Review
Oncology
Qian Bai, Zhenjie Pan, Ghulam Nabi, Farooq Rashid, Yang Liu, Suliman Khan
Summary: Thyroid cancer is the most common endocrine malignancy, and non-coding RNAs play important roles in its development. Competing endogenous RNA is a mechanism of regulatory interactions, and multiple ceRNA networks are deregulated in thyroid cancer development, metastasis, and drug resistance. Further research on these deregulations is needed for early detection and effective treatment of thyroid cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Psychiatry
Rongjie Li, Qiaoye Wang, Yufen Qiu, Youshi Meng, Lei Wei, Hao Wang, Ruikang Mo, Donghua Zou, Chunbin Liu
Summary: This study investigated the relationship among ceRNA, autophagy, and Schizophrenia by analyzing gene expression profiles of SZ patients. Enrichment analysis revealed associations with cellular responses to oxygen concentration and pathways such as ErbB, AMPK, and mTOR signaling. The study also constructed an autophagy-related ceRNA network and found high diagnostic efficiency of miRNA in SZ, particularly hsa-miR-423-5p and hsa-miR-4532.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Natalia Gil-Jaramillo, Andres Felipe Aristizabal-Pachon, Maria Alejandra Luque Aleman, Valentina Gonzalez Gomez, Hans Deyvy Escobar Hurtado, Laura Camila Giron Pinto, Juan Sebastian Jaime Camacho, Alexis Felipe Rojas-Cruz, Yeimy Gonzalez-Giraldo, Andres Pinzon, Janneth Gonzalez
Summary: Neurodegenerative diseases (NDs) are characterized by progressive deterioration of neuronal function, leading to motor and cognitive damage in patients. This study presents a comprehensive competing endogenous RNA (ceRNA) network to explore the key regulatory mechanisms related to NDs, using transcriptomic data and experimentally validated non-coding RNA (ncRNA) interactions. The findings provide insights into the pathogenesis of NDs and potential targets for diagnostic molecules and pharmacologic treatments.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Bo Chen, Ying Deng, Bo Wang, Zhongyi Tian, Jindong Tong, Bo Yu, Weijun Shi, Jingdong Tang
Summary: Thromboangiitis obliterans (TAO) is a vascular inflammatory disease, and this study identified differentially expressed lncRNAs and miRNAs in TAO patients. A ceRNA network associated with TAO was constructed, revealing a potential regulatory network involving NEAT1/miR-1-3p/GNA12 signaling in TAO progression. Dual luciferase reporter assays confirmed the interaction between NEAT1, miR-1-3p, and GNA12.
Review
Neurosciences
Mohammad Reza Asadi, Samin Abed, Ghazal Kouchakali, Fateme Fattahi, Hani Sabaie, Marziyeh Sadat Moslehian, Mirmohsen Sharifi-Bonab, Bashdar Mahmud Hussen, Mohammad Taheri, Soudeh Ghafouri-Fard, Maryam Rezazadeh
Summary: Parkinson's disease (PD) is a unique clinical syndrome with multiple causes and clinical manifestations. Research on ceRNA axes is increasing, highlighting their importance in PD. Understanding these axes may help elucidate the causes of PD and provide innovative therapeutic targets.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Oncology
Soudeh Ghafouri-Fard, Arash Safarzadeh, Bashdar Mahmud Hussen, Mehdi Akhavan-Bahabadi, Mohammad Taheri, Guive Sharifi
Summary: This study constructed putative ceRNA networks based on expression profiles of GBM tissues and identified differentially expressed mRNAs, lncRNAs, and miRNAs, as well as 10 hub genes in the ceRNA network. This provides novel insights into molecular events during GBM pathogenesis and potential therapeutic targets for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Yang Liu, Suliman Khan, Lin Li, Timo L. M. ten Hagen, Mojtaba Falahati
Summary: Thyroid cancer is the most common malignancy of the endocrine system, with recent research suggesting a significant role of non-coding RNAs in its progression, particularly in the competitive endogenous RNA networks. Understanding these mechanisms could lead to early diagnosis of thyroid cancer patients and the discovery of effective therapeutic targets.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Kun Du, Xue Bai, Li Chen, Yu Shi, Hao-ding Wang, Ming-cheng Cai, Wen-qiang Sun, Jie Wang, Shi-yi Chen, Xian-bo Jia, Song-jia Lai
Summary: This study revealed the ceRNA networks during BAT whitening in rabbits, providing new insights into BAT-based obesity treatments.
Article
Multidisciplinary Sciences
Dulari K. Jayarathna, Miguel E. Renteria, Jyotsna Batra, Neha S. Gandhi
Summary: This study identified stage-specific competing endogenous RNAs (ceRNAs) in breast cancer using cancer genome atlas data and investigated their molecular functions and prognostic ability. Five genes and one long non-coding RNA were found to be unique to the stage IV ceRNA network, and these genes have been described in previous breast cancer studies. Survival analysis identified prognostic microRNAs in stages I, II, and III. These findings reveal a set of unique ceRNAs in metastatic breast cancer, and further experimental work is needed to evaluate their role in metastasis. Identifying stage-specific ceRNAs will also contribute to the understanding of personalized therapeutics in breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Yanjie Zhao, Heng Zhang, Qiang Ju, Xinmei Li, Yuxin Zheng
Summary: This study identified hundreds of RNAs related to the survival time of gastric cancer patients and constructed a survival-related network comprising lncRNAs, miRNAs, and mRNAs. Eight RNAs associated with prognosis were used to build prognostic prediction models.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Zijun Xiao, Shanshan Wei, Jie Huang, Jiaqin Liu, Jian Liu, Bikui Zhang, Wenqun Li
Summary: This study systematically investigated alterations in the expression levels of ncRNAs in a DIC mouse model through deep RNA sequencing, identifying aberrantly expressed lncRNAs, circRNAs, miRNAs, and mRNAs. Comprehensive ceRNA networks were constructed and functional enrichment analyses were performed for differentially expressed genes.
DNA AND CELL BIOLOGY
(2022)
Article
Oncology
Saihua Chen, Guanjun Ju, Jianmei Gu, Minxin Shi, Yilang Wang, Xiaodan Wu, Qing Wang, Liyun Zheng, Ting Xiao, Yihui Fan
Summary: This study identified potential biomarkers related to ESCA progression by analyzing lncRNAs, miRNAs, and mRNA expression profiles, and constructed a ceRNA network containing 5 DEmiRNAs, 582 DEmRNAs, and 764 DElncRNAs. Survival analysis revealed 39 genes significantly associated with overall survival in patients with EC.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Xiao-Jun Wang, Jing Gao, Qin Yu, Min Zhang, Wei-Dong Hu
Summary: This study integrated multi-omics profiles to elucidate ceRNA characteristics, pathways, and drug candidates in SCLC, identifying downregulated mRNAs (CSF3R/GAA), lncRNAs (AC005005.4-201/DLX6-AS1-201/NEAT1-203), circRNAs (hsa_HLA-B_1/hsa_VEGFC_8), and upregulated miRNAs (hsa-miR-4525/hsa-miR-6747-3p) as part of the ceRNA regulatory networks. Further analysis revealed potential therapeutic targets like CSF3R and GAA, involved in autophagy and glucose metabolism pathways, respectively.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Median Zhao, Jianguo Feng, Liling Tang
Summary: CeRNAs can regulate biological processes through complex networks, potentially leading to cancer when imbalanced; Dysregulated RNAs in lung cancer may serve as ceRNAs to regulate various biological functions; CeRNAs are also being explored as potential prognostic and diagnostic biomarkers in lung cancer.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Genetics & Heredity
Liang Cen, Ruochen Liu, Wei Liu, Qianqian Li, Hongjuan Cui
Summary: The ceRNA mechanism plays a crucial role in gliomas, with dysregulated networks leading to abnormal expression of cancer driver genes and the establishment of glioma hallmarks. These findings open up new avenues for understanding gliomas and provide potential new targets for treatment.
FRONTIERS IN GENETICS
(2021)
Article
Neurosciences
Yifei Cai, Ziling Sun, Huizhen Jia, Hongxue Luo, Xiaoyang Ye, Qi Wu, Yi Xiong, Wei Zhang, Jun Wan
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Neurosciences
Jun Mukai, Enrico Cannavo, Gregg W. Crabtree, Ziyi Sun, Anastasia Diamantopoulou, Pratibha Thakur, Chia-Yuan Chang, Yifei Cai, Stavros Lomvardas, Atsushi Takata, Bin Xu, Joseph A. Gogos
Article
Neurosciences
Jing Guo, Yifei Cai, Xiaoyang Ye, Nana Ma, Yuan Wang, Bo Yu, Jun Wan
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Peng Yuan, Mengyang Zhang, Lei Tong, Thomas M. Morse, Robert A. McDougal, Hui Ding, Diane Chan, Yifei Cai, Jaime Grutzendler
Summary: In this study, amyloid-plaque-associated axonal spheroids were identified as prominent contributors to neural network dysfunction in Alzheimer's disease. The study found that the accumulation of endolysosomal vesicles and the growth of spheroids were linked with a potential Alzheimer's-disease-associated risk gene, Pld3. Modulation of endolysosomal biogenesis in neurons could potentially reverse axonal spheroid-induced neural circuit abnormalities in Alzheimer's disease, independent of amyloid removal.