayanth Ivvala, Harpreet S. Arora, Sajal K. Ghosh, Harpreet S. Grewal
Summary: Inspired by biological systems, a study focused on large scale fabrication of superhydrophobic and multifunctional aluminum surfaces with excellent antibacterial activity and corrosion resistance. The coated surfaces have self-cleaning ability and prevent biofouling, making them suitable for biological environment and marine components.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
T. Krenek, V Jandova, T. Kovarik, M. Pola, D. Moskal, J. Pola, T. Stich, D. Docheva, R. Fajgar, P. Mikysek, Z. Kolska
Summary: The unexplored effect of chemical treatment on laser micro/nanostructured titanium surfaces was investigated, showing the formation of crystalline CaCO3 and doubts about the role of an intermediary CaTiO3 in biomimetic apatite formation. The study assessed the physicochemical changes on the treated titanium surfaces in simulated body fluid, finding that the biomimetic formation of Ca phosphate occurred on the surface and in the bulk solution. Additionally, the growth and osteogenic differentiation of hMSCs were impeded on surfaces modified by the NaOH-CaCl2-heat-water treatment.
MATERIALS CHEMISTRY AND PHYSICS
(2021)
Article
Chemistry, Physical
Oleksandr Tisov, Alina Yurchuk, Mykhaylo Pashechko, Iryna Pohreliuk, Dariusz Chocyk, Myroslav Kindrachuk
Summary: This paper investigates the microstructure, phase composition, and tribological response of BT22 bimodal titanium alloy samples. By selectively laser-processing the samples before nitriding, a nano-fine cell-type microstructure was achieved. The nitrided layer exhibited an average grain size of 300-400 nm, with some smaller cells measuring 30-100 nm. XRD tests confirmed the formation of Ti2N. The combined laser-thermochemical processing resulted in improved wear resistance compared to solely nitrided samples.
Article
Nanoscience & Nanotechnology
Anna Mariano, Claudia Latte Bovio, Valeria Criscuolo, Francesca Santoro
Summary: The development of a functional nervous system depends on interactions between neurons and cues in the neural extracellular matrix (ECM). ECM topographical cues strongly influence neuronal function and behavior. This article discusses how the blueprint of the brain's ECM organization can inspire the design of biomimetic substrates that enhance neural interfaces and control neuronal behavior. Strategies to mimic cell-ECM and cell-cell interactions are explored, including the use of roughness and 3D scaffolds. Anisotropic features such as grooves and fibers can guide neuronal development, while isotropic topographical cues can reproduce neuron-neuron interactions. Advanced techniques like two-photon polymerization and dynamic interfaces are paving the way for smart biointerfaces in neural tissue engineering and repair strategies.
