Article
Plant Sciences
Bin Li, Baoke Zhang, Zhenyu Li, Shasha Li, Jun Li, Aiwu Wang, Jinling Hou, Jiping Xu, Rui Zhang
Summary: The study aimed to investigate the potential of ginkgolide C (GC), an active ingredient in Ginkgo biloba leaves, to attenuate cerebral ischemia/reperfusion injury (CI/RI) and its anti-inflammatory effect through suppression of the CD40/NF-kappa B pathway. The results showed that GC reduced neurological scores, cerebral infarct rate, and brain edema, while improving microvessel ultrastructure and blood-brain barrier integrity. GC also inhibited the release of inflammatory mediators and enhanced cell viability. These effects were mediated through the suppression of the CD40/NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Jing Li, Xuming Ma, Jun Yang, Luzhen Wang, Yan Huang, Yan Zhu
Summary: This study demonstrates for the first time that lupeol has a cardioprotective effect against I/R-induced myocardial infarction in rats, possibly due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The results also reveal the mechanisms of the NF-kappa B and Nrf2 signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Fengguang Li, Yan Xu, Xing Li, Xinghua Wang, Zhigang Yang, Wanli Li, Wei Cheng, Gangli Yan
Summary: The study demonstrated the therapeutic effect of NC in a rat model of cerebral ischemia/reperfusion injury by reducing NF-kappa B-p65 protein and inflammatory cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Medicinal
Xiaobo Dong, Lei Wang, Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen, Gesheng Wang
Summary: The study demonstrates that physcion protects neuronal cells against I/R injury by inhibiting the TLR4/NF-kB pathway, reducing inflammatory response and oxidative stress, and decreasing apoptosis, suggesting a promising therapeutic candidate for ischemic stroke.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Neurosciences
Zhijun Pu, Shengnan Xia, Pengfei Shao, Xinyu Bao, Dan Wu, Yun Xu
Summary: This study is the first to demonstrate that dauricine exerts its anti-inflammatory effects and neuroprotection by targeting the STAT5-NF-kappa B pathway, suggesting its potential as a therapeutic target for neuroinflammation and post-ischemia-reperfusion injury.
Article
Urology & Nephrology
Seonghun Kim, Sul A. Lee, Heakyung Yoon, Myung Yoon Kim, Jae-Kwang Yoo, So-Hee Ahn, Cheol Hyoung Park, Jimin Park, Bo Young Nam, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Nam Hee Kim, Hyun Sil Kim, Dawool Han, Jong In Yook, Chulhee Choi, Tae-Hyun Yoo
Summary: Ischemia-reperfusion injury is a major cause of acute kidney injury, and immune responses play a significant role in this process. Treatment with Exo-srI kappa B can reduce post-ischemic damage in mice by decreasing NF-kappa B activity and modulating immune cell populations.
KIDNEY INTERNATIONAL
(2021)
Article
Environmental Sciences
Yuming Zhang, Zhen Zhang, Jun Wang, Xiajing Zhang, Jing Zhao, Ning Bai, Annamalai Vijayalakshmi, Qifan Huo
Summary: Scutellarin protects rats from cerebral ischemic injury by inhibiting the inflammatory process through the nuclear factor kappa-B p65 and p38 mitogen-activated protein kinase signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gang Zhang, Xiaofeng Sun, Dongying Zhang, Xiwen Zhang, Kun Yu
Summary: This study investigated the role and molecular mechanism of nuclear factor kappa B (NFκB) and serine protease inhibitor A3 (SerpinA3) interaction in myocardial ischemia-reperfusion (IR) injury. The results demonstrated that increased expression of SerpinA3 activates NFκB and contributes to myocardial infarction. Silencing of SerpinA3 reduces inflammation, oxidative stress, and apoptosis, thus protecting the myocardium.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
E. C. Mooney, S. E. Sahingur
Summary: Inflammation is triggered by innate sensors, and immune cell activation is a strictly regulated process supported by negative feedback mechanisms. Ubiquitination plays a critical role in regulating the immune system, with A20 serving as an important ubiquitin-editing enzyme in inflammation.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aihua Li, Xin Zhang, Qiuping Luo
Summary: Neohesperidin (NEO) mitigates myocardial ischemia-reperfusion (I/R) injury by inhibiting inflammation, oxidative stress, and cell apoptosis, making it a potential therapeutic agent for myocardial I/R therapy.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2021)
Article
Immunology
Yang Yang, Fenglong Zhao, Zhe Yuan, Chuanqiang Wang, Ke Chen, Wenliang Xiao
Summary: miR-218-5p regulates the MEF2C/NF-kappa B axis to alleviate oxidative stress and inflammation in myocardial ischemia-reperfusion injury, reducing myocardial cell damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenjuan Sun, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: The study demonstrates the renoprotective effect of maslinic acid (MA) on acute kidney injury (AKI) induced by renal ischemia-reperfusion injury (IRI) through inhibiting inflammation and apoptosis-related signaling pathways. MA shows promising potential as a therapeutic agent for kidney diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Gaode Zou, Zhiyu Zhou, Xiaoqing Xi, Ruizhen Huang, Honglin Hu
Summary: The study investigated the role of the NF-kappa B signaling pathway and inflammation in ameliorating renal ischemia-reperfusion injury (IRI) using pioglitazone in rats. Pioglitazone treatment decreased the levels of creatinine and urea nitrogen post-IRI, reduced necrosis, elevated PPAR-gamma protein expression, and decreased NF-kappa B-related proteins. Additionally, pioglitazone reduced the mRNA expression of inflammatory cytokines TNF-alpha and MCP-1 in renal tissue, indicating its potential therapeutic effect in alleviating renal IRI.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Yadong Li, Li Zhang, Ping Zhang, Zhiying Hao
Summary: The study demonstrated that dehydrocorydaline (Deh) alleviates sepsis-induced cardiomyocyte injury by inhibiting the TRAF6/NF-kappa B pathway, showing anti-inflammatory and anti-oxidative stress properties.
FRONTIERS IN PHARMACOLOGY
(2021)