Review
Biochemistry & Molecular Biology
Zehua Liang, Yuquan He, Xin Hu
Summary: Chemotherapy-induced cardiovascular toxicity has become a major concern in cancer therapy. Traditional Chinese medicine formulations and the emerging field of reverse cardio-oncology provide promising approaches for prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lee S. Nguyen, Marie Bretagne, Jennifer Arrondeau, Noel Zahr, Stephane Ederhy, Baptiste Abbar, Bruno Pinna, Yves Allenbach, Jean-Paul Mira, Javid Moslehi, Michelle Rosenzwajg, Joe-Elie Salem
Summary: This article describes a case in which nearly lethal immune-checkpoint inhibitor (ICI)-induced myocarditis was reversed by the treatment of abatacept with adjusted dosage. This provides a basis for personalized treatment of patients with severe ICI adverse events.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Cong Wang, Jinyi Lin, Yan Wang, David H. Hsi, Jiahui Chen, Tianshu Liu, Yuhong Zhou, Zhenggang Ren, Zhaochong Zeng, Leilei Cheng, Junbo Ge
Summary: By conducting a retrospective analysis of ICI-associated myocarditis, we identified two subgroups based on corticosteroid responsiveness: corticosteroid-sensitive and corticosteroid-resistant. Corticosteroid-resistant patients require larger doses and longer duration of corticosteroid treatment, with a higher mortality rate. The use of tofacitinib in corticosteroid-resistant patients may offer a new therapeutic option for ICI-associated myocarditis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Vera Vaz Ferreira, Arjun K. Ghosh
Summary: Cardio-oncology is a subspecialty that provides cardiac care for cancer patients. Cardiovascular toxicity (CVT) caused by newer oncological agents has emerged as a concern, emphasizing the need for baseline assessment and individualized surveillance during and after cancer therapy. Early diagnosis and management strategies are crucial.
Article
Biology
Raffaella Calabretta, Philipp B. Staber, Christoph Kornauth, Xia Lu, Patrick Binder, Verena Pichler, Markus Mitterhauser, Alexander Haug, Xiang Li, Marcus Hacker
Summary: The study demonstrated that immune checkpoint inhibitor therapy may play a critical role in regulating arterial inflammation, potentially increasing the risk of future cardiovascular events in young oncological patients.
Article
Chemistry, Medicinal
Danielle Delombaerde, Johan De Sutter, Lieselot Croes, Delphine Vervloet, Veronique Moerman, Nico van de Veire, Anne-Marie Willems, Kristien Wouters, Marc Peeters, Hans Prenen, Christof Vulsteke
Summary: The lack of solid data and prospective studies has resulted in a lack of clear guidelines for cardiovascular monitoring in patients receiving immune checkpoint inhibitors (ICIs). In order to address this issue, we have initiated the CAVACI trial to investigate the short- and long-term cardiovascular effects of ICIs. Patient recruitment started in January 2022.
Article
Cardiac & Cardiovascular Systems
Jason Kuniyoshi, Ricky Huang, Horyun Choi, Monika Bernas, Witina Techasatian, Yoshito Nishimura
Summary: ICIs have revolutionized cancer treatment by targeting molecules to activate T-cells and show curative responses for patients with metastatic melanoma, non-small cell lung cancer, head and neck, and renal cancers. However, the occurrence of life-threatening immune-related adverse events should be taken into consideration.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Joerg Herrmann, Daniel Lenihan, Saro Armenian, Ana Barac, Anne Blaes, Daniela Cardinale, Joseph Carver, Susan Dent, Bonnie Ky, Alexander R. Lyon, Teresa Lopez-Fernandez, Michael G. Fradley, Sarju Ganatra, Giuseppe Curigliano, Joshua D. Mitchell, Giorgio Minotti, Ninian N. Lang, Jennifer E. Liu, Tomas G. Neilan, Anju Nohria, Rupal O'Quinn, Iskra Pusic, Charles Porter, Kerry L. Reynolds, Kathryn J. Ruddy, Paaladinesh Thavendiranathan, Peter Valent
Summary: The discipline of Cardio-Oncology focuses on the cardiovascular care of cancer patients and the management of cardiovascular complications of cancer therapies. This document provides consensus definitions for common cardiovascular toxicities and aims to improve communication and outcomes in clinical practice and research.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Yuansong Zhuang, Quanxu An, Fuhang Wang, Dongjian Han, Zhentao Qiao, Qingjiao Jiang, Miaomiao Liu, Yuhang Li, Jiahong Shangguan, Xuanye Bi, Deliang Shen
Summary: This study identified a group of circulating biomarkers that can accurately predict the 30-day mortality rate of immune-related myocarditis. These biomarkers include PLT, ALT, AST, LDH, troponin I, PLR, LAR, and AAR. Among them, LDH, LAR, troponin I, and AAR demonstrated excellent predictive ability.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Immunology
Naoki Hamada, Ayaka Maeda, Kaoru Takase-Minegishi, Yohei Kirino, Yumiko Sugiyama, Ho Namkoong, Nobuyuki Horita, Ryusuke Yoshimi, Hideaki Nakajima
Summary: Immune checkpoint inhibitor (ICI)-related myositis is a rare and potentially fatal condition with a low incidence rate and diverse clinical features, emphasizing the importance of early recognition and intervention. The development of myositis induced by ICI, particularly PD-1 inhibitors, is associated with a higher risk of concomitant myocarditis, highlighting the need for close monitoring and appropriate treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Rishi Rikhi, Jaret Karnuta, Muzna Hussain, Patrick Collier, Pauline Funchain, Wai Hong Wilson Tang, Timothy A. Chan, Rohit Moudgil
Summary: The use of immune checkpoint inhibitors has significantly impacted oncology, but can also lead to immune-related adverse events like myocarditis. Different ICI targets can result in distinct myocardial infiltrates, with caution needed in assessing cardiac status before treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Nicolas L. Palaskas, Ana Segura, Laura Lelenwa, Bilal A. Siddiqui, Sumit K. Subudhi, Juan Lopez-Mattei, Jean B. Durand, Anita Deswal, Bihong Zhao, L. Maximilian Buja, Cezar Iliescu
Summary: A grading system was developed for ICI myocarditis based on degree of inflammatory infiltrate, with some patients able to continue ICI without immunosuppressive therapy and have good cardiovascular outcomes. Further studies are needed to identify low-risk patients who can safely receive ICI therapy.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Biochemistry & Molecular Biology
Siqi Li, Kazuko Tajiri, Nobuyuki Murakoshi, DongZhu Xu, Saori Yonebayashi, Yuta Okabe, Zixun Yuan, Duo Feng, Keiko Inoue, Kazuhiro Aonuma, Yuzuno Shimoda, Zoughu Song, Haruka Mori, Honglan Huang, Kazutaka Aonuma, Masaki Ieda
Summary: Deficiency of PD-L2 exacerbates myocardial inflammation in mice with experimental autoimmune myocarditis (EAM) by enhancing CD4(+) T cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Satoru Mitsuboshi, Hirofumi Hamano, Takahiro Niimura, Aya F. Ozaki, Pranav M. Patel, Tsung-Jen Lin, Yuta Tanaka, Ikuya Kimura, Naohiro Iwata, Shoya Shiromizu, Masayuki Chuma, Toshihiro Koyama, Yoshihiro Yamanishi, Yasunari Kanda, Keisuke Ishizawa, Yoshito Zamami
Summary: This study found that concomitant use of diuretics increases the risk of myocarditis in patients receiving immune checkpoint inhibitor therapy. These findings may aid in predicting the risk of myocarditis in patients receiving immune checkpoint inhibitors.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Sarah Waliany, Daniel Lee, Ronald M. Witteles, Joel W. Neal, Patricia Nguyen, Mark M. Davis, Joe-Elie Salem, Sean M. Wu, Javid J. Moslehi, Han Zhu
Summary: ICIs alter the immune system's response to cancerous tissues but can lead to varying degrees of autoimmunity, with cardiovascular complications such as myocarditis emerging as significant side effects. Understanding the mechanisms underlying these toxicities may help improve patient outcomes by reducing treatment-related morbidity.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Review
Cardiac & Cardiovascular Systems
Tobias Taeger, Lutz Frankenstein, Dan Atar, Stefan Agewall, Norbert Frey, Morten Grundtvig, Andrew L. Clark, John G. F. Cleland, Hanna Froehlich
Summary: This study evaluated the efficacy of different SGLT2 inhibitors in heart failure patients and the impact of their receptor selectivity on efficacy. Results suggest that non-selective SGLT2 inhibitors may have superior efficacy in heart failure outcomes.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Anesthesiology
Guido Michels, Johann Bauersachs, Bernd W. Boettiger, Hans-Joerg Busch, Burkhard Dirks, Norbert Frey, Carsten Lott, Nadine Rott, Wolfgang Schoels, P. Christian Schulze, Holger Thiele
Summary: This article summarizes and comments on the revised recommendations on basic measures, advanced resuscitation measures, and post-resuscitation treatment in adults in the European guidelines on cardiopulmonary resuscitation.
Article
Cardiac & Cardiovascular Systems
Nicolas A. Geis, Philipp Schlegel, Markus B. Heckmann, Hugo A. Katus, Norbert Frey, Patricia Crespo Lopez, Philip W. J. Raake
Summary: Transcatheter edge-to-edge repair using the PASCAL or MitraClip device results in favorable and comparable outcomes regarding safety, efficacy, and clinical improvement after 1 year.
Article
Cardiac & Cardiovascular Systems
Martin J. Volz, Isabel Hoerbrand, Mathias H. Konstandin, Derliz Mereles, Celine Weiss, Gregor Warnecke, Norbert Frey, Matthias Aurich, Philip W. Raake
Summary: In a single-center retrospective analysis, direct tricuspid valve leaflet repair using the transcatheter PASCAL Ace implant system was associated with reduced TR severity and improved cardiopulmonary exercise capacity.
Article
Cardiac & Cardiovascular Systems
Matthias Pauschinger, Stefan Stoerk, Christiane E. Angermann, Johann Bauersachs, Raffi Bekeredjian, Friedhelm Beyersdorf, Michael Boehm, Norbert Frey, Jan Gummert, Ingrid Kindermann, Stefan Perings, P. Christian Schulze, Wolfgang von Scheidt, Philip Raake
Summary: Despite major advances in the treatment of heart failure, it remains the leading cause of hospitalization in Germany with a high mortality risk. To improve heart failure care, a joint initiative by the German Cardiac Society, the German Society for Thoracic and Cardiovascular Surgery, and the Working Group of Leading German Hospital Cardiologists aimed to define the profile and certification process of heart failure networks. These networks, organized in modules called HF units, seek to ensure faster diagnosis and high-quality treatment for patients with acute decompensated chronic or new onset heart failure.
Article
Cardiac & Cardiovascular Systems
Fabian Linden, Norbert Frey, Christian Erbel
Summary: Polyvascular disease refers to relevant atherosclerosis in two or more vascular regions, with a higher risk of cardiovascular events and mortality, requiring intensive prevention measures.
AKTUELLE KARDIOLOGIE
(2022)
Review
Medicine, General & Internal
Klaus Kallenbach, Anca Remes, Oliver J. Mueller, Rawa Arif, Marcin Zaradzki, Andreas H. Wagner
Summary: The researchers first provided an overview of the historical background and characterization of Marfan syndrome, and found that gene therapy, which is used in genetic diseases, may have a therapeutic effect on this disorder.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Xiling Zhang, Thomas Puehler, Lars Sondergaard, Derk Frank, Hatim Seoudy, Baland Mohammad, Oliver J. Mueller, Stephanie Sellers, David Meier, Janarthanan Sathananthan, Georg Lutter
Summary: This article introduces the newest devices for transcatheter mitral valve repair and replacement and presents clinical trial data to identify current challenges and directions for future research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Deborah Siry, Johannes Riffel, Janek Salatzki, Florian Andre, Lukas Damian Weberling, Marco Ochs, Noura A. Atia, Elizabeth Hillier, David Albert, Hugo A. Katus, Evangelos Giannitsis, Norbert Frey, Matthias G. Friedrich
Summary: This study compared the diagnostic performance of different myocardial strain imaging techniques for identifying cardiac pathology, with fSENC and LVLAS showing comparable ability to differentiate healthy myocardium from dysfunction, while FT-derived strain did not allow for differentiation between ACS and non-cardiac patients.
BMC MEDICAL IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Janek Salatzki, Evangelos Giannitsis, Anastasia Hegenbarth, Matthias Mueller-Hennessen, Florian Andre, Hugo A. Katus, Norbert Frey, Moritz Biener
Summary: This study validates the correlation between high-sensitivity cardiac Troponin T (hs-cTnT) values at different time points and contrast-enhanced magnetic resonance imaging (CE-MRI) infarct mass in patients with acute myocardial infarction (AMI). The results demonstrate that hs-cTnT values on admission have a superior correlation with CE-MRI infarct mass.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2022)
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Johann Bauersachs, Samira Soltani, Matthias Eden, Norbert Frey, Michael Boehm
Summary: Heart failure remains a global healthcare challenge despite significant developments in pharmacotherapies. There are concerns regarding low medication dosages and incomplete drug classes in real-world settings, and current guidelines lack detailed recommendations. A practical approach algorithm is proposed to assist physicians in treating HF patients.
Article
Pharmacology & Pharmacy
Panagiotis Xynogalos, Ann-Kathrin Rahm, Sebastian Fried, Safak Chasan, Daniel Scherer, Claudia Seyler, Hugo A. Katus, Norbert Frey, Edgar Zitron
Summary: This study analyzed the effect of the antiarrhythmic drug verapamil on the inwardly rectifying potassium current of cardiomyocytes. The results showed that verapamil inhibited the Kir2.1, Kir2.2, and Kir2.3 channels, with the inhibition of Kir2.3 being a previously unknown finding. Further experiments revealed that the inhibition of Kir2.3 by verapamil was dependent on specific binding sites and interference with PIP2 activation. This finding provides a potential target for the development of selective antiarrhythmic drugs targeting Kir2.3 channels.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Cell Biology
Ricarda Haustein, Felix A. Trogisch, Merve Keles, Susanne Hille, Manuela Fuhrmann, Nina Weinzierl, Shruthi Hemanna, James Thackeray, Yanliang Dou, Carolin Zwadlo, Natali Froese, Julio Cordero, Frank Bengel, Oliver J. Mueller, Johann Bauersachs, Gergana Dobreva, Joerg Heineke
Summary: Endothelial-derived CTRP9 plays a protective role in diabetic cardiomyopathy by improving insulin signaling, glucose uptake, and oxidative energy production in the heart. CTRP9 also acts as an anti-inflammatory mediator, reducing leukocyte accumulation in the myocardium.
Article
Medicine, General & Internal
Nina Sophie Pommert, Xiling Zhang, Thomas Puehler, Hatim Seoudy, Katharina Huenges, Jan Schoettler, Assad Haneya, Christine Friedrich, Janarthanan Sathananthan, Stephanie L. Sellers, David Meier, Oliver J. Mueller, Mohammed Saad, Derk Frank, Georg Lutter
Summary: Transaortic transcatheter aortic valve implantation via intercostal access provides a safe and effective treatment option for aortic valve stenosis, with comparable outcomes to the traditional transaortic approach but fewer complications and shorter hospital stays.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Lena C. Schroeder, Derk Frank, Oliver J. Mueller
Summary: Cardiac-targeted transgene delivery provides new treatment opportunities for cardiovascular diseases by using cis-regulatory elements to restrict gene transfer and protect extracardiac organs. Tissue-specific promoters for targeted transcription in specific cardiac cells have been identified, some of which are induced at pathological states and could potentially act as induction-by-disease switches in gene therapy.
