Article
Engineering, Chemical
Chengcheng Wang, Hao Sun, Naixin Wang, Quan-Fu An
Summary: In this study, ZIF-8 nanoparticles were assembled in situ in the pores of a porous alumina substrate using a freezing-assisted counter-diffusion method. The obtained nano-confined composite membrane showed good antibiotic desalination performance, with a rejection rate of tetracycline above 99% and a rejection rate of sodium chloride below 20%. The ZIF-8 membrane exhibited a permeance of 23.5 LMH/bar, and its sulfurization improved stability and increased permeance to 31.3 LMH/bar for 100 hours.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Chen Hang, Zhou Wei, Xiang Jieyu, Li Man, Yiru Ye, Zhou Ling, Wang Min, Chen Danyang, Guo Liang
Summary: To overcome the limitations of conventional medical materials, a composite of polycaprolactone (PCL) and curcumin-incorporated zeolitic imidazolate framework-8 (PCL/ZIF-8/CUR) was prepared. PCL/ZIF-8/CUR showed excellent biocompatibility, permeability, thermal stability, hydrophilicity, and antibacterial activity, with a H2O2-scavenging efficiency of 95.01 ± 0.15%. Moreover, ZIF-8/CUR exhibited pH-responsive controlled release of Zn2+ in an acidic environment. In vitro and in vivo studies and immunohistochemical staining demonstrated that PCL/ZIF-8/CUR promotes wound healing by regulating angiogenesis and inflammation. The PCL/ZIF-8/CUR nanofiber membrane has the potential to replace conventional wound dressings in future clinical applications.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Applied
Vahid Zeyni, Soheyla Karimi, Hassan Namazi
Summary: In this study, a zinc-based metal-organic framework/magnetic hydroxyapatite nanocomposite was synthesized and coated with a biocompatible layer of polyethylene glycol as a targeting drug delivery system. The nanocomposites were characterized and utilized as carriers to encapsulate the anticancer drug doxorubicin. Both nanocomposites showed pH-dependent drug release and the Korsmeyer-Peppas model was the best fit to describe the release mechanism. The synthesized systems showed no significant toxicity and exhibited higher toxicity against lung cancer cell lines. Additionally, the nanocomposites demonstrated excellent antioxidant activity. These findings suggest that the prepared drug systems have potential for targeted drug delivery applications.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Physical
Jia Wen, Xiaohong Hu
Summary: This paper focused on the influence of co-existing ions on the adsorption performance of epigallo-catechin gallate (EGCG) modified ZIF-8 in a multi-metal system. It was found that Cu(II) exhibited the highest adsorption capacity and interfered with the adsorption of other metals. Natural anions significantly impeded Cr(VI) adsorption, while natural cations facilitated the adsorption of Cd(II), Cu(II) and Ni(II).
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Jinguo Qiu, Mhd Anas Tomeh, Yi Jin, Bo Zhang, Xiubo Zhao
Summary: This study presented a high-performance microfluidic device to fabricate ACP loaded nanoparticles (NPs) with controllable properties. The encapsulated ACP showed reduced toxicity, controlled release, and increased cell uptake, leading to enhanced anticancer effects. The development of At3 loaded NPs provides a promising approach for ACP-based cancer therapy.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Environmental Sciences
Song Ma, Yanzheng Ji, Yongjie Dong, Siqi Chen, Yingjie Wang, Shaoyu Lu
Summary: An environmentally friendly synthesis strategy has been developed in this study to integrate pesticide and fertilizer into a combination system, which enhances the stability of pesticide and efficiency of nutrient supply, leading to positive effects on plant protection and nutrition supply.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Physical
Maryam Sadeghpour, Maryam Homayoonfal, Fatemeh Davar
Summary: In this research, pH sensitive bilayer membranes were used for separating a pH-sensitive drug. The presence of specific components in the membrane layers led to improved porosity, roughness reduction, and enhanced separation performance. The synergistic effect of pH-sensitive agents in both layers of the membrane resulted in significant enhancements in flux, separation, and flux recovery compared to membranes with only one pH-sensitive layer.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Nanoscience & Nanotechnology
Yingjian Ma, Rui Zhao, Hongyi Shang, Shuo Zhen, Linjie Li, Xinyu Guo, Meng Yu, Yong Xu, Jianguo Feng, Xuemin Wu
Summary: This study successfully prepared a pH-responsive delivery nanoparticle to control termites. The nanoparticle has precise controlled release modes, improving pesticide targeting and reducing toxic side effects. It showed longer duration of termite control compared to commercial pesticides and lower acute toxicity to earthworms, zebrafish, and human hepatocyte cells.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Nahar Jannatun, Yuqian Zhang, Ben Wu, Qingle Song, Guoli Cao, Wenhe Luo, Feng Yuan, Qi Li, Yanqiao Zeng, Guofang Zhang, Guocheng Wang, Yang Li
Summary: In this study, a nanomedicine based on EGCG was developed for efficient tumor-targeting EGCG delivery. The results showed that the EZP nanoparticles were capable of inhibiting the expression of ICP molecules and modulating the inflammatory tumor microenvironment, leading to an inspiring antitumor effect.
ACS APPLIED NANO MATERIALS
(2023)
Article
Engineering, Environmental
Xiaolin Zhang, Xiangang Hu, Hao Wu, Li Mu
Summary: This study reveals the significant impacts of ZIFs on algae, showing that the effects are reversible. Different types of ZIFs (such as ZIF-8 and ZIF-67) induce toxicity effects and are internalized differently, while factors related to oxidative phosphorylation are crucial for the persistence of plant toxicity.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Mingzhu Wu, Xuedan Chen, Juan Du, Jiankang Ye, Ang Ye, Conghui Zhou, Qingshan Fu
Summary: Metal-organic framework materials (MOFs) have been widely used for adsorptive removal of dyes from water, but their stability often limits their applications in harsh environments. Here, we synthesized and carbonized zeolitic imidazolate framework-8 (ZIF-8) particles to create carbonaceous particles with different sizes. The derived carbon particles showed shrinkage compared to their parental MOFs, and the smallest MOF particles exhibited the highest shrinkage (43%). The ZIF-8-derived carbon particles with the largest size had the largest specific surface area (1144 m^2 g^(-1)) and the best adsorption capacity (1461.988 mg g^(-1)) for methylene blue (MB) from aqueous solution.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chanjong Yu, Young Jae Kim, Jongbum Kim, Kiwon Eum
Summary: The control of structure, shape, and components in metal-organic frameworks is crucial in electrochemical applications. This study successfully controlled the morphology of ZIF-8 through systematic controls of synthesis variables and achieved modulation of adsorption and pore characteristics through partial substitution insertion of a new organic precursor.
Article
Electrochemistry
Bo Huang, Wen Zeng, Yanqiong Li
Summary: This study presents an effective strategy for the development of high-response volatile organic compounds (VOC) sensors by coating nano-metal oxides with metal-organic frameworks (MOF). The composite material, consisting of ZnO and ZIF-8, is able to form numerous pores and interface defects, enhancing the gas detection performance. The composite sensor exhibits optimal operating temperature at 350 degrees C and shows more than tripled response to 50 ppm gases compared to the ZnO sensor.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Biology
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Aisha A. Alsfouk, Bshra A. Alsfouk, Dalal Z. Husein, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Ahmed M. Metwaly
Summary: A new lead compound, T-1-PCPA, was designed as an antiangiogenic EGFR inhibitor that can bind with the catalytic pocket of EGFR protein. Through computational studies and experimental validation, it was confirmed that T-1-PCPA has a high level of reactivity and inhibitory effect on EGFR. T-1-PCPA showed potent inhibition against EGFR(WT) and malignant cell lines A549 and HCT-116, with comparable or better efficacy than erlotinib.
Article
Engineering, Biomedical
Yangge Du, Tian Deng, Yihong Cheng, Qin Zhao, Haibin Xia, Yaoting Ji, Yufeng Zhang, Qing He
Summary: In this study, a novel nanoparticle platform CDC20@ZIF-8@eM-Apt is introduced, which can enhance osteogenic differentiation of bone marrow mesenchymal stem cells and promote bone regeneration. This nanoparticle possesses biocompatibility, loading capacity, targeted delivery, and osteogenesis promotion, providing a new therapeutic strategy for bone defects and related diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xuerui Chen, Li Zhang, Shiping Ding, Qunfang Lei, Wenjun Fang
Article
Nanoscience & Nanotechnology
Xuerui Chen, Rongliang Tong, Zheqi Shi, Beng Yang, Hua Liu, Shiping Ding, Xu Wang, Qunfang Lei, Jian Wu, Wenjun Fang
ACS APPLIED MATERIALS & INTERFACES
(2018)
Article
Oncology
Yu Chen, Haifeng Zhuang, Xuerui Chen, Zheqi Shi, Xu Wang
Article
Chemistry, Multidisciplinary
Li Zhang, Xuerui Chen, Jianzhou Wu, Shiping Ding, Xu Wang, Qunfang Lei, Wenjun Fang
Article
Materials Science, Biomaterials
Zheqi Shi, Xuerui Chen, Li Zhang, Shiping Ding, Xu Wang, Qunfang Lei, Wenjun Fang
BIOMATERIALS SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Xuerui Chen, Bingbing Liu, Rongliang Tong, Shiping Ding, Jian Wu, Qunfang Lei, Wenjun Fang
Summary: EGCG palmitate exhibits better chemical stability compared to EGCG, showing strong cytotoxic effects on cancer cells and relatively lower impact on normal cells. This suggests that EGCG palmitate may have the potential to serve as a promising prodrug in anticancer treatment.
Article
Chemistry, Multidisciplinary
Xuerui Chen, Xuelian Yin, Lin Zhan, Junfeng Zhang, Yuxi Zhang, Yinghua Wu, Jiale Ju, Yajie Li, Qianghua Xue, Xu Wang, Chenchen Li, Rui L. Reis, Yanli Wang
Summary: Direct delivery to an organelle-specific point can significantly enhance therapy efficacy. A designed mitochondrial anchored biomimetic nanoplatform, CZACN, is able to reverse tumor hypoxia microenvironment by releasing therapeutic payloads in ATP-overexpressed mitochondria. Combining chemotherapy and photothermal therapy, CZACNs achieved effective tumor growth inhibition under NIR treatment by targeting cancer cells and providing in situ oxygen self-sufficiency.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Junfeng Zhang, Chenchen Li, Qianghua Xue, Xuelian Yin, Yajie Li, Wen He, Xuerui Chen, Jian Zhang, Rui L. Reis, Yanli Wang
Summary: The study developed a new nanodrug delivery system using carbon-based nanomaterials as a carrier for doxorubicin, effectively increasing the accumulation of DOX in tumor cell nuclei and tissues, leading to tumor growth inhibition.
Review
Medicine, Research & Experimental
Xuerui Chen, Liyun Zhu, Xu Wang, Junjie Xiao
Summary: This article introduces the application of hydrogels in cardiac repair following myocardial infarction (MI). Hydrogels with heart-specific mimicry and extracellular matrix (ECM)-like functionality can mechanically constrain the infarct and act as localized transport of bioactive ingredients to refresh the dysfunctional heart. The article also summarizes the advantages of heart-tailored architectures of hydrogels in cardiac repair and proposes challenges and prospects in the clinical translation of hydrogels for cardiac repair and regeneration after MI.
MOLECULAR PHARMACEUTICS
(2023)
Article
Materials Science, Multidisciplinary
Xuelian Yin, Lin Zhan, Lin Ding, Xuerui Chen, Junfeng Zhang, Chenchen Li, Yuxi Zhang, Murad Khan, Rui L. Reis, Yanli Wang
Summary: We report a facile synthesis method for mitochondria-specific anchored nano-complexes (AG-C-NP) comprised of a skeleton of gold and carbon atoms for cancer therapy. Compared to gold nanoclusters (Au NCs), AG-C-NP showed enhanced fluorescence imaging effects, which can be used for tumor monitoring. AG-C-NP targeted the mitochondria and increased ROS damage in cancer cells, leading to a significant inhibition of tumor growth.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Biomaterials
Lin Zhan, Xuelian Yin, Yuxi Zhang, Jiale Ju, Yinghua Wu, Lin Ding, Chenchen Li, Xuerui Chen, Yanlin Wang
Summary: Cutting off glucose provision by glucose oxidase (GOx) can assist chemotherapy in eliminating cancer cells. Co-encapsulating GOx and chemotherapeutics within pH-sensitive metal-organic frameworks (MOFs) disrupts cancer cells' metabolic pathways and generates excessive intracellular reactive oxygen species (ROS). With the addition of polydopamine (PDA) to prevent premature leaching of GOx, the delivery system gains photothermal conversion ability. The nanoscaled co-delivery system (DGZPNs) remains stable under simulated physiological conditions and releases the drugs in the tumor microenvironment for reinforced chemotherapy with the help of NIR laser irradiation.
BIOMATERIALS ADVANCES
(2023)
Review
Nanoscience & Nanotechnology
Liyun Zhu, Danni Meng, Xu Wang, Xuerui Chen
Summary: This article introduces ferroptosis, a non-apoptotic programmed cell death highly relevant to tumor development, and focuses on the emerging trends and challenges of ferroptosis-driven nanotherapeutics in reversing drug resistance in cancer treatment.
ACS APPLIED BIO MATERIALS
(2022)
Review
Materials Science, Biomaterials
Xuerui Chen, Bingbing Liu, Rongliang Tong, Lin Zhan, Xuelian Yin, Xin Luo, Yanan Huang, Junfeng Zhang, Wen He, Yanli Wang
Summary: Personalized cancer therapy is becoming increasingly important, and the use of cell membrane-coated nanoparticles allows for individualized treatment, improving the efficacy of anticancer therapy.
BIOMATERIALS SCIENCE
(2021)
Article
Materials Science, Biomaterials
Xuerui Chen, Rongliang Tong, Bingbing Liu, Hua Liu, Xiaode Feng, Shiping Ding, Qunfang Lei, Guping Tang, Jian Wu, Wenjun Fang
BIOMATERIALS SCIENCE
(2020)
