Article
Chemistry, Analytical
Anastasia Korpeti, Natalia Manousi, Abuzar Kabir, Kenneth G. Furton, Paraskevas D. Tzanavaras, Constantinos K. Zacharis
Summary: In this study, a simple and rapid method combining fabric phase sorptive extraction (FPSE) and high performance liquid chromatography-ultraviolet detection (HPLC-UV) was developed for monitoring salivary vitamin B12 levels. Sol-gel Carbowax 20M coated polyester membranes were chosen for the selective extraction of the target analyte. The method showed good precision with a relative standard deviation better than 8.2% and the sol-gel Carbowax 20M coated FPSE membranes were found to be reusable for up to 25 times.
Article
Medicine, General & Internal
Maria Aranzazu Martin Iglesias, Rosa Garcia Rodriguez, Alberto Palacios Canas, Jaime Vinicio Meneses Sotomayor, Miriam Clar Castello, Francisco Feo Brito
Summary: This study evaluated a new treatment option for LTP syndrome, which involved SLIT-peach followed by OIT with commercial peach juice. The results demonstrated that this protocol was safe and effective, improving the quality of life for patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Susan Sarhadi, Seyedeh Alia Moosavian, Mohammad Mashreghi, Niloufar Rahiman, Shiva Golmohamadzadeh, Mohsen Tafaghodi, Kayvan Sadri, Jamshidkhan Chamani, Mahmoud Reza Jaafari
Summary: This study prepared B12-targeted PEGylated liposomal insulin to improve the stability and absorption of orally administered insulin. The results showed that B12-targeted liposomes were more stable than non-functionalized liposomes in the gastrointestinal environment and exhibited enhanced cellular uptake and insulin accumulation. This suggests that B12-targeted liposomes could be an effective formulation for oral delivery of insulin.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Hematology
Betul Orhan Kilic, Serhat Kilic, Elif Sahin Eroglu, Eylem Gul, Fatma Burcu Belen Apak
Summary: Vitamin B12 deficiency can cause growth and developmental retardation in children, with oral, sublingual, and intramuscular treatments being effective. Sublingual methylcobalamin was found to be as effective as oral and intramuscular cyanocobalamin in improving vitamin B12 levels in children aged 0-3 years.
Article
Immunology
Tian-Ping Zhang, Rui Li, Li-Jun Wang, Fei Tang, Hong-Miao Li
Summary: In the Chinese Han population, there is no significant association between vitamin B12 level and single nucleotide polymorphisms (SNPs) in vitamin B12 metabolic genes with pulmonary tuberculosis (PTB). However, several SNPs in TCN2, CUBN, and MUT genes might be associated with multiple clinical manifestations in PTB.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Bishwajit Bhowmik, Tasnima Siddiquee, Ibrahimu Mdala, Liya Quamrun Nesa, Samsad Jahan Shelly, Zahid Hassan, Nayla Cristina do Moreira, Ishrat Jahan, A. K. Azad Khan, Graham A. Hitman, Akhtar Hussain
Summary: The study did not show the efficacy of vitamin D3 or B12 supplementation during pregnancy. Most pregnant women had normal levels of vitamin D and B12 at term, and there were no significant differences in pregnancy or birth outcomes among different supplementation groups.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Review
Nutrition & Dietetics
Yann Nguyen, Johanna Sigaux, Jean-Guillaume Letarouilly, Pauline Sanchez, Sebastien Czernichow, Rene-Marc Flipo, Martin Soubrier, Luca Semerano, Raphaele Seror, Jeremie Sellam, Claire Daien
Summary: Oral vitamin supplementation did not show significant reduction in RA activity, however, folic acid supplementation can prevent methotrexate-related side effects, and vitamin D can prevent musculo-skeletal complications in patients with vitamin D deficiency.
Article
Food Science & Technology
Sara Al-Musharaf, Ghadeer S. Aljuraiban, Lama Al-Ajllan, Noura Al-Khaldi, Esra'a A. Aljazairy, Syed Danish Hussain, Abdullah M. Alnaami, Shaun Sabico, Nasser Al-Daghri
Summary: This study found that the abundance and diversity of gut microbiota are associated with vitamin B12 levels and obesity in young females.
Article
Multidisciplinary Sciences
Imane Bahbouhi, Maryem Aboudourib, Ouafa Hocar, Said Amal
Summary: A 47-year-old north african male patient with pernicious anemia developed a vitamin B12-induced acneiform eruption after 6 weeks of intramuscular hydroxocobalamin treatment. The eruption was sudden, extensive, and monomorphic, affecting the face and trunk, with associated pruritus and comedones on the chest. Discontinuation of hydroxocobalamin and initiation of lymecycline resulted in complete resolution of the lesions within 3 months. The characteristics distinguishing acneiform eruptions from acne vulgaris include drug intake, uncommon age of onset, pruritus, monomorphic pattern, and involvement of extra-seborrheic areas.
Review
Chemistry, Applied
A. J. M. Santos, S. Khemiri, S. Simo, C. Prista, I. Sousa, A. Raymundo
Summary: Vitamins are essential organic compounds that are necessary for good health but cannot be synthesized by the human body. Vitamins B6 and B12 are hydrophilic vitamins that play vital roles in cellular operation, growth, and development. This review focuses on the important aspects of vitamins B6 and B12, including their roles, consequences of deficiency, food sources, and chromatographic techniques developed in the last two decades for their determination.
Article
Nutrition & Dietetics
Anna T. Reischl-Hajiabadi, Sven F. Garbade, Patrik Feyh, Karl Heinz Weiss, Ulrike Muetze, Stefan Koelker, Georg F. Hoffmann, Gwendolyn Gramer
Summary: This study assesses the characteristics of maternal vitamin B-12 deficiency detected by newborn screening, finding that the cause of deficiency is often unknown and there is low adherence to vitamin supplementation. Maternal vitamin B-12, folic acid, and homocysteine levels are significantly correlated with child's blood levels.
Article
Microbiology
E. E. Putnam, J. Abellon-Ruiz, B. J. Killinger, J. J. Rosnow, A. G. Wexler, E. Folta-Stogniew, A. T. Wright, B. van den Berg, A. L. Goodman
Summary: This study focuses on a new protein called BtuH in gut Bacteroidetes, which plays a key role in vitamin B-12 transport and competitive fitness in the gut. It suggests that accessory proteins encoded in Bacteroides cobamide transport system loci can have significant impacts on vitamin acquisition in the gut, demonstrating the complexity of the gut microbiome.
Review
Plant Sciences
Soojin Oh, Gareth Cave, Chungui Lu
Summary: Developing a resilient food supply is crucial in delivering necessary nutrients to consumers and addressing micronutrient deficiencies that can lead to severe health issues. Therefore, focus should be on enhancing minerals and nutrients in food through various methods to improve the sustainability of the food system.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J. J. Heyes, Muralidharan Shanmugam, Adam Brookfield, Linus O. O. Johannissen, Colin W. W. Levy, Laura N. N. Jeffreys, Shaowei Zhang, Michiyo Sakuma, Jacques-Philippe Colletier, Sam Hay, Giorgio Schiro, Martin Weik, Nigel S. S. Scrutton, David Leys
Summary: This study provides insights into the mechanism of CarH, a photoreceptor involved in transcriptional regulation. The authors show that the response of CarH to light integrates both B-12 photochemistry and redox changes to drive large-scale conformational changes.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Asako Ueno, Tadanori Hamano, Soichi Enomoto, Norimichi Shirafuji, Miwako Nagata, Hirohiko Kimura, Masamichi Ikawa, Osamu Yamamura, Daiki Yamanaka, Tatsuhiko Ito, Yohei Kimura, Masaru Kuriyama, Yasunari Nakamoto
Summary: Vitamin B-12 deficiency is associated with cognitive impairment, but the effectiveness of vitamin B-12 supplementation in recovering cognition remains controversial. A study found that vitamin B-12 supplementation improved short-term cognitive function and reduced homocysteine levels in patients with vitamin B-12 deficiency.
Article
Toxicology
Alex H. Wang, Daniel Gordon, Michael J. Drescher, Shachaf Shiber
Article
Rheumatology
Gil Amarilyo, Gabriel Chodick, Jonathan Zalcman, Gideon Koren, Yoel Levinsky, Ido Somekh, Liora Harel
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2019)
Meeting Abstract
Biophysics
Anatoli Y. Kabakov, Karni Moshal, YiChun Lu, Karim Roder, Turan Nilufer, Weiyan Li, Kevin Murphy, Dmitry Terentyev, Gideon Koren
BIOPHYSICAL JOURNAL
(2019)
Meeting Abstract
Biophysics
Brett Baggett, Kevin Murphy, Yueming Cao, Nilufer Turan, YiChun Lu, Lorraine Schofield, Tae Yun Kim, Dmitry Terentyev, Bum Rak Choi, John Sedivy, Gideon Koren
BIOPHYSICAL JOURNAL
(2019)
Article
Gastroenterology & Hepatology
Idan Goren, Revital Barkan, Irit A. Biron, Haim Leibovitzh, Maya A. Golan, Hagar B. Eran, Yifat Snir, Yelena Broitman, Tom Konikoff, Hadar Amir-Barak, Hadar Yafee, Edna Adani, Shachaf Shiber, Hadas Steiner, Michael J. Drescher, Iris Dotan, Henit Yanai
Summary: The study aimed to evaluate the impact of proactive specialized inflammatory bowel diseases (IBD) emergency department (ED) consultation and multidisciplinary IBD team (IBD-MDT) intervention on IBD-related patient outcomes after discharge. The results demonstrated that this intervention significantly reduced the rate of ED revisits for at least 6 months after hospital discharge.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Infectious Diseases
Adi Turjeman, Muhammad Awwad, Shachaf Shiber, Tanya Babich, Noa Eliakim-Raz, Angela Huttner, Stephan Harbarth, Leonard Leibovici, Dafna Yahav
Summary: This study aimed to assess the external validity of a randomized controlled trial on treatment for uncomplicated urinary tract infection. The results showed that excluded patients were more likely to require hospitalization after initial visits and had higher rates of clinical and microbiological failures compared to included participants.
INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Shachaf Shiber, Vitaly Kliminski, Katia Orvin, Iftach Sagy, Mordehay Vaturi, Ran Kornowski, Michael Drescher, Yair Molad
Summary: The study demonstrates that plasma sTREM-1 levels are significantly elevated in patients with acute coronary syndrome (ACS), serving as a potential biomarker to differentiate ACS from nonspecific chest pain (NSCP) and predict severity and outcome of ACS.
MEDIATORS OF INFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Romain Martischang, Maciek Godycki-Cwirko, Anna Kowalczyk, Katarzyna Kosiek, Adi Turjeman, Tanya Babich, Shachaf Shiber, Leonard Leibovici, Elodie von Dach, Stephan Harbarth, Angela Huttner
Summary: In women with lower UTI, age 52 and above, fosfomycin use, and UTI caused by Escherichia coli are associated with clinical and microbiological treatment failure, while diabetes and other comorbidities are not independent risk factors.
Letter
Immunology
Amir Sharabi, Shachaf Shiber, Yair Molad
CLINICAL IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Aviv Gelber, Michael Drescher, Shachaf Shiber
Summary: The study found that male patients were more likely to be admitted by physicians based on the HEART Pathway predictions. This suggests that women may be disproportionately excluded, leading to a potential risk of serious coronary artery disease being overlooked even in those who seek timely medical assistance.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Emergency Medicine
Safwat Saleem, Roman Sonkin, Iftach Sagy, Refael Strugo, Eli Jaffe, Michael Drescher, Shachaf Shiber
Summary: This study compared the effects of mechanical and manual out-of-hospital chest compressions of similar duration on the rate of return of spontaneous circulation (ROSC). The study found that the use of LUCAS did not provide additional benefits in terms of ROSC rate and did not increase the risk of traumatic injury. ACD devices may be more useful in cases of delayed ambulance response times or events in remote locations.
OPEN ACCESS EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Iftach Sagy, Alona Finkel-Oron, Eviatar Naamany, Leonid Barski, Mahmoud Abu-Shakra, Yair Molad, Shachaf Shiber
Summary: Diagnosing adult-onset Still disease (AOSD) is challenging due to its ambiguous clinical presentation and lack of specific serological markers. This study aimed to evaluate the diagnostic utility of clinical, laboratory, and serum ferritin features in established AOSD patients. The results showed that joint involvement had the highest diagnostic utility, while serum ferritin showed variation and poorer results depending on the chosen cutoff. Clinicians should rely on thorough clinical evaluation rather than solely elevated ferritin levels for the diagnosis of AOSD.
Meeting Abstract
Infectious Diseases
Jeroen Stas, Cesar A. Arias, Richard Bachur, Susanna Esposito, Salim Halabi, Sheldon K. Kaplan, Adi Klein, Sergey M. Motov, Richard Rothman, Leticia M. Ryan, Shachaf Shiber, Tobias Tenenbaum, Alexandra Weissman
JAC-ANTIMICROBIAL RESISTANCE
(2022)
Article
Critical Care Medicine
Eviatar Naamany, Shachaf Shiber, Hadar Duskin-Bitan, Dafna Yahav, Jihad Bishara, Iftach Sagy, Nadav Granat, Michael Drescher
Summary: The study compared the clinical, radiological, and pathological differences between polymicrobial and monomicrobial NSTI, finding that polymicrobial NSTI had a better prognosis with shorter ICU stay, lower mortality, and less use of vasopressors.
TRAUMA SURGERY & ACUTE CARE OPEN
(2021)
Article
Medicine, General & Internal
Yonatan Edel, Iftach Sagy, Elisheva Pokroy-Shapira, Shirty Oren, Arleta Dortort Lazar, Mohammad Egbarial, Shachaf Shiber', Bat Sheva Tal, Yair Molad
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2020)
