Article
Chemistry, Multidisciplinary
Guillaume Zante, Christopher E. Elgar, Katherine George, Andrew P. Abbott, Jennifer M. Hartley
Summary: The study explores the properties of concentrated ionic fluids and distinguishes them from concentrated aqueous brines. It demonstrates a continuous relationship between molar conductivity and fluidity, regardless of cation, charge density, or ionic radius. The diffusion coefficients of specific metal chlorides in various ionic fluids show a linear correlation with fluidity. By adjusting chloride and water activity, selective etching of mixed metal waste streams can be achieved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Alexander M. M. Curreri, Jayoung Kim, Michael Dunne, Pavimol Angsantikul, Morgan Goetz, Yongsheng Gao, Samir Mitragotri
Summary: Proteins, commonly used for treating various diseases, face limitations in current injectable therapies due to poor absorption and slow pharmacokinetics. A deep eutectic-based delivery strategy is used to enhance protein absorption after subcutaneous injections, showing significant improvements in both large and small proteins. Mechanistic studies reveal the potential of deep eutectics to reduce protein interactions with the subcutaneous matrix, offering new possibilities for subcutaneous delivery of therapeutic proteins.
Article
Chemistry, Physical
Yilin Li, Jialu Luo, Shuyi Shan, Yuanyuan Cao
Summary: Amino acid-based deep eutectic solvents (DESs) are considered as green and low toxic materials for efficient CO2 capture, conversion and utilization. However, it is discovered for the first time that amino acid-based DESs are actually super toxic. The toxicity of amino acid-based DESs can be reduced by tuning hydrogen-bonding acceptor, hydrogen-bonding donor, mole ratio, and intermolecular interaction, providing a basis for designing less or even non-toxic green solvents for better and sustainable CO2 capture, conversion, and utilization.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Multidisciplinary
Tao Zhang, Thomas Doert, Hui Wang, Suojiang Zhang, Michael Ruck
Summary: This review explores the application of ionic liquids and deep eutectic solvents in the synthesis of inorganic materials, covering various types of deep eutectic solvents and ionic liquids, as well as their chemical reactions. It also highlights the caution that needs to be taken regarding their chemical reactivity, and provides guidelines for their proper use.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Energy & Fuels
Filipa Lima, Luis C. Branco, Armando J. D. Silvestre, Isabel M. Marrucho
Summary: This review article presents the use of deep eutectic solvents (DES) in removing sulfur pollutants from transportation fuels, highlighting the urgent need to reduce the impact of fossil fuels impurities on outdoor air pollution. A comparative evaluation with Ionic Liquids (ILs) shows that DES has advantages in extracting sulfur contaminants, but the efficiency gap between simulated matrices and real fuels is still a challenge to be addressed.
Article
Chemistry, Physical
Yuanyuan Cao, Shuyi Shan, Yitong Lu, Jialu Luo, Yilin Li, Rongzhang Hao
Summary: Low toxicity is a crucial property for the sustainable use of polyethylene glycol-based deep eutectic solvents (PEG-based DESs) in various fields. However, the specific toxicity of PEG-based DESs has not been reported, and guidelines for reducing toxicity need to be explored. This study evaluated the cytotoxicity of several PEG-based DESs against lung cancer cells (A549) and proposed strategies for minimizing toxicity, such as adjusting mole ratio, hydrogen-bonding donor, hydrogen-bonding acceptor, components numbers, and solvent concentration. The results showed that DESs are more toxic than their individual components, generally following the toxicity order of the individual components, except for the hydrogen-bonding donor. This research offers potential approaches for reducing the toxicity of DESs in sustainable and green chemistry.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Multidisciplinary
Aline Andrea Quintana, Alaina Maria Sztapka, Valeria de Carvalho Santos Ebinuma, Christian Agatemor
Summary: This Review discusses the sustainability of ILs and DESs as solvents and how they contribute to sustainable chemical processes by tuning their properties and selecting appropriate precursors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Jakub Hoppe, Ewa Byzia, Magdalena Szyma, Radoslaw Drozd, Marcin Smiglak
Summary: A series of new deep eutectic solvents were prepared and characterized. Their physicochemical properties were determined and their effectiveness as additives in enzymatic reactions was investigated. The results showed that these deep eutectic solvents had desirable viscosity, thermal stability, and density, and they could stabilize enzymes and enhance their activity. One of the deep eutectic solvents significantly increased the lactose hydrolysis yield by more than threefold.
Article
Chemistry, Multidisciplinary
George M. Neville, Ana-Maria Dobre, Gavin J. Smith, Samantha Micciulla, Nick J. Brooks, Thomas Arnold, Tom Welton, Karen J. Edler
Summary: Mixtures of choline and geranic acid have been found to facilitate the transdermal delivery of larger pharmaceuticals, such as insulin. However, little is known about the mechanism of activity, hindering the efficient discovery of new materials. This study investigates the biophysical interactions between membrane-active deep eutectic solvents and ionic liquids with solid-supported model lipid bilayers using neutron reflectivity.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Physical
Mariana T. Donato, Rogerio Colaco, Luis C. Branco, Benilde Saramago
Summary: This paper reviews the most relevant research in the field of lubrication using IL additives and DES in the last decade, aiming to find more efficient and green alternatives for lubricants.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Chemistry, Multidisciplinary
Lifang Chen, Yuhang Xiong, Hao Qin, Zhiwen Qi
Summary: This review summarizes the recent progress in experimental and theoretical studies on the dehydration of carbohydrates to produce 5-hydroxymethylfurfural (HMF) using ionic liquids (ILs) and deep eutectic solvents (DESs) as catalysts or solvents. It also provides an overview of catalytic transformations of HMF to downstream products using ILs and DESs. The challenges and prospects of ILs and DESs for the production of HMF and its derivatives from biomass are discussed.
Article
Chemistry, Physical
Jie Zhu, Hui Shao, Lin Feng, Yingzhou Lu, Hong Meng, Chunxi Li
Summary: The absorption behavior and stability of three ChCl-based deep eutectic solvents in removing HCl gas were studied, with ChCl-Gly showing higher viability for adsorption of HCl-bearing gas.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Agricultural Engineering
Wenrui Huang, Xingchen He, Jiacong Wu, Xinnan Ma, Juan Han, Lei Wang, Yun Wang
Summary: In this study, the effects of ILs, DESs, and their components on cellulase were evaluated. The cellulase activity was preserved in ILs/DESs below 60 degrees C. Adding DES composed of betaine and ethylene glycol promoted cellulose dissolution and improved enzyme accessibility. DESs were found to be compatible with cellulase and have the potential to improve cellulase properties for the conversion of cellulose to fermentable sugars.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Physical
Rashid Sulthan, Arunima Reghunadhan, Sreedha Sambhudevan
Summary: Chitin is a valuable natural source of mucopolysaccharides that has applications in various biomedical fields. The primary source of chitin mass production is the waste biomass from the fish industry. Recent advancements in the utilization of biowastes offer a promising step towards green chemistry and sustainable development. Various techniques have been adopted for efficient extraction of chitin, with ionic liquids and Deep Eutectic Solvents being the more environmentally friendly options. The extracted chitin's purity, crystallinity, and yield vary depending on the reagents, methods, and biomass source used. Chitin derivatives, chitosan, chitin hydrogels, and chitin nanofibers/nanowhiskers have been studied and found suitable for biomedical and non-biomedical applications. This review compares the dissolution and extraction strategies of chitin using Ionic Liquids and Deep Eutectic Solvents.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Chemical
Dmitriy M. Makarov, Yuliya A. Fadeeva, Vasiliy A. Golubev, Arkadiy M. Kolker, G. A. Krestov
Summary: This study proposes a two-step screening process using data-driven methods and machine learning models to design novel deep eutectic solvents (DESs) as CO2 absorbents. Through prediction and experimental validation, it was found that these DESs have strong CO2 absorption capacity and can potentially be used for CO2 capture.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Environmental Sciences
Matilde Vieira Sanches, Rosa Freitas, Matteo Oliva, Angelica Mero, Lucia De Marchi, Alessia Cuccaro, Giorgia Fumagalli, Andrea Mezzetta, Greta Colombo Dugoni, Monica Ferro, Andrea Mele, Lorenzo Guazzelli, Carlo Pretti
Summary: The traditional use of organic solvents is being rethought due to their high volatility, toxicity, and interaction with biological membranes. Green Chemistry focuses on developing sustainable and cost-effective solvent alternatives such as Ionic Liquids (ILs), bio-based solvents, and natural deep eutectic solvents (NADESs). This study screened 15 NADESs for ecotoxicity using marine and freshwater bioassays, finding no toxicity to invertebrates but potential biostimulation effects on algae. However, the intentional or accidental release of NADESs into aquatic systems may pose risks to ecosystem functioning.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Physics, Applied
Nicola Melchioni, Giacomo Trupiano, Giorgio Tofani, Riccardo Bertini, Andrea Mezzetta, Federica Bianco, Lorenzo Guazzelli, Fabio Beltram, Christian Silvio Pomelli, Stefano Roddaro, Alessandro Tredicucci, Federico Paolucci
Summary: Controlling charge density in low-dimensional materials using an electrostatic potential is a powerful tool to explore and manipulate their electronic and optical properties. Ionic liquid (IL) gating, which only requires a metallic electrode in contact with IL, provides an alternative method with excellent gating properties. However, many ILs are not suitable for optical experiments in the mid-IR region due to low optical transparency and degradation. In this study, we present two electrolytes based on bromide ILs dissolved in PMMA, which can achieve high charge densities and exhibit optical transparency, making them promising candidates for electronic and mid-IR optoelectronic devices.
APPLIED PHYSICS LETTERS
(2023)
Article
Chemistry, Physical
Angelica Mero, Spyridon Koutsoumpos, Panagiotis Giannios, Ilias Stavrakas, Konstantinos Moutzouris, Andrea Mezzetta, Lorenzo Guazzelli
Summary: Within the field of green chemistry, deep eutectic solvents (DESs) are becoming increasingly important due to their unique physicochemical properties. In this study, a comparative analysis was conducted on six different DESs to investigate the effects of various parameters such as the nature of the hydrogen bond acceptor (HBA) and donor (HBD) and their molar ratio on properties including density, viscosity, refractive index, thermal stability, and thermal behavior. The results showed that DESs based on ethylene glycol (EG) exhibited the lowest density and viscosity, while those based on glycerol (Gly) had the highest values. Switching from choline chloride (ChCl) to betaine (Bet) as the HBA resulted in higher viscosity and density. Increasing the amount of HBD in the DESs led to lower viscosity, increased density for Gly-based DESs, and decreased density for EG and levulinic acid (LevA)-based DESs. The refractive index decreased with increasing HBD portion, but using ChCl instead of Bet as the HBA resulted in a higher refractive index. The thermal stability of the DESs was strongly influenced by the HBD used, with EG-based DESs being less stable than LevA-based ones and Gly-based DESs exhibiting the highest stability. Additionally, three characteristic mass loss events were observed in all DESs, attributed to the evaporation/degradation of the HBD, HBD-HBA interaction, and the HBA. Finally, differential scanning calorimetry (DSC) analyses showed that all DESs can be used as solvents due to their liquid state at room temperature and their ability to maintain liquid state over a wide temperature range.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Aida Cavallo, Tamer Al Kayal, Angelica Mero, Andrea Mezzetta, Anissa Pisani, Ilenia Foffa, Cecilia Vecoli, Marianna Buscemi, Lorenzo Guazzelli, Giorgio Soldani, Paola Losi
Summary: Marine collagen, derived from marine organisms, is an abundant and eco-friendly source of collagen that possesses several advantages over mammalian collagen such as easy extraction, water solubility, avoidance of transmissible diseases, and antibacterial activity. This study investigated the use of collagen extracted from basa fish skin for the development of a bioink for 3D bioprinting of a bilayered skin model. The bioink was successfully formulated and showed good printability, supporting cell viability and proliferation of fibroblasts and keratinocytes.
Article
Biochemistry & Molecular Biology
Sharon Monaci, Daniela Minudri, Lorenzo Guazzelli, Andrea Mezzetta, David Mecerreyes, Maria Forsyth, Anthony Somers
Summary: Corrosion is a major problem that affects structures and buildings, leading to premature failure and economic loss. Biobased lignin and ionic liquids have shown potential as corrosion inhibitors. This study investigated the inhibitory properties of new biobased lignin ionic liquids and found that one of them exhibited promising performance.
Article
Engineering, Biomedical
Aida Cavallo, Tamer Al Kayal, Angelica Mero, Andrea Mezzetta, Lorenzo Guazzelli, Giorgio Soldani, Paola Losi
Summary: Three-dimensional bioprinting with a blend of fibrinogen and alginate-based bioink has been successfully used to print skin equivalents with a tissue-like structure resembling native skin. This study demonstrates the potential of bioprinting technology as a promising approach for wound healing applications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Environmental Sciences
Matilde Vieira Sanches, Rosa Freitas, Matteo Oliva, Alessia Cuccaro, Gianfranca Monni, Andrea Mezzetta, Lorenzo Guazzelli, Carlo Pretti
Summary: The potential release of ionic liquids into aquatic systems has led to concerns about their ecotoxicological effects on aquatic microorganisms and invertebrate species. This review examines 103 studies on ionic liquids and their toxicity to aquatic organisms, focusing on the factors influencing their toxicity. Freshwater species were studied more frequently than marine species, with algal species being the most commonly assessed. The combination of imidazolium cations with long alkyl-chain anions was found to be the most toxic.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Luca Guglielmero, Andrea Mezzetta, Felicia D'Andrea, Lorenzo Guazzelli, Christian Silvio Pomelli
Summary: A panel of novel vanadium(iv)-betaine complexes has been synthesized and their stability under different temperature and acidity conditions has been studied. The results showed that the betaine ligands significantly affect the stability of aqueous vanadium(V) solutions. The species formed in the betaine rich vanadium(V) solutions have been spectroscopically identified and confirmed through computational techniques. Furthermore, the vanadium-betaine based electrolyte solutions have been tested in lab-scale redox flow battery setup.
DALTON TRANSACTIONS
(2023)
