Review
Biochemistry & Molecular Biology
Irmina Olejniczak-Staruch, Magdalena Ciazynska, Dorota Sobolewska-Sztychny, Joanna Narbutt, Malgorzata Skibinska, Aleksandra Lesiak
Summary: Numerous scientific studies have shown significant skin and gut dysbiosis in patients with psoriasis, with changes in abundance of specific bacterial taxa. Treatments for psoriasis have been found to significantly influence skin and gut microbiome, with orally administered probiotics having a positive impact on the course of the disease. Further research is needed to understand the influence of microbiome on the development of inflammatory skin diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Fernando Ortiz-Marquez, Pablo Cabezudo-Garcia, Claudia Padilla-Leiva, Gisela Diaz-Cordoves Rego, Luis Munoz-Becerra, Teresa Ramirez-Garcia, Jose Manuel Lisbona-Montanez, Sara Manrique-Arija, Arkaitz Mucientes, Esmeralda Nunez-Cuadros, Rocio Galindo Zavala, Pedro Jesus Serrano-Castro, Antonio Fernandez-Nebro
Summary: This study aimed to evaluate cognitive decline in adult patients with juvenile idiopathic arthritis (JIA) and identify associated factors. The results showed that almost one third of the patients experienced cognitive decline after 24 months of follow-up. Average C-reactive protein level, depression, and treatment with biologics were found to be associated with cognitive decline in JIA patients.
Article
Rheumatology
Gustaf Bruze, Johan Askling, AnnaCarin Horne, Martin Neovius
Summary: This study compared the trajectories of marriage and parenthood in individuals with JIA and the general population. The results showed that there was no significant difference between JIA patients and the general population in terms of the timing of first marriage and parenthood, suggesting that adolescents with JIA follow a similar path into family life as their community peers. However, a subgroup of patients with systemic onset JIA had a lower rate of becoming parents for the first time compared to the general population.
Article
Medicine, General & Internal
Barbara Zapala, Tomasz Stefura, Magdalena Wojcik-Pedziwiatr, Radoslaw Kabut, Marta Balajewicz-Nowak, Tomasz Milewicz, Alicja Dudek, Anastazja Stoj, Monika Rudzinska-Bar
Summary: The study compared the gut microbiota composition between patients diagnosed with Parkinson's disease and those treated only with Levodopa to healthy controls, finding that PD patients have significantly different gut microbiota profiles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Junhui Li, Tarini Shankar Ghosh, Rachel McCann, Patrick Mallon, Colin Hill, Lorraine Draper, David Schult, Liam J. Fanning, Robert Shannon, Corinna Sadlier, Mary Horgan, Liam O'Mahony, Paul W. O'Toole
Summary: In this meta-analysis, the association between the gut microbiome and COVID-19 disease severity was investigated. It was found that disease severity was associated with taxonomic and functional microbiome differences, which peaked between 7-30 days after diagnosis and gradually returned to a configuration similar to that of healthy individuals. A core set of species consistently associated with disease severity was identified, and Actinomyces oris abundance was found to predict the mortality rate of COVID-19. Additionally, the composition of intestinal archaeal, fungal, viral, and parasitic communities was associated with disease severity.
Article
Evolutionary Biology
Elin Videvall, Hanna M. Bensch, Anel Engelbrecht, Schalk Cloete, Charlie K. Cornwallis
Summary: Coprophagy, a behavior observed in various species including birds and mammals, involves the consumption of feces. This study investigates the effects of ostrich chicks ingesting adult feces on their gut microbiota development, growth, feeding behavior, pathogen abundance, and mortality. The results show that coprophagy leads to significant changes in the juvenile gut microbiota, promotes growth, alters feeding behavior, reduces a common gut pathogen, and lowers mortality associated with gut disease.
Article
Medicine, General & Internal
Roosa Jokela, Alise J. Ponsero, Evgenia Dikareva, Xiaodong Wei, Kaija-Leena Kolho, Katri Korpela, Willem M. de Vos, Anne Salonen
Summary: This study comprehensively assessed the determinants of the infant gut microbiota composition and analyzed the factors influencing it. The results showed that the DNA extraction batch, delivery mode, defecation frequency, and perinatal factors were among the major factors affecting the variation in the infant gut microbiota. This study is of great importance for a deeper understanding of the formation and development of the infant gut microbiota.
Article
Microbiology
Karen Leth Nielsen, Markus Harboe Olsen, Albert Palleja, Soren Roddik Ebdrup, Nikolaj Sorensen, Oksana Lukjancenko, Rasmus L. Marvig, Kirsten Moller, Niels Frimodt-Moller, Frederik Boetius Hertz
Summary: This study investigated the effects of antibiotics on the gut microbiome and resistome of antibiotic-naive patients during neurointensive care. It was found that narrow-spectrum antibiotic treatment increased microbial richness, while broad-spectrum treatment had diverse effects on different patients. Additionally, post-treatment broad-spectrum treatment resulted in higher abundance of antibiotic resistance genes.
Article
Food Science & Technology
Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Yongai Xiong, Xun Song, Nazim Hussain, Qinchang Zhu, Zhendan He
Summary: This review discusses the roles of microbiota and nanomaterials in cancer therapy, microbiota interventions via nanomaterials, microbial inspiration via nanomaterials, and challenges associated with using nanomaterials in humans and animals. The potential of nanomaterials to alter the cancer-causing microbiome/microbiota and their metabolites, as well as the cancer microenvironment, suggests novel strategies for cancer treatment. Further in vivo clinical trials are needed to determine the exact mechanisms of action in treating cancer with nanomaterials.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Haijian Sun, Yunke Guo, Haidan Wang, Ailing Yin, Jing Hu, Tianjie Yuan, Shuxin Zhou, Weichen Xu, Peng Wei, Shusheng Yin, Panru Liu, Xi Guo, Yizhao Tang, Yujiao Yan, Zichen Luo, Majie Wang, Qingqing Liang, Peng Wu, Aifeng Zhang, Zhuxiu Zhou, Yueyue Chen, Yongming Li, Jing Li, Jinjun Shan, Wei Zhou
Summary: This study found that the food-derived Parabacteroides distasonis can ameliorate the development of rheumatoid arthritis (RA) and is negatively correlated with disease activity in RA patients. In addition, 3-oxoLCA and isoLCA can inhibit the development of RA by stimulating TGR5 and promoting macrophage polarization.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Jakob J. Malin, Christian J. H. von Wintersdorff, John Penders, Paul H. M. Savelkoul, Petra F. G. Wolffs
Summary: This study investigated the longitudinal fluctuations in prevalent antimicrobial resistance genes (ARGs) in non-travelling healthy volunteers and found that the abundance changes of prevalent ARGs were independent of travel behavior.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Nutrition & Dietetics
Ana Fernandes, Ana Oliveira, Raquel Soares, Pedro Barata
Summary: This review examines the impact of ionizing radiation exposure on the gut microbiota, finding associations with reduced diversity and richness, increased abundance of pathogenic bacteria, and decreased beneficial bacteria. Larger population studies are needed to better understand these effects.
Review
Medicine, General & Internal
Yilun Wang, Jie Wei, Weiya Zhang, Michael Doherty, Yuqing Zhang, Haibin Xie, Wei Li, Ning Wang, Guanghua Lei, Chao Zeng
Summary: Dysbiosis in gut microbiota may be associated with the occurrence or development of rheumatic diseases. The review of existing evidence suggests that there is a decrease in alpha-diversity indices in rheumatic diseases, but the specific associations with different rheumatic diseases are inconsistent. Alterations in certain microbial populations in the gut may be related to rheumatic diseases.
Review
Biology
Matthew J. Dalby
Summary: The role of gut microbiota in determining body fatness has received significant attention, but recent attempts to translate findings into humans have been unsuccessful. This review examines the mouse research that initiated this area of study and evaluates whether the results were supported by subsequent human studies.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Rheumatology
Michelle M. A. Kip, Sytze de Roock, Gillian Currie, Deborah A. Marshall, Luiza R. Grazziotin, Marinka Twilt, Rae S. M. Yeung, Susanne M. Benseler, Sebastiaan J. Vastert, Nico Wulffraat, Joost F. Swart, Maarten J. IJzerman
Summary: This study investigates medication prescription patterns in children with JIA, revealing the complexity of pharmacological treatment in terms of the variety of mono- and combination therapies prescribed, significant variation in medication prescriptions between subtypes, most patients receiving multiple treatment lines, and a large number of unique treatment sequences.
Article
Rheumatology
Natalie J. Shiff, Peter Shrader, Colleen K. Correll, Anne Dennos, Thomas Phillips, Timothy Beukelman
Summary: This study describes the trajectories of disease activity scores in patients with Juvenile Arthritis (JIA) over a two-year period. Five distinct trajectories were identified, and their associated baseline characteristics were analyzed.
Article
Rheumatology
Ann-Sophie De Craemer, Torsten Witte, Triana Lobaton Ortega, Anne Hoorens, Martine De Vos, Claude Cuvelier, Sebastiaan J. Vastert, Xenofon Baraliakos, Filip Van den Bosch, Dirk Elewaut
Summary: Serum anti-CD74 IgA is a potentially useful diagnostic biomarker for axSpA, but is not associated with gut inflammation or other disease-specific features.
Article
Immunology
Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer, Albert Garcia-Lopez, Marlot van der Wal, Silvia Fibi-Smetana, Axel Dietschmann, Thomas Sommermann, Tamara Cikovic, Leila Taher, Mark S. Gresnigt, Sebastiaan J. Vastert, Femke van Wijk, Gianni Panagiotou, Daniel Krappmann, Olaf Gross, Christina E. Zielinski
Summary: In this study, it was discovered that human T cells express GSDME, which is associated with durable viability and the release of IL-1 alpha. This property is only present in a subset of human helper type 17 T cells with specificity for Candida albicans, regulated by the T cell-intrinsic NLRP3 inflammasome. The release of IL-1 alpha is mediated by a proteolytic cascade involving caspase-8, caspase-3, and GSDME cleavage, as well as T cell receptor stimulation and calcium-licensed calpain maturation of pro-IL-1 alpha form. This finding expands our understanding of the functional diversity and mechanism of T cells and has implications for antifungal immunity.
Article
Rheumatology
Janneke G. C. Peeters, Arjan Boltjes, Rianne C. Scholman, Stephin J. Vervoort, Paul J. Coffer, Michal Mokry, Sebastiaan J. Vastert, Femke van Wijk, Jorg van Loosdregt
Summary: This study investigates the epigenetic changes in monocytes derived from inflamed joints of JIA patients and reveals the role of the local inflammatory environment in regulating these changes. The activation phenotype of synovial-derived monocytes is found to be regulated on the epigenetic level, with increased expression and epigenetic alterations in IFN signaling-associated genes. Treatment with the JAK inhibitor ruxolitinib transforms the activated enhancer landscape and reduces disease-associated gene expression, thus inhibiting the inflammatory phenotype.
Article
Rheumatology
Emanuela Del Giudice, Sytze de Roock, Sebastiaan J. Vastert, Nico M. Wulffraat, Joost F. Swart, Evert H. P. van Dijkhuizen
Summary: This study aimed to identify factors associated with satisfaction with JIA care reported by patients and parents. The study found that satisfaction was related to factors such as duration of morning stiffness, age at disease onset, disease duration, and patient well-being. For parents, satisfaction was related to disease activity, school problems, and quality of life. These findings highlight the importance of incorporating patient and parent perspectives into shared decision-making to improve the quality of medical care.
Article
Biology
Gerdien Mijnheer, Nila Hendrika Servaas, Jing Yao Leong, Arjan Boltjes, Eric Spierings, Phyllis Chen, Liyun Lai, Alessandra Petrelli, Sebastiaan Vastert, Rob J. de Boer, Salvatore Albani, Aridaman Pandit, Femke van Wijk, Di Chen
Summary: Autoimmune inflammation is characterized by tissue infiltration and expansion of antigen-specific T cells. In this study, the authors used CyTOF analysis and TCR sequencing to investigate the immune cell composition and expansion of specific T cell clones in juvenile idiopathic arthritis (JIA). They found that the infiltrates in different affected joints of the same patient were similar, and dominant T cell clones, including Tregs, persisted over time. These findings suggest the presence of autoantigen-driven expansion of T cell clones in localized autoimmune disease.
Article
Immunology
Milou Ohm, Joeri W. van Straalen, Marieke Zijlstra, Gerrie de Joode-Smink, Anne Jasmijn Sellies, Joost F. Swart, Sebastiaan J. Vastert, Joris M. van Montfrans, Marije Bartels, Annet van Royen-Kerkhof, Joanne G. Wildenbeest, Caroline A. Lindemans, Victorien M. Wolters, Roos A. W. Wennink, Joke H. de Boer, Mirjam J. Knol, Marloes W. Heijstek, Elisabeth A. M. Sanders, Frans M. Verduyn-Lunel, Guy A. M. Berbers, Nico M. Wulffraat, Marc H. A. Jansen
Summary: This study investigated the immunogenicity of the meningococcal serogroup ACWY conjugate vaccine in minors with juvenile idiopathic arthritis (JIA) and inflammatory bowel disease (IBD). The results showed that the concentrations of antibodies for serotypes A and W were lower in patients compared to healthy controls, and patients using anti-TNF therapy had lower immune response. Therefore, an extra booster vaccination should be considered for these patients.
Article
Cell Biology
Enric Mocholi, Laura Russo, Keshav Gopal, Andrew G. Ramstead, Sophia M. Hochrein, Harmjan R. Vos, Geert Geeven, Adeolu O. Adegoke, Anna Hoekstra, Robert M. van Es, Jose Ramos Pittol, Sebastian Vastert, Jared Rutter, Timothy Radstake, Jorg van Loosdregt, Celia Berkers, Michal Mokry, Colin C. Anderson, Ryan M. O'Connell, Martin Vaeth, John Ussher, Boudewijn M. T. Burgering, Paul J. Coffer
Summary: Upon antigen-specific TCR engagement, the generation of extramitochondrial pyruvate is crucial for acetyl-CoA production and subsequent histone acetylation remodeling. PDH-deficient T cells show that PDH-dependent acetyl-CoA production is a rate-limiting step during T cell activation. This study highlights the integration of metabolic and histone-modifying enzymes in CD4+ T cell activation, suggesting a potential therapeutic approach for regulating antigen-driven T cell activation.
Article
Medicine, General & Internal
Harsita Patel, Amalia Sintou, Rasheda A. Chowdhury, Stephen Rothery, Alma Octavia Iacob, Sanjay Prasad, Peter P. Rainer, Federico Martinon-Torres, Vanessa Sancho-Shimizu, Chisato Shimizu, Kirsten Dummer, Adriana H. Tremoulet, Jane C. Burns, Susanne Sattler, Michael Levin
Summary: This study investigated the presence of anticardiac autoantibodies in MIS-C or COVID-19 vaccine-induced myocarditis and found no evidence of antibody binding to cardiac tissue in these conditions. This suggests that the cardiac pathology in MIS-C and vaccine-induced myocarditis is unlikely to be driven by direct anticardiac antibody-mediated mechanisms.
Article
Rheumatology
Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid Bassiri, Edward M. Behrens, Joseph Carcillo, Linda Carl, Winn Chatham, Jeffrey Cohen, Randy Q. Cron, Erik Drewniak, Alexei A. Grom, Lauren A. Henderson, Annacarin Horne, Michael B. Jordan, Kim E. Nichols, Grant Schulert, Sebastiaan Vastert, Erkan Demirkaya, Raphaela Goldbach-Mansky, Fabrizio de Benedetti, Rebecca A. Marsh, Scott W. Canna, HLH MAS Task Force
Summary: Haemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperinflammatory syndromes that can develop in many inflammatory conditions. Early identification and management are crucial to prevent organ failure and mortality. This effort aimed to provide evidence-based guidance to assist clinicians in optimizing decision-making in the early stages of HLH/MAS.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Bita Shakoory, Ashley Geerlinks, Marta Wilejto, Kate Kernan, Melissa Hines, Micol Romano, David Piskin, Angelo Ravelli, Rashmi Sinha, Daniel Aletaha, Carl Allen, Hamid Bassiri, Edward M. Behrens, Joseph Carcillo, Linda Carl, Winn Chatham, Jeffrey I. Cohen, Randy Q. Cron, Erik Drewniak, Alexei A. Grom, Lauren A. Henderson, Annacarin Horne, Michael B. Jordan, Kim E. Nichols, Grant Schulert, Sebastiaan Vastert, Erkan Demirkaya, Raphaela Goldbach-Mansky, Fabrizio de Benedetti, Rebecca A. Marsh, Scott W. Canna
Summary: This study aims to provide evidence-based and consensus-based guidance for clinicians in the early diagnosis, treatment, and monitoring of HLH/MAS. Through research, questionnaires, and expert opinions, 6 overarching statements and 24 specific points to consider were developed, covering various aspects including early recognition, diagnosis, treatment, and monitoring. The involvement of multidisciplinary expertise is crucial for timely intervention and management.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Marco Gattorno, Laura Obici, Inmaculada Calvo Penades, Tilmann Kallinich, Susanne Benseler, Elise Dekker, Jeremy Levy, Fabrizio De Benedetti, Helen Lachmann
Summary: This study assessed the efficacy, safety, and tolerability of canakinumab in TRAPS patients during a 72-week long-term, open-label extension. The results showed that long-term canakinumab treatment effectively controlled disease activity and reduced flare incidence in TRAPS patients. No new safety concerns were identified.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Remco G. A. Erkens, Jorg J. A. Calis, Anouk Verwoerd, Sytze De Roock, Nienke M. Ter Haar, Gerda Den Engelsman, Lars T. van der Veken, Robert F. Ernst, Hanneke W. M. Van Deutekom, Alex Pickering, Rianne C. Scholman, Marc H. A. Jansen, Joost F. Swart, Rashmi Sinha, Johannes Roth, Grant S. Schulert, Alexei A. Grom, Jorg Van Loosdregt, Sebastiaan J. Vastert
Summary: Using anakinra as first-line treatment in new-onset sJIA patients resulted in high rates of clinical inactive disease, regardless of HLA-DRB1 or IL1RN variants. Early initiation of biologic therapy may be more appropriate for patients with different genetic susceptibility backgrounds.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Fabrizio De Benedetti, Alexei A. Grom, Paul A. Brogan, Claudia Bracaglia, Manuela Pardeo, Giulia Marucci, Despina Eleftheriou, Charalampia Papadopoulou, Grant S. Schulert, Pierre Quartier, Jordi Anton, Christian Laveille, Rikke Frederiksen, Veronica Asnaghi, Maria Ballabio, Philippe Jacqmin, Cristina de Min
Summary: The objective of this study was to confirm the adequacy of an emapalumab dosing regimen in relation to interferon-γ (IFN-γ) activity and assess its efficacy and safety in treating MAS secondary to sJIA or AOSD. The results showed that emapalumab was efficacious in inducing remission of MAS and viral infections were observed.
ANNALS OF THE RHEUMATIC DISEASES
(2023)