A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis

Antigen 85 complex as a powerful Mycobacterium tuberculosis immunogene: Biology, immune-pathogenicity, applications in diagnosis, and vaccine design

(2017) Mohsen Karbalaei Zadeh Babaki et al.   MICROBIAL PATHOGENESIS

The dynamics of immune responses to Mycobacterium tuberculosis during different stages of natural infection: A longitudinal study among Greenlanders

(2017) Sascha Wilk Michelsen et al.   PLoS One

Evaluation of a New IFN-γ Release Assay for Rapid Diagnosis of Active Tuberculosis in a High-Incidence Setting

(2017) Gen Li et al.   Frontiers in Cellular and Infection Microbiology

Mycobacterium tuberculosis Latent Antigen Rv2029c from the Multistage DNA Vaccine A39 Drives TH1 Responses via TLR-mediated Macrophage Activation

(2017) Haibo Su et al.   Frontiers in Microbiology

Mycobacterium tuberculosis DosR Regulon Gene Rv2004c Encodes a Novel Antigen with Pro-inflammatory Functions and Potential Diagnostic Application for Detection of Latent Tuberculosis

(2017) Sankara Narayana Doddam et al.   Frontiers in Immunology

Age-Stratified T Cell Responses in Children Infected with Mycobacterium tuberculosis

(2017) Alexandra Dreesman et al.   Frontiers in Immunology

Immune characterization of the HBHA-specific response in Mycobacterium tuberculosis-infected patients with or without HIV infection

(2017) Teresa Chiacchio et al.   PLoS One

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis

(2017) Srabanti Rakshit et al.   Scientific Reports

Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia

(2016) Leonar Arroyo et al.   Clinical and Vaccine Immunology

The Secreted Protein Rv1860 of Mycobacterium tuberculosis Stimulates Human Polyfunctional CD8+T Cells

(2016) Vijaya Satchidanandam et al.   Clinical and Vaccine Immunology

Potential novel markers to discriminate between active and latent tuberculosis infection in Chinese individuals

(2016) Xue-juan Bai et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Interferon-Gamma Release Assays for the Diagnosis of Tuberculosis: A Systematic Review and Meta-analysis

(2016) Peng Lu et al.   LUNG

Lack of Response to HBHA in HIV-Infected Patients with Latent Tuberculosis Infection

(2016) G. Delogu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Host immunity to Mycobacterium tuberculosis and risk of tuberculosis: A longitudinal study among Greenlanders

(2016) Sascha Wilk Michelsen et al.   VACCINE

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

(2016) Mariateresa Coppola et al.   Scientific Reports

Contribution of a heparin-binding haemagglutinin interferon-gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV-infected patients: comparison with the tuberculin skin test and the QuantiFERON®-TB Gold In-tube

(2015) Chloé Wyndham-Thomas et al.   BMC INFECTIOUS DISEASES

Evaluation of cytokine and chemokine response elicited by Rv2204c and Rv0753c to detect latent tuberculosis infection

(2015) Balaji Pathakumari et al.   CYTOKINE

PpiA antigen specific immune response is a potential biomarker for latent tuberculosis infection

(2015) Balaji Pathakumari et al.   TUBERCULOSIS

Profile of interferon-gamma response to latency-associated and novel in vivo expressed antigens in a cohort of subjects recently exposed to Mycobacterium tuberculosis

(2015) Leonardo Silva de Araujo et al.   TUBERCULOSIS

A Mycobacterium tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette–Guérin-vaccinated Individuals

(2015) Delfina Peña et al.   EBioMedicine

Pro- and Anti-Inflammatory Cytokines against Rv2031 Are Elevated during Latent Tuberculosis: A Study in Cohorts of Tuberculosis Patients, Household Contacts and Community Controls in an Endemic Setting

(2015) Mulugeta Belay et al.   PLoS One

Novel concepts in the epidemiology, diagnosis and prevention of childhood tuberculosis

(2015) N Ritz et al.   SWISS MEDICAL WEEKLY

Cytokine response to selected MTB antigens in Ghanaian TB patients, before and at 2 weeks of anti-TB therapy is characterized by high expression of IFN-γ and Granzyme B and inter- individual variation

(2014) Gloria Ivy Mensah et al.   BMC INFECTIOUS DISEASES

Systematic review and meta-analysis on the utility of Interferon-gamma release assays for the diagnosis of Mycobacterium tuberculosis infection in children: a 2013 update

(2014) S Sollai et al.   BMC INFECTIOUS DISEASES

Key Role of Effector Memory CD4+T Lymphocytes in a Short-Incubation Heparin-Binding Hemagglutinin Gamma Interferon Release Assay for the Detection of Latent Tuberculosis

(2014) Chloé Wyndham-Thomas et al.   Clinical and Vaccine Immunology

Immunogenicity of 60 novel latency-related antigens of Mycobacterium tuberculosis

(2014) Mᵃdel Mar Serra-Vidal et al.   Frontiers in Microbiology

Innovative Strategies to Identify M. tuberculosis Antigens and Epitopes Using Genome-Wide Analyses

(2014) Annemieke Geluk et al.   Frontiers in Immunology

Systematic Review: T-Cell–based Assays for the Diagnosis of Latent Tuberculosis Infection: An Update

(2013) Madhukar Pai et al.   ANNALS OF INTERNAL MEDICINE

Differential cellular recognition pattern to M. tuberculosis targets defined by IFN-γ and IL-17 production in blood from TB + patients from Honduras as compared to health care workers: TB and immune responses in patients from Honduras

(2013) Nancy Alvarez-Corrales et al.   BMC INFECTIOUS DISEASES

Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan

(2013) H. Hozumi et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

The Mycobacterium tuberculosis regulatory network and hypoxia

(2013) James E. Galagan et al.   NATURE

Characterization of Phosphofructokinase Activity in Mycobacterium tuberculosis Reveals That a Functional Glycolytic Carbon Flow Is Necessary to Limit the Accumulation of Toxic Metabolic Intermediates under Hypoxia

(2013) Wai Yee Phong et al.   PLoS One

Analysis of Host Responses to Mycobacterium tuberculosis Antigens in a Multi-Site Study of Subjects with Different TB and HIV Infection States in Sub-Saharan Africa

(2013) Jayne S. Sutherland et al.   PLoS One

Interferon-γ responses to Mycobacterium tuberculosis Rpf proteins in contact investigation

(2013) Wei Huang et al.   TUBERCULOSIS

Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting

(2012) Novel N Chegou et al.   BMC INFECTIOUS DISEASES

Analysis of Immune Responses against a Wide Range of Mycobacterium tuberculosis Antigens in Patients with Active Pulmonary Tuberculosis

(2012) Desta Kassa et al.   Clinical and Vaccine Immunology

Heparin-Binding Hemagglutinin Induces IFN-γ+IL-2+IL-17+Multifunctional CD4+T Cells during Latent but Not Active Tuberculosis Disease

(2012) André G. Loxton et al.   Clinical and Vaccine Immunology

Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area

(2012) Novel N. Chegou et al.   PLoS One

T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia

(2012) Felipe Riaño et al.   TUBERCULOSIS

Effect of Chemotherapy on Whole-Blood Cytokine Responses to Mycobacterium tuberculosis Antigens in a Small Cohort of Patients with Pulmonary Tuberculosis

(2011) Sylvie Bertholet et al.   Clinical and Vaccine Immunology

Identification of Human T-Cell Responses to Mycobacterium tuberculosis Resuscitation-Promoting Factors in Long-Term Latently Infected Individuals

(2011) Susanna Commandeur et al.   Clinical and Vaccine Immunology

Tuberculosis patients are characterized by a low–IFN-γ/high–TNF-α response to methylated HBHA produced in M. smegmatis

(2011) Paola Molicotti et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Double- and monofunctional CD4+ and CD8+ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals

(2011) Susanna Commandeur et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Components of the Rv0081-Rv0088 Locus, Which Encodes a Predicted Formate Hydrogenlyase Complex, Are Coregulated by Rv0081, MprA, and DosR in Mycobacterium tuberculosis

(2011) H. He et al.   JOURNAL OF BACTERIOLOGY

Methylated HBHA Produced in M. smegmatis Discriminates between Active and Non-Active Tuberculosis Disease among RD1-Responders

(2011) Giovanni Delogu et al.   PLoS One

Novel M tuberculosis Antigen-Specific T-Cells Are Early Markers of Infection and Disease Progression

(2011) Davinder P. S. Dosanjh et al.   PLoS One

A 100 year update on diagnosis of tuberculosis infection

(2010) A. Lalvani et al.   BRITISH MEDICAL BULLETIN

TubercuList – 10 years after

(2010) Jocelyne M. Lew et al.   TUBERCULOSIS

Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease

(2010) Lerisa Govender et al.   VACCINE

Exploring the immune response against Mycobacterium tuberculosis for a better diagnosis of the infection

(2009) Giovanni Ferrara et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of Mycobacterium tuberculosis in Three High-Burden Populations in Africa

(2009) G. F. Black et al.   Clinical and Vaccine Immunology

Response to Rv2628 latency antigen associates with cured tuberculosis and remote infection

(2009) D. Goletti et al.   EUROPEAN RESPIRATORY JOURNAL

Novel recombinant RD2- and RD11-encoded Mycobacterium tuberculosis antigens are potential candidates for diagnosis of tuberculosis infections in BCG-vaccinated individuals

(2009) Jiazhen Chen et al.   MICROBES AND INFECTION

Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection

(2009) Sebastian D. Schuck et al.   PLoS One

Whole genome identification of Mycobacterium tuberculosisvaccine candidates by comprehensive data mining and bioinformatic analyses

(2008) Anat Zvi et al.   BMC Medical Genomics