Journal
CHEMELECTROCHEM
Volume 5, Issue 24, Pages 3881-3886Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/celc.201801129
Keywords
organic thin-film transistor; wearable biosensor; non-invasive; printed electronics; healthcare
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Funding
- Center of Innovation Program (COI) from the Japan Science and Technology Agency, JST
- Ministry of Education, Culture, Sports, Science and Technology, Japan [18K04910]
- Grants-in-Aid for Scientific Research [18K04910] Funding Source: KAKEN
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A printed extended-gate-type organic transistor-based enzyme sensor for the continuous monitoring of D-glucose has been developed through a simple modification of the electrical circuit. The sensor is composed of a glucose oxidase (GOx)/ Prussian blue (PB)-modified extended-gate electrode and an Ag/AgCI reference electrode, which are connected to the gate and source electrodes of an organic transistor, respectively. The GOx/PB-modified extended-gate electrode and Ag/AgCl reference electrode were short-circuited by an external resistor to spontaneously induce redox cycling of PB. Continuous monitoring of the source-drain current of the organic transistor for various concentrations of D-glucose was successfully demonstrated in this system. This is the first report of the transistor -based enzyme sensor exhibiting reversible response to the analytes in physiologically buffered solution without the addition of any chemical reagents. This new type of printed organic transistor-based enzyme sensor will greatly contribute to the development of wearable biosensors for non-invasive monitoring of biomarkers in externally secreted bodily fluids such as tears, saliva, and sweat.
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