Article
Medicine, General & Internal
Wei-Yu Lai, Pei-Chin Lin, Chun-Hao Yin, Kuang-Tsu Yang, En-Jie Shih, Jin-Shuen Chen
Summary: This study investigated the relationship between hematocrit (Hct) levels and retinal artery occlusion (RAO). The results showed that Hct levels ≥40% were associated with the occurrence of RAO. In male patients, there was a trend of a non-linear dose-response association between Hct levels and ischemic vascular events. Hct levels ≥40% in patients older than 65 years with at least six comorbidities could be associated with RAO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Andrea Dsouza, Saylee Jangam, Shruti Soni, Priyanka Agarwal, Vishwanath Naik, J. Manjula, Chandrasekhar B. Nair, Bhushan J. Toley
Summary: Technologies for preservation of specimens in the absence of cold chains are essential for optimal utilization of existing laboratory services in developing countries. The prototype, SPECTRA-tube, enables the collection, drying, transportation, and recovery of large-volume specimens. Compared to existing dry storage technologies, SPECTRA-tube increases the volume of liquid specimens that can be transported in the dry state and allows for the recovery of the entire sample in the liquid state, making it compatible with conventional downstream analysis methods.
Article
Clinical Neurology
Eldar Hochman, Becca Feldman, Abraham Weizman, Amir Krivoy, Shay Gur, Eran Barzilay, Hagit Gabay, Ohad Levinkron-Fisch, Gabriella Lawrence
Summary: This study aimed to investigate the association between gestational hemodilution, represented by decreased hematocrit levels, and the risk of postpartum depression (PPD). The results showed that higher levels of gestational hemodilution were associated with a higher risk of PPD. This finding suggests that monitoring gestational hematocrit levels could be a biomarker for PPD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Chemistry, Analytical
Sangji Woo, Nordiana Rosli, Seohyun Choi, Ha-Jeong Kwon, Young Ahn Yoon, Sunhyun Ahn, Ji Youn Lee, Seon-Pyo Hong, Ji-Seon Jeong
Summary: This study developed dried blood spot (DBS) CRMs for amino acid analysis using isotope-dilution liquid chromatography-mass spectrometry (ID-MS), ensuring measurement traceability to the International System of Units (SI). The certified values are traceable to SI through both gravimetric preparation and the primary method in certification, ID-MS.
ANALYTICAL CHEMISTRY
(2022)
Article
Neurosciences
Vivek Bhat, G. S. Thanmayi, Sanjukta S. Rao, G. R. K. Sarma, Sai Kanth Deepalam
Summary: This study analyzed the clinical and radiological characteristics of CVD in 56 patients with polycythemia, finding that ischemic stroke was common and the incidence of CVD was higher in primary polycythemia patients. Neuroimaging revealed multiple large vessel intracranial stenoses and hyperdense vessels, with other neurological manifestations such as headache, seizures, and dizziness reported.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Clinical Neurology
Joao Pedro Marto, Alexander Salerno, Errikos Maslias, Dimitris Lambrou, Ashraf Eskandari, Davide Strambo, Patrik Michel
Summary: The study assessed the management of in-stroke-unit ischemic stroke (ISUS) and found that patients with ISUS had more known stroke onset time, fewer missed treatment opportunities, higher endovascular treatment rates, and better long-term outcomes compared to other strokes occurring in the stroke unit.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Amir Horev, Anat Horev, Adi Gordon-Irshai, Michal Gordon, Nicolas Andre, Gal Ifergane
Summary: Herpes zoster (HZ) is a serious health problem due to its prevalence and complications, including stroke and acute myocardial infarction. A retrospective cohort study was conducted to analyze the association between HZ and Major Adverse Cardiac and Cerebrovascular Events (MACCE). The study found that HZ patients had a 19% higher risk of MACCE in the first year of follow-up and antiviral treatment did not improve long-term survival. Further studies are needed to evaluate the risk of HZ and the impact of HZ vaccination on this risk.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Merelijne A. Verschoof, Laura C. C. van Meenen, M. Valerie E. Andriessen, Danielle M. C. Brinkman, Sylvia Kamphuis, Taco W. Kuijpers, Helen L. Leavis, G. Elizabeth Legger, Catharina M. Mulders-Manders, Anne P. J. de Pagter, Abraham Rutgers, Gijs T. J. van Well, Jonathan M. Coutinho, A. Elisabeth Hak, Joris M. van Montfrans, Femke C. C. Klouwer
Summary: In this cohort study, the frequency and recurrence rates of neurological manifestations in patients with adenosine deaminase 2 (ADA2) deficiency before and after initiation of tumor necrosis factor a (TNF-a) inhibiting therapy were analyzed. The results showed that neurological manifestations, especially transient ischaemic attack/ischaemic stroke, are common and often the presenting symptom in patients with ADA2 deficiency, highlighting the importance of awareness among neurologists and pediatricians.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Milou Cecilia Madsen, Dennis van Dijk, Chantal Maria Wiepjes, Elfi Barbara Conemans, Abel Thijs, Martin den Heijer
Summary: This study found a high prevalence of erythrocytosis in trans men using testosterone therapy, with factors such as smoking, injection method, age, body mass index (BMI), and pulmonary conditions being associated with increased risk. Recommendations for care include advising smoking cessation, switching to transdermal administration, and weight loss for those with high BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Neurosciences
Durgesh Chaudhary, Isabel Friedenberg, Vishakha Sharma, Pragyan Sharma, Vida Abedi, Ramin Zand, Jiang Li
Summary: This study aimed to investigate the incidence of depression in stroke patients and factors associated with post-stroke depression. Findings showed that women, patients with a history of prior stroke or myocardial infarction, and those with Medicaid insurance were more likely to develop post-stroke depression.
Article
Cardiac & Cardiovascular Systems
Casey Crump, Jan Sundquist, Kristina Sundquist
Summary: This study found that preterm delivery is associated with an increased risk of stroke, which remains elevated for at least 40 years after delivery and is independent of other factors and familial influences.
Article
Medicine, General & Internal
Lijuan Wang, Jiaojiao Ge, Ying Chen, Ying Liu, Cong Li, Yanan Dong, Li Liu, Yingqi Xing
Summary: The study identified predictors of unfavorable outcomes and stroke recurrence in young Chinese patients with ischemic stroke, with high NIHSS score and severe vascular stenosis as independent predictors of poor prognosis, and age and atrial fibrillation as predictors of recurrence.
Article
Medicine, General & Internal
Li Zhang, Zi-Hao Zhang, Qing-Rui Wang, Ying-Ju Su, Ying-Yi Lu, Cong-Liang Zhang, Hung-Pei Tsai, Chieh-Hsin Wu
Summary: This study aimed to estimate osteoporosis risk in Taiwan patients who had a stroke. The results showed that the risk of osteoporosis was 1.82-fold higher in patients with a history of stroke compared to those without. The impact of stroke on osteoporosis risk was more significant in males and younger age groups. Addressing stroke-targeted treatment modalities may help minimize adverse outcomes of osteoporosis.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Peripheral Vascular Disease
Lan Huang, Cui Song, Qin Liu, Xiaoyue Liang, Yanling Ren, Daochao Huang, Xianmin Guan, Xizhou An, Xiaohua Liang
Summary: Uncontrolled pediatric hypertension may increase the risk of hypertension in adulthood. This study found that hematological parameters are associated with blood pressure levels in children and adolescents. Participants with elevated blood pressure had higher red blood cell counts, hemoglobin counts, and hematocrit levels compared to those with normal blood pressure. The study also showed that increasing levels of hematological parameters were linked to significantly increased systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Furthermore, there was an increased risk of prehypertension and hypertension with higher levels of red blood cell counts, hemoglobin counts, hematocrit levels, and iron.
HYPERTENSION RESEARCH
(2023)
Article
Nutrition & Dietetics
Jingyun Tang, Jia-Yi Dong, Ehab S. Eshak, Renzhe Cui, Kokoro Shirai, Keyang Liu, Ryoto Sakaniwa, Akiko Tamakoshi, Hiroyasu Iso
Summary: The research found that having an irregular supper timing is associated with an increased risk of hemorrhagic stroke mortality, while there is no significant association with mortality risk from other types of stroke, coronary heart disease, and cardiovascular disease.
Article
Clinical Neurology
Runting Li, Fa Lin, Yu Chen, Junlin Lu, Heze Han, Li Ma, Yahui Zhao, Debin Yan, Ruinan Li, Jun Yang, Shihao He, Zhipeng Li, Haibin Zhang, Kexin Yuan, Ke Wang, Qiang Hao, Xun Ye, Hao Wang, Hongliang Li, Linlin Zhang, Guangzhi Shi, Jianxin Zhou, Yang Zhao, Yukun Zhang, Youxiang Li, Shuo Wang, Xiaolin Chen, Yuanli Zhao
Summary: This study aimed to establish a scoring model based on early brain injury indicators to predict the functional outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) at 90 days. The model, named TAPS, showed good discrimination and calibration in both the derivation and validation cohorts, and proved to be an easy handle tool for clinicians to predict the 90-day outcomes and identify patients at risk for poor prognosis.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Endocrinology & Metabolism
Siqi Jin, Qingli Zhu, Li Huo, Ou Wang, Xiaoping Xing, Quan Liao, Li Ma, Jianchu Li, Yuxin Jiang, He Liu
Summary: The study aimed to evaluate the value of second-look ultrasound (US) for preoperative localization in patients with primary hyperparathyroidism with negative or discordant imaging results. The sensitivity, positive predictive value, and accuracy of second-look US were found to be 92.1%, 95.1%, and 88.1%, respectively. Overall, second-look US is a promising method for preoperative localization, especially for patients with negative or discordant imaging findings.
ENDOCRINE PRACTICE
(2023)
Article
Oncology
Xiaobo Zhang, Xiao Zhang, Xiaoyi Ding, Zhongmin Wang, Yong Fan, Guang Chen, Xiaokun Hu, Jiasheng Zheng, Zhixiao Xue, Xiaofeng He, Xin Zhang, Yingtian Wei, Zhongliang Zhang, Jing Li, Jie Li, Jie Yang, Xiaodong Xue, Li Ma, Yueyong Xiao
Summary: This study demonstrated that the safety and efficacy of IRE in the treatment of solid liver tumors is non-inferior to a regular radiofrequency device.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jin-Lei Wang, Yu-Jie Ma, Li Ma, Na Ma, Diao-Mei Guo, Lian-Sheng Ma
Summary: Baishideng Publishing Group's Reference Citation Analysis (RCA) editorial team has released the 2022 Article Influence Index (2022 AII) of 632 scholars, following three rounds of rigorous evaluation. Gastroenterology & Hepatology is the research category with the highest number of RCA scholars.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Orthopedics
Jin-Lei Wang, Yu-Jie Ma, Li Ma, Na Ma, Diao-Mei Guo, Lian-Sheng Ma
Summary: Baishideng's RCA database has released the 2022 Journal Article Influence Index (2022 JAII) and a list of high-quality academic journals in orthopedics. This article introduces 21 high-quality academic journals and describes the evaluation process and inclusion principles. The RCA core journal list is valuable for authors, readers, and editors.
WORLD JOURNAL OF ORTHOPEDICS
(2022)
Editorial Material
Clinical Neurology
Zongze Li, Li Ma, Yuanli Zhao, Chunde Li
Article
Oncology
Hui Zhang, Yi Hu, Yan Wang, Xia Song, Ying Hu, Li Ma, Xinjie Yang, Kun Li, Na Qin, Jinghui Wang, Jialin Lv, Xi Li, Xinyong Zhang, Quan Zhang, Yuhua Wu, Guangyin Yao, Shucai Zhang
Summary: This study assessed the performances of droplet digital polymerase chain reaction (ddPCR) and next-generation sequencing (NGS) in detecting EGFR T790M mutation in the plasma samples of NSCLC patients. The results showed that ddPCR had a high sensitivity and specificity in detecting EGFR T790M mutation. Furthermore, a higher EGFR T790M abundance was associated with a better response to third-generation EGFR-TKIs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Analytical
Zhengyin Yan, Li Ma, Julie Huang, Pasquale Carione, Jane R. Kenny, Cornelis E. C. A. Hop, Matthew Wright
Summary: Determination of drug binding kinetics in plasma is challenging, and this study introduces a new parameter called dynamic free fraction to describe drug-protein binding kinetics. The dynamic free fraction can be determined by coupling the drug binding assay with a reporter enzyme and high-resolution mass spectrometry. This methodology bypasses the challenges in existing methods and allows assessment of the impact of protein binding kinetics on drug properties.
ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Li Ma, Juan Ma, Xin Sun, Honggang Liu
Summary: T cells play a crucial role in the cell-mediated antitumour response. Bispecific antibodies (Bi-Abs) have shown promise in recruiting T cells for killing tumours. This study demonstrates the expression of CD155 in a wide range of human haematologic tumours and highlights the effectiveness of the bispecific antibody anti-CD3 x anti-CD155 in activating T cells to target malignant haematologic cells. The results show that CD155Bi-Ab-armed T cells exhibit enhanced cytotoxicity and increased secretion of cell-killing mediators and T-cell-derived cytokines, indicating that CD155 could be a novel target for immunotherapy against haematologic malignancies.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Surgery
Yu Chen, Heze Han, Hengwei Jin, Xiangyu Meng, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan, Haibin Zhang, Kexin Yuan, Ke Wang, Yang Zhao, Yukun Zhang, Weitao Jin, Runting Li, Fa Lin, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Dezhi Gao, Jun Pu, Zhiyong Shi, Xiaofeng Chao, Zhengfeng Lin, Junlin Lu, Jiangan Li, Shibin Sun, Ali Liu, Xiaolin Chen, Youxiang Li, Yuanli Zhao, Shuo Wang
Summary: This study compared the long-term outcome of hemorrhagic stroke or death in patients with conservative management or stand-alone embolization for AVM. The results showed that embolization did not prevent long-term hemorrhagic stroke or death compared with conservative management in the overall cohort, as well as in the unruptured and ruptured AVM subgroups. Stratified analysis suggested that target embolization might be beneficial for unruptured AVMs, while curative embolization improved the outcomes of ruptured AVMs. The long-term neurological status was similar between the two strategies.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Xiaoyong Xiang, Peng Chen, Fengming Lan, Li Ma, Jing Jin, Ye Zhang
Summary: This study retrospectively analyzed the clinical data of 206 patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC). The findings showed that adding PD-1 inhibitor to induction chemotherapy significantly improved short-term efficacy without intolerable adverse effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yu Chen, Heze Han, Xiangyu Meng, Hengwei Jin, Dezhi Gao, Li Ma, Ruinan Li, Zhipeng Li, Debin Yan, Haibin Zhang, Kexin Yuan, Ke Wang, Yukun Zhang, Yang Zhao, Weitao Jin, Runting Li, Fa Lin, Xiaofeng Chao, Zhengfeng Lin, Qiang Hao, Hao Wang, Xun Ye, Shuai Kang, Youxiang Li, Shibin Sun, Ali Liu, Shuo Wang, Yuanli Zhao, Xiaolin Chen
Summary: In this study, a scoring system was developed and validated to predict the rupture risk of AVMs, performing well in different cohorts. Patients can be stratified based on the scoring system to avoid unnecessary interventions according to their rupture risk.
Article
Chemistry, Analytical
Qin Sun, Li Ma, Fernando Ferreira, Chelsea Brown, Brian Reid, Min Zhao
Summary: The uptake of oxygen by cells and tissues is an important indicator of metabolic demand, microenvironment changes, and pathophysiology. Using a non-invasive optical fiber oxygen sensor, researchers have revealed a spatiotemporal profile of oxygen uptake at the ocular surface of rodents and non-human primates. The results showed a distinct oxygen uptake gradient in mice, with a higher influx at the limbus and conjunctiva regions compared to the center of the cornea. The findings provide valuable insights for comparative studies and understanding the response of the cornea and other tissues to various insults or environmental changes.
Article
Clinical Neurology
Yu Chen, Pingting Chen, Ruinan Li, Heze Han, Zhipeng Li, Li Ma, Debin Yan, Haibin Zhang, Fa Lin, Runting Li, Xiangyu Meng, Hengwei Jin, Youxiang Li, Xun Ye, Shuai Kang, Hao Wang, Xiaolin Chen, Yuanli Zhao
Summary: In this study, quantitative digital subtraction angiography (QDSA) was used to explore the hemorrhagic quantitative hemodynamic indicators of brain arteriovenous malformation (AVM) nidus. The results showed that a higher stasis index and slower transnidal relative velocity (TRV) were significantly correlated with AVM rupture and could be used as effective indicators to predict future hemorrhage risk.
JOURNAL OF NEUROSURGERY
(2023)
Article
Health Care Sciences & Services
Luying Gao, Jianchu Li, Yang Gu, Li Ma, Wen Xu, Xixi Tao, Ruojiao Wang, Rui Zhang, Yixuan Zhang, Hongyan Wang, Yuxin Jiang
Summary: With the growing demand for breast screening, ultrasound departments in China are facing tremendous challenges. The utilization rate of BI-RADS templates and per capita GDP are positively associated with the diagnostic accuracy of breast cancer ultrasound.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
