Trophic Factors in Inflammation and Regeneration: The Role of MANF and CDNF

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

(2018) Luca Peruzzotti-Jametti et al.   Cell Stem Cell

NGF steers microglia toward a neuroprotective phenotype

(2018) Caterina Rizzi et al.   GLIA

MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

(2018) Kuan-Yin Tseng et al.   MOLECULAR THERAPY

Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities

(2018) Sang-Bing Ong et al.   PHARMACOLOGY & THERAPEUTICS

Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection

(2018) Meirong Bai et al.   Nature Communications

Poststroke delivery of MANF promotes functional recovery in rats

(2018) Kert Mätlik et al.   Science Advances

Cerebral dopamine neurotrophic factor protects H9c2 cardiomyocytes from apoptosis

(2017) H. Liu et al.   HERZ

Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering

(2017) Joshua D Bernstock et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential

(2017) Maria Lindahl et al.   NEUROBIOLOGY OF DISEASE

Identification of Mesencephalic Astrocyte-Derived Neurotrophic Factor as a Novel Neuroprotective Factor for Retinal Ganglion Cells

(2017) Feng-Juan Gao et al.   Frontiers in Molecular Neuroscience

Mesencephalic astrocyte-derived neurotrophic factor attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-κB and phosphorylation of p38-MAPKs pathways

(2016) Wei Zhu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Microglia in central nervous system repair after injury

(2016) Xuemei Jin et al.   JOURNAL OF BIOCHEMISTRY

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

(2016) Sales Ibiza et al.   NATURE

Immune modulation by MANF promotes tissue repair and regenerative success in the retina

(2016) J. Neves et al.   SCIENCE

Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes

(2016) Emilia Galli et al.   Scientific Reports

Local Injection of Lenti–BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice

(2015) Xin-Chao Ji et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging

(2015) Joana Neves et al.   DEVELOPMENTAL CELL

High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders

(2015) Tarunashree Yavarna et al.   HUMAN GENETICS

ER stress-inducible protein MANF selectively expresses in human spleen

(2015) Jun Liu et al.   HUMAN IMMUNOLOGY

Differential regulation of macrophage phenotype by mature and pro-nerve growth factor

(2015) Kimberly S. Williams et al.   JOURNAL OF NEUROIMMUNOLOGY

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization

(2015) Joanne Tonkin et al.   MOLECULAR THERAPY

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

(2015) Josiane Budni et al.   Aging and Disease

Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners

(2015) Hong Lei et al.   Frontiers in Pharmacology

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

(2015) Lijian Chen et al.   Scientific Reports

Deficiency of IRE1 and PERK Signal Pathways in Systemic Lupus Erythematosus

(2014) Qiyao Cheng et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Immune Modulation of Stem Cells and Regeneration

(2014) Arin B. Aurora et al.   Cell Stem Cell

Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice

(2014) B. Johannesson et al.   Disease Models & Mechanisms

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

(2014) Rasajna Nadella et al.   Journal of Neuroinflammation

Transplantation of Cerebral Dopamine Neurotrophic Factor Transducted BMSCs in Contusion Spinal Cord Injury of Rats: Promotion of Nerve Regeneration by Alleviating Neuroinflammation

(2014) Hua Zhao et al.   MOLECULAR NEUROBIOLOGY

The neurotrophic factor receptor RET drives haematopoietic stem cell survival and function

(2014) Diogo Fonseca-Pereira et al.   NATURE

Age-Dependent Decrease in Chaperone Activity Impairs MANF Expression, Leading to Purkinje Cell Degeneration in Inducible SCA17 Mice

(2014) Su Yang et al.   NEURON

MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

(2014) Maria Lindahl et al.   Cell Reports

Overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviates endoplasmic reticulum stress-induced cell damage and inflammatory cytokine secretion

(2013) Lei Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Oxygen–Glucose Deprivation-Induced Cell Damage and Inflammation by Suppressing Endoplasmic Reticulum Stress in Rat Primary Astrocytes

(2013) Hua Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia

(2013) Hua Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Autocrine and immune cell-derived BDNF in human skeletal muscle: implications for myogenesis and tissue regeneration

(2013) Emanuela Colombo et al.   JOURNAL OF PATHOLOGY

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing

(2013) Jérémy Chéret et al.   WOUND REPAIR AND REGENERATION

Manipulation of the Recipient Retinal Environment by Ectopic Expression of Neurotrophic Growth Factors Can Improve Transplanted Photoreceptor Integration and Survival

(2012) E. L. West et al.   CELL TRANSPLANTATION

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Secretion and Cell Surface Binding Are Modulated by KDEL Receptors

(2012) Mark J. Henderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion

(2012) Christopher C. Glembotski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between neural stem cells and immune cells: the key to better brain repair?

(2012) Zaal Kokaia et al.   NATURE NEUROSCIENCE

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

(2012) Sandra Moreira Rocha et al.   NEUROBIOLOGY OF DISEASE

p38/MKP-1–regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair

(2011) Eusebio Perdiguero et al.   JOURNAL OF CELL BIOLOGY

Neuroprotection and progenitor cell renewal in the injured adult murine retina requires healing monocyte-derived macrophages

(2011) Anat London et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human Neurotrophin Receptor p75NTR Defines Differentiation-Oriented Skeletal Muscle Precursor Cells: Implications for Muscle Regeneration

(2011) Emanuela Colombo et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neurotrophins modulate monocyte chemotaxis without affecting macrophage function

(2010) B. Samah et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Brain-derived Neurotrophic Factor Regulates Satellite Cell Differentiation and Skeltal Muscle Regeneration

(2010) Charlene Clow et al.   MOLECULAR BIOLOGY OF THE CELL

NGF and heart: Is there a role in heart disease?

(2010) Stefano Govoni et al.   PHARMACOLOGICAL RESEARCH

Long-Term Survival of Photoreceptors Transplanted into the Adult Murine Neural Retina Requires Immune Modulation

(2010) Emma L. West et al.   STEM CELLS

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats

(2009) Mikko Airavaara et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

(2009) M. H. Voutilainen et al.   JOURNAL OF NEUROSCIENCE

The Low-Affinity Receptor for Neurotrophins p75NTR Plays a Key Role for Satellite Cell Function in Muscle Repair Acting via RhoA

(2009) Daniela Deponti et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

(2009) M. Palgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart

(2008) Archana Tadimalla et al.   CIRCULATION RESEARCH

Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death

(2008) A APOSTOLOU et al.   EXPERIMENTAL CELL RESEARCH