Perspective: Spectrin-Like Repeats in Dystrophin Have Unique Binding Preferences for Syntrophin Adaptors That Explain the Mystery of How nNOSμ Localizes to the Sarcolemma

Syntrophin binds directly to multiple spectrin-like repeats in dystrophin and mediates binding of nNOS to repeats 16–17

(2018) Marvin E Adams et al.   HUMAN MOLECULAR GENETICS

Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy

(2016) David G. Allen et al.   PHYSIOLOGICAL REVIEWS

Truncating Mutation in the Nitric Oxide Synthase 1 Gene Is Associated With Infantile Achalasia

(2015) Eyal Shteyer et al.   GASTROENTEROLOGY

Sarcolemmal targeting of nNOSμ improves contractile function ofmdxmuscle

(2015) Daniela L. Rebolledo et al.   HUMAN MOLECULAR GENETICS

Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

(2015) Nicolas A Dumont et al.   NATURE MEDICINE

Loss of nNOS inhibits compensatory muscle hypertrophy and exacerbates inflammation and eccentric contraction-induced damage in mdx mice

(2014) S. C. Froehner et al.   HUMAN MOLECULAR GENETICS

Nitric oxide synthase deficiency and the pathophysiology of muscular dystrophy

(2014) James G. Tidball et al.   JOURNAL OF PHYSIOLOGY-LONDON

 2 and  3 helices of dystrophin R16 and R17 frame a microdomain in the  1 helix of dystrophin R17 for neuronal NOS binding

(2012) Y. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle

(2010) Justin M. Percival et al.   JOURNAL OF CLINICAL INVESTIGATION

The 8th and 9th tandem spectrin-like repeats of utrophin cooperatively form a functional unit to interact with polarity-regulating kinase PAR-1b

(2009) Kazunari Yamashita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

(2009) Yi Lai et al.   JOURNAL OF CLINICAL INVESTIGATION