Article
Clinical Neurology
Laura O'Connor, Clas Malmestrom, Rui Da Silva Rodrigues, Susanna Brauner, Anna-Karin Wikstrom, Anna Rostedt Punga
Summary: This nationwide study in Sweden provides reassuring results, indicating generally safe pregnancy outcomes for women with MG and their infants.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kathrine Bendixen, Rene B. K. Brund, Thilde B. Jorgensen, Nanna K. Kristiansen, Ulrik S. Kesmodel, Kirsten Fonager, Signe Heuckendorff
Summary: The study aimed to investigate the inequality in maternal smoking between subgroups of pregnant women and the significant risk factors associated with maternal smoking. The results showed a decrease in the prevalence of maternal smoking, but significant differences in smoking prevalence between subgroups and an increasing trend of inequality from 2000 to 2016. Additionally, factors such as low age, low education, living alone, and moderate/severe mental health conditions were found to be associated with a higher probability of maternal smoking.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Immunology
Kristian Kragholm, Mikkel Porsborg Andersen, Thomas A. Gerds, Jawad H. Butt, Lauge Ostergaard, Christoffer Polcwiartek, Matthew Phelps, Charlotte Andersson, Gunnar H. Gislason, Christian Torp-Pedersen, Lars Kober, Morten Schou, Emil L. Fosbol
Summary: Male COVID-19 patients have over 50% higher risk of severe infection, death, or ICU admission compared to females, and this excess risk is not explained by age and comorbidities.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Luise Moelenberg Begtrup, Camilla Sandal Sejbaek, Esben Meulengracht Flachs, Anne Helene Garde, Ina Olmer Specht, Johnni Hansen, Henrik A. Kolstad, Jens Peter Ellekilde Bonde, Paula Edeusa Cristina Hammer
Summary: The study found no increased risk of having a small for gestational age (SGA) child among healthcare workers who worked night shifts during pregnancy. Better data on pregnancy discomforts and complications are needed to rule out the potential impact of healthy worker survivor bias (HWSB).
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Clinical Neurology
Nete Munk Nielsen, Morten Frisch, Sanne Gortz, Egon Stenager, Kristin Skogstrand, David M. Hougaard, Alberto Ascherio, Klaus Rostgaard, Henrik Hjalgrim
Summary: This study found that smoking during pregnancy increases the risk of developing multiple sclerosis in offspring. These findings further support the association between smoking and the development of multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Johanna Balslev Andersen, Malthe Faurschou Wandall-Holm, Melinda Magyari
Summary: The study investigated the association of adverse perinatal outcomes in newborns with maternal or paternal exposure to teriflunomide, and found no increased prevalence of spontaneous abortion, preterm birth, congenital malformations, low Apgar score, or being small for gestational age in newborns with exposure to teriflunomide compared to the general population.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
Mikkel Porsborg Andersen, Rikke Wiingreen, Talip E. Eroglu, Helle Collatz Christensen, Laura Bech Polcwiartek, Stig Nikolaj Fasmer Blomberg, Kristian Kragholm, Christian Torp-Pedersen, Kathrine Kold Sorensen
Summary: The aim of the National Child Health Registry is to provide comprehensive insight into children's health and growth in Denmark by continuously monitoring their health status. The registry includes information on secondhand smoking exposure, breastfeeding duration, and anthropometric measurements. It can be linked to other national health and social registers for longitudinal follow-up.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Aino K. Rantala, German Tapia, Maria C. Magnus, Lars C. Stene, Jouni J. K. Jaakkola, Ketil Stordal, Oystein Karlstad, Wenche Nystad
Summary: Maternal antibiotic use and infections during pregnancy are associated with an increased risk of offspring asthma. The use of antibiotics during pregnancy is linked to asthma at the age of 7, while maternal infections during pregnancy are associated with asthma at both 7 and 13 years old. However, the effect of antibiotics may reflect a shared underlying susceptibility rather than a direct cause.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Marcella Broccia, Bo Molholm Hansen, Julie Marie Winckler, Thomas Larsen, Katrine Strandberg-Larsen, Christian Torp-Pedersen, Ulrik Schioler Kesmodel
Summary: Heavy prenatal alcohol exposure is associated with adverse obstetric and birth outcomes, with high proportions of maternal low educational level, psychiatric disease, and lifestyle risk behaviors. These findings highlight the need for holistic public health programs and policy attention on improving pre-conceptional care and antenatal care.
LANCET PUBLIC HEALTH
(2023)
Article
Rheumatology
Sofie Mork, Anne Voss, Soren Moller, Mette Bliddal
Summary: Pregnancies in women with spondyloarthritis were more likely to be complicated by adverse pregnancy outcomes, such as moderately preterm birth, cesarean section, emergency cesarean section, and use of epidural. However, spondyloarthritis was not significantly associated with small for gestational age birth and preeclampsia.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Multidisciplinary Sciences
Viktoria Papp, Mathias Due Buron, Volkert Siersma, Peter Vestergaard Rasmussen, Zsolt Illes, Matthias Kant, Claudia Hilt, Zsolt Mezei, Homayoun Roshanisefat, Tobias Sejbaek, Arkadiusz Weglewski, Janneke van Wingerden, Svend Sparre Geertsen, Stephan Bramow, Finn Sellebjerg, Melinda Magyari
Summary: The study investigated the real-world clinical outcomes of teriflunomide treatment for multiple sclerosis patients in Denmark between 2013-2019. The results showed that 72.7% of patients were still on teriflunomide treatment one year after initiation, with 47.5% discontinuing treatment over the full follow-up period. Patients on teriflunomide for 5 years had a relapse-free rate of 63% and 85% were free of disability worsening at the end of follow-up, demonstrating the efficacy and treatment persistence of teriflunomide in real-world settings.
Article
Obstetrics & Gynecology
H. Valgeirsdottir, T. Kunovac Kallak, I. Sundstrom Poromaa, M. Jonsson, N. Roos, L. Lindstrom, A-K Wikstrom
Summary: A nationwide register-based cohort study in Sweden found that women with polycystic ovary syndrome (PCOS) have an increased risk of stillbirth, particularly in late pregnancy. Compared to women without PCOS, women with PCOS had a 50% higher risk of stillbirth. However, women with PCOS and a severe hyperandrogenic profile did not show a stronger association with stillbirth compared to those without this profile.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Endocrinology & Metabolism
Bochra Zareini, Kathrine Kold Sorensen, Pia A. Eiken, Thea K. Fischer, Peter Lommer Kristensen, Maria Elisabeth Lendorf, Ulrik Pedersen-Bjergaard, Christian Torp-Pedersen, Runa L. M. Nolsoe
Summary: This study compared the incidence of type 1 diabetes (T1D) before and during the COVID-19 pandemic and found that there was an increase in T1D cases during April-June 2021, but it was not associated with SARS-CoV-2 infection.
Article
Obstetrics & Gynecology
L. Kolding, V Ehrenstein, L. Pedersen, P. Sandager, O. B. Petersen, N. Uldbjerg, L. H. Pedersen
Summary: The study shows that exposure to venlafaxine is associated with an increased risk of cardiac malformations, but the absolute risk is low. Potential mechanisms include direct effects or confounding by indication. Venlafaxine exposure may serve as a marker for high-risk pregnancies that may benefit from fetal echocardiography.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Jakob Bie Granild-Jensen, Alma Becic Pedersen, Eskild Bendix Kristiansen, Bente Langdahl, Bjarne Moller-Madsen, Charlotte Sondergaard, Stense Farholt, Esben Thyssen Vestergaard, Gija Rackauskaite
Summary: Fracture rates in children with cerebral palsy (CP) are not significantly increased compared to peers, but fracture locations suggest bone fragility in non-ambulant children. All children with epilepsy and on anti-seizure medication had increased fracture rates. Bone health optimization is recommended for these groups.
CLINICAL EPIDEMIOLOGY
(2022)
Letter
Rheumatology
Tine Iskov Kopp, Benedicte Delcoigne, Elizabeth Arkema, Melinda Magyari, Henning Locht, Finn Thorup Sellebjerg, Rene Lindholm Cordtz, Dorte Jensen, Johan Askling, Lene Dreyer
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Clinical Neurology
Tine Iskov Kopp, Ojvind Lidegaard, Melinda Magyari
Summary: This Danish cohort study investigated the association between hormone therapy (HT) and disease activity and disability accrual among women with multiple sclerosis (MS). The study found no significant association between HT and disability accrual, although there was a trend for increased risk with longer duration of use. However, current users of HT had a 20% increased risk of recurrent relapse compared to non-users.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Carmen Tur, Anne-Laure Dubessy, Susana Otero-Romero, Maria Pia Amato, Tobias Derfuss, Franziska Di Pauli, Ellen Iacobaeus, Marcin Mycko, Hesham Abboud, Anat Achiron, Angelo Bellinvia, Alexey Boyko, Jean-Laurent Casanova, David Clifford, Ruth Dobson, Mauricio F. Farez, Massimo Filippi, Kathryn C. Fitzgerald, Mattia Fonderico, Riadh Gouider, Yael Hacohen, Kerstin Hellwig, Bernhard Hemmer, Ludwig Kappos, Filipa Ladeira, Christine Lebrun-Frenay, Celine Louapre, Melinda Magyari, Matthias Mehling, Celia Oreja-Guevara, Lekha Pandit, Caroline Papeix, Fredrik Piehl, Emilio Portaccio, Isabel Ruiz-Camps, Krzysztof Selmaj, Steve Simpson-Yap, Aksel Siva, Per Soelberg Sorensen, Maria Pia Sormani, Maria Trojano, Adi Vaknin-Dembinsky, Sandra Vukusic, Brian Weinshenker, Heinz Wiendl, Alexander Winkelmann, Maria Isabel Zuluaga Rodas, Mar Tintore, Bruno Stankoff
Summary: In recent years, there have been rapid developments in the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), with a wide range of disease-modifying treatments (DMTs) now available. However, most DMTs come with the risk of adverse events, particularly infections. To address this, an international workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) was held in April 2021 to review the current knowledge on infection risks associated with DMT use in MS and NMOSD patients, and to discuss strategies for risk mitigation. The workshop also explored specific populations, such as children, pregnant women, individuals with comorbidities, and those living in regions with high infection burden, as well as the impact of the ongoing SARS-CoV-2 pandemic on DMT-associated infectious risks.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Morten Riemenschneider, Lars G. Hvid, Steffen Ringgaard, Mikkel Karl Emil Nygaard, Simon Fristed Eskildsen, Tobias Gaemelke, Melinda Magyari, Henrik Boye Jensen, Helle Hvilsted Nielsen, Matthias Kant, Masoud Falah, Thor Petersen, Egon Stenager, Ulrik Dalgas
Summary: Early supervised aerobic exercise did not reduce relapse rate or global brain atrophy in patients with MS, but it positively affected the microstructural integrity of important motor-related tracts and nuclei.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Computer Science, Artificial Intelligence
Shuo Liu, Jing Han, Estela Laporta Puyal, Spyridon Kontaxis, Shaoxiong Sun, Patrick Locatelli, Judith Dineley, Florian B. Pokorny, Gloria Dalla Costa, Letizia Leocani, Ana Isabel Guerrero, Carlos Nos, Ana Zabalza, Per Soelberg Sorensen, Mathias Buron, Melinda Magyari, Yatharth Ranjan, Zulqarnain Rashid, Pauline Conde, Callum Stewart, Amos A. Folarin, Richard J. B. Dobson, Raquel Bailon, Srinivasan Vairavan, Nicholas Cummins, Vaibhav A. Narayan, Matthew Hotopf, Giancarlo Comi, Bjoern Schuller
Summary: This study introduces a contrastive convolutional auto-encoder (contrastive CAE) to identify potential COVID-19 infection in participants with multiple sclerosis (MS) based on heart-rate data, achieving high classification performance with effective symptom detection and low false alarm rate.
PATTERN RECOGNITION
(2022)
Article
Clinical Neurology
Johanna Balslev Andersen, Malthe Faurschou Wandall-Holm, Melinda Magyari
Summary: The study investigated the association of adverse perinatal outcomes in newborns with maternal or paternal exposure to teriflunomide, and found no increased prevalence of spontaneous abortion, preterm birth, congenital malformations, low Apgar score, or being small for gestational age in newborns with exposure to teriflunomide compared to the general population.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Malthe Faurschou Wandall-Holm, Mads Albrecht Andersen, Mathias Due Buron, Melinda Magyari
Summary: Danish patients with MS are at a higher risk of losing all income from earnings and at a much higher risk of receiving disability pension compared with healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Johanna Balslev Andersen, Finn Sellebjerg, Melinda Magyari
Summary: This study found no increased association of adverse pregnancy outcomes in newborns with fetal exposure to disease-modifying drugs (DMDs) when compared with either DMD-unexposed pregnancies or the general population.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Alessio Signori, Johannes Lorscheider, Sandra Vukusic, Maria Trojano, Pietro Iaffaldano, Jan Hillert, Robert Hyde, Fabio Pellegrini, Melinda Magyari, Nils Koch-Henriksen, Per Soelberg Sorensen, Tim Spelman, Anneke van Der Walt, Dana Horakova, Eva Havrdova, Marc Girard, Sara Eichau, Francois Grand'Maison, Oliver Gerlach, Murat Terzi, Serkan Ozakbas, Olga Skibina, Vincent Van Pesch, Maria Jose Sa, Julie Prevost, Raed Alroughani, Pamela A. McCombe, Riadh Gouider, Saloua Mrabet, Tamara Castillo-Trivino, Chao Zhu, Koen de Gans, Jose Luis Sanchez-Menoyo, Bassem Yamout, Samia Khoury, Maria Pia Sormani, Tomas Kalincik, Helmut Butzkueven
Summary: This study identifies different subgroups of patients with secondary progressive multiple sclerosis (SPMS) based on their longitudinal trajectories of disability. The findings suggest that SPMS patients progress at greatly different rates and the identification of distinct trajectories can guide better patient selection in future clinical trials. Additionally, the distinct trajectories may reflect heterogeneous pathological mechanisms of progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Zsofia Kokas, Anett Jardanhazy, Daniel Sandi, Tamas Biernacki, Zsanett Fricska-Nagy, Judit Fuvesi, Halina Bartosik-Psujek, Vanja Basic Kes, Thomas Berger, Achim Berthele, Jelena Drulovic, Bernhard Hemmer, Dana Horakova, Alenka Horvat Ledinek, Eva Kubala Havrdova, Melinda Magyari, Konrad Rejdak, Cristina Tiu, Peter Turcani, Peter Klivenyi, Zsigmond Tamas Kincses, Laszlo Vecsei, Krisztina Bencsik
Summary: In most Central-Eastern European countries, the recommendations for multiple sclerosis (MS) care units are met, but there are still some deficiencies, such as the lack of speech therapists, specialists for continence, pain and spasticity, neuro-ophthalmologists, and otoneurologists. Although multiple disease-modifying therapies (DMTs) are reimbursed, not every center provides all available DMTs. Additionally, only Austria and the Czech Republic require national registry use. Therefore, in countries where MSCU recommendations are not fulfilled, a strictly regulated center system similar to the Austrian and Czech model, with a registry-based quality control, may ensure appropriate care for MS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Nils Iorgen Koch-Henriksen, Lau Caspar Thygesen, Per Soelberg Sorensen, Melinda Magyari
Summary: This study demonstrates the use of instrumental variables to reduce bias in observational studies and confirms the effectiveness of treatment in delaying disability in multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Chemistry, Analytical
Spyridon Kontaxis, Estela Laporta, Esther Garcia, Matteo Martinis, Letizia Leocani, Lucia Roselli, Mathias Due Buron, Ana Isabel Guerrero, Ana Zabala, Nicholas Cummins, Srinivasan Vairavan, Matthew Hotopf, Richard J. B. A. Dobson, Vaibhav Narayan, Maria Libera La Porta, Gloria Dalla Costa, Melinda Magyari, Per Soelberg Sorensen, Carlos Nos, Raquel Bailon, Giancarlo Comi, RADAR CNS Consortium
Summary: The aim of this study was to investigate the feasibility of automatically assessing the 2-Minute Walk Distance (2MWD) for monitoring people with multiple sclerosis (pwMS). The study collected the 2MWDs as evaluated by clinicians and derived from accelerometer data from 154 pwMS, along with MS-related clinical outcomes. The results showed that estimating the 2MWD using a wearable device yielded a low error rate and had strong correlations with clinical outcomes.
Article
Clinical Neurology
Josefine Windfeld-Mathiasen, Henrik Horwitz, Johanna Balslev Andersen, Elisabeth Framke, Christina Gade, Jon Traerup Andersen, Melinda Magyari
Summary: This retrospective matched cohort study investigated the impact of exposure to interferon-beta during pregnancy on the risk of significant infections in early childhood. The study included 510 children born to mothers with multiple sclerosis who were exposed to interferon-beta in utero. The results showed that exposure to interferon-beta had little to no impact on the risk of acquiring significant infections during the first five years of childhood.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Dominika Stastna, Frederik Elberling, Luigi Pontieri, Elisabeth Framke, Dana Horakova, Jiri Drahota, Petra Nytrova, Melinda Magyari
Summary: This study evaluated the difference in relapse occurrence pre- and post-COVID-19 vaccination in Danish patients with relapsing multiple sclerosis. The findings showed that there was no significant increase in relapse activity following the administration of the first dose of the COVID-19 vaccine.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Richard Nicholas, Jeff Rodgers, James Witts, Annalaura Lerede, Tim Friede, Jan Hillert, Lars Forsberg, Anna Glaser, Ali Manouchehrinia, Ryan Ramanujam, Tim Spelman, Pernilla Klyve, Jiri Drahota, Dana Horakova, Hanna Joensen, Luigi Pontieri, Melinda Magyari, David Ellenberger, Alexander Stahmann, Helmut Butzkueven, Anneke Van der Walt, Vladimir Bezlyak, Carol Lines, Rod Middleton
Summary: This study analyzed registry data from multiple countries and found variations in DMT usage, with factors such as gender, disability level, and monitoring influencing the likelihood of receiving DMTs. The study also explored the impact of diagnosis on DMT usage in clinical SPMS.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
