Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Multisite Investigation of Strategies for the Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy

(2018) Philip E. Empey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention

(2018) Larisa H. Cavallari et al.   JACC-Cardiovascular Interventions

Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics

(2017) LM Nielsen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Biomarkers of adverse drug reactions

(2017) Daniel F Carr et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Influence of different proton pump inhibitors on the pharmacokinetics of voriconazole

(2017) Fang Qi et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty

(2017) Brian F. Gage et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The influence of combination use of CYP450 inducers on the pharmacokinetics of voriconazole: a systematic review

(2017) T.-y. Li et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

ABCB1 genotype is associated with fentanyl requirements in critically ill children

(2017) Christopher M Horvat et al.   PEDIATRIC RESEARCH

Effect of CYP2D6 polymorphisms on the pharmacokinetics of propafenone and its two main metabolites

(2017) Mohammad-Reza Rouini et al.   THERAPIE

Evidence and resources to implement pharmacogenetic knowledge for precision medicine

(2016) K. E. Caudle et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Pharmacogenomics and pharmacogenetics for the intensive care unit: a narrative review

(2016) Meghan MacKenzie et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Antithrombotic Therapy for VTE Disease

(2016) Clive Kearon et al.   CHEST

Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America

(2016) Thomas F. Patterson et al.   CLINICAL INFECTIOUS DISEASES

Zero-order metoprolol pharmacokinetics after therapeutic doses: severe toxicity and cardiogenic shock

(2016) Geoffrey K. Isbister et al.   CLINICAL TOXICOLOGY

Population Pharmacokinetics of Fentanyl in the Critically Ill*

(2016) Leena Choi et al.   CRITICAL CARE MEDICINE

Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC)

(2016) Kelly E. Caudle et al.   GENETICS IN MEDICINE

Human Genetic Variability Contributes to Postoperative Morphine Consumption

(2016) Manuela De Gregori et al.   JOURNAL OF PAIN

Reduced number of cardiovascular events and increased cost-effectiveness by genotype-guided antiplatelet therapy in patients undergoing percutaneous coronary interventions in the Netherlands

(2016) B. A. L. M. Deiman et al.   Netherlands Heart Journal

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting

(2015) LV Kalman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of the Cytochrome P450 2B6 (CYP2B6) Gene Polymorphism c.516G>T (rs3745274) on Propofol Dose Variability

(2015) Artemísia L. Mourão et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Gain-of-function single nucleotide variants of the CYP2C19 gene (CYP2C19*17) can identify subtherapeutic voriconazole concentrations in critically ill patients: a case series

(2015) Joachim D. Weigel et al.   INTENSIVE CARE MEDICINE

Classics in Chemical Neuroscience: Diazepam (Valium)

(2014) Nicholas E. Calcaterra et al.   ACS Chemical Neuroscience

OPRM1 A118G Gene Variant and Postoperative Opioid Requirement

(2014) In Cheol Hwang et al.   ANESTHESIOLOGY

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin-Induced Myopathy: 2014 Update

(2014) L B Ramsey et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for Cytochrome P450 2D6 Genotype and Codeine Therapy: 2014 Update

(2014) K R Crews et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing

(2014) K E Caudle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Association of ABCB1 Polymorphisms With the Efficacy of Ondansetron in Chemotherapy-induced Nausea and Vomiting

(2014) Hui He et al.   CLINICAL THERAPEUTICS

Serious Adverse Events Associated With Vasopressin and Norepinephrine Infusion in Septic Shock*

(2014) Nattachai Anantasit et al.   CRITICAL CARE MEDICINE

Incorporation of Pharmacogenomics into Routine Clinical Practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline Development Process

(2014) Kelly Caudle et al.   CURRENT DRUG METABOLISM

Integration of modeling and simulation to support changes to ondansetron dosing following a randomized, double-blind, placebo-, and active-controlled thorough QT study

(2014) Peiying Zuo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Effects of opioids on human serotonin transporters

(2014) M. Barann et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study

(2014) Daniel T. Barratt et al.   Pharmacogenetics and Genomics

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics

(2014) S Sadhasivam et al.   PHARMACOGENOMICS JOURNAL

Interpatient Variability in Dexmedetomidine Response: A Survey of the Literature

(2014) Samantha F. Holliday et al.   TheScientificWorldJOURNAL

Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

(2014) Lecia M. Nielsen et al.   Pain Practice

Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity

(2014) Yassine Bouatou et al.   AIDS Research and Therapy

Digging Up the Human Genome: Current Progress in Deciphering Adverse Drug Reactions

(2014) Shih-Chi Su et al.   Biomed Research International

Practice Guidelines for Postanesthetic Care

(2013) Jeffrey L. Apfelbaum et al.   ANESTHESIOLOGY

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing

(2013) S G Leckband et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C19 Genotype and Clopidogrel Therapy: 2013 Update

(2013) S A Scott et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Case-report of Unpredictable and Massive Voriconazole Intoxication in a Patient with Extensive CYP2C19 and CYP2C9 Polymorphisms

(2013) Florian Lemaitre et al.   Drug Metabolism and Pharmacokinetics

Association of the CYP2B6 c.516G>T Polymorphism with High Blood Propofol Concentrations in Women from Northern Greece

(2013) Orthodoxia Mastrogianni et al.   Drug Metabolism and Pharmacokinetics

A Randomized Trial of Genotype-Guided Dosing of Warfarin

(2013) Munir Pirmohamed et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenetic predictors of nausea and vomiting of pregnancy severity and response to antiemetic therapy: a pilot study

(2013) Amalia S Lehmann et al.   BMC Pregnancy and Childbirth

Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors

(2013) Jai Moo Shin et al.   Journal of Neurogastroenterology and Motility

Implementing Personalized Medicine: Development of a Cost-Effective Customized Pharmacogenetics Genotyping Array

(2012) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of UGT1A6, UGT2B7, and CYP2C9 Genotypes on Plasma Concentrations of Valproic Acid in Chinese Children with Epilepsy

(2012) Yingjie Guo et al.   Drug Metabolism and Pharmacokinetics

CYP2A6 genetic variation and dexmedetomidine disposition

(2012) Utkarsh Kohli et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Opioid Metabolism

(2012) Howard S. Smith   MAYO CLINIC PROCEEDINGS

CYP2D6- and CYP3A-Dependent Enantioselective Plasma Concentrations of Ondansetron in Postanesthesia Care

(2011) Ulrike M. Stamer et al.   ANESTHESIA AND ANALGESIA

CYP2C19 But Not PON1 Genetic Variants Influence Clopidogrel Pharmacokinetics, Pharmacodynamics, and Clinical Efficacy in Post–Myocardial Infarction Patients

(2011) Jean-Sébastien Hulot et al.   Circulation-Cardiovascular Interventions

Pharmacogenetics: From Bench to Byte— An Update of Guidelines

(2011) J J Swen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

(2011) Mark McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influence from genetic variability on opioid use for cancer pain: A European genetic association study of 2294 cancer pain patients

(2011) P. Klepstad et al.   PAIN

Prospective–retrospective biomarker analysis for regulatory consideration: white paper from the industry pharmacogenomics working group

(2011) Scott D Patterson et al.   PHARMACOGENOMICS

Carvedilol pharmacokinetics and pharmacodynamics in relation toCYP2D6andADRBpharmacogenetics

(2011) Daniel Sehrt et al.   PHARMACOGENOMICS

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups

(2010) N. A. Limdi et al.   BLOOD

Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison Studies

(2010) D J Angiolillo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic predisposition to adverse drug reactions in the intensive care unit

(2010) Philip E. Empey   CRITICAL CARE MEDICINE

Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone

(2010) Oliver Kummer et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population

(2010) Takeshi Ozeki et al.   HUMAN MOLECULAR GENETICS

The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery

(2010) Seyhan Yağar et al.   MOLECULAR BIOLOGY REPORTS

Common risk allele in aromatic antiepileptic-drug induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Han Chinese

(2010) Shuen-Iu Hung et al.   PHARMACOGENOMICS

Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype

(2009) Ina Scholz et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents

(2009) Roger J. M. Brüggemann et al.   CLINICAL INFECTIOUS DISEASES

Transporter Pharmacogenetics and Statin Toxicity

(2009) M Niemi   CLINICAL PHARMACOLOGY & THERAPEUTICS

Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning

(2009) Alexander H. Schmidt et al.   HUMAN IMMUNOLOGY

Effects of the CYP2D6 Gene Duplication on the Pharmacokinetics and Pharmacodynamics of Tramadol

(2009) Julia Kirchheiner et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects

(2009) Deepak Voora et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adverse drug reactions in medical intensive care unit of a tertiary care hospital

(2009) Lisha Joshua et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers

(2009) Jörn Lötsch et al.   Pharmacogenetics and Genomics

Respiratory Depression with Tramadol in a Patient with Renal Impairment and CYP2D6 Gene Duplication

(2008) Ulrike M. Stamer et al.   ANESTHESIA AND ANALGESIA

Antifungal Therapeutic Drug Monitoring: Established and Emerging Indications

(2008) D. Andes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic variation and response to morphine in cancer patients

(2008) Joy R. Ross et al.   CANCER

Propafenone for the Prevention of Atrial Tachyarrhythmias After Cardiac Surgery: A Randomized, Double-blind Placebo-controlled Trial

(2008) K Mörike et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of the CYP2D6 Genotype on the Clinical Effects of Metoprolol: A Prospective Longitudinal Study

(2008) T Rau et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction

(2008) Ksenia Goryachkina et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank

(2008) Shu-Hui Wen et al.   HUMAN IMMUNOLOGY

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Genetic variability of the μ-opioid receptor influences intrathecal fentanyl analgesia requirements in laboring women☆

(2008) Ruth Landau et al.   PAIN

Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy

(2008) Philippe Couvert et al.   PHARMACOGENOMICS

Voriconazole Therapeutic Drug Monitoring in Patients with Invasive Mycoses Improves Efficacy and Safety Outcomes

(2007) A. Pascual et al.   CLINICAL INFECTIOUS DISEASES