Editorial Material
Cell & Tissue Engineering
Valerie Horsley
Summary: In this study, scientists used multi-omics approaches to identify the essential role of the transcription factor Trps1 in Yap-inhibited fibroblasts' tissue regenerative responses in murine skin, providing new insights into the mechanisms underlying the limited tissue repair ability of adult mammals.
Review
Biochemistry & Molecular Biology
Yaotao Guo, Yajuan Song, Wei Liu, Tong Wang, Xianjie Ma, Zhou Yu
Summary: TRPV3, a non-selective cation channel, is highly expressed in keratinocytes in the skin. It plays a role in multiple physiological and pathological processes of the skin, including itching, heat pain, and hair development. Recent studies suggest that cytokines and EGFR signaling pathways may be involved in TRPV3 functions. However, conflicting results have been reported regarding the role of TRPV3 in heat pain. Additionally, TRPV3 has been found to promote skin regeneration, indicating its potential as a target for regulating skin regeneration.
Article
Biochemistry & Molecular Biology
Tiancheng Wang, Zhenwei Zhou, Enjing Luo, Jinghong Zhong, Daqing Zhao, Haisi Dong, Baojin Yao
Summary: This study compared the gene expression patterns between keratinocytes and fibroblasts, identifying a large number of differentially expressed genes. Keratinocytes and fibroblasts have distinct molecular characteristics, providing a resource for investigating novel biomarkers related to skin diseases.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xiaoyan Sun, Jiangbing Xiang, Runkai Chen, Zhijun Geng, Lintao Wang, Yiqiong Liu, Shuaifei Ji, Huating Chen, Yan Li, Cuiping Zhang, Peng Liu, Tao Yue, Lei Dong, Xiaobing Fu
Summary: The research introduces a practical strategy for engineering functional human sweat glands via cell reprogramming and organoid technology. The successful regeneration of functional sweat glands in vitro and in vivo highlights the translational potential for personalized sweat gland regeneration in patients with extensive skin defects.
Article
Biochemistry & Molecular Biology
Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Kazuo Kishi
Summary: The expression of sonic hedgehog (Shh) is involved in the regeneration of texture during wound healing, especially in epidermal keratinocyte migration and division.
Article
Biochemistry & Molecular Biology
Kento Takaya, Noriko Aramaki-Hattori, Shigeki Sakai, Keisuke Okabe, Toru Asou, Kazuo Kishi
Summary: Skin wounds in developing mouse fetuses can heal without scar formation, unlike adult mammalian wounds. It has been found that the fibroblast growth factor (FGF) family plays a crucial role in fetal wound healing, with FGF7 potentially being associated with scar formation. Administration of FGF7 can inhibit fibrosis and promote epithelialization, providing a potential therapeutic option for scarless wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yeongyun Jung, Hui Song Cui, Eun Kyung Lee, So Young Joo, Cheong Hoon Seo, Yoon Soo Cho
Summary: This study investigated the effects of various factors on the scar microbiome composition in patients with burns and identified factors associated with burn scar microbiome composition. The findings suggest that these factors should be considered in the management of burn scars using skin microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell & Tissue Engineering
Shengxi Zhou, Mengbo Xie, Jingjing Su, Bingjie Cai, Jingan Li, Kun Zhang
Summary: Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar-free wound repair has been greatly expanded. This paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on scar prevention and strategies for scar-free wound repair.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Zun-jiang Zhao, De-jin Wu, Da-lun Lv, Bao-de Zhang, Lei Chen, Yin-qiao Sun
Summary: This study aimed to determine the role of ellagic acid (EA) in hypertrophic scar (HS) formation and its possible mechanism. In vitro experiments showed that EA inhibited the viability and migration of HS fibroblasts (HSFs), upregulated the expression of basic fibroblast growth factor (bFGF), and downregulated the expression of collagen-I (COL-I) and fibronectin 1 (FN1) in HSFs. Furthermore, EA prevented the activation of transforming growth factor (TGF)-beta/Smad signaling pathway in HSFs.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Veterinary Sciences
Zhen-Zhen Liu, Yong-Jun Yang, Feng-Hua Zhou, Ke Ma, Xiao-Qi Lin, Shi-Qing Yan, Yu Gao, Wei Chen
Summary: Gasdermin D (GSDMD) plays a crucial role in protecting against Staphylococcus aureus skin infection by suppressing the Cxcl1-Cxcr2 signaling pathway. GSDMD deficiency results in larger abscesses, increased bacterial colonization, exacerbated skin damage, and inflammation. Inhibition of the Cxcl1-Cxcr2 axis rescues host defense defects in GSDMD-deficient mice, highlighting the importance of GSDMD in controlling pathogens and preventing tissue damage during cutaneous S. aureus infection.
VETERINARY RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Guangliang Zhang, Gaobiao Cao, Cheng Gu, Yi Fu, Guangzhe Jin, Linfeng Tang, Huan Wang, Jiaying Li, Yingying Le, Shengjun Cao, Fengxuan Han, Jihui Ju, Bin Li, Ruixing Hou
Summary: The quality of the vascular network is crucial for the success of skin transplants. Prevascularization of bioengineered tissues is essential for establishing high-quality vascular networks. Through the use of 3D bioprinting, researchers have found that the size of the polycaprolactone framework can control vascular branch formation in prevascularized tissues, while also discovering a relationship between the width of cell-fibrin strip, force magnitude, and number of vascular branches in bioprinted tissues.
APPLIED MATERIALS TODAY
(2022)
Article
Biotechnology & Applied Microbiology
Camila Francisco Moreira, Puebla Cassini-Vieira, Maria Cecilia Campos Canesso, Mariane Felipetto, Hedden Ranfley, Mauro Martins Teixeira, Jacques Robert Nicoli, Flaviano Santos Martins, Luciola Silva Barcelos
Summary: The study showed that oral treatment with Lactobacillus rhamnosus accelerates skin wound closure, reduces scar formation, alleviates inflammation and fibrogenesis, and improves angiogenesis in wounded skin.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Review
Biochemistry & Molecular Biology
Matus Coma, Veronika Lachova, Petra Mitrengova, Peter Gal
Summary: Estrogen plays a complex role in wound healing and cancer, with current research focusing on naturally occurring SERMs. By utilizing natural products isolated from plants, such as genistein in soy, as potential alternatives, tissue-specific effects can be achieved in a promising manner.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Li-Ping Liu, Dong-Xu Zheng, Zheng-Fang Xu, Hu-Cheng Zhou, Yun-Cong Wang, Hang Zhou, Jian-Yun Ge, Daisuke Sako, Mi Li, Kazunori Akimoto, Yu-Mei Li, Yun-Wen Zheng
Summary: This study reveals the commonalities and differences between amniotic epithelial stem cells (AESCs) and keratinocytes (KCs) through transcriptomics analysis and functional evaluation. The analysis shows that AESCs are involved in epidermis-associated biological processes shared with KCs, but they also exhibit distinct features. The overexpression of TP63 and activation of NOTCH signaling can enhance AESC stemness and improve their differentiation features.
Article
Dermatology
Mingzhu Jin, Xiao Xu
Summary: This study explores the mechanism and interventions of scar formation from the perspective of miRNA. The results show that miR-182-5p inhibits hypertrophic scar formation by decreasing the proliferation and migration of fibroblasts via the SMAD4 pathway. miR-182-5p is expected to become a novel therapeutic target for hypertrophic scars.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Oncology
Dianbao Zhang, Chunhe Li, Luting Zhang, Bo Li, Yu Wang, Rui Wang, Zaixing Chen, Liang Xu, Tao Liu
Summary: The study discovered that cannabisin D from the dried stem of Sinomenium acutum has inhibitory effects on the proliferation and migration of glioblastoma cells, potentially through inducing cell apoptosis and cell cycle arrest. Additionally, cannabisin D was found to act by activating the MAPKs signaling pathway.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Lili Jin, Yuxin Sun, Yuying Li, Hanyu Zhang, Wenxue Yu, Yiling Li, Yi Xin, Saeed Ali Alsareii, Qiuyu Wang, Dianbao Zhang
Summary: AWRK6, a synthetic peptide developed based on antimicrobial peptide, showed potential as a novel GLP-1 receptor agonist in treating metabolic associated fatty liver disease (MAFLD). The peptide ameliorates MAFLD by improving lipid and glucose metabolism homeostasis, mediated by the PI3K/AKT/AMPK/ACC signaling pathway, which offers promising prospects for preventing the disease.
Article
Biochemistry & Molecular Biology
Lili Jin, Haibo Ding, Volkan Degirmenci, Hongchuan Xin, Qifan Miao, Qiuyu Wang, Dianbao Zhang
Summary: AWRK6, a synthesized peptide based on the natural peptide dybowskin-2CDYa, was analyzed in rat plasma using a LC-MS/MS method. Pharmacokinetic studies showed AWRK6 peaked in rat plasma at 1.2 hours after intraperitoneal injection and had a terminal half-life of approximately 2.8 hours.
Article
Oncology
Rui Wang, Tingting Liu, Jiayu Chen, Dianbao Zhang
Summary: This study found that paradol can inhibit the viability and migration of GBM cells by inducing cell cycle arrest and apoptosis, and activating signaling pathways.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Lili Jin, Beibei Duan, Jiaxin Liu, Xiaopeng Zhang, Xuanjing Li, Xiaoyu Zhu, Yi Xin, Yiling Li, Saeed Ali Alsareii, Qiuyu Wang, Dianbao Zhang
Summary: Research has shown that dietary betaine can alleviate obesity by normalizing glucose and lipid metabolism, and also reverse the elevated expression of certain microRNAs in obese mice. These findings confirm the anti-obesity effect of dietary betaine and offer a new perspective on understanding its underlying mechanisms.
SCIENCE OF ADVANCED MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Xiaoshuai Li, Tingting Liu, Jiayu Chen, Abdulrab Ahmed M. Alkhanjaf, Dianbao Zhang
Summary: Ginkgolic acid (GA) showed effective inhibition on cell proliferation and migration of glioblastoma cells by inducing cell cycle arrest and apoptosis. Additionally, GA triggered accumulation of intracellular reactive oxygen species and upregulated phosphorylation of ERK and p38 MAPK, indicating its anti-GBM effects are associated with oxidative stress and MAPK signaling pathways.
SCIENCE OF ADVANCED MATERIALS
(2021)
Review
Physiology
Ji Sun, Dianbao Zhang, Yiling Li
Summary: Extracellular vesicles (EVs) play a significant role in the development of metabolic associated fatty liver disease (MAFLD). They modulate communication between adipose tissue and liver through their bioactive cargos, and participate in the processes of liver inflammation and fibrosis. Therefore, EVs have the potential to be a therapeutic target and can be utilized for drug delivery in MAFLD.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haoyu Tian, Shuairan Zhang, Ying Liu, Yifan Wu, Dianbao Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a chronic condition associated with metabolic dysfunction and obesity, and has become an epidemic worldwide. There is currently no FDA-approved drug for NAFLD, but fibroblast growth factors (FGFs) have shown promising therapeutic benefits in clinical trials. FGF-based therapies, particularly FGF analogs, have been effective in treating NAFLD by alleviating steatosis, liver inflammation, and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shujiao Li, Yuying Li, Ying Liu, Yifan Wu, Qiuyu Wang, Lili Jin, Dianbao Zhang
Summary: Various lung diseases pose a threat to people's health, and antimicrobial peptides (AMPs) are considered as a viable alternative to traditional antibiotics. AMPs exhibit broad-spectrum antibacterial activity and immunomodulatory properties, showing remarkable effects on animal and cell models of acute lung injury, pulmonary fibrosis, and lung cancer. This paper outlines the potential therapeutic effects and mechanisms of peptides in these three types of lung diseases, which may be used as a future treatment strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dianbao Zhang, Yunmei Fu, Ying Liu, Yifan Wu, Jiayu Chen, Luting Zhang, Rui Wang, Zaixing Chen, Tao Liu
Summary: Colorectal cancer (CRC) is a prevalent and lethal tumor, and new strategies for prevention and therapy are urgently needed. In this study, 8-methoxyflindersine (8-MF) was isolated from Dictamni cortex and found to inhibit cell viability and induce apoptosis and cell cycle disorder in CRC cells. The activation of MAPK signaling and the protein-protein interaction of 8-MF with cyclins and MAPKs were also observed. These findings suggest that 8-MF could be a potential lead compound for the development of anti-tumor drugs for CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lili Jin, Ying Liu, Yifan Wu, Yi Huang, Dianbao Zhang
Summary: Chromatin modifications are crucial for gene expression regulation. REST, a repressor element-1 silencing transcription factor, plays a significant role in gene transcription regulation by binding to chromatin and recruiting chromatin-modifying enzymes. Dysregulation of REST is associated with various diseases and cancers, and targeted strategies have been developed. This paper provides a comprehensive summary of the research progress in understanding the effects and mechanisms of REST in physiological and pathological contexts, aiming to identify potential therapeutic targets for related diseases.
Article
Multidisciplinary Sciences
Rui Wang, Tingting Liu, Jiayu Chen, Dianbao Zhang
Summary: This study found that Atractylenolide-II (AT-II) can inhibit the viability and migration of glioblastoma (GBM) cells, and achieve this inhibitory effect by inducing cell cycle arrest.
Article
Nanoscience & Nanotechnology
Haoyu Tian, Yingying Guo, Jinyu Zhang, Zhuoli Zhang, Shuomin Chen, Ying Liu, Abdulrab Ahmed M. Alkhanjaf, Tao Liu, Dianbao Zhang
Summary: Aspergillumarin A inhibits the proliferation of HCC cells by inducing cell cycle arrest at the G(0)/G(1) phase. It shows promise as a novel candidate for HCC therapy.
SCIENCE OF ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jiayu Chen, Rui Wang, Ying Li, Chunhe Li, Tao Liu, Yi Xin, Yiling Li, Dianbao Zhang
Summary: Ginkgolic acid (GA) inhibits the proliferation and migration of hepatocellular carcinoma (HCC) cells by inducing G0/G1 cell cycle arrest through activation of p38 MAPK, making it a potential candidate for HCC treatment.
Article
Nanoscience & Nanotechnology
Jiayu Chen, Ji Sun, Ye Yuan, Haolin Wang, Sihan Kang, Abdulrab Ahmed M. Alkhanjaf, Yiling Li, Dianbao Zhang
Summary: This study found that miR-9 plays a crucial role in cell proliferation and migration in CRC cells by targeting the REST gene. The inhibition of miR-9 led to decreased cell viability and migration in CRC cells, indicating its potential as a therapeutic target for colorectal cancer.
SCIENCE OF ADVANCED MATERIALS
(2021)