Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

Tescalcin/c-Src/IGF1Rβ-mediated STAT3 activation enhances cancer stemness and radioresistant properties through ALDH1

(2018) Jei Ha Lee et al.   Scientific Reports

Drug Repurposing Screening Identifies Tioconazole as an ATG4 Inhibitor that Suppresses Autophagy and Sensitizes Cancer Cells to Chemotherapy

(2018) Pei-Feng Liu et al.   Theranostics

Drug Resistance Driven by Cancer Stem Cells and Their Niche

(2017) Marta Prieto-Vila et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling

(2017) Wan-Chi Tsai et al.   Oncotarget

Network Modularity in Breast Cancer Molecular Subtypes

(2017) Sergio Antonio Alcalá-Corona et al.   Frontiers in Physiology

Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530

(2016) Mariko Morii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer

(2016) Sameerah Shaheen et al.   Stem Cell Reviews and Reports

Triple negative breast cancer: shedding light onto the role of pi3k/akt/mtor pathway

(2016) Daniela Massihnia et al.   Oncotarget

Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer

(2016) Sameerah Shaheen et al.   Stem Cell Reviews and Reports

Tyrosine Phosphorylation of Caspase-8 Abrogates Its Apoptotic Activity and Promotes Activation of c-Src

(2016) Jennifer LY Tsang et al.   PLoS One

A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins

(2015) Adriaan H. de Wilde et al.   JOURNAL OF VIROLOGY

Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy

(2015) Feixiong Cheng et al.   Oncotarget

Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal cancer

(2014) Scott Kopetz et al.   BMC CANCER

RIG-I Modulates Src-Mediated AKT Activation to Restrain Leukemic Stemness

(2014) Xian-Yang Li et al.   MOLECULAR CELL

Measures of Outcome in Metastatic Breast Cancer: Insights From a Real-World Scenario

(2014) M. Bonotto et al.   ONCOLOGIST

Applications of RNA interference high-throughput screening technology in cancer biology and virology

(2014) Shan Gao et al.   Protein & Cell

SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma

(2014) Jung-Chen Su et al.   NEOPLASIA

Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention

(2014) Ailian Xiong et al.   Cancers

Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells

(2013) Zhiqiang Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells

(2013) J G van Oosterwijk et al.   BRITISH JOURNAL OF CANCER

Molecular Pathways: ROS1 Fusion Proteins in Cancer

(2013) K. D. Davies et al.   CLINICAL CANCER RESEARCH

Histone deacetylase 4 mediates SMAD family member 4 deacetylation and induces 5-fluorouracil resistance in breast cancer cells

(2013) SEONG-LAN YU et al.   ONCOLOGY REPORTS

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

(2013) S. Loi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Data-Driven Modeling of Src Control on the Mitochondrial Pathway of Apoptosis: Implication for Anticancer Therapy Optimization

(2013) Annabelle Ballesta et al.   PLoS Computational Biology

Rapamycin Resistance Is Linked to Defective Regulation of Skp2

(2012) H. Totary-Jain et al.   CANCER RESEARCH

Metformin targets Stat3 to inhibit cell growth and induce apoptosis in triple-negative breast cancers

(2012) Xin-Sheng Deng et al.   CELL CYCLE

Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik

(2012) J Lopez et al.   CELL DEATH AND DIFFERENTIATION

Definition and Impact of Pathologic Complete Response on Prognosis After Neoadjuvant Chemotherapy in Various Intrinsic Breast Cancer Subtypes

(2012) Gunter von Minckwitz et al.   JOURNAL OF CLINICAL ONCOLOGY

The role of BRAF V600 mutation in melanoma

(2012) Paolo A Ascierto et al.   Journal of Translational Medicine

Prognostic significance of STAT3 expression and its correlation with chemoresistance of non-small cell lung cancer cells

(2011) Zhenjie Yin et al.   ACTA HISTOCHEMICA

Src: a potential target for the treatment of triple-negative breast cancer

(2011) D. Tryfonopoulos et al.   ANNALS OF ONCOLOGY

Targeting Src family kinases in anti-cancer therapies: turning promise into triumph

(2011) Siyuan Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

(2010) David O Azorsa et al.   BMC GENOMICS

Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

(2010) F. Hochgrafe et al.   CANCER RESEARCH

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas

(2009) K. Hu et al.   MOLECULAR CANCER THERAPEUTICS

The multifaceted roles of the receptor tyrosine kinase ROS in development and cancer

(2008) Jaime Acquaviva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER