Article
Parasitology
Joseneide Viana de Almeida, Cristian Ferreira de Souza, Andressa Alencastre Fuzari, Christie A. Joya, Hugo O. Valdivia, Daniella Castanheira Bartholomeu, Reginaldo Pecanha Brazil
Summary: This study conducted in the State of Roraima, Brazil, provides insights into the diversity of Leishmania species circulating in the region, identifying nine different species. The findings pave the way for further research on leishmaniasis transmission, vector and reservoir surveillance, and intensified investigation and control activities against CL in the northernmost Brazilian State.
PARASITES & VECTORS
(2021)
Article
Microbiology
Nirmitha Lalindi De Silva, Viraji Nefertiti Hiromel De Silva, Arachchige Theja Hemapala Deerasinghe, Upeksha Lakmini Rathnapala, Makoto Itoh, Hidekazu Takagi, Mirani Vasanthamala Weerasooriya, Hirotomo Kato, Thishan Channa Yahathugoda
Summary: The recent surge in cutaneous leishmaniasis in Sri Lanka has made clinical diagnosis difficult, highlighting the importance of laboratory confirmation. A modified PCR-RFLP method has been developed, showing higher sensitivity and accuracy in detecting parasite DNA compared to traditional methods like microscopic examination.
Article
Environmental Sciences
Tahereh Davoodi, Ali Khamesipour, Saeed Shahabi, Fatemeh Gholizadeh, Daniel Pourkamal, Gholamreza Hatam
Summary: This study investigated the molecular identification and geographical distribution of anthroponotic and zoonotic cutaneous leishmaniasis in southern Iran, revealing that ACL was only detected in Shiraz city, while ZCL was observed in both Shiraz and most counties of Fars Province. Additionally, the district 8 of Shiraz municipality showed the highest number of CL infections, suggesting the need for further attention.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Microbiology
Romain Blaizot, Stephane Simon, Marine Ginouves, Ghislaine Prevot, Denis Blanchet, Christophe Ravel, Pierre Couppie, Magalie Demar, Cecile Nabet
Summary: Recent studies have shown that a new noninvasive sampling and real-time PCR method for Leishmania detection in South America is highly sensitive and accurate, making it suitable for species identification and diagnosis of cutaneous leishmaniasis.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Valdir Sabbaga Amato, Regina Maia de Souza, Lucas Augusto Moyses Franco, Roberta Cristina Ruedas Martins, Camila Alves Maia da Silva, Christini Takemi Emori, Beatriz Julieta Celeste, Gabriel Victor Castanheira, Felipe Francisco Tuon
Summary: We present a case of cutaneous leishmaniasis with atypical clinical symptoms in a patient receiving methotrexate treatment for rheumatoid arthritis, showing cutaneous manifestations and parasite recovery in blood using next-generation sequencing.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Immunology
Srija Moulik, Shilpa Sengupta, Mitali Chatterjee
Summary: With the consolidation phase of the Visceral Leishmaniasis/Kala-azar Elimination Program in South Asia, the focus is on case detection, vector control, and identifying potential sources of infection to curb transmission. Post Kala-azar Dermal Leishmaniasis (PKDL) cases are considered potential disease reservoirs, and immunological tests are gradually replacing tissue aspirates for diagnosis of VL.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Arezki Izri, Amina Bendjaballah-Laliam, Denis Sereno, Mohammad Akhoundi
Summary: This study investigated the geographical distribution of Leishmania spp. causing cutaneous affection in Algeria, identifying L. major as the most common parasite among patients. Utilizing microscopy, PCR, and PCR-RFLP techniques, the presence of multiple Leishmania species was confirmed, providing additional insights into the epidemiology of cutaneous leishmaniasis in Algeria.
Article
Microbiology
Ana Victoria Ibarra-Meneses, Carmen Chicharro, Carmen Sanchez, Emilia Garcia, Sheila Ortega, Joseph Mathu Ndung'u, Javier Moreno, Israel Cruz, Eugenia Carrillo
Summary: Loop-mediated isothermal amplification allows rapid, sensitive, and specific amplification of DNA without complex equipment, displaying high sensitivity and specificity in the diagnosis of cutaneous and visceral leishmaniasis caused by L. infantum. Loopamp shows comparable performance to conventional and real-time PCR, with excellent concordance and correlation between Tp and Ct. Further investigation is needed to determine the accuracy of Loopamp in quantifying parasite load in tissues.
Article
Parasitology
Nargis Shaheen, Chaitenya Verma, Thalia Pacheco-Fernandez, Greta Volpedo, Aneeqa Hamid, Ismail Zeb, Syed Aizaz Ali Shah, Shah Fahad, Attiya Iqbal, Asma Ashraf, Amjad Khan, Misbah Gul, Muhammad Ilyas Khan, Huma Fatima, Muhammad Afzal, Abhay R. Satoskar, Naveeda Akhter Qureshi
Summary: This study aimed to elucidate the molecular characterization and genetic diversity of Leishmania spp. in North Eastern Pakistan. The findings confirmed the presence of Leishmania tropica, Leishmania major, and Leishmania infantum, with Leishmania tropica showing significantly higher nucleotide variation. Recommendations for more extensive investigations to understand the molecular epidemiology of Leishmania in the region were made.
Article
Polymer Science
Pietro Chiarantoni, Cristian Micheletti
Summary: Molecular dynamics simulations were used to investigate the properties of poly[n]catenanes, revealing that stiffer rings result in more extended and flexible backbones. The internal dynamics of catenanes also slow down with increasing rigidity. Furthermore, it was found that catenanes with rigid rings hinder each other's motion more and have smaller diffusion coefficients in crowded solutions.
Article
Polymer Science
Josh Ragotskie, Nathaniel Morrison, Christopher Stackhouse, Ryan C. Blair, Alexander R. Klotz
Summary: We used graph theory simulations and single molecule experiments to investigate the percolation properties of kinetoplasts, which are the topologically linked mitochondrial DNA from trypanosome parasites. It was found that the largest component after the network de-percolates is a remnant of the edge loop, before undergoing a second percolation transition and breaking apart. This suggests that removing minicircles from kinetoplast DNA could isolate large polycatenanes for future experiments.
JOURNAL OF POLYMER SCIENCE
(2023)
Review
Microbiology
Simona Amodeo, Irina Bregy, Torsten Ochsenreiter
Summary: This article summarizes the diversity of mitochondrial DNA replication and proposes a new replication model using Trypanosoma brucei as an example, providing a mechanism for the maintenance of mitochondrial genetic diversity.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Parasitology
Taiebeh Karimi, Iraj Sharifi, Mohammad Reza Aflatoonian, Behnaz Aflatoonian, Mohammad Ali Mohammadi, Ehsan Salarkia, Zahra Babaei, Farzaneh Zarinkar, Fatemeh Sharifi, Nima Hatami, Ahmad Khosravi, Arsalan Eskandari, Elyas Solimani, Mehdi Shafiee, Masoumeh Mozaffari, Amireh Heshmatkhah, Rezvan Amiri, Saeideh Farajzadeh, Alireza Kyhani, Abbas Aghaei Afshar, Abdollah Jafarzadeh, Mehdi Bamorovat
Summary: The study on a long-lasting epidemic of anthroponotic cutaneous leishmaniasis in peri-urban areas of Kerman city between 2005 and 2019 revealed a significant increase in cases from 2005 to 2016, followed by a gradual decline. The risk of contracting the disease in peri-urban areas was 7.6 times higher compared to the city of Kerman. The causative agent, Leishmania tropica, is transmitted primarily by female Phlebotomus sergenti sandflies from person to person.
PARASITES & VECTORS
(2021)
Article
Public, Environmental & Occupational Health
Aracelis del C. Miranda, Kadir A. Gonzalez, Franklyn Samudio, Vanessa J. Pineda, Jose E. Calzada, Zeuz Capitan-Barrios, Ana Jimenez, Juan Castillo, Yaxelis Mendoza, Jose A. Suarez, Betsi Ortiz, Juan Mendez, Juan M. Pascale, Max Grogl, Nestor Sosa, Azael Saldana
Summary: The predominant species causing cutaneous leishmaniasis in Panama is Leishmania (Viannia) panamensis, with other species circulating to a lesser degree. The presence of genetic variants and hybrid isolates suggests implications for the epidemiology and clinical follow-up of cutaneous leishmaniasis in Panama. No evidence of parasites from the Leishmania (Leishmania) mexicana complex was found in this study in Panama.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Multidisciplinary Sciences
Hasara Nuwangi, Thilini Chanchala Agampodi, Helen Philippa Price, Thomas Shepherd, Kosala Gayan Weerakoon, Suneth Buddhika Agampodi
Summary: Leishmaniasis has three main types: cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). CL and MCL can cause disfiguring skin pathology and are highly stigmatizing. This systematic review aims to identify and synthesize evidence on the stigma associated with CL and MCL, as well as any preventive strategies/interventions adopted to address this condition. The review will help fill the knowledge gap in CL-associated stigma and inform future interventions.
Article
Chemistry, Organic
Nargis Sultana, Muhammad Sarfraz, Sidra Akram, Umer Rashid, Syed Ali Raza Naqvi, Muhammad I. Tariq, Khalid Mahmood Zia, Muhammad Ramzan Saeed Ashraf Janjua
Summary: By using density functional theory (DFT) calculations, we investigated the reactivity of synthesized quinazolinone towards bromination and nitration. The results showed a good agreement with experimental data, with a correlation above 90%. The optimized molecular geometries were compared with X-ray structures, and the nucleophilic site was determined through computational analysis.
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mohammed A. Huneif, Mater H. Mahnashi, Muhammad Saeed Jan, Muhammad Shah, Sultan A. Almedhesh, Seham M. Alqahtani, Mohammad Jamaan Alzahrani, Muhammad Ayaz, Farhat Ullah, Umer Rashid, Abdul Sadiq
Summary: Diabetes mellitus (DM) is a metabolic disorder resulting from pancreatic dysfunction, characterized by reduced insulin production or insulin resistance. In this study, we designed and synthesized new succinimide-thiazolidinedione hybrids for the treatment of DM. We successfully synthesized five new derivatives (10a-e) with different substitution patterns on the N-atom of the succinimide ring. Compound 10d showed the most potential as an antidiabetic agent in in vitro assays. Further investigations in experimental animals confirmed its promising antidiabetic activity. Molecular docking studies also demonstrated the interaction of compound 10d with target enzymes involved in diabetes. Overall, we have identified a new class of compounds with potential as antidiabetic agents.
Article
Multidisciplinary Sciences
Umer Rashid, Maha Saddal, Ghazanfar Farooq, Muazzam Ali Khan, Naveed Ahmad
Summary: Nowadays, with the exponential growth of online production and extensive perceptual power of visual contents, users' information needs have become complicated. Research has shown that users have a keen interest in accessing image objects to satisfy their visual information needs. However, existing search engines hinder image exploration due to linear lists or grid layouts that sort image results by relevancy. This research proposes a Search User Interface (SUI) approach to enable non-linear reachability of image results by offering interactive exploration and visualization options, resulting in high satisfaction (76.83%) and usability (83.73%) scores according to usability tests.
Article
Chemistry, Multidisciplinary
Muhammad Imran Qayyum, Sami Ullah, Obaidullah, Umer Rashid, Mater H. Mahnashi, Mohammed Merae Alshahrani, Amer Al Ali, Abdulaziz Asiri, Ahmed Abdullah Al Awadh, Osama M. Alshehri, Abdul Sadiq
Summary: In this study, a newly synthesized compound (Succ-5) was analyzed through spectral methods and molecular docking. It was pre-clinically evaluated for therapeutic effects and safety profile. The results showed that Succ-5 had significant cardioprotective, hepatoprotective, and lipolytic effects in 5-FU-induced toxicity.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Bushra Ansari, Haroon Khan, Muhammad Saeed Jan, Khalaf F. Alsharif, Khalid J. Alzahrani, Umer Rashid, Abdul Saboor Pirzada
Summary: Various derivatives of thiazolidine-2,4-dione (C1-C5) were synthesized through chemical reaction and modification, and their chemical structures were determined by NMR spectroscopy. In silico ADME studies revealed the pharmacokinetic properties of the compounds, including rotatable bonds, lipophilicity, water solubility, GI absorption, blood-brain barrier permeability, and drug metabolism. The study also evaluated the drug likeness properties of the derivatives. The results suggest that these compounds have potential for improving pharmacokinetic profiles and reducing toxicity.
JOURNAL OF CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Muhammad Aamir Javed, Muhammad Saeed Jan, Abdullah M. Shbeer, Mohammed Al-Ghorbani, Abdur Rauf, Polrat Wilairatana, Abdul Mannan, Abdul Sadiq, Umar Farooq, Umer Rashid
Summary: Alzheimer's disease is a complex and multifactorial neurodegenerative ailment. This study applied a multitarget strategy to tackle the multifactorial nature of the disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Aneela Gohar, Gowhar Ali, Umer Rashid, Khalid Rauf, Mehreen Arif, Muhammad Sona Khan, Yasser M. S. A. Alkahramaan, Robert D. E. Sewell
Summary: This study evaluated the effects of GBP1F, a complex of fluoxetine and gabapentin, on locomotor activity, anxiety, depression-like behavior, and cognitive behavior in mice. The results showed that GBP1F mildly suppressed locomotor activity, improved anxiety and depression-like behavior, had no effect on cognitive behavior, and increased serotonin and 5-HIAA concentrations in the hippocampus and striatum, as well as dopamine and vitamin C levels in the striatum. Thus, GBP1F has anxiolytic and antidepressant-like effects, but further studies are needed to investigate its precise mechanism of action.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Engineering, Chemical
Abdur Rauf, Umer Rashid, Zafar Ali Shah, Gauhar Rehman, Kashif Bashir, Johar Jamil, Iftikhar, Abdur Rahman, Abdulrahman Alsahammari, Metab Alharbi, Abdulmajeed Al-Shahrani, Giovanni Ribaudo
Summary: This study aimed to investigate the anti-inflammatory and anti-diabetic effects of ferruginan, a compound isolated from Olea ferruginea. The results showed that ferruginan exhibited promising anti-inflammatory activity and increased glucose uptake in yeast cells, indicating its potential anti-inflammatory and anti-diabetic properties.
Article
Chemistry, Medicinal
Muhammad Shah, Muhammad Saeed Jan, Abdul Sadiq, Sara Khan, Umer Rashid
Summary: Metabolic disorders like Diabetes mellitus (DM) can be treated by targeting abnormally expressed key enzymes. A vanillin-thiazolidine-2,4-dione hybrid compound was reported as a multitarget inhibitor, but only showed good in-vitro DPP-4 inhibition. Current research aims to optimize this lead compound for diabetes treatment by manipulating multiple pathways simultaneously.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Hasnain Mehmood, Tashfeen Akhtar, Muhammad Haroon, Muhammad Shah, Umer Rashid, Simon Woodward
Summary: In search of alternative solutions to diabetes and its complications, this study examined the antidiabetic potential of hydrazinylthiazole carboxylates. Compounds 3e and 3h showed excellent antidiabetic properties, with significant inhibition of a-amylase and glycation.
FUTURE MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Qarib Ullah, Zarshad Ali, Umer Rashid, Gowhar Ali, Nisar Ahmad, Rasool Khan, Sami Ullah, Muhammad Ayaz, H. C. Ananda Murthy
Summary: This study evaluated a novel indazolone derivative for its activity against pain, neuropathy, and inflammation. The results showed that the derivative exhibited significant inhibitory effects on nociception and inflammation, suggesting its potential as a therapeutic agent for the treatment of pyrexia, chemotherapy-induced neuropathic pain, and nociceptive inflammatory pain in the future.
Article
Medicine, General & Internal
Qaisar Abbas, Yassine Daadaa, Umer Rashid, Mostafa E. A. Ibrahim
Summary: This paper presents the development of a dermatologist-like automatic classification system using a separable vision transformer (SVT) technique to recognize nine different classes of pigmented skin lesions (PSLs) and assist in early skin cancer detection.
Article
Computer Science, Artificial Intelligence
Umer Rashid, Maha Saddal, Abdur Rehman Khan, Sadia Manzoor, Naveed Ahmad
Summary: This research focuses on exploring web image search results from a multidimensional perspective and uncovers usability issues with traditional grid layouts. By using cubic graphs to visualize search results and incorporating textual annotations and descriptions for deep browsing, this study provides a nonlinear browsing approach. Usability tests and statistical analysis confirm the effectiveness of cubic presentation, enhancing overall user satisfaction and system capabilities.
PEERJ COMPUTER SCIENCE
(2023)
Article
Mathematical & Computational Biology
Muhammad Hassan Jamal, Muazzam A. Khan, Safi Ullah, Mohammed S. Alshehri, Sultan Almakdi, Umer Rashid, Abdulwahab Alazeb, Jawad Ahmad
Summary: In recent years, there have been numerous high-impact attacks on industrial networks. To address these threats, security systems have been implemented, but they only respond after the attacks have occurred and do not actively prevent them. Identifying malicious attacks is crucial for industrial networks as they can cause system malfunctions, network disruptions, data corruption, and sensitive information theft. This study proposes a hybrid model that combines convolutional neural networks (CNN) and deep belief networks (DBN) for intrusion detection in industrial networks, utilizing the MSCAD dataset and various evaluation metrics to test its effectiveness.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Haleema Ali, Rasool Khan, Xiandao Pan, Farzana Shaheen, Almas Jabeen, Abdur Rauf, Muhammad Shah, Umer Rashid, Yahya S. Al-Awthan, Omar S. Bahattab, Mohammed A. Al-Duais, Mohammad S. Mubarak
Summary: A series of novel tetrahydro-2H-1,3,5-thiadiazine-2-thiones compounds were synthesized and characterized. The compounds showed promising anticancer activity against HeLa cell line, especially compounds 3, 5, 6, and 9 with IC50 values <4 μM. The compounds also exhibited potent anti-inflammatory potential by inhibiting nitric oxide (NO). Docking studies revealed strong interactions between the compounds and inducible NO synthase enzyme, supporting the in vitro results. These compounds could serve as potential candidates for the development of anticancer drugs.
GREEN PROCESSING AND SYNTHESIS
(2023)
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.
