Article
Immunology
Magdalena Rutkowska, Maria Pokorska-Spiewak
Summary: The study characterized pediatric patients with hepatitis associated with primary Epstein-Barr Virus (EBV) infection. Liver aminotransferases activity and abdominal ultrasonography results were analyzed. Medical records of 166 immunocompetent children diagnosed with primary EBV hepatitis were retrospectively studied. Elevated ALT activity was noted in the first three weeks of the disease, and AST activity showed two peaks in the first and third weeks. Transient cholestatic liver disease was found in 10.8% of children, with older patients being more affected. Hepatitis associated with primary EBV infection is usually mild, but severe cases can show significantly elevated liver enzymes and features of cholestatic liver disease.
Review
Medicine, General & Internal
Shen Fei-fei, Ren Xiao-dan, Liu Hai-qiang, Zhang He-wei
Summary: This meta-analysis protocol aims to systematically review the diagnostic value of anti-hepatitis B virus in serum tested by the enzyme linked immunosorbent assay in patients with hepatitis B. The study will search electronic databases to include all relevant studies published at home and abroad, and use MetaDisc 1.4 software to calculate pooled effect size.
Review
Chemistry, Medicinal
Fengling Zhou, Wei She, Lin He, Jiuqun Zhu, Lu Gu
Summary: The study did not find any significant changes in liver enzyme levels in metabolic disorder patients who received anthocyanin supplementation. The dose and duration of supplementation may contribute to the heterogeneity in results. Further high-quality studies are needed to confirm these findings.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Zeming Liu, Di Hu, Jinpeng Li, Qing Xia, Yan Gong, Zhengwei Li, Qian Wu, Meilin Yi, Yihui Huang, Meng Wu, Liang Guo, Xiaohui Wu
Summary: Elevated levels of AST and AST/ALT are correlated with severity and mortality of COVID-19. Liver function tests may aid clinicians in determining prognosis for patients undergoing treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yu-Ting Yen, Joo-Hyun Park, Seung-Hyun Kang, Today Su, Howard Cheng, Wu-Che Wen, Shin-Shiou Lin, Yu-Ling Tai, Pei-Ni Chen, Shih-Chang Tsai
Summary: This study evaluated the protective effects of Golden-Antrodia camphorata on liver function in human subjects after alcohol consumption.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Evelyn Ferri, Paolo D. Rossi, Martina Scichilone, Tiziano A. Lucchi, Beatrice Arosio
Summary: Dysfunctions in liver metabolic activities may be associated with an increased risk of cognitive impairment and dementia, with attention to sex differences in liver function.
Review
Nutrition & Dietetics
Hang Huang, Yunmei Qiu, Anyang Tang, Wanzhi Li, Wanyi Yao, Mei Zhong, Ting Yang, Tangbin Zou
Summary: A meta-analysis revealed that there is an association between food restriction and liver enzyme levels, including ALT, AST, and GGT. Dietary restriction can reduce ALT and GGT levels, and it also has a decreasing effect on AST levels in the medium-term. However, further consideration is needed for the long-term maintenance of healthy liver enzyme levels.
Article
Immunology
Chun-Jen Liu, I-Shyan Sheen, Chi-Yi Chen, Wan-Long Chuang, Horng-Yuan Wang, Kuo-Chih Tseng, Ting-Tsung Chang, Jenny Yang, Benedetta Massetto, Vithika Suri, Gregory Camus, Deyuan Jiang, Fangqiu Zhang, Anuj Gaggar, Tsung-Hui Hu, Yu-Chun Hsu, Gin-Ho Lo, Chi-Jen Chu, Jyh-Jou Chen, Cheng-Yuan Peng, Rong-Nan Chien, Pei-Jer Chen
Summary: This study analyzed the reactivation of hepatitis B in 111 Taiwanese patients coinfected with hepatitis C during hepatitis C treatment. In most patients, hepatitis B virologic reactivation was asymptomatic; only a small proportion initiated hepatitis B treatment.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Chemistry, Analytical
Hui Li, Menglu Li, Yucai Yang, Fei Wang, Feng Wang, Chao Li
Summary: A direct method has been described to establish the correlation between non-nucleic acid analytes and the CRISPR/Cas12a system using rationally designed DNA strands, enabling ultrasensitive detection of biomarkers from different species. The signal output is highly optional and the sensing principle is akin to ELISA, allowing for direct application on the currently available ELISA platform, further facilitating its use in medical diagnostics.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Weihong Qiu, Yun Zhou, Heng He, Bin Wang, Ge Mu, Min Zhou, Jixuan Ma, Zhuang Zhang, Limin Cao, Lili Xiao, Jing Yuan, Weihong Chen
Summary: The study found that short-term exposure to air pollutants has adverse effects on liver function among urban adults, with the adverse effects lasting longer in high-pollution areas than in low-pollution areas.
ATMOSPHERIC ENVIRONMENT
(2021)
Article
Public, Environmental & Occupational Health
Wangcheng Xie, Weidi Yu, Shanshan Chen, Zhilong Ma, Tingsong Yang, Zhenshun Song
Summary: The study highlights the value of AST/ALT ratio as a predictor for diabetes, with lower ratio associated with higher diabetes risk. A non-linear correlation was observed between AST/ALT ratio and diabetes risk, with risk increasing as the ratio decreases when <= 1.18.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Elnaz Lorzadeh, Mohsen Akhondi-Meybodi, Hassan Mozaffari-Khosravi, Masoud Mirzaei, Amin Salehi-Abargouei
Summary: This study in Iranian adults found that a western dietary pattern was associated with adverse effects on serum GGT levels, increasing the likelihood of developing abnormal enzyme levels. However, traditional and hydrogenated fat and sugar dietary patterns did not show the same association with liver enzymes.
Article
Materials Science, Multidisciplinary
Bo Kyeong Yoon, Tun Naw Sut, Ki Yeol Yoo, Seung Hwa Lee, Youngkyu Hwang, Joshua A. Jackman, Nam-Joon Cho
Summary: A streamlined ELISA strategy using lipid nanoparticles as a blocking agent was developed, showing fewer processing steps, quicker protocol time, and superior detection performance compared to conventional BSA blocking. This method has been successfully applied to COVID-19 antibody detection and is broadly applicable for rapid ELISA diagnostics development.
APPLIED MATERIALS TODAY
(2021)
Article
Gastroenterology & Hepatology
Narayanasamy Krishnasamy, Karthick Rajendran, Parimita Barua, Arunkumar Ramachandran, Priyadarshini Panneerselvam, Muthukumaran Rajaram
Summary: This study found that comorbidity combined with elevated liver enzymes at admission independently increased the risk of death in COVID-19 by at least 5-fold.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Food Science & Technology
Xiya Zhang, Mingyue Ding, Chensi Zhang, Yexuan Mao, Youyi Wang, Peipei Li, Haiyang Jiang, Zhanhui Wang, Xuezhi Yu
Summary: The researchers developed a rapid icELISA method for monitoring brevetoxin levels in oysters, providing a useful tool for the detection of these toxins in shellfish samples.