Article
Nutrition & Dietetics
Sebastian Andone, Lenard Farczadi, Silvia Imre, Zoltan Bajko, Anca Motataianu, Smaranda Maier, Laura Barcutean, Rodica Balasa
Summary: Stroke prevention is crucial and can be achieved by addressing risk factors, particularly modifiable lifestyle factors. Our study investigated the relationship between ischemic-stroke risk factors and fatty acids in 274 patients using a prospective observational study. We found that age, sex, smoking, atrial fibrillation, dyslipidemia, and previous stroke history were directly related to fatty acids. Smoking had the most significant negative impact, while dyslipidemia and atrial fibrillation had a positive correlation, particularly in female patients and those with recurrent strokes. Better management of risk factors could improve fatty-acid profiles and the balance of Omega-3 and Omega-6 in ischemic stroke patients.
Article
Nutrition & Dietetics
Talat Bashir Ahmed, Merete Eggesbo, Rachel Criswell, Olaf Uhl, Hans Demmelmair, Berthold Koletzko
Summary: This study aimed to investigate the relationship between fatty acid (FA) and polar lipid species composition in human milk. The results showed that there were no differences in major FA, phosphatidylcholine, or sphingomyelin species percentages between milk with high or low fat content. However, milk with high fat content had lower ratios of phospholipid-to-total-FA and sphingomyelin-to-phosphatidylcholine compared to milk with low fat content.
Article
Multidisciplinary Sciences
Marumi Ohno, Siddabasave Gowda B. Gowda, Toshiki Sekiya, Naoki Nomura, Masashi Shingai, Shu-Ping Hui, Hiroshi Kida
Summary: This study elucidated the impact of influenza virus infection on lipid metabolism by measuring the lipid profiles of mice infected with different doses of the virus. The most prominent feature of the lipid profile in lethally infected mice was the elevated concentrations of phosphatidylethanolamines (PEs) containing polyunsaturated fatty acid (PUFA). The facilitation of PUFA-containing phospholipid production in the lungs, but not in the liver, was suggested by gene expression and lipidomic analysis. These findings have important implications for understanding the severity of infectious diseases and developing therapeutic interventions.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Alexander Morin, Benoit Mouzon, Scott Ferguson, Daniel Paris, Nicole Saltiel, Mackenzie Browning, Mike Mullan, Fiona Crawford
Summary: The study investigated the efficacy of delayed treatment with an anti-inflammatory compound anatabine in two different r-mTBI models, showing that delayed treatment can reduce astrogliosis and improve cognitive function, with treatment outcomes influenced by the heterogeneity of r-mTBI. The findings suggest that the diversity of r-mTBI may impact treatment effectiveness in clinical populations.
SCIENTIFIC REPORTS
(2021)
Article
Agriculture, Dairy & Animal Science
My Tuyen T. Nguyen, Jieun Kim, Nari Seo, A. Hyun Lee, Yong-Ki Kim, Ji A. Jung, Dan Li, Xuan Hong M. To, Khanh Trang N. Huynh, Thanh Van Le, Beenish Israr, Anum Nazir, Jung-A Seo, Daum Lee, Hyun Joo An, Jaehan Kim
Summary: The study found significant differences in human milk fatty acid compositions among different Asian countries, with Pakistani breast milk having high saturated fat content and low unsaturated fatty acids, indicating the need for DHA supplementation in infants. Additionally, the average DHA: ARA ratio in Asian human milk was 1.01.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Respiratory System
Leonardo Terranova, Patrizia Rise, Andrea Gramegna, Christian Pinna, Carlo Agostoni, Marie-Louise Syren, Stefano Turolo, Paola Marchisio, Francesco Amati, Stefano Aliberti, Angelo Sala, Francesco Blasi
Summary: The study found that pro-inflammatory mediators derived from arachidonic acid metabolism in sputum of bronchiectasis patients were positively associated with neutrophil elastase, Pseudomonas aeruginosa identifications, and radiological gravity index. On the other hand, pro-resolution mediators derived from docosahexaenoic acid were associated with better health status, showing an inverse correlation with radiological gravity index, bacterial infections, and sputum volume production.
RESPIRATORY RESEARCH
(2022)
Article
Nutrition & Dietetics
Kaylee Hahn, Joseph R. Hardimon, Doug Caskey, Douglas A. Jost, Patrick J. Roady, J. Thomas Brenna, Ryan N. Dilger
Summary: The study found that the use of sodium and potassium salts of arachidonic acid was bioequivalent to triglyceride form in terms of ARA accretion in the brain and retinal tissue of young pigs. The experimental diets did not significantly affect growth performance, liver histology, or hematological outcomes compared to the control diet.
Article
Agriculture, Multidisciplinary
Xiao-Yu Cui, Shan Jiang, Cheng-Cheng Wang, Jin-Yue Yang, Ying-Cai Zhao, Chang-Hu Xue, Yu-Ming Wang, Tian-Tian Zhang
Summary: The study demonstrated that EPA-PC, EPA-LPC, and DHA-LPC have different effects on DHA or EPA recovery and supplementation efficiency in different tissues, providing important references for understanding the time course of DHA or EPA recovery in phospholipid molecular species in different tissues.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Nutrition & Dietetics
Belal N. Alshaikh, Adriana Reyes Loredo, Kamran Yusuf, Ahmed Maarouf, Tanis R. Fenton, Sarfaraz Momin
Summary: Supplementation of DHA alone may increase the risk of necrotizing enterocolitis in preterm infants, while concurrent supplementation of ARA may help reduce the incidence of this disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Sarah E. Hancock, Michael G. Friedrich, Todd W. Mitchell, Roger J. W. Truscott, Paul L. Else
Summary: This study examined the changes in phospholipid composition in the mitochondrial and microsomal membranes of the human cerebellum and motor cortex with age, comparing the results with previous analyses of other brain regions.
Article
Nutrition & Dietetics
Isabelle Demonty, Kellie Langlois, Linda S. Greene-Finestone, Rana Zoka, Loan Nguyen
Summary: The study found that nearly 40% of Canadians have undesirable Omega-3 Index (OI), with factors such as fish intake, Omega-3 supplement use, and race being most strongly associated with undesirable OI scores. The prevalence of undesirable OI was significantly higher in certain subgroups.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Welma Stonehouse, Bianca Benassi-Evans, Jana Bednarz, Andrew D. Vincent, Stephen Hall, Catherine L. Hill
Summary: This study showed that a commercially available krill oil supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. The supplement is safe to consume.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Biology
Emilio Herrera, Henar Ortega-Senovilla
Summary: There are limitations for animals to modify fatty acid changes, including their roles in inflammatory mediators synthesis as well as gene expression regulation. LCPUFAs are susceptible to autoxidation, prevented by antioxidants and enzymes. Fetus acquires essential fatty acids and LCPUFAs from the mother, with a release of LCPUFAs from maternal adipose tissue during late pregnancy, and their uptake by maternal liver for circulation and transfer to the fetus.
Review
Chemistry, Medicinal
Ines Ferreira, Amelia P. Rauter, Narcisa M. Bandarra
Summary: Alzheimer's disease is a complex and progressive disease with no cure yet, but there are compounds that can decrease symptoms. The valorization of natural marine sources, particularly docosahexaenoic acid (DHA), has shown to be effective in reducing Alzheimer's symptoms. Fisheries and aquaculture by-products, which are rich in DHA and DHA-rich phospholipids, should also be considered for sustainable future.
Review
Nutrition & Dietetics
Clemens von Schacky
Summary: The structure and function of the brain rely on a sufficient supply of EPA and DHA through the bloodstream. Lower Omega-3 Index levels are associated with increased risks, highlighting the importance of adequate intake of these essential fatty acids for optimal brain health.
Article
Clinical Neurology
Joseph O. Ojo, Benoit Mouzon, Moustafa Algamal, Paige Leary, Cillian Lynch, Laila Abdullah, James Evans, Michael Mullan, Corbin Bachmeier, William Stewart, Fiona Crawford
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2016)
Article
Biochemistry & Molecular Biology
Moustafa Algamal, Rashik Ahmed, Naeimeh Jafari, Bilal Ahsan, Joaquin Ortega, Giuseppe Melacini
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Neurosciences
Benoit Mouzon, Nicole Saltiel, Scott Ferguson, Joseph Ojo, Carlyn Lungmus, Cillian Lynch, Moustafa Algamal, Alexander Morin, Benjamin Carper, Gayle Bieler, Elliott J. Mufson, William Stewart, Michael Mullan, Fiona Crawford
Article
Behavioral Sciences
Moustafa Algamal, Joseph O. Ojo, Carlyn P. Lungmus, Phillip Muza, Constance Cammarata, Margaret J. Owens, Benoit C. Mouzono, David M. Diamond, Michael Mullan, Fiona Crawford
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2018)
Article
Clinical Neurology
Joseph O. Ojo, Paige Leary, Caryln Lungmus, Moustafa Algamal, Benoit Mouzon, Corbin Bachmeier, Michael Mullan, William Stewart, Fiona Crawford
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2018)
Article
Geriatrics & Gerontology
Joseph O. Ojo, Gogce Crynen, Jon M. Reed, Rosa Ajoy, Prashanthi Vallabhaneni, Moustafa Algamal, Paige Leary, Naomi G. Rafi, Benoit Mouzon, Michael Mullan, Fiona Crawford
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Article
Neurosciences
Joseph O. Ojo, Moustafa Algamal, Paige Leary, Laila Abdullah, Benoit Mouzon, James E. Evans, Michael Mullan, Fiona Crawford
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Critical Care Medicine
Moustafa Algamal, Nicole Saltiel, Andrew J. Pearson, Bryan Ager, Ioana Burca, Benoit Mouzon, David M. Diamond, Michael Mullan, Joseph O. Ojo, Fiona Crawford
JOURNAL OF NEUROTRAUMA
(2019)
Article
Neurosciences
Phillip Muza, Corbin Bachmeier, Benoit Mouzon, Moustafa Algamal, Naomi G. Rafi, Carlyn Lungmus, Laila Abdullah, James E. Evans, Scott Ferguson, Michael Mullan, Fiona Crawford, Joseph O. Ojo
Article
Clinical Neurology
Andrew Pearson, Rosa Ajoy, Gogce Crynen, Jon M. Reed, Moustafa Algamal, Michael Mullan, Dushyant Purohit, Fiona Crawford, Joseph O. Ojo
Article
Endocrinology & Metabolism
Cillian E. Lynch, Maxwell Eisenbaum, Moustafa Algamal, Matilde Balbi, Scott Ferguson, Benoit Mouzon, Nicole Saltiel, Joseph Ojo, Ramon Diaz-Arrastia, Mike Mullan, Fiona Crawford, Corbin Bachmeier
Summary: Research indicates that decreased cerebrovascular responsiveness may lead to cognitive impairment in chronic r-mTBI mouse models, with CVR being a valid preclinical measure of TCVI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Moustafa Algamal, Andrew J. Pearson, Coral Hahn-Townsend, Ioana Burca, Michael Mullan, Fiona Crawford, Joseph O. Ojo
Summary: This study assessed the impact of chronic stress on HPA axis function and fear memory deficits in a mouse model, finding that mice exposed to chronic stress exhibited exaggerated fear memory recall and weakened HPA axis functionality. Neuroendocrinal testing suggested that alterations in adrenal MC2 receptor reactivity may be related to the attenuated stress response in the model.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biology
Moustafa Algamal, Alyssa N. N. Russ, Morgan R. R. Miller, Steven S. S. Hou, Megi Maci, Leon P. P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. J. Bacskai, Ksenia V. V. Kastanenka
Summary: This study used in vivo calcium imaging with multiphoton microscopy to compare the activity of excitatory and inhibitory interneurons in APP/PS1 and control mice. The results showed that inhibitory interneurons were hyperactive in APP/PS1 mice, while excitatory neuron activity was decreased. These findings highlight the complexity of neuron-specific deficits in Alzheimer's disease.
COMMUNICATIONS BIOLOGY
(2022)
Article
Neurosciences
Joseph O. Ojo, Gogce Crynen, Moustafa Algamal, Prashanti Vallabhaneni, Paige Leary, Benoit Mouzon, Jon M. Reed, Michael Mullan, Fiona Crawford