Journal
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
Volume 5, Issue 12, Pages 724-730Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.estlett.8b00563
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Funding
- National Natural Science Foundation of Jiangsu Province [BK20160175]
- National Natural Science Foundation of China Program [31871773, 31530056, 31820103010]
- National First Class Discipline Program of Food Science and Technology [JUFSTR20180102]
- Collaborative innovation center of food safety and quality control in Jiangsu Province
- BBSRC Newton Fund Joint Centre Award [BB/J004529/1]
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Variations in selenium (Se) intake have been reported to affect the barrier function and immune responses in the gut. Previous studies mainly focused on the role of Se itself or its metabolites, while the influences of the Se-intake-related microbiota on gut health were not thoroughly studied. This study compared the effects of different dietary Se supplementation (Se-deficient, Se-adequate, and Se-supranutritional) on the gut microbiota of mice. Fecal microbiota transplantation (FMT) was further conducted to bypass the effect of Se itself and provided direct evidence that the effects of dietary Se supplementation on the intestinal barrier and immune responses are associated with its modulation of the gut microbiota. Deficient Se supplementation can result in a phenotype of gut microbiota that is more susceptible to dextran sulfate sodium (DSS)-induced colitis and Salmonella typhimurium infection. Sufficient or supranutritional Se intake can optimize the gut microbiota for protection against these intestinal dysfunctions.
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