Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Dabao Yao, Shuo Zhang, Zhengwei Hu, Haiyang Luo, Chengyuan Mao, Yu Fan, Mibo Tang, Fen Liu, Si Shen, Liyuan Fan, Mengjie Li, Jingjing Shi, Jiadi Li, Dongrui Ma, Yuming Xu, Changhe Shi
Summary: The study showed that overexpression of CHIP may exert neuroprotective effects by attenuating necroptosis and inflammation during CIR injury.
Article
Immunology
Yahong Fu, Junxian Gao, Yanqing Li, Xi Yang, Yun Zhang
Summary: This study demonstrates the significant role of tripartite motif-containing protein 21 (TRIM21) in cerebral ischemia/reperfusion injury. Inhibition of TRIM21 can alleviate the damage to neurons caused by oxygen-glucose deprivation/reoxygenation (OGD/R). This protective effect may be achieved by regulating the Keap1/Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Letter
Neurosciences
Shitao Lv, Haiyan Yang, Pengcheng Jing, Haiying Song
Summary: Alpha-tocopherol has shown antioxidant, anti-inflammatory, and anti-apoptotic abilities in rat brain tissue, mitigating nerve damage caused by cerebral ischemia-reperfusion injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, Research & Experimental
Li Yu, Yangyang Zhang, Qianqian Chen, Yu He, Huifen Zhou, Haitong Wan, Jiehong Yang
Summary: Formononetin has anti-inflammatory effects and may exert a protective effect against cerebral ischemia-reperfusion injury by inhibiting relevant targets in the JAK2/STAT3 signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Sheung-Fat Ko, Pei Hsun Sung, Chih Chao Yang, John Y. Chiang, Hon Kan Yip
Summary: This study aimed to investigate whether combined dapagliflozin and entresto treatment is more effective than individual treatments in preserving left-ventricular ejection fraction (LVEF) after ischemia-reperfusion (IR) injury in rats. The results showed that treatment with sacubitril/valsartan and dapagliflozin reversed the increased levels of reactive oxygen species, mitochondrial permeability transition pore, and oxidative-stress/DNA-damaged markers in H9C2 cells exposed to hydrogen peroxide. Additionally, the expression of antioxidants exhibited an opposite trend.
BIOMEDICAL JOURNAL
(2023)
Article
Immunology
Ji-Bing He, Xin-Yi Ma, Wen-Jie Li, Ying-Ying Liu, Ding-Sheng Lin
Summary: The study showed that Exenatide can increase the survival area of random skin flaps, improve microvascular density and blood flow intensity, up-regulate SOD level, down-regulate MDA level, enhance VEGF expression, reduce expression of inflammatory cytokines, promote angiogenesis, and inhibit inflammation in a rat model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Kang Huo, Jing Xu, Meng Wei, Kaige Ma, Jianyi Wang, Jianfeng Han
Summary: Solasonine exhibits neuroprotective effects on cerebral ischemia/reperfusion injury by reducing inflammatory responses, oxidative stress, and neuronal apoptosis, and improving neurological function and neuronal damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Ying Li, Min Gong
Summary: The treatment of cerebral ischemia-reperfusion injury remains a challenge, with GLP-1 receptor agonist Liraglutide showing promising effects in alleviating this type of injury. This study aimed to clarify the physiological protection role of Liraglutide in MCAO mice, revealing that it significantly reduced infarct volume and induced various effects on protein expression levels and phosphorylation. These findings contribute to identifying novel therapeutic targets for ischemia-reperfusion injury.
BRAIN AND BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Qianghua Yuan, Yan Yuan, Yan Zheng, Rong Sheng, Li Liu, Fan Xie, Jing Tan
Summary: Cerebral ischemia-reperfusion injury can lead to serious brain diseases and polysaccharides may be a potential treatment. Research shows that polysaccharides can improve neural damage through various mechanisms such as anti-oxidation and anti-inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoli Min, Linping Zhao, Ying Shi, Jian Wang, Hongling Lv, Xiaoxiao Song, Qunyuan Zhao, Qing Zhao, Rui Jing, Jiayi Hu
Summary: This study investigates the role of Gomisin J in cerebral ischemia-reperfusion injury and finds that it has anti-apoptotic, antioxidant, and anti-inflammatory effects, reducing the severity of the injury.
Article
Neurosciences
Wenjing Lv, Junqi Jiang, Yi Xu, Zhiyuan Chen, Zixuan Wang, Ang Xing, Xueping Zheng, Tingting Qu, Qi Wan
Summary: By using a comprehensive analysis approach, including DEG analysis, WGCNA, and pathway analysis, the genetic transcription profile of brain ischemic and reperfusion injury was studied. It was found that there were 58 upregulated DEGs and some validated core genes associated with stroke in mouse and rat models. Factors such as ischemic treatment and reperfusion time were important confounding factors in gene profile changes. Additionally, modules related to reperfusion time, inflammation, and thrombo-inflammation were identified, and core hub genes within these modules were identified as well. Overall, these findings expand our understanding of the genetic profile involved in brain ischemia and reperfusion, emphasizing the crucial role of inflammatory disequilibrium.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Fengguang Li, Yan Xu, Xing Li, Xinghua Wang, Zhigang Yang, Wanli Li, Wei Cheng, Gangli Yan
Summary: The study demonstrated the therapeutic effect of NC in a rat model of cerebral ischemia/reperfusion injury by reducing NF-kappa B-p65 protein and inflammatory cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Immunology
Yunong Li, Jiaolin Zheng, Yanmei Zhu, Youyang Qu, Rui Suo, Yulan Zhu
Summary: Methylcobalamin demonstrates neuroprotective effects on cerebral ischemic injury by increasing cell viability and autophagy, reducing inflammation and apoptosis, and activating the ERK1/2 pathway. Its potential as a novel neuroprotective therapy for ischemic stroke is promising.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)