Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

KIR genotyping data of more than three million individuals are available for global unrelated stem cell donor searches (Comment to: Weisdorf D, Cooley S, Wang T, et al. KIR donor selection: feasibility in identifying better donors. Biol Blood Marrow Transplant. 2018; doi: 10.1016/j.bbmt.2018.08.022.)

(2018) Alexander H. Schmidt et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

KIR Donor Selection: Feasibility in Identifying better Donors

(2018) Daniel Weisdorf et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Frequencies of gene variant CCR5-Δ32 in 87 countries based on next-generation sequencing of 1.3 million individuals sampled from 3 national DKMS donor centers

(2017) Ute V. Solloch et al.   HUMAN IMMUNOLOGY

TypeLoader: A fast and efficient automated workflow for the annotation and submission of novel full-length HLA alleles

(2017) V. Surendranath et al.   HLA

Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles

(2017) V. Albrecht et al.   HLA

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing

(2016) Paul J. Norman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ABO allele-level frequency estimation based on population-scale genotyping by next generation sequencing

(2016) Kathrin Lang et al.   BMC GENOMICS

Hematopoietic stem cell transplantation: Improving alloreactive Bw4 donor selection by genotyping codon 86 of KIR3DL1/S1

(2016) Claudia Alicata et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans

(2016) J A Hollenbach et al.   GENES AND IMMUNITY

OR30 Dual redundant reference sequencing (DR2S): a computational approach for phase-defined full-length HLA-gene characterization

(2016) Gerhard Schöfl et al.   HUMAN IMMUNOLOGY

Deciphering the killer-cell immunoglobulin-like receptor system at super-resolution for natural killer and T-cell biology

(2016) Vivien Béziat et al.   IMMUNOLOGY

KIR3DL1 and HLA-B Density and Binding Calibrate NK Education and Response to HIV

(2016) Jeanette E. Boudreau et al.   JOURNAL OF IMMUNOLOGY

qKAT: a high-throughput qPCR method for KIR gene copy number and haplotype determination

(2016) W. Jiang et al.   Genome Medicine

Haploidentical hematopoietic transplantation from KIR ligand-mismatched donors with activating KIRs reduces nonrelapse mortality

(2015) A. Mancusi et al.   BLOOD

The effect of donor characteristics on survival after unrelated donor transplantation for hematologic malignancy

(2015) C. Kollman et al.   BLOOD

Inhibitory KIR3DL1 alleles are associated with psoriasis

(2015) R.S. Ahn et al.   BRITISH JOURNAL OF DERMATOLOGY

Minimum information for reporting next generation sequence genotyping (MIRING): Guidelines for reporting HLA and KIR genotyping via next generation sequencing

(2015) Steven J. Mack et al.   HUMAN IMMUNOLOGY

Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction

(2015) Ashley Moffett et al.   IMMUNOLOGICAL REVIEWS

Cost-efficient high-throughput HLA typing by MiSeq amplicon sequencing

(2014) Vinzenz Lange et al.   BMC GENOMICS

HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients

(2014) X-Y Zhao et al.   BRITISH JOURNAL OF CANCER

Synergistic Polymorphism at Two Positions Distal to the Ligand-Binding Site Makes KIR2DL2 a Stronger Receptor for HLA-C Than KIR2DL3

(2014) A. K. Moesta et al.   JOURNAL OF IMMUNOLOGY

Donor Killer Cell Ig-like Receptor B Haplotypes, Recipient HLA-C1, and HLA-C Mismatch Enhance the Clinical Benefit of Unrelated Transplantation for Acute Myelogenous Leukemia

(2014) S. Cooley et al.   JOURNAL OF IMMUNOLOGY

The IPD and IMGT/HLA database: allele variant databases

(2014) James Robinson et al.   NUCLEIC ACIDS RESEARCH

Development of a Novel Multiplex PCR Assay to Detect Functional Subtypes of KIR3DL1 Alleles

(2014) Jeanette E. Boudreau et al.   PLoS One

Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR

(2014) Chrissy h Roberts et al.   Genome Medicine

Killer Immunoglobulin-like Receptors and Tumor Immunity

(2014) D. M. Benson et al.   Cancer Immunology Research

Extensive Variation in Gene Copy Number at the Killer Immunoglobulin-Like Receptor Locus in Humans

(2013) Sanne Vendelbosch et al.   PLoS One

Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string

(2013) R. P. Milius et al.   TISSUE ANTIGENS

Co-evolution of Human Leukocyte Antigen (HLA) Class I Ligands with Killer-Cell Immunoglobulin-Like Receptors (KIR) in a Genetically Diverse Population of Sub-Saharan Africans

(2013) Paul J. Norman et al.   PLoS Genetics

Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors

(2012) W. Jiang et al.   GENOME RESEARCH

HLA-C–Dependent Prevention of Leukemia Relapse by Donor ActivatingKIR2DS1

(2012) Jeffrey M. Venstrom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Allele-Level Haplotype Frequencies and Pairwise Linkage Disequilibrium for 14 KIR Loci in 506 European-American Individuals

(2012) Cynthia Vierra-Green et al.   PLoS One

Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

(2011) Kerry S. Campbell et al.   IMMUNOLOGY

The MHC, disease and selection

(2011) John Trowsdale   IMMUNOLOGY LETTERS

Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia

(2010) S. Cooley et al.   BLOOD

Different Patterns of Evolution in the Centromeric and Telomeric Regions of Group A and B Haplotypes of the Human Killer Cell Ig-Like Receptor Locus

(2010) Chul-Woo Pyo et al.   PLoS One

KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation

(2009) K Ludajic et al.   BONE MARROW TRANSPLANTATION

The influence of NK alloreactivity on matched unrelated donor and HLA identical sibling haematopoietic stem cell transplantation

(2009) Campbell S Witt   CURRENT OPINION IN IMMUNOLOGY

Dimorphic Motifs in D0 and D1+D2 Domains of Killer Cell Ig-Like Receptor 3DL1 Combine to Form Receptors with High, Moderate, and No Avidity for the Complex of a Peptide Derived from HIV and HLA-A*2402

(2009) D. Sharma et al.   JOURNAL OF IMMUNOLOGY

A novel real-time PCR method for KIR genotyping

(2009) L. G. T. Alves et al.   TISSUE ANTIGENS

A novel duplex SSP-PCR typing method forKIRgene profiling

(2009) E. Ashouri et al.   TISSUE ANTIGENS

Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5

(2008) A. Gonzalez et al.   TISSUE ANTIGENS