Correction
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: An amendment to this paper has been published and can be accessed via the original article.
Review
Oncology
Dechao Yuan, Jie Tian, Xiang Fang, Yan Xiong, Nishant Banskota, Fuguo Kuang, Wenli Zhang, Hong Duan
Summary: This study clarified the relationships between SNPs and osteosarcoma risk through a comprehensive meta-analysis, identifying significant associations in multiple genes and SNPs. The evaluation of epidemiological evidence provided useful information for future studies evaluating the risk of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amrit Sudershan, Agar Chander Pushap, Hardeep Kumar, Parvinder Kumar
Summary: The present meta-analysis found that MTHFR-C677T is significantly associated with an increased risk of migraine and its clinical subtype. ACE I/D also significantly increases the risk of overall migraine and both clinical subtypes. MTHFR A1289C only increases the risk of migraine in certain genetic models.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Obstetrics & Gynecology
Dema Alset, Inna O. Pokudina, Elena Butenko, Tatiana P. Shkurat
Summary: This meta-analysis found that ESR1 (Pvull, T397C) is associated with an increased risk of uterine leiomyoma in Asian populations, while COMT (Val158Met) is significantly associated with a lower risk of leiomyoma.
REPRODUCTIVE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gergo Berke, Noemi Gede, Leticia Szadai, Klementina Ocskay, Peter Hegyi, Miklos Sahin-Toth, Eszter Hegyi
Summary: Heterozygous CFTRBD variants, except for p.R75Q, increase the risk of developing CP by 2-4 times.
Review
Genetics & Heredity
Zorana Dobrijevic, Suzana Matijasevic, Tijana Isic Dencic, Dusanka Savic-Pavicevic, Olgica Nedic, Goran Brajuskovic
Summary: This study conducted a meta-analysis to investigate the association between genetic variants within the DICER1 gene and overall cancer risk, finding a statistically significant relationship with rs1057035. The results suggest that rs1057035 may serve as a potential biomarker for cancer risk and should be further validated in larger studies.
Review
Oncology
Tommy Nyberg, Marc Tischkowitz, Antonis C. Antoniou
Summary: BRCA1 and BRCA2 pathogenic variants are associated with prostate cancer risk with varying relative risks reported. The heterogeneity in estimates may be influenced by factors such as age, family history, and study-level differences in ethnicity composition. Subgroup analyses suggest risks may be modified by age, ethnicity, and PV location within BRCA2 for future risk estimation studies.
BRITISH JOURNAL OF CANCER
(2022)
Review
Health Care Sciences & Services
Aline Ruilowa de Pinho Coelho, Luciana Carvalho Silveira, Kamilla de Faria Santos, Rodrigo da Silva Santos, Angela Adamski da Silva Reis
Summary: This study used a systematic review and meta-analysis to investigate the relationship between the ACE gene (I/D) polymorphism and the development and progression of DR in type 2 diabetic patients. The results showed no significant association between the polymorphism and DR risk, indicating that the I/D polymorphism is not involved in the susceptibility to and progression of DR in type 2 diabetic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Huaying Liu, Lili Sun, Xiaoping Liu, Ruichai Wang, Qinqin Luo
Summary: This study systematically reviewed and analyzed the association between non-coding RNA polymorphisms and ovarian cancer risk. The results suggest that H19 rs2107425, miR-146a rs2910164, and miR-196a rs11614913 polymorphisms are significantly associated with the risk of ovarian cancer.
Article
Environmental Sciences
Beatriz Alvarez-Gonzalez, Patricia Porras-Quesada, Veronica Arenas-Rodriguez, Alba Tamayo-Gomez, Fernando Vazquez-Alonso, Luis Javier Martinez-Gonzalez, Antonio F. Hernandez, Maria Jesus Alvarez-Cubero
Summary: The development and progression of prostate cancer are influenced by the interaction between genetic, environmental, and dietary factors. Chemical exposures and genetic polymorphisms in genes encoding xenobiotic metabolizing enzymes, antioxidant enzymes, and DNA repair enzymes play a major role in cancer development. Understanding the causal risk factors for prostate cancer can help identify high-risk individuals and develop effective detection and prevention methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Genetics & Heredity
Kajal Gupta, Gaganpreet Kaur, Tejal Pathak, Indranil Banerjee
Summary: This study provides a synthesis of evidence on the genetic determinants implicated in COVID-19 so far and shows a correlation between certain genetic polymorphisms and susceptibility to and severity of COVID-19.
Review
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: The meta-analysis showed no significant association between the ACE I/D polymorphism and lung cancer risk, and subgroup analysis by ethnicity did not yield significant results.
Article
Ophthalmology
Jun Zhang, Peng Zhou, Shuqiong Hu, Jian Qi
Summary: This study conducted a meta-analysis to explore the association between genetic variants of PTPN22 and CTLA-4 with uveitis susceptibility. The results showed that PTPN22 rs2488457 was associated with increased susceptibility to uveitis, especially in the Asian region. CTLA-4 rs231775 was found to confer protection against uveitis in African populations, while CTLA-4 rs4553808 was associated with an increased risk of Behcet's disease.
OPHTHALMIC RESEARCH
(2022)
Article
Genetics & Heredity
Qing Xin, Yameng Dong, Wencong Guo, Xiangzhong Zhao, Zhiying Liu, Xiaomeng Shi, Yanhua Lang, Leping Shao
Summary: This study analyzed the genotype of 21 Chinese patients with primary hyperoxaluria (PH) and identified correlations between genotype and phenotype. Four novel variants were found and the study expanded the variant spectrum of PH in the Chinese population.
FRONTIERS IN GENETICS
(2023)
Review
Genetics & Heredity
Yulian Fang, Yaqiong Cui, Zhaoqing Yin, Mengzhu Hou, Pan Guo, Hanjie Wang, Nan Liu, Chunquan Cai, Mingbang Wang
Summary: This study conducted a systematic review and meta-analysis on the association between genetic variants and autism spectrum disorder (ASD) risk. The results revealed significant associations between certain single nucleotide polymorphisms (SNPs) of candidate genes, including CNTNAP2, MTHFR, OXTR, and VDR, and increased ASD risk.
Article
Biochemistry & Molecular Biology
Saif Khan, Mahvish Khan, Mohtashim Lohani, Saheem Ahmad, Subuhi Sherwani, Sundeep Bhagwath, Mohd Wajid A. Khan, Mohd Wahid, Farrukh Aqil, Shafiul Haque
Summary: This study investigated the unfolding of Mycobacterium Aspartate beta semialdehyde dehydrogenase (ASADH) using spectroscopic techniques and size exclusion chromatography. The unfolding of the apo ASADH was found to be non-cooperative, while the unfolding of the holoenzyme was cooperative. The presence of NADP/H stabilizes the tryptophan environment and the native NADP/H-bound enzyme. The folded holoenzyme was shown to be conformationally more stable compared to the apo state. These findings are important for the discovery of novel drugs targeting ASADH.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biotechnology & Applied Microbiology
Mahvish Khan, Saif Khan, Mohtashim Lohani, Mohd Murshad Ahmed, Diksha Sharma, Romana Ishrat, Saheem Ahmad, Subuhi Sherwani, Shafiul Haque, Sundeep S. Bhagwath
Summary: Leprosy is a global health concern associated with fear and stigma. Despite advancements in treatment and understanding, its epidemiology remains insufficient. Challenges include prolonged incubation period, slow occurrence rates, and deceiving clinical presentation. Improved diagnostics and therapies are needed to prevent leprosy-related mortality.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Review
Biotechnology & Applied Microbiology
Subham Suvankar, Sunali Padhi, Hala Abubaker Bagabir, Abhijit Pati, Mohd Wahid, Raju K. Mandal, Shafiul Haque, Aditya K. Panda
Summary: This meta-analysis found a significant association between the CTLA-4 +49 A/G variant and susceptibility to systemic lupus erythematosus (SLE) development, as well as a link between the -1722 T/C variant and protection against SLE. The other two SNPs in the CTLA-4 gene did not show a connection to SLE. Interestingly, the association with CTLA-4 +49 A/G was only observed in the Asian population.
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS
(2023)
Letter
Immunology
Nisha Nayak, Abhijit Pati, Y. Pavani, Sourav Sahu, Sudhanshu Ranjan, Aditya K. Panda
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Rheumatology
Surjyapratap Sarangi, Suraj K. Nahak, Sunali Padhi, Bidyutprabha Pradhan, Nisha Nayak, Abhijit Pati, Aditya K. Panda
Summary: The role of interferon-gamma (IFN-gamma) in autoimmune disorders, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), has been extensively studied. This meta-analysis aimed to determine the association between a specific polymorphism in the IFN-gamma gene and the susceptibility to RA and SLE. The results showed a significant association between the IFN-gamma polymorphism and the development of SLE.
Article
Biochemistry & Molecular Biology
Nisha Nayak, Abhijit Pati, Suraj Kumar Nahak, Surjyapratap Sarangi, Bidyutprabha Pradhan, Sunali Padhi, Aditya K. K. Panda
Summary: In this study, the researchers found a significant negative correlation between the TLR2 rs111200466 polymorphism and susceptibility to SARS-CoV-2 infection and related mortality. This suggests that TLR2 may play an important role in SARS-CoV-2 infection, and further research is needed to validate these findings.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2023)
Review
Mycology
Chhavi Gupta, Shukla Das, Vishal Gaurav, Praveen K. Singh, Gargi Rai, Shyama Datt, Richa A. Tigga, Deepika Pandhi, Sambit N. Bhattacharya, Mohammad A. Ansari, Sajad A. Dar
Summary: Dermatophytosis is a common fungal infection of the skin caused by dermatophytes. The proteolytic enzymes released by the fungi contribute to the persistence of infection. Abnormal host immune response leads to inflammation in chronic dermatophytosis. Increasing antifungal resistance and recalcitrant infections pose challenges in clinical management.
JOURNAL DE MYCOLOGIE MEDICALE
(2023)
Article
Biochemistry & Molecular Biology
Elhan Khan, Mahvish Khan, Saif Khan, Mohtashim Lohani, Nashwa Zaki Ali Bushara, Hussein Abdul Aziz Marouf, Kurian Punnoose, Iffat Zareen Ahmad
Summary: Melanoma is a dangerous and complex disease, making diagnosis and treatment difficult. Marine biomass plays a crucial role in preserving biodiversity. Research suggests that TLR activation, in addition to its role in innate immunity, may be connected to the development of cancer, making TLR agonists potential candidates for cancer medications. Scytonemin shows significant binding potential to TLR3 and TLR4, indicating its potential as a therapeutic agent.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Medicine, General & Internal
Suchita Gautam, Shukla Das, Praveen Kumar Singh, Gargi Rai, Charu Jain, Rumpa Saha, Narendra Pal Singh, Sunil Gomber, Raga Eltayeb, Sajad Ahmad Dar
Summary: Limited studies from developing countries show a high incidence, high morbidity and a unique epidemiology of candidemia in pediatric patients with malignancy. This prospective observational study investigated the prevalence of invasive candidiasis, particularly candidemia, in febrile pediatric patients with lymphoreticular malignancy. The colonization of candida and the detection of mannan antigen were evaluated as indicators of impending candidemia. The study revealed a 5% prevalence of candidemia, predominantly caused by non-albicans candida, and demonstrated an association between candida colonization and candidemia.
Article
Chemistry, Physical
Zeeshan Rafi, Mahvish Khan, Saif Khan, Manish Srivastava, Shafiul Haque, Sundeep S. Bhagwath, Kurian Punnoose, Mohd. Sajid Khan
Summary: This study investigated the effects of isoferulic acid (IFA) and its gold nanoparticle (IFA-AuNPs) bioconjugated formulations on protein glycation, cancer, and α-amylase activity. The results showed that IFA and IFA-AuNPs significantly reduced the harmful substances produced during glycation and had less impact on protein structure. Additionally, they demonstrated inhibitory effects on cancer cell growth.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Immunology
Gargi Rai, Shukla Das, Mohammad Ahmad Ansari, Praveen Kumar Singh, Sajad Ahmad Dar, Neelima Gupta, Sonal Sharma, Vishnampettai Ganapathysubramanian Ramachandran, Charu Jain
Summary: T cell subsets (CD4 and CD8) are crucial in the development of chronic rhinosinusitis with nasal polyposis (CRSwNP) induced by Aspergillus flavus. The colonization of A. flavus triggers the recruitment of T cells into the nasal mucosa, leading to the progression of nasal polyps. In this study, biopsies from 50 CRSwNP patients and 50 healthy controls were analyzed. The percentage of CD3(+)CD4(+) T cells increased after A. flavus stimulation in patients compared to healthy controls. Moreover, there was a significant reduction in the expression of CD4(+)CD45RA(+) cells in patients, while CD4(+)CD45RO(+) expression increased upon A. flavus stimulation. Continuous exposure to inhaled fungal spores induces an aberrant immune response and contributes to the development of CRSwNP by promoting inflammation through CD4(+)T cell responses.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Nizar A. Khamjan, Saba Beigh, Abdullah Algaissi, Kanu Megha, Mohtashim Lohani, Majid Darraj, Nader Kamli, Faisal Madkhali, Sajad Ahmad Dar
Summary: Apart from a few vaccines, there is currently no cure for HPV infection. However, there are various medications and formulations that can be used topically to remove HPV infection at an early precancerous stage. This article provides information on both natural and synthetic options, including their potential efficacy and adverse effects.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Review
Chemistry, Multidisciplinary
Riyamol, Jeevitha Gada Chengaiyan, Sandeep Singh Rana, Faraz Ahmad, Shafiul Haque, Esra Capanoglu
Summary: This Review discusses the chemistry of pectin and the issues with traditional extraction methods. It proposes alternative green approaches for the extraction of pectin and evaluates their effectiveness and the characteristics of the extracted pectin. Further research is needed in this field to develop more efficient methods for pectin extraction.
Review
Psychology, Clinical
Lakshmi Pillai, Shayna Srivastava, Akhil Ajin, Sandeep Singh Rana, Darin Mansor Mathkor, Shafiul Haque, Murtaza M. Tambuwala, Faraz Ahmad
Summary: This article systematically reviews the impact of recent unfavorable environmental and geopolitical factors on postpartum depression. The results indicate that contemporary socio-geopolitical and environmental circumstances have a detrimental effect on the etiology and incidence of postpartum depression. A combination of socio-economic and psychological factors may contribute to a drastic increase in the incidence of postpartum depression. The article also outlines potential treatment regimens, including interpersonal psycho- and art-based therapies, which may be effective in alleviating postpartum depression symptoms.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Saif Khan, Gourav Jain, Alka Srivastava, Praveen C. Verma, Veena Pande, Rama S. Dubey, Mahvish Khan, Shafiul Haque, Saheem Ahmad
Summary: The need for alternative and environment-friendly fuels has led to the exploration of methanol as a renewable fuel. Methanol can be synthesized from waste biomass using different routes, such as through the involvement of methanotrophs or the enzyme PME. This review discusses the methodologies for utilizing biogas from waste biomass as a feedstock for methanol production and identifies areas for future research to overcome limitations.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
