Calcium-sensing receptor: evidence and hypothesis for its role in nephrolithiasis

Calcium-sensing receptor gene polymorphism (rs7652589) is associated with calcium nephrolithiasis in the population of Yi nationality in Southwestern China

(2018) Hao Li et al.   ANNALS OF HUMAN GENETICS

Claudins: a tale of interactions in the thick ascending limb

(2018) Eric Olinger et al.   KIDNEY INTERNATIONAL

Calcium receptor signaling and citrate transport

(2018) Ryan W. Walker et al.   Urolithiasis

Multiplex epithelium dysfunction due to CLDN10 mutation: the HELIX syndrome

(2017) Smail Hadj-Rabia et al.   GENETICS IN MEDICINE

Inhibition of osteo/chondrogenic transformation of vascular smooth muscle cells by MgCl2 via calcium-sensing receptor

(2017) Ioana Alesutan et al.   JOURNAL OF HYPERTENSION

A Novel Hypokalemic-Alkalotic Salt-Losing Tubulopathy in Patients withCLDN10Mutations

(2017) Ernie M.H.F. Bongers et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Parathyroid hormone controls paracellular Ca2+transport in the thick ascending limb by regulating the tight-junction protein Claudin14

(2017) Tadatoshi Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Calcium Absorption among Hypercalciuric Patients with or without Calcium Kidney Stones

(2016) G. Vezzoli et al.   Clinical Journal of the American Society of Nephrology

Genetic variants in the promoter region of the calcium-sensing receptor gene are associated with its down-regulation in neuroblastic tumors

(2016) Laia Masvidal et al.   MOLECULAR CARCINOGENESIS

Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+and Mg2+transport

(2016) Susanne Milatz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histological aspects of the “fixed-particle” model of stone formation: animal studies

(2016) Saeed R. Khan   Urolithiasis

What is nephrocalcinosis?

(2015) Linda Shavit et al.   KIDNEY INTERNATIONAL

Polymorphisms in CaSR and CLDN14 Genes Associated with Increased Risk of Kidney Stone Disease in Patients from the Eastern Part of India

(2015) Manalee Guha et al.   PLoS One

Common and rare variants associated with kidney stones and biochemical traits

(2015) Asmundur Oddsson et al.   Nature Communications

pH-sensitive expression of calcium-sensing receptor (CaSR) in type-B intercalated cells of the cortical collecting ducts (CCD) in mouse kidney

(2014) Yukiko Yasuoka et al.   Clinical and Experimental Nephrology

The role of the calcium-sensing receptor in disorders of abnormal calcium handling and cardiovascular disease

(2014) Hakan R. Toka et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Risk of nephrolithiasis in primary hyperparathyroidism is associated with two polymorphisms of the calcium-sensing receptor gene

(2014) Giuseppe Vezzoli et al.   JOURNAL OF NEPHROLOGY

Mechanisms of human kidney stone formation

(2014) Andrew P. Evan et al.   Urolithiasis

Stimulation of calcium-sensing receptor increases biochemical H+-ATPase activity in mouse cortex and outer medullary regions

(2013) Fernando Casare et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Calcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action

(2013) Lucie Hénaut et al.   CARDIOVASCULAR RESEARCH

History of Kidney Stones and the Risk of Coronary Heart Disease

(2013) Pietro Manuel Ferraro et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Decreased Transcriptional Activity ofCalcium-sensing receptorGene Promoter 1 Is Associated With Calcium Nephrolithiasis

(2013) Giuseppe Vezzoli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Claudin-14 Underlies Ca++-Sensing Receptor-Mediated Ca++ Metabolism via NFAT-microRNA-Based Mechanisms

(2013) Y. Gong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule

(2013) Giovambattista Capasso et al.   KIDNEY INTERNATIONAL

Excessive Signal Transduction of Gain-of-Function Variants of the Calcium-Sensing Receptor (CaSR) Are Associated with Increased ER to Cytosol Calcium Gradient

(2013) Marianna Ranieri et al.   PLoS One

Calcium-sensing receptor gene polymorphisms in patients with calcium nephrolithiasis

(2012) Giuseppe Vezzoli et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Claudin-14 regulates renal Ca++transport in response to CaSR signalling via a novel microRNA pathway

(2012) Yongfeng Gong et al.   EMBO JOURNAL

Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone-Independent Hypocalciuria

(2012) H. R. Toka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deletion of claudin-10 (Cldn10) in the thick ascending limb impairs paracellular sodium permeability and leads to hypermagnesemia and nephrocalcinosis

(2012) T. Breiderhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Calcium-Sensing Receptor Beyond Extracellular Calcium Homeostasis: Conception, Development, Adult Physiology, and Disease

(2011) Daniela Riccardi et al.   Annual Review of Physiology

Sodium Reabsorption in the Thick Ascending Limb in Relation to Blood Pressure

(2011) Jeesun Jung et al.   HYPERTENSION

Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude

(2011) M. P. Grant et al.   Science Signaling

Effect of Calcium and the Calcimimetic AMG 641 on Matrix-Gla Protein in Vascular Smooth Muscle Cells

(2010) Francisco J. Mendoza et al.   CALCIFIED TISSUE INTERNATIONAL

Polymorphisms at the regulatory regions of the CASR gene influence stone risk in primary hyperparathyroidism

(2010) Giuseppe Vezzoli et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels

(2010) Conall M. O'Seaghdha et al.   HUMAN MOLECULAR GENETICS

Common Genetic Variants Associate with Serum Phosphorus Concentration

(2010) B. Kestenbaum et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region

(2010) G. Vezzoli et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Nephrolithiasis is associated with an increased prevalence of cardiovascular disease

(2010) F. Domingos et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Association between calcium-sensing receptor gene polymorphisms and recurrent calcium kidney stone disease: A comprehensive gene analysis

(2010) Nasser Shakhssalim et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

Genome-Wide Meta-Analysis for Serum Calcium Identifies Significantly Associated SNPs near the Calcium-Sensing Receptor (CASR) Gene

(2010) Karen Kapur et al.   PLoS Genetics

Heterogeneous Disease Modeling for Hardy-Weinberg Disequilibrium in Case-Control Studies: Application to Renal Stones and Calcium-Sensing Receptor Polymorphisms

(2009) D. C. Hamilton et al.   ANNALS OF HUMAN GENETICS

Roles of Calcium-Sensing Receptor (CaSR) in Renal Mineral Ion Transport

(2009) Giuseppe Vezzoli et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Calcium-Sensing Receptor Promotes Urinary Acidification to Prevent Nephrolithiasis

(2009) K. Y. Renkema et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells

(2008) Masih-ul Alam et al.   CARDIOVASCULAR RESEARCH

Thick ascending limb: the Na+:K+:2Cl− co-transporter, NKCC2, and the calcium-sensing receptor, CaSR

(2008) Gerardo Gamba et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of a polyvalent cation-sensing receptor decreases magnesium transport via claudin-16

(2007) Akira Ikari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Calcium-sensing Receptor Attenuates AVP-induced Aquaporin-2 Expression via a Calmodulin-dependent Mechanism

(2007) M. Bustamante et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY