Hacking Aging: A Strategy to Use Big Data From Medical Studies to Extend Human Life

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age

(2018) J Graham Ruby et al.   eLife

Facing up to the global challenges of ageing

(2018) Linda Partridge et al.   NATURE

Extracting biological age from biomedical data via deep learning: too much of a good thing?

(2018) Timothy V. Pyrkov et al.   Scientific Reports

A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice

(2017) K. Rockwood et al.   Scientific Reports

Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study

(2016) Toshitaka Odamaki et al.   BMC MICROBIOLOGY

Epigenetic dysregulation in the developing Down syndrome cortex

(2016) Nady El Hajj et al.   Epigenetics

Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals

(2016) Xinyu Zhang et al.   Epigenetics

Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan

(2016) Peter K. Joshi et al.   Nature Communications

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Gene therapy returns to centre stage

(2015) Luigi Naldini   NATURE

Therapeutic genome editing: prospects and challenges

(2015) David Benjamin Turitz Cox et al.   NATURE MEDICINE

Knocking down disease: a progress report on siRNA therapeutics

(2015) Anders Wittrup et al.   NATURE REVIEWS GENETICS

Stability analysis of a model gene network links aging, stress resistance and negligible senescence

(2015) Valeria Kogan et al.   Scientific Reports

DNA methylation age of blood predicts all-cause mortality in later life

(2015) Riccardo E Marioni et al.   GENOME BIOLOGY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Information-based fitness and the emergence of criticality in living systems

(2014) J. Hidalgo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphogenesis at criticality

(2014) D. Krotov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influence of skeletal muscle on systemic aging and lifespan

(2013) Fabio Demontis et al.   AGING CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Glycans Are a Novel Biomarker of Chronological and Biological Ages

(2013) Jasminka Krištić et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Diversity of ageing across the tree of life

(2013) Owen R. Jones et al.   NATURE

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

(2012) Irina M. Conboy et al.   CELL CYCLE

Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

(2012) M. E. Levine   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

Age-Dependent Changes in the Cerebrospinal Fluid Proteome by Slow Off-Rate Modified Aptamer Array

(2011) Geoffrey S. Baird et al.   AMERICAN JOURNAL OF PATHOLOGY

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

(2008) E. D. Smith et al.   GENOME RESEARCH

What is principal component analysis?

(2008) Markus Ringnér   NATURE BIOTECHNOLOGY