Article
Food Science & Technology
Anna V. Begunova, Olga S. Savinova, Olga A. Glazunova, Konstantin V. Moiseenko, Irina V. Rozhkova, Tatyana V. Fedorova
Summary: Bioactive peptides derived from milk proteins have positive effects on various physiological systems and are considered promising ingredients for functional food. These peptides are usually inactive within parent proteins and can be released during milk fermentation by specific proteolytic systems of different Lactobacillus spp.
Article
Microbiology
Haripriya Gupta, Sung Hun Kim, Seul Ki Kim, Sang Hak Han, Hak Cheol Kwon, Ki Tae Suk
Summary: This study investigated the effects of probiotic treatment on alcoholic hepatitis patients by restoring gut microbial balance. The results showed that probiotics improved liver function, decreased lipopolysaccharide levels, and modulated the composition of gut microbiota.
Article
Biochemistry & Molecular Biology
Levini A. A. Msimbira, Sowmyalakshmi Subramanian, Judith Naamala, Mohammed Antar, Donald L. L. Smith
Summary: This study evaluated the effects of pH on the secretome of two bacterial strains. The results showed that acidity decreased protein production, while alkalinity increased protein production. Additionally, different pH conditions led to the production of unique and new proteins in these bacteria, suggesting their adaptation to pH stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fuli Zheng, Zhi Wang, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Hao Zhang, Bo Yang, Wei Chen
Summary: In this study, it was found that strains of L. reuteri and L. rhamnosus significantly slowed weight gain in mice, alleviated blood glucose and lipid disorders, tissue damage, and gut microbiota disorders, produced SCFAs to induce satiety hormones, inhibit food intake, and increase satiety, ultimately improving metabolic syndrome.
Article
Food Science & Technology
Jiayan Jiang, Ke Li, Yuanliang Wang, Zhongqin Wu, Huiqin Ma, Shilin Zheng, Zongjun Li
Summary: This study isolated and identified 104 strains of LAB from traditionally fermented vegetables, fresh milk, healthy infant feces, and other environments. The strains were evaluated for their antibacterial properties, acid and bile salts resistance, digestive enzymes resistance, and adhesion ability. Three LAB strains with good comprehensive performance were obtained, which exhibited broad-spectrum antibacterial properties, good acid resistance, and adhesion ability. These strains met the required characteristics and safety evaluation criteria for potential probiotics.
Article
Biochemistry & Molecular Biology
Shun Lu, Jing Xu, Zihao Zhao, Yuheng Guo, Hanwen Zhang, Peter W. Jurutka, Dechun Huang, Chongjiang Cao, Shujie Cheng
Summary: Combination of food probiotics (LGG-EV) with immunotherapy can enhance the efficacy of colorectal cancer treatment and regulate intestinal immune function and microbiota diversity.
Article
Immunology
Yanan Li, Yaohong Zhu, Bingxin Chu, Ning Liu, Shiyan Chen, Jiufeng Wang
Summary: Escherichia coli infection induces NLRP3 inflammasome assembly, Caspase-1 activation, and apoptosis, along with mitochondrial damage and ROS production. Pretreatment with probiotic Lactobacillus rhamnosus GR-1 alleviates these effects by inhibiting ROS and promoting mitophagy. In a mouse mastitis model, LGR-1 pretreatment has preventive and protective effects, reducing cytokine levels and preserving mitochondrial function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiwen Ge, Xuan Bao, Zhiyu Li, Xiaohong Chen, Wei Li, Xin Rui, Junjun Wu, Qiuqin Zhang, Mingsheng Dong
Summary: This study investigated the mechanism of high viscosity in Sayram ketteki yogurt. It analyzed the growth, acidification properties, and in situ exopolysaccharides (EPS) production of Lactobacillus helveticus MB2-1 in milk medium. The microstructure of the yogurt was analyzed, and the characteristics of in situ EPS were studied using various analytical techniques. The results showed that the in situ EPS produced by L. helveticus MB2-1 were closely connected with proteins, effectively filling the three-dimensional network structure of casein clusters, resulting in high viscosity of the yogurt. The in situ EPS was determined to be a new heteropolysaccharide containing fucose, making it unique.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Jianjun Tian, Xueqian Yang, Kaiping Zhang, Yanhong Zhao, Feng Cheng, Ye Jin
Summary: In this study, two Lactobacillus helveticus strains, ZF22 and TR1-1-3, were selected from traditional Inner Mongolian air-dried meat products due to their potent antibacterial activity and tolerance to acid, salt, and nitrite. The volatiles of fermented sausages inoculated with Lactobacillus helveticus ZF22 and TR1-1-3 were studied during fermentation and storage. The results showed that the inoculation increased the proportion of acids, ketones, and alkanes in the sausages, and certain esters were more abundant in ZF22 and TR1-1-3 than in ZR. The volatile compound compositions of the three sausages differed significantly, indicating that inoculating them with Lactobacillus helveticus TR1-1-3 and ZF22 can improve flavor by enhancing the type and amount of flavor compounds.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Xiaoyang Ma, Yoon-Jung Shin, Hyo-Min Jang, Min-Kyung Joo, Jong-Wook Yoo, Dong-Hyun Kim
Summary: The study showed that human fecal Lactobacillus rhamnosus NK210 and Bifidobacterium longum NK219 have positive effects on immune homeostasis, particularly in controlling immune imbalance and gut dysbiosis.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Xiaozhen Gu, Nanxi Bi, Tian Wang, Chengqing Huang, Rongrong Wang, Yi Xu, Hui-Li Wang
Summary: Adolescent exposure to lead impairs spatial learning and memory abilities, decreases gut microbiota diversity, and reduces abundance of Lactobacillus. Administration of Lactobacillus rhamnosus GR-1 can reverse lead-induced cognitive deficits by restoring gut microbiota diversity.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Xin Zhong, Xueying Zhao, Liyuan Zhang, Ning Liu, Sa Shi, Yuwen Wang
Summary: This study found that the donor of hydrogen sulfide, sodium hydrosulfide, can inhibit endothelial cell injury and neutrophil activation in type 1 diabetes mellitus rats through the IL-8/CXCR2/ROS/NF-kappa B axis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kyle S. Draleau, Faycal Chettibi, Chafia Touil-Boukoffa, Djamel Djennaoui, Taha Merghoub, Mehdi Bourouba, Ahmed Amine Zergoun
Summary: In this study, the plasmatic secretomes of NPC untreated and relapsing patients were analyzed to identify novel prognostic biomarkers. The results showed upregulation of certain cytokines in untreated and relapsing patients. There were also correlations found between different cytokines in different patient groups. The study suggests that the High IL-8/Low NO signature may be a predictor of poor prognosis for NPC patients.
Article
Biotechnology & Applied Microbiology
Yuli Ge, Huiling Sun, Lanman Xu, Weiping Zhang, Jiaojian Lv, Yongping Chen
Summary: The study found that Lactobacillus rhamnosus Gorbach-Goldin (LGG) protects against chronic alcohol-induced intestinal and liver injury by regulating the intestinal IL-22 signaling pathway.
Article
Biochemistry & Molecular Biology
Jinzhao Xu, Mengqi Tang, Xinyu Wu, Xiangli Kong, Yini Liu, Xiaoxi Xu
Summary: Lactobacillus rhamnosus (L. rhamnosus) zz-1 has been found to prevent and alleviate depression caused by chronic stress by regulating the gut microbiota and improving intestinal environment. This study provides new evidence for the mental benefits of probiotics.
Article
Nutrition & Dietetics
Sandra T. Clarke, Julia M. Green-Johnson, Stephen P. J. Brooks, D. Dan Ramdath, Premysl Bercik, Christian Avila, G. Douglas Inglis, Judy Green, L. Jay Yanke, L. Brent Selinger, Martin Kalmokoff
BRITISH JOURNAL OF NUTRITION
(2016)
Article
Food Science & Technology
Padmaja Shastri, Justin L. McCarville, Stephen P. J. Brooks, Martin Kalmokoff, Julia M. Green-Johnson
JOURNAL OF FUNCTIONAL FOODS
(2016)
Article
Food Science & Technology
Qiuye Lin, Olivier Mathieu, Thomas A. Tompkins, Nicole D. Buckley, Julia M. Green-Johnson
JOURNAL OF FUNCTIONAL FOODS
(2016)
Article
Food Science & Technology
Padmaja Shastri, Judy Green, Fernando Matias, Martin L. Kalmokoff, Julia M. Green-Johnson, Stephen P. J. Brooks
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Agriculture, Dairy & Animal Science
C. Adams, F. Sawh, J. M. Green-Johnson, H. Jones Taggart, J. L. Strap
JOURNAL OF DAIRY SCIENCE
(2020)
Article
Immunology
Michael P. Jeffrey, Chad W. MacPherson, Olivier Mathieu, Thomas A. Tompkins, Julia M. Green-Johnson
JOURNAL OF IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
I. Patlan, M. P. Jeffrey, D. Lewis, J. Green-Johnson, S. Dogra
Summary: This study compared the effects of exercise in cold-dry and normal conditions on salivary cytokine levels and airway response in young healthy males. The results showed that IL-8 levels increased in normal conditions but not in cold-dry conditions, while the opposite trend was observed for IL-1RA.
Article
Allergy
Carley D. O'Neill, Ilana Patlan, Michael Jeffery, Danielle Lewis, Michael Jenkins, Holly Jones-Taggart, Julia Green-Johnson, Shilpa Dogra
Summary: The study found that a 6-week HIIT intervention led to increased maximal oxygen consumption and maximal ventilation in both asthma patients and non-asthma controls, with a significant decrease in salivary interferon-gamma-inducible-protein levels in asthma patients.
Article
Biochemistry & Molecular Biology
C. D. O'Neill, N. O'Rourke, M. Jeffrey, J. M. Green-Johnson, S. Dogra
Summary: The study aimed to compare the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on young, healthy adults. The results showed that MICT led to greater reductions in IL-8 compared to HIIT, while improvements in VO2max were similar in both groups.
Article
Microbiology
Michael P. P. Jeffrey, Chad W. W. MacPherson, Thomas A. A. Tompkins, Julia M. M. Green-Johnson
Summary: In this study, the ability of certain lactic acid bacteria to modulate inflammatory gene transcription and cytokine production in interactions between intestinal epithelial cells and antigen-presenting cells was investigated. The results demonstrated that the secretome of the bacteria could suppress pro-inflammatory responses and enhance the integrity of the epithelial barrier.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Physiology
Nicholas O'Rourke, Emmeline Meens-Miller, Michael Jeffrey, Lin Saleem, Julia Green-Johnson, Shilpa Dogra
Summary: Experimental studies have shown that prolonged sitting can cause changes in vascular and metabolic markers, while the response of pro-inflammatory cytokines is relatively unexplored. This study aimed to determine the response of IL-8 to prolonged and interrupted sitting. The results showed that prolonged sitting increased IL-8 concentrations, while interrupted sitting attenuated this response. Sex may moderate this relationship.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Food Science & Technology
Michael P. Jeffrey, Holly Jones Taggart, Janice L. Strap, Gibran Edun, Julia M. Green-Johnson
CURRENT RESEARCH IN FOOD SCIENCE
(2020)
Article
Rehabilitation
Shilpa Dogra, Mitchell Wolf, Michael P. Jeffrey, Ryan C. A. Foley, Heather Logan-Sprenger, Holly Jones-Taggart, Julia M. Green-Johnson
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2019)
Article
Nutrition & Dietetics
Sandra T. Clarke, Stephen P. J. Brooks, G. Douglas Inglis, L. Jay Yanke, Judy Green, Nicholas Petronella, D. Dan Ramdath, Premysl Bercik, Julia M. Green-Johnson, Martin Kalmokoff
BRITISH JOURNAL OF NUTRITION
(2017)