Review
Peripheral Vascular Disease
Natalie A. Cameron, Ian K. Everitt, Kristen A. Lee, Lynn M. Yee, Sadiya S. Khan
Summary: Hypertension is a significant risk factor for cardiovascular disease in the US, and its prevalence during pregnancy has almost doubled in the past decade. High blood pressure during pregnancy is concerning due to increased risks of maternal and fetal complications and long-term cardiovascular risks. Identifying chronic hypertension during pregnancy can provide insights into cardiovascular disease risk and offer opportunities for risk reduction. Equitable healthcare interventions during the peripartum period can have a significant impact on preventing chronic hypertension and reducing lifetime cardiovascular disease risk.
Review
Biochemistry & Molecular Biology
Sebastian Spencer, Robert Desborough, Sunil Bhandari
Summary: Assessing kidney function is vital for diagnosing and managing kidney diseases. The widely used indicator, glomerular filtration rate (GFR), has challenges in direct measurement. Serum creatinine, a commonly used marker, has limitations in accuracy. Cystatin C, unaffected by muscle mass, shows stronger associations with cardiovascular disease and mortality. Equations have been developed combining creatinine and cystatin C to estimate GFR, improving accuracy. Cystatin C-based estimates outperform creatinine-based estimates in predicting outcomes, especially in elderly and non-white ethnic groups, aiding in early detection of kidney disease and guiding decision-making.
Review
Peripheral Vascular Disease
Kavia Khosla, Sarah Heimberger, Kristin M. Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana
Summary: Women with a history of hypertensive disorders of pregnancy have higher rates of long-term cardiovascular events, and the American Heart Association calls for early identification and risk reduction by physicians. This review discusses the epidemiology, pathophysiology, and outcomes of HDP-associated cardiovascular disease.
Article
Biochemistry & Molecular Biology
Ilona Hromadnikova, Katerina Kotlabova, Ladislav Krofta
Summary: The study aims to assess the predictive capabilities of cardiovascular disease-associated microRNAs in early pregnancy for the subsequent onset of hypertensive pregnancy-related complications and chronic hypertension. The results suggest that cardiovascular disease-associated microRNAs may serve as potential biomarkers for predicting the occurrence of pregnancy-induced hypertension.
Article
Obstetrics & Gynecology
Sapir Nachshon, Eran Hadar, Ron Bardin, Shiri Barbash-Hazan, Adi Borovich, Marius Braun, Anat Shmueli
Summary: This study found an association between preexisting chronic liver disease and preeclampsia, with pregnant women with chronic liver disease having a 2.6-fold increased risk of preeclampsia. Although there was no difference in gestational weeks at delivery between the groups, newborns of women with chronic liver disease had lower birth weight.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Toxicology
Marcus Garcia, Raul Salazar, Thomas Wilson, Selita Lucas, Guy Herbert, Tamara Young, Jessica Begay, Jesse L. Denson, Katherine Zychowski, Ryan Ashley, Stephanie Byrum, Samuel Mackintosh, Barry E. Bleske, Andrew K. Ottens, Matthew J. Campen
Summary: Exposure to ozone during early placental formation in pregnancy can lead to more adverse cardiovascular effects in rats at term, with changes consistent with markers of preeclampsia. Additionally, exposure to 0.3 ppm ozone at GD10 induced late-stage cardiovascular outcomes in dams that were not seen in GD20-exposed dams.
TOXICOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Young Youl Hyun, Kyu-Beck Lee, Hyoungnae Kim, Yaeni Kim, Wookyung Chung, Hayne Cho Park, Seung Hyeok Han, Yun Kyu Oh, Sue Kyung Park, Kook-Hwan Oh
Summary: This study found that a higher serum creatinine/cystatin C ratio is associated with a lower risk of adverse outcomes, especially all-cause mortality, in non-dialysis chronic kidney disease (CKD) patients, even after adjusting for estimated glomerular filtration rate (eGFR). Therefore, the serum creatinine/cystatin C ratio can be considered a useful prognostic marker in CKD patients.
FRONTIERS IN NUTRITION
(2022)
Article
Medicine, General & Internal
Jeong Ah Hwang, Younghoon Song, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang Jee Ko, Young Joo Kwon, Ji Eun Kim
Summary: This study found a U-shaped relationship between mortality and CCR levels in normal renal function, as well as an increased risk of mortality in CKD patients with elevated CCR.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Jeanne A. Ishimwe, Adesanya Akinleye, Ashley C. Johnson, Michael R. Garrett, Jennifer M. Sasser
Summary: The study suggests that there may be an association between chronic hypertension and gut microbiome dysbiosis in pregnancy, which hinders gut microbial composition remodeling during superimposed preeclampsia.
PHYSIOLOGICAL GENOMICS
(2021)
Article
Biology
Malgorzata Koziarska-Rosciszewska, Anna Gluba-Brzozka, Beata Franczyk, Jacek Rysz
Summary: The study found statistically significant correlations between hsCRP and age, gender, obesity, dyslipidemia, diabetes, hyperuricemia, and vitamin D concentration. Patients with CVD, hypertension, diabetes, or visceral obesity had significantly higher levels of hsCRP. Vitamin D concentration may play a role in modulating systemic inflammation.
Article
Cardiac & Cardiovascular Systems
Yanjun Zhang, Sisi Yang, Jia Chen, Zhuxian Zhang, Panpan He, Chun Zhou, Mengyi Liu, Ziliang Ye, Qimeng Wu, Huan Li, Yuanyuan Zhang, Chengzhang Liu, Xianhui Qin
Summary: The study found a positive association between serum cystatin C and its increase with new-onset cardiovascular disease in the Chinese general population.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Obstetrics & Gynecology
Ayamo Oben, Jeff M. Szychowski, Peter Ketch, Cooper Elkins, Rachel Sinkey, William W. Andrews, Suzanne Oparil, Alan Tita
Summary: This retrospective cohort study aimed to estimate the incidence of severe chronic hypertension in women with mild hypertension during pregnancy, within 5-7 years after delivery. The study found that one in three women with mild hypertension progressed to severe hypertension, with black women and smokers experiencing a faster progression.
OBSTETRICS AND GYNECOLOGY
(2022)
Review
Endocrinology & Metabolism
Shiyu Yan, Jinlang Lyu, Zheng Liu, Shuang Zhou, Yuelong Ji, Haijun Wang
Summary: This study conducted a systematic review and meta-analysis to evaluate the association between maternal gestational hypertension/preeclampsia and offspring adiposity outcomes. The results suggested that exposure to these pregnancy disorders was associated with obesity in offspring, extending from early childhood to adolescence. The meta-analysis showed a significant association between preeclampsia and higher BMI in female offspring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Guan Wang, Yanbo Zhang, Sijin Li, Jun Zhang, Dongkui Jiang, Xiuzhen Li, Yulin Li, Jie Du
Summary: This study developed a model based on machine learning to predict postpartum cardiovascular risk in preeclamptic women. The Random Forest algorithm showed the best performance in predicting cardiovascular risk, with good calibration and high net benefit.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Parya Amini, Mehran Amrovani, Zohre Saleh Nassaj, Parisa Ajorlou, Aiyoub Pezeshgi, Bahareh Ghahrodizadehabyaneh
Summary: Preeclampsia (PE) is a complication during pregnancy that poses a threat to pregnant women, with high blood pressure being one of its main symptoms. Studies have shown that PE can increase the risk of developing cardiovascular disease and mortality. By understanding the signaling pathways involved in blood pressure regulation, appropriate treatment strategies can be developed to reduce blood pressure in PE individuals, thus reducing the risk of cardiovascular disease and mortality.
CARDIOVASCULAR TOXICOLOGY
(2022)
Review
Obstetrics & Gynecology
Alisse Hauspurg, Arun Jeyabalan
Summary: High blood pressure in the postpartum period can occur in women with antenatal hypertensive disorders or develop de novo. The distinction between postpartum preeclampsia or eclampsia and those with antepartum onset is unclear. The diagnosis of postpartum preeclampsia should be considered in women with new-onset hypertension 48 hours to 6 weeks after delivery. There are limited evidence-based guidelines for the diagnosis and management of this condition. Risk factors for postpartum preeclampsia include older maternal age, black race, maternal obesity, and cesarean delivery. Prompt recognition and treatment are important, as delayed-onset postpartum preeclampsia can lead to maternal morbidity. Further research is needed to better understand the pathophysiology and specific risk factors. Improved understanding of postpartum preeclampsia is crucial for patient care, counseling, and reducing maternal morbidity and mortality in the postpartum period.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Kathleen P. Tebb, Christine Dehlendorf, Felicia Rodriguez, Margaret Fix, Daniel J. Tancredi, Reiley Reed, Claire D. Brindis, Eleanor Bimla Schwarz
Summary: The SpeakOut intervention did not improve contraceptive communication, knowledge or use among participating teens or their peers. While primary participants receiving SpeakOut were less likely to discontinue contraception within 9 months, this difference did not reach statistical significance. Most secondary participants reported peer communication about contraception, and contraceptive knowledge remained incomplete in all study groups.
Article
Obstetrics & Gynecology
Daniel Grossman, Sarah Raifman, Natalie Morris, Andrea Arena, Lela Bachrach, Jessica Beaman, M. Antonia Biggs, Curtiss Hannum, Stephanie Ho, Eleanor B. Schwarz, Marji Gold
Summary: The study findings indicate that medication abortion with mail-order pharmacy dispensing of mifepristone is effective, feasible, and acceptable to patients. The majority of participants expressed satisfaction with receiving medications by mail and stated they would use the service again if needed. The rate of adverse events was low and not related to mail-order pharmacy dispensing.
Article
Obstetrics & Gynecology
Nina W. Ragunanthan, Jordan Lamb, Alisse Hauspurg, Stacy Beck
Summary: This study investigated the relationship between race and counseling/prescription and uptake of aspirin among women with chronic hypertension. The findings suggest that black women are equally likely to receive counseling about aspirin as women of other races, but their rates of uptake are lower.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alisse Hauspurg, Derek J. Marsh, Rebecca B. McNeil, C. Noel Bairey Merz, Philip Greenland, Adam C. Straub, Caroline E. Rouse, William A. Grobman, Victoria L. Pemberton, Robert M. Silver, Yii-Der Ida Chen, Brian M. Mercer, Lisa D. Levine, Afshan Hameed, Matthew K. Hoffman, Hyagriv N. Simhan, Janet M. Catov
Summary: Hypertensive disorders of pregnancy are linked to future cardiovascular disease, potentially due to pre-pregnancy subclinical cardiac dysfunction. This study examined the association between higher NT-proBNP concentrations in early pregnancy and hypertensive disorders of pregnancy and hypertension 2 to 7 years postpartum. The findings suggest that higher NT-proBNP concentrations are associated with a lower risk of these conditions.
Letter
Obstetrics & Gynecology
Alisse Hauspurg, Arun Jeyabalan
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Health Care Sciences & Services
Eleanor Bimla Schwarz, Carrie A. Lewis, Melanie S. Dove, Eryn Murphy, Diana Zuckerman, Claudia Nunez-Eddy, Daniel J. Tancredi, Raegan McDonald-Mosley, Sarita Sonalkar, Mark Hathaway, Aileen M. Gariepy
Summary: This study compares the effectiveness and safety of intrauterine contraceptives (IUC) to laparoscopic tubal ligation for Medicaid clients. The results indicate that IUC is at least as effective as tubal ligation in preventing pregnancy at 1-year post-procedure, with lower rates of infection and pelvic pain 6 to 12 months post-procedure.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rachel Bennett, Zuber D. Mulla, Pavan Parikh, Alisse Hauspurg, Talayeh Razzaghi
Summary: This study predicts preeclampsia using a new method that considers the imbalanced and sparse nature of the data, as well as racial disparities. The researchers validated their model using diverse data sources and identified influential factors for the general population and minority groups. Their models outperformed existing techniques and provided evidence of the predictive power of clinical databases for preeclampsia prediction among minority populations.
Article
Obstetrics & Gynecology
Malamo E. Countouris, Amy L. Marino, Megan Raymond, Alisse Hauspurg, Kathryn L. Berlacher
Summary: Intravenous drug abuse is an increasing risk factor for peripartum infective endocarditis. Peripartum IE carries a high risk of complications, including maternal mortality, and requires multidisciplinary management at a tertiary care center.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Alisse Hauspurg, Derek Marsh, Janet Catov
Article
Chemistry, Analytical
Simion Kreimer, Ali Haghani, Aleksandra Binek, Alisse Hauspurg, Saeed Seyedmohammad, Alejandro Rivas, Amanda Momenzadeh, Jesse G. Meyer, Koen Raedschelders, Jennifer E. Van Eyk
Summary: Proteomic analysis requires rapid mass spectrometry methods to capture population and biological heterogeneity. This study used a short liquid chromatography gradient and rapid mass spectrometry data acquisition to reproducibly quantify a set of moderate analytes. By using the dual-trap single-column configuration, the study achieved high IU in rapid analysis and enables high-throughput epidemiological research and cell-based perturbation screening.
ANALYTICAL CHEMISTRY
(2022)
Letter
Health Care Sciences & Services
Eleanor Bimla Schwarz, Aileen Gariepy, Sarita Sonalkar
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Jennifer L. Michener, David A. Hirsh, Pelin Batur, Rachel S. Casas, Vidya Gopinath, Lydia E. Pace, Christine Prifti, Jennifer Rusiecki, Eleanor Bimla Schwarz, Megha Shankar, Mindy Sobota, Deborah Gomez Kwolek
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Francis M. Hacker, Arun Jeyabalan, Beth Quinn, Alisse Hauspurg
Summary: This study explored the feasibility of a patient-driven universal postpartum home blood pressure monitoring program, which was found to be feasible and may require closer monitoring in women, especially those with risk factors or limited medical resources.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Review
Psychiatry
Nina E. Ross, Tinsley G. Webster, Camille A. Tastenhoye, Alisse K. Hauspurg, Jill E. Foust, Priya R. Gopalan, Susan Hatters Friedman
Summary: This article provides a systematic review of existing literature on capacity evaluations in women with psychiatric illness making reproductive decisions. The results show that decisions about termination of pregnancy were most common, and schizophrenia was the most common psychiatric diagnosis. Psychiatric illness adds complexity to obstetrical medical decision-making, requiring multidisciplinary collaboration and advanced care planning.
JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
(2022)
