Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 106, Issue -, Pages 104-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2016.04.023
Keywords
Cell therapy; Progenitor cell; Stem cell; Cell retention; Myocardial repair
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Funding
- Netherlands CardioVascular Research Initiative (CVON): the Dutch Heart Foundation
- Dutch Federation of University Medical Centers
- Netherlands Organization for Health Research and Development
- Royal Netherlands Academy of Sciences
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Stem cell-based therapies form an exciting new class of medicine that attempt to provide the body with the building blocks required for the reconstruction of damaged organs. However, delivering cells to the correct location, while preserving their integrity and functional properties, is a complex undertaking. These challenges have led to the development of a highly dynamic interdisciplinary research field, wherein medical, biological, and chemical sciences have collaborated to develop strategies to overcome the physiological barriers imposed on the cellular therapeutics. In this respect, improving the acute retention and subsequent survival of stem cells is key to effectively increase the effect of the therapy, while proper tissue integration is imperative for stem cells to functionally replace lost cells in damaged organs. In this review, we will use the heart as an example to highlight the current knowledge of therapeutic stem cell utilization, the existing pitfalls and limitations, and the approaches that have been developed to overcome them. (C) 2016 Elsevier B.V. All rights reserved.
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