Article
Biochemistry & Molecular Biology
Mio Fukuda, Yo Tojo, Ami Sato, Hiroko Saito, Akira Nakanishi, Yoshio Miki
Summary: Germline mutations in the BRCA2 gene are associated with hereditary breast cancer, with BRCA2 playing a role in DNA damage repair during the S phase of the cell cycle. The exact mechanism of BRCA2 in estrogen induction remains unclear.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Brendan Zotter, Or Dagan, Jacob Brady, Hasna Baloui, Jayshree Samanta, James L. Salzer
Summary: Peripheral nerves are organized into compartments and Gli1 is a crucial transcriptional effector involved in nerve development, regulation of extracellular matrix production, and nerve vascular organization. Gli1 and Dhh have nonredundant roles in peripheral nerve development.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Lennart J. van Winden, Maik Kok, Manon Acda, Vincent Dezentje, Sabine Linn, Run-Zhang Shi, Huub H. van Rossum
Summary: The study validated a method for quantitation of serum estradiol and estrone, demonstrating superior sensitivity for E2 analysis compared to immunoassay. Differences in E2 quantitation between the two methods were highlighted, especially among post-menopausal women.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Clinical Neurology
Aiko Okuma, Tomohiko Nakamura, Masahisa Katsuno, Tadashi Matsushita
Summary: This study examined the relationship between the immature development of the myelin sheath in children and the occurrence of bimodal waveforms in sensory nerve conduction studies. The findings showed that the frequency of bimodal waveforms and interpeak latency decreased with age, indicating that the bimodal waveform is present until the age of 15-16 years. This suggests that the underlying cause of the bimodal waveform is an immature myelin sheath.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Oncology
Yongbin Ma, Chuan Wei, Xin Qi, Yanan Pu, Liyang Dong, Lei Xu, Sha Zhou, Jifeng Zhu, Xiaojun Chen, Xuefeng Wang, Chuan Su
Summary: Peripheral nerve injury is a global disease affecting millions of people annually, and finding ways to promote nerve repair is crucial. Research has shown that the schistosome-derived molecule SJMHE1 can promote peripheral myelin growth and regeneration through a macrophage-dependent mechanism, highlighting its therapeutic potential for improving peripheral nerve repair.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Peng Yu, Guanhua Zhang, Bo Hou, Enpeng Song, Jiaming Wen, Yueyang Ba, Donglin Zhu, Gangwei Wang, Feng Qin
Summary: Complete myelination and formation of myelinated fibers are essential for functional nerve regeneration after peripheral nerve injury. Suboptimal myelin regeneration is common and can hinder ideal nerve regeneration. Therefore, closely monitoring and supporting myelin regeneration in patients with PNI is important for optimal outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicole Petersen, Andrea J. Rapkin, Kyoji Okita, Kaitlin R. Kinney, Tomi Mizuno, Mark A. Mandelkern, Edythe D. London
Summary: Research on 16 women aged 23-45 found no significant difference in dopamine D-2-type receptor availability in the striatum subregions during high-estrogen vs. low-estrogen phases of the menstrual cycle, suggesting that circulating estrogen levels do not affect dopamine D-2-type receptor availability in the human striatum.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Anton Borger, Sarah Stadlmayr, Maximilian Haertinger, Lorenz Semmler, Paul Supper, Flavia Millesi, Christine Radtke
Summary: miRNAs play a crucial role in peripheral nerve injuries by regulating specific pathways and proteins, which is essential for understanding the molecular mechanisms of nerve regeneration and providing targets for precision medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Atsuhiko Okura, Koichi Inoue, Eisuke Sakuma, Hiroshi Takase, Takatoshi Ueki, Mitsuhito Mase
Summary: Schwann cells are crucial for peripheral myelination and the activation of the SGK1 signaling pathway plays a significant role in determining cell fate during nerve injury and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Environmental Sciences
Shengwei Zhang, Jing Li, Yanxia Li, Linshu Jiang, Yan Zhao, Xiaoman Jiang, Xuelian Zhang, Wenzhuo Shi
Summary: This study investigated the assimilation behaviors of conjugated steroid estrogens (CSEs) in wheat plants and their impact on plant growth and transpiration. The results showed that wheat can absorb CSEs, with higher assimilation in the roots compared to the shoots. However, the metabolic activity in the shoots limits the transfer of CSEs from roots to shoots. Additionally, CSEs have oxidative damage effects on wheat tissues, leading to wilting and reduced transpiration. Further research is needed to understand the cumulative impact of environmental estrogen contaminants and develop strategies to mitigate their contamination in agriculture.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Cardiac & Cardiovascular Systems
Zahra Hajializadeh, Mohammad Khaksari
Summary: Cardiac hypertrophy (CH) is a major cause of morbidity and mortality worldwide, leading to heart failure. Sex differences in CH may be caused by sex hormones or their receptors, with the incidence increasing in postmenopausal women due to the decrease in female sex hormone 17-beta estradiol (E2). E2 and its receptors inhibit CH, while Silent information regulator 1 (SIRT1) plays a crucial role in biological processes and has a protective effect against CH.
HEART FAILURE REVIEWS
(2022)
Article
Agriculture, Dairy & Animal Science
Sihai Lu, Yaju Tang, Ru Yao, Rui Xu, Hui Zhang, Jie Liu, Yan Gao, Qiang Wei, Xiaoe Zhao, Jianpeng Liu, Bin Han, Meng-Hao Pan, Baohua Ma
Summary: This study suggests that FSH mediates meiotic arrest of oocytes in goat follicles through the promotion of 17-beta-estradiol synthesis and the expression of ER beta. Additionally, the E-2/ER signaling pathway prevents meiotic recovery of oocytes by inhibiting NPR2 expression and cGMP synthesis.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Geriatrics & Gerontology
Xiuting Xiang, LiangZhen Xie, Jieqi Lin, Rahmawati Pare, Guanshen Huang, Jianming Huang, Yuyan Wang, Shicong Song, Yunjun Ruan
Summary: Atherosclerosis, a major cause of cardiovascular diseases, is mainly caused by vascular endothelial cell (VECs) senescence. It has been shown that 17 beta-estradiol (17 beta-E-2) can protect VECs from senescence by activating autophagy, but the underlying mechanism is still unclear. This study aims to investigate the role of estrogen receptor (ER) alpha and beta in the effects of 17 beta-E-2 on vascular autophagy and aging using in vitro and in vivo models.
Article
Biochemistry & Molecular Biology
Yanhui Zhao, Yanan Wu, Jie Wang, Chongshan Liao, Xiaohui Mi, Fengshan Chen
Summary: The study revealed that Dbp promotes rat calvarial osteoprogenitors osteogenic differentiation through the Kiss1/GnRH/E2 signaling pathway loop. Dbp overexpression increased the expression of osteogenic-related genes and calcium nodule formation, while Dbp knockdown had the opposite effects.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Phu Duong, Ki H. Ma, Raghu Ramesh, John J. Moran, Seongsik Won, John Svaren
Summary: The study indicates that H3K27 demethylation is not necessary for the induction of injury response genes in Schwann cells, suggesting other mechanisms may be involved in activating Polycomb-repressed injury genes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Neurosciences
Tuo Yang, YuJuan Dai, Gang Chen, ShuSen Cui
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Neurosciences
Lingyan Xing, Yunyun Cai, Tuo Yang, Weiwei Yu, Mengdie Gao, Rui Chai, Sujun Ding, Jinhuan Wei, Jingying Pan, Gang Chen
Summary: RNA methylation plays a dynamic and conserved role in spinal cord regeneration following injury, with differential m6A-tagged genes showing hypomethylation and upregulated transcription levels, indicating a potential contribution to the regeneration process.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Neurosciences
Yunyun Cai, Lingyan Xing, Tuo Yang, Rui Chai, Jiaqi Wang, Jingyin Bao, Weixing Shen, Sujun Ding, Gang Chen
Summary: Dopamine, a critical neurotransmitter in both the central and peripheral nervous systems, plays important roles in various biological processes. Dysfunction in dopaminergic signaling may lead to developmental disorders, yet the exact roles in these diseases are not fully understood. Analyzing current research in this area can provide guidance for future studies.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Yu WeiWei, Fei WenDi, Cui Mengru, Yang Tuo, Gang Chen
Summary: The rostral ventromedial medulla (RVM) plays a crucial role in chronic pain, but its specific role remains unclear, presenting challenges for drug development targeting this area.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Immunology
Jinhuan Wei, Wenfeng Su, Yayu Zhao, Zhongya Wei, Yuchen Hua, Peng Xue, Xiang Zhu, Ying Chen, Gang Chen
Summary: Application of MaR1 to mice with peripheral nerve injury significantly promoted nerve regeneration and alleviated neuropathic pain, suggesting that MaR1 is a promising therapeutic agent for treating peripheral nerve injury.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell & Tissue Engineering
WenDi Fei, JunLin Wu, MengDie Gao, Qian Wang, Ya Yu Zhao, ChunLi Shan, Yu Shen, Gang Chen
Summary: The study demonstrated that Muse cells can alleviate scratching symptoms, reduce epidermal inflammation, and promote wound healing in a mouse model of atopic dermatitis. Additionally, Muse cells showed anti-inflammatory effects on human HaCat cells and promoted keratinocyte proliferation and wound healing.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Bin Zhang, Wenfeng Su, Junxia Hu, Jinghui Xu, Parizat Askar, Shuangxi Bao, Songlin Zhou, Gang Chen, Yun Gu
Summary: Enhancing remyelination after injury is crucial for nerve function recovery. This study reveals the importance of Sin3A and other transcription factors and chromatin regulators in the process of myelination by Schwann cells (SCs). Sin3A affects SC migration, differentiation, and proliferation, as well as the remyelination of regenerating axons. These findings provide insights for developing new treatments to enhance remyelination and nerve regeneration.
NEUROSCIENCE BULLETIN
(2022)
Article
Multidisciplinary Sciences
Jinhuan Wei, Rui Shang, Jiaqi Wang, Shengze Zhu, JianQiang Yin, Ying Chen, Yayu Zhao, Gang Chen
Summary: This study investigated the use of ACE2-MSCs for COVID-19 treatment. The results showed that ACE2-MSCs were more effective in reducing inflammatory factors and pyroptosis factors compared to using MSCs or rh-ACE2 alone, and they alleviated lung injury.
Article
Multidisciplinary Sciences
Long Zhao, Hao Luo, Yu Ma, Shengze Zhu, Yongjiang Wu, Muxing Lu, Xiaojun Yao, Xin Liu, Gang Chen
Summary: The lack of effective and safe analgesics for chronic pain management has long been a health issue. Analgesic peptides, without opioid-related adverse effects, have recently shown promise for pain treatment. This study discovers that the peptide H-20 binds to PD-1, reduces nociceptive signals, and displays effective analgesia in preclinical pain models, making it a promising candidate drug for chronic pain treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Biochemistry & Molecular Biology
Lingyan Xing, Rui Chai, Jiaqi Wang, Jiaqi Lin, Hanyang Li, Yueqi Wang, Biqin Lai, Junjie Sun, Gang Chen
Summary: Using single-cell RNA sequencing, this study reveals the heterogeneity of pMN progenitors in zebrafish, with distinct fates and molecular signatures. Two different motor neuron lineages are characterized, and the critical roles of myt1 and lbr in neural progenitor fate transition are validated.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Anesthesiology
JingYing Pan, YaYu Zhao, Rui Sang, RiYun Yang, JingYin Bao, YongJiang Wu, Ying Fei, Jian Wu, Gang Chen
Summary: It was discovered that HAP1 deficiency can suppress mechanical allodynia and hyperalgesia, reduce neuronal excitability, and inhibit neuroinflammation, suggesting its significant role in the pathogenesis of neuropathic pain in Huntington disease.
Review
Clinical Neurology
Long Zhao, Yu Ma, Xiaofei Song, Yongjiang Wu, Pengjie Jin, Gang Chen
Summary: Chronic pain is a common health problem that can be effectively managed by targeting the PD-1 pathway. PD-1 agonists have the potential to modulate neuronal excitability and attenuate pain with minimal opioid-related adverse effects.
Article
Cell Biology
Zhong-Ya Wei, Hui-Lin Qu, Yu-Juan Dai, Qian Wang, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Wei-Xing Shen, Gang Chen
Summary: Pannexin 1 (Panx 1) is a large-pore membrane channel highly permeable to ATP and other signaling molecules. Studies have shown its expression in the nervous system, but its distribution and function in the peripheral nervous system remains unclear. Blocking Panx 1 function pharmacologically or with RNA interference has been shown to reduce ATP release in Schwann cells, suggesting a role in regulating RhoA and cytoskeleton for ATP release.
NEURAL REGENERATION RESEARCH
(2021)