Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 103, Issue -, Pages 90-104Publisher
ELSEVIER
DOI: 10.1016/j.addr.2016.05.018
Keywords
HIV-1/AIDS; Point-of-care; Emerging technologies; Nanotechnology; Microfluidics
Categories
Funding
- Ministry of Science and Technology of the People's Republic of China [2016YFSF100062]
- Foundation for AIDS Research (amfAR) [R21AI110277, R21AI113117]
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HIV-1 is a major global epidemic that requires sophisticated clinical management. There have been remarkable efforts to develop new strategies for detecting and treating HIV-1, as it has been challenging to translate them into resource-limited settings. Significant research efforts have been recently devoted to developing point-of-care (POC) diagnostics that can monitor HIV-1 viral load with high sensitivity by leveraging micro- and nano scale technologies. These POC devices can be applied to monitoring of antiretroviral therapy, during mother-to-child transmission, and identification of latent HIV-1 reservoirs. In this review, we discuss current challenges in HIV-1 diagnosis and therapy in resource-limited settings and present emerging technologies that aim to address these challenges using innovative solutions. (C) 2016 Elsevier B.V. All rights reserved.
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