Article
Medicine, General & Internal
Maria Hernandez-Ainsa, Raul Velamazan, Angel Lanas, Patricia Carrera-Lasfuentes, Elena Piazuelo
Summary: This study analyzed the ability of inflammatory markers such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and a new marker called NP/LHb (combining SII and hemoglobin concentration) as diagnostic tools for colorectal cancer (CRC). The researchers found that NP/LHb had high specificity and positive predictive value for diagnosing CRC and could be useful in early diagnosis. Significant differences were also observed in these markers according to CRC-related variables.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Zhenhua Liu, Haijue Ge, Zhilong Miao, Shoupeng Shao, Hongtai Shi, Congsong Dong
Summary: The systemic inflammation response index (SIRI) is a reliable indicator for evaluating the prognosis of patients with operable gastric cancer. The dynamic change in SIRI before and after surgery is significantly related to the prognosis of patients with gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Mate Naszai, Alina Kurjan, Timothy S. Maughan
Summary: Inflammation is closely related to cancer, and NLR from routine blood testing serves as an easily accessible prognostic biomarker, aiding in assessing clinical outcomes in colorectal cancer patients. Combining results from numerous studies, high NLR was found to be associated with poor clinical outcomes, despite limitations in some studies, it should be routinely collected in clinical trials.
Article
Oncology
Shi-Qi Lin, Hai-Lun Xie, Yi-Zhong Ge, Guo-Tian Ruan, Qi Zhang, Meng-Meng Song, He-Yang Zhang, Xi Zhang, Xiang-Rui Li, Meng Tang, Xian Shen, Chun-Hua Song, Wei Li, Han-Ping Shi
Summary: The neutrophil-to-lymphocyte ratio (NLR) is negatively associated with overall survival (OS), while the intracellular water/total body water (ICW/TBW) ratio is positively correlated with OS in colorectal cancer (CRC) patients. The combination of NLR and ICW/TBW ratio, known as the inflammation-water score (IWS), has better predictive ability for prognosis compared to its individual components.
FRONTIERS IN ONCOLOGY
(2022)
Article
Veterinary Sciences
Ryan C. Fries, Saki Kadotani, Jonathan P. Stack, Leah Kruckman, Gabrielle Wallace
Summary: This study assessed the predictive value of NLR for cardiac death in cats with hypertrophic cardiomyopathy. The results showed that cats with higher NLR had a higher risk of cardiac death, and NLR was significantly associated with echocardiographic measurements.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
Xinran Li, Jiamin Zheng, Min Yan, Ye Lu, Xiangtao Pan
Summary: The combination of fibrinogen and neutrophil to lymphocyte ratio significantly improves the accuracy of predicting prognosis in patients with gastric cancer, with differences in levels of fibrinogen and NLR showing statistical significance between survival and death groups.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pawel Jarmuzek, Piotr Defort, Marcin Kot, Edyta Wawrzyniak-Gramacka, Barbara Morawin, Agnieszka Zembron-Lacny
Summary: Cytokines play a critical role in tumor cell development and multiplication, but their involvement in glioblastoma (GBM) is still not well understood. This study evaluated the inflammatory profile and identified potential molecular signatures specific to GBM. The results showed elevated neutrophils and neutrophil-to-lymphocyte ratio (NLR) in GBM patients, with an inverse correlation between neutrophil count and survival time. Pro-inflammatory cytokines IL-1 beta, IL-6, and IL-8 were significantly higher in GBM, while TNF alpha and HMGB1 were lower. IL-6 and IL-8 had the highest diagnostic potential for clinical prognosis, with a three-fold higher probability of GBM development above certain threshold values.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Yuyang Hou, Hua Li, Hongkuan Yang, Rudong Chen, Jiasheng Yu
Summary: This study found that the fibrinogen and neutrophil to lymphocyte ratio (F-NLR) score is associated with functional outcomes after aneurysmal subarachnoid hemorrhage (aSAH). A higher F-NLR score predicts the occurrence of unfavorable functional outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Chunhua Xu, Fenfang Wu, Lailing Du, Yeping Dong, Shan Lin
Summary: This meta-analysis suggests that high baseline NLR is a reliable predictor of poor prognosis or relapse in HCC patients, especially in high-incidence East Asian populations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Hou-Qun Ying, Yu-Cui Liao, Fan Sun, Hong-Xin Peng, Xue-Xin Cheng
Summary: The study compared various inflammation-based biomarkers for predicting recurrence-free survival in stage II-III colorectal cancer patients and found that the platelet to lymphocyte ratio, lymphocyte to monocyte ratio, and other markers were related to patient outcomes. However, only certain markers remained independent predictors in multivariate analysis. The fibrinogen and neutrophil to lymphocyte ratio score emerged as a superior prognostic indicator, particularly for predicting recurrence in surgical CRC patients.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Oncology
Kohei Yasui, Dai Shida, Yuya Nakamura, Yuka Ahiko, Shunsuke Tsukamoto, Yukihide Kanemitsu
Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.
BRITISH JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Yerim Cho, Su Bee Park, Jin Young Yoon, Min Seob Kwak, Jae Myung Cha
Summary: This study aimed to investigate the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in stage II to III colorectal cancer (CRC) patients who underwent surgery. The results showed that NLR was significantly associated with overall survival (OS) and could be used as a simple and useful parameter for predicting OS in these patients.
Article
Multidisciplinary Sciences
JunHu Li, Na Zhu, Cheng Wang, LiuPing You, WenLong Guo, ZhiHan Yuan, Shuai Qi, HanZheng Zhao, JiaYong Yu, YueNan Huang
Summary: The immunonutritional status, assessed by Albumin-to-globulin ratio (AGR) and the prognostic nutrition index (PNI), plays a crucial role in predicting outcomes for colorectal cancer (CRC) patients. Low AGR and low PNI levels are associated with poor overall survival and progression-free survival. Therefore, preoperative AGR and PNI can serve as effective indicators for predicting survival in CRC patients and aid in the development of adjuvant therapy schedules.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Hailun Xie, Lishuang Wei, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Shunhui Gao, Qiwen Wang, Xin Lin, Shuangyi Tang, Jialiang Gan
Summary: This study aimed to explore the prognostic value of the preoperative neutrophil-albumin ratio (NAR) in patients with colorectal cancer (CRC) undergoing surgical treatment. High NAR was found to be closely associated with various negative factors, and it was an independent risk factor for postoperative complications and worse progression-free survival (PFS) and overall survival (OS) in CRC patients. NAR-based research could provide helpful information for prognostic judgment and clinical decision-making in CRC patients.
FRONTIERS IN NUTRITION
(2022)
Article
Surgery
Xiao Li, Bang An, Qi Zhao, Jianni Qi, Wenwen Wang, Di Zhang, Zhen Li, Chengyong Qin
INTERNATIONAL JOURNAL OF SURGERY
(2018)
Article
Oncology
Xiao Li, Qi Zhao, Bang An, Jianni Qi, Wenwen Wang, Di Zhang, Zhen Li, Chengyong Qin
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Cell Biology
Shouyang Song, Zhen Yu, Yajing You, Chenxi Liu, Xiaoyu Xie, Huanran Lv, Feng Xiao, Qiang Zhu, Chengyong Qin
Summary: This study confirms the crucial role of EGFR/MET in HCC, as they promote liver cancer metastasis by regulating signaling pathways and resisting immune attacks.
CELL DEATH & DISEASE
(2022)