Article
Respiratory System
Jianmeng Zhou, Fang Yi, Feng Wu, Pusheng Xu, Meihua Chen, Huahao Shen, Lin Lin, Yunhui Zhang, Suyun Li, Changgui Wu, Yadong Yuan, Gang Wang, Xianwei Ye, Ping Zhang, Huaping Tang, Qianli Ma, Lanqing Huang, Zhongmin Qiu, Haiyan Deng, Chen Qiu, Guochao Shi, Jiayu Pan, Wei Luo, Kian Fan Chun, Nanshan Zhong, Kefang Lai
Summary: This study compared the clinical and pathophysiological characteristics of different phenotypes of asthma, and found differences in cough sensitivity and airflow obstruction between patients with cough predominant asthma and patients with cough variant asthma.
RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Hirono Nishiyama, Yoshihiro Kanemitsu, Johsuke Hara, Kensuke Fukumitsu, Norihisa Takeda, Ryota Kurokawa, Keima Ito, Tomoko Tajiri, Satoshi Fukuda, Takehiro Uemura, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Masaya Takemura, Akio Niimi
Summary: This study evaluated the efficacy of bronchial thermoplasty (BT) for cough in severe uncontrolled asthma. The results showed that BT significantly improved cough-related indices and cough sensitivity, especially in patients with cough-predominant symptoms. However, larger cohort studies are needed to confirm the effect of BT for cough in asthma.
RESPIRATORY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Satoru Terada, Hisako Matsumoto, Kenta Nishi, Mariko Kogo, Natsuko Nomura, Noriyuki Tashima, Chie Morimoto, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Yoshinari Nakatsuka, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Kazuhiro Sonomura, Fumihiko Matsuda, Kazuo Chin, Toyohiro Hirai
Summary: This study found a significant association between low plasma citric acid and new-onset prolonged cough, even after adjusting for confounding factors. The association remained consistent in participants with certain pre-existing conditions and in those who had prolonged cough at follow-up.
SCIENTIFIC REPORTS
(2023)
Article
Respiratory System
Johanna Tuulikki Kaulamo, Anne Marika Latti, Heikki Olavi Koskela
Summary: This study investigated the prevalence and risk factors of acute, subacute, and chronic cough in an elderly population in Finland. The results showed that chronic cough was more prevalent in the elderly than in younger adults and had multiple risk factors.
Letter
Respiratory System
Aleksandra Rybka-Fraczek, Marta Dabrowska, Elzbieta M. Grabczak, Katarzyna Bialek-Gosk, Karolina Klimowicz, Olga Truba, Rafal Krenke
Summary: Bronchial hyperresponsiveness may be considered as a predictor of cough variant asthma in non-smoking adults with chronic cough, showing a high positive predictive value in this population. Cough severity and cough related quality of life were not related to the severity of bronchial hyperresponsiveness in CVA patients.
RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
Lorcan P. McGarvey, Surinder S. Birring, Alyn H. Morice, Peter V. Dicpinigaitis, Ian D. Pavord, Jonathan Schelfhout, Allison Martin Nguyen, Qing Li, Anjela Tzontcheva, Beata Iskold, Stuart A. Green, Carmen La Rosa, David R. Muccino, Jaclyn A. Smith
Summary: Gefapixant, an oral P2X(3) receptor antagonist, has been shown to be effective and safe in the treatment of refractory chronic cough and unexplained chronic cough. Two phase 3 trials demonstrated the efficacy and safety of Gefapixant, with the 45 mg twice daily dose showing significant reductions in cough frequency compared to placebo at 12 weeks and 24 weeks.
Article
Critical Care Medicine
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The article summarizes key recommendations from GINA 2021 and the recent changes, highlighting the importance of not relying solely on short-acting beta(2)-agonists for asthma treatment and provides targeted treatment suggestions based on severity and age.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Physiology
Matthew G. Drake, Madeline Cook, Allison D. Fryer, David B. Jacoby, Gregory D. Scott
Summary: Recent advancements in studying airway sensory nerves have revealed their heterogeneity and potential roles in respiratory diseases like asthma and chronic cough, leading to emerging treatments targeting these nerves for therapeutic implications.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pediatrics
Laurel Teoh, Mark D. Chatfield, Jason P. Acworth, Gabrielle B. McCallum, Anne B. Chang
Summary: The study aimed to evaluate the determinants of prolonged cough and poorer quality of life questionnaires in children with asthma exacerbations during the recovery phase. Results showed that children on regular inhaled corticosteroids were more likely to have prolonged cough and poorer quality of life during recovery.
PEDIATRIC PULMONOLOGY
(2021)
Article
Respiratory System
Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
Summary: The GINA 2021 Strategy Report provides updated evidence-based recommendations for managing and preventing asthma, including the use of ICS-formoterol as a reliever and additional recommendations for moderate-to-severe asthma. It also introduces new treatment options for children aged 6-11. Regular personalized assessment, modifiable risk factor treatment, self-management education, and appropriate medication adjustment are highlighted as essential for optimizing asthma outcomes.
Review
Respiratory System
Nermin Diab, Matthew Patel, Paul O'Byrne, Imran Satia
Summary: Chronic cough is a debilitating condition that affects 10-12% of the population. It is associated with various diseases such as asthma, gastro-esophageal reflux disease, and upper airways cough syndrome. Mechanistic studies have identified increased neuronal sensitivity and central sensitization as contributing factors to chronic cough.
Article
Multidisciplinary Sciences
Frank A. J. L. Scheer, Michael F. Hilton, Heather L. Evoniuk, Sally A. Shiels, Atul Malhotra, Rena Sugarbaker, R. Timothy Ayers, Elliot Israel, Anthony F. Massaro, Steven A. Shea
Summary: The study found that asthma patients experience worsened lung function and exacerbation of symptoms at night, often masked by sleep. Asthma patients exhibit significant circadian rhythms throughout the day and are more likely to use bronchodilators during the night.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Linchen He, Christina Norris, Xiaoxing Cui, Zhen Li, Karoline K. Barkjohn, Collin Brehmer, Yanbo Teng, Lin Fang, Lili Lin, Qian Wang, Xiaojian Zhou, Jianguo Hong, Feng Li, Yinping Zhang, James J. Schauer, Marilyn Black, Michael H. Bergin, Junfeng Jim Zhang
Summary: This study found that increased personal exposure to PM2.5 oxidative potential was associated with higher airway resistance, increased airway impedance, decreased lung function, and worsened asthma symptoms. Organic matters largely of indoor origin were the main contributors to PM2.5 oxidative potential. Reducing PM2.5 oxidative potential, particularly by reducing organic matter in indoor PM2.5, is suggested as a targeted strategy in asthma management.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Eulalia M. Amador, Claudia Cabrera, Michael S. Benninger
Summary: The study aimed to establish a correlation between persistent cough and asthma diagnosis and its severity, finding that patients with persistent cough may have more severe asthma diagnosis and poor treatment responsiveness. The results showed that patients with persistent cough, especially those positive to allergens such as cat dander, dog dander, house dust, Alternaria tenuis, or lamb's quarter, may present with more severe asthma.
Review
Respiratory System
Jingwen Zhang, Jennifer L. Perret, Anne B. Chang, Nur S. Idrose, Dinh S. Bui, Adrian J. Lowe, Michael J. Abramson, E. Haydn Walters, Caroline J. Lodge, Shyamali C. Dharmage
Summary: The study systematically synthesized evidence on etiological risk factors for chronic cough in adult patients, finding that asthma, persistent smoking, and lower education/socioeconomic status were associated with an increased risk. Further investigation is needed for longitudinal associations between other factors mentioned, with the recommendation of objective and standardized measurement methods.
Article
Allergy
Peter V. Dicpinigaitis, Surinder S. Birring, Michael Blaiss, Lorcan P. McGarvey, Alyn H. Morice, Ian D. Pavord, Imran Satia, Jaclyn A. Smith, Carmen La Rosa, Qing Li, Allison Martin Nguyen, Jonathan Schelfhout, Anjela Tzontcheva, David Muccino
Summary: This study reports the baseline medical history and clinical characteristics of patients with refractory or unexplained chronic cough enrolled in two large phase 3 trials. The findings indicate that participants had long cough duration and substantial impairment to quality of life.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Environmental Sciences
Andy Deprato, Himasha Rao, Hannah Durrington, Robert Maidstone, Ana Adan, Jose Francisco Navarro, Anna Palomar-Cros, Barbara N. Harding, Prasun Haldar, Saibal Moitra, Tanusree Moitra, Lyle Melenka, Manolis Kogevinas, Paige Lacy, Subhabrata Moitra
Summary: This study aims to systematically evaluate the association between artificial light at night (ALAN) exposure and asthma and allergy, mental health, and cancer outcomes. By conducting comprehensive literature searches, screenings, and data analyses, we hope to understand how ALAN exposure may affect these health outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Neurosciences
Jaclyn A. Smith, Imran Satia, Huda Badri, Paul Marsden
Summary: In recent years, our understanding of the neurophysiological basis of cough has increased, as well as the concepts surrounding chronic coughing. Dysregulation of neuronal pathways mediating cough has been recognized to play a crucial role in certain phenotypes of chronic cough. This review aims to summarize current clinical evidence supporting the hyperexcitability of neuronal pathways contributing to chronic coughing and suggest their alignment with clinical features observed in patients.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Devin Amanda Simpkins, Polly Downton, Kathryn J. Gray, Suzanna H. Dickson, Robert J. Maidstone, Joanne E. Konkel, Matthew R. Hepworth, David W. Ray, David A. Bechtold, Julie Elizabeth Gibbs
Summary: The gut microbiota plays an important role in host health and immune system function. Rheumatoid arthritis, an autoimmune disease, is associated with imbalances in gut microbiota. The composition and metabolism of the microbiome exhibit daily oscillations, influenced by food intake timing and circadian clock function in the gut. Inflammatory arthritis leads to changes in circadian rhythmicity in the gut and microbiome, affecting gene expression, barrier integrity, and the composition of the microbiota. These findings highlight the impact of altered circadian rhythmicity on gut integrity and microbiome function during inflammatory diseases.
Article
Respiratory System
Lorcan McGarvey, Jaclyn A. Smith, Alyn Morice, Surinder S. Birring, Kian Fan Chung, Peter Dicpinigaitis, Akio Niimi, Michael S. Benninger, Mandel Sher, Yuko Matsunaga, Sayaka Miyazaki, Mitsuaki Machida, Hiroyuki Ishihara, Adnan Mahmood, Juan-Carlos Gomez
Summary: The goal of this study was to determine the optimal dose of sivopixant for refractory or unexplained chronic cough. The results showed that the 300 mg dose had the greatest improvements in cough frequency and patient-reported outcomes, with mild to moderate reversible taste disturbance.
Article
Cardiac & Cardiovascular Systems
Kimberley J. Holt, John Belcher, Jaclyn A. Smith
Summary: Through capsaicin cough challenges, the novel endpoints Emax and ED50 were found to effectively discriminate between healthy controls and refractory chronic cough patients, showing potential as a tool to identify patients with cough hyper-excitability.
RESPIRATORY MEDICINE
(2023)
Letter
Critical Care Medicine
Surinder S. Birring, Peter V. Dicpinigaitis, Jaclyn A. Smith, Alyn H. Morice, Lorcan P. McGarvey, Ian D. Pavord, Allison Martin Nguyen, Jonathan Schelfhout, Qing Li, Beata Iskold, Stuart A. Green, George Philip, David R. Muccino, Carmen La Rosa
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Surinder S. Birring, Alyn H. Morice, Peter V. Dicpinigaitis, Lorcan P. McGarvey, Ian D. Pavord, Stuart A. Green, George Philip, Jaclyn A. Smith
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Medicine, Research & Experimental
Peter S. Cunningham, Callum Jackson, Amlan Chakraborty, Jafar Cain, Hannah J. Durrington, John F. Blaikley
Summary: Circadian regulation causes biological processes to vary over a 24-h cycle. The pathological effects of this variation have been studied through pre-clinical models and observational clinical studies, providing insights into circadian mechanisms and their regulation by the molecular oscillator. This review compares and contrasts findings from these approaches in relation to four respiratory diseases, and discusses potential methods to measure circadian oscillations, which can be used as outcome measures in future human trials targeting circadian mechanisms.
Article
Respiratory System
James Wingfield Digby, Jenny King, Robert Lord, Jaclyn Ann Smith, Paul Marsden
Article
Respiratory System
Benjamin Gaston, Donna D. Gardner, Kenzie Mahan, Praveen Akuthota, Eneida A. Mendonca, Hannah Durrington, Nadzeya Marozkina, Rocio T. Martinez-Nunez, Dawn Newcomb, Benjamin Ainsworth, Arthur H. Owora, Kian Fan Chung, Samantha Walker, Stephen J. Fowler, Salman Siddiqui, Tonya Winders, Joe Zein, Nizar Jarjour, Yvonne J. Huang, Katherine N. Cahill, Ratko Djukanovic
Summary: The International Collaborative Asthma Network (ICAN) was established to facilitate the sharing of innovative research, development of new therapies, and engagement of early-stage investigators in asthma research. The first ICAN forum focused on discussing innovation, collaboration, and research translation, and covered various areas of asthma research.
Article
Cardiac & Cardiovascular Systems
James Wingfield Digby, Jenny King, Bashar Al-Sheklly, Paul Marsden, Steve Fowler, Jaclyn Smith
Summary: This study investigated the bronchoscopy, bronchoalveolar lavage (BAL) cell differential, and microbiology findings in patients with refractory/unexplained cough (RUCC) who had mucus production. The results showed that most patients had BAL neutrophilia and excessive dynamic airway collapse (EDAC), which were specific treatable traits for RUCC with mucus production.
RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Peter Saunders, Zhe Wu, William A. Fahy, Iain D. Stewart, Gauri Saini, David J. F. Smith, Rebecca Braybrooke, Carmel Stock, Elisabetta A. Renzoni, Simon R. Johnson, R. Gisli Jenkins, Maria G. Belvisi, Jaclyn A. Smith, Toby M. Maher, Philip L. Molyneaux
Summary: This study aims to assess the burden of cough and its impact on quality of life in newly diagnosed IPF patients. The results indicate that cough burden in IPF is high, but cough-specific quality of life does not have prognostic value and is not associated with MUC5B promoter polymorphism.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Michael Yoon, Min Hyung Ryu, Ryan D. Huff, Maria G. Belvisi, Jaclyn Smith, Chris Carlsten
Summary: In a controlled human exposure study, a genetic risk score (GRS) based on cough-related single-nucleotide polymorphisms (SNPs) was found to be correlated with cough count. This suggests that individuals with a high GRS are more susceptible to developing cough, regardless of their exposure. However, further confirmation is needed to determine if this susceptibility is more prominent in the context of traffic-related air pollution.
RESPIRATORY RESEARCH
(2022)
